Hans I-Chen Harn, PhD

Hans Harn’s research focuses on mechanobiology, regenerative medicine, and wound healing. He has extensively studied tissue mechanics in skin development and regeneration, including wound-induced hair follicle neogenesis and the self-organization of skin organoids. His work has contributed to understanding the role of mechanical forces in tissue regeneration and the development of bioinspired strategies for wound healing.

• Author Correction: Conserved regulatory switches for the transition from natal down to juvenile feather in birds Nat Commun. 2024 Jun 25; 15(1):5367. . View in PubMed
• Conserved regulatory switches for the transition from natal down to juvenile feather in birds Nat Commun. 2024 May 16; 15(1):4174. . View in PubMed
• Histone Trimethylations and HDAC5 Regulate Spheroid Subpopulation and Differentiation Signaling of Human Adipose-Derived Stem Cells Stem Cells Transl Med. 2024 Mar 15; 13(3):293-308. . View in PubMed
• Epidermal-dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures NPJ Regen Med. 2023 Nov 23; 8(1):65. . View in PubMed
• Transition from natal downs to juvenile feathers: conserved regulatory switches in Neoaves Res Sq. 2023 Oct 03. . View in PubMed
• The mechano-chemical circuit drives skin organoid self-organization Proc Natl Acad Sci U S A. 2023 09 05; 120(36):e2221982120. . View in PubMed
• Bioinspired Strategies for Wound Regeneration Cold Spring Harb Perspect Biol. 2023 07 05; 15(7). . View in PubMed
• Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis Sci Transl Med. 2023 03 22; 15(688):eabq2395. . View in PubMed
• Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis Pharmaceutics. 2022 Sep 12; 14(9). . View in PubMed
• Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice Nat Commun. 2021 05 10; 12(1):2595. . View in PubMed
• Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging Front Cell Dev Biol. 2021; 9:635340. . View in PubMed
• Self-assembly of biological networks via adaptive patterning revealed by avian intradermal muscle network formation Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10858-10867. . View in PubMed
• The tension biology of wound healing Exp Dermatol. 2019 04; 28(4):464-471. . View in PubMed
• Comparative regenerative biology of spiny (Acomys cahirinus) and laboratory (Mus musculus) mouse skin Exp Dermatol. 2019 04; 28(4):442-449. . View in PubMed
• Turing patterning with and without a global wave PLoS Biol. 2019 03; 17(3):e3000195. . View in PubMed
• Mechanical forces in skin disorders J Dermatol Sci. 2018 Jun; 90(3):232-240. . View in PubMed
• Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts J Invest Dermatol. 2018 01; 138(1):208-218. . View in PubMed
• Vibrio vulnificus MARTX cytotoxin causes inactivation of phagocytosis-related signaling molecules in macrophages J Biomed Sci. 2017 Aug 19; 24(1):58. . View in PubMed
• Revealing the three dimensional architecture of focal adhesion components to explain Ca2+-mediated turnover of focal adhesions Biochim Biophys Acta Gen Subj. 2017 Mar; 1861(3):624-635. . View in PubMed
• Spatial distribution of filament elasticity determines the migratory behaviors of a cell Cell Adh Migr. 2016 07 03; 10(4):368-77. . View in PubMed
• Mechanosensitive store-operated calcium entry regulates the formation of cell polarity J Cell Physiol. 2015 09; 230(9):2086-97. . View in PubMed
• Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing Oncotarget. 2015 Aug 28; 6(25):20946-58. . View in PubMed
• Mechanical coupling of cytoskeletal elasticity and force generation is crucial for understanding the migrating nature of keloid fibroblasts Exp Dermatol. 2015 Aug; 24(8):579-84. . View in PubMed
• A nanopatterned cell-seeded cardiac patch prevents electro-uncoupling and improves the therapeutic efficacy of cardiac repair Biomater Sci. 2014 Mar 04; 2(4):567-80. . View in PubMed
• Enhancement of renal epithelial cell functions through microfluidic-based coculture with adipose-derived stem cells Tissue Eng Part A. 2013 Sep; 19(17-18):2024-34. . View in PubMed
• Comparison of the electromyographic activation level and unilateral selectivity of erector spinae during different selected movements Int J Rehabil Res. 2012 Dec; 35(4):345-51. . View in PubMed
• Apoptosis and Fas-ligand expression correlate to the histopathological grade of gastric smooth muscle tumors J Surg Res. 2001 Feb; 95(2):92-8. . View in PubMed

• Chuong, Cheng-Ming
• Armstrong, David
• Chai, Yang
• Widelitz, Randall
• Woodley, David