Harvey R. Kaslow, PhD

Associate Professor of Physiology & Neuroscience

Image of Harvey R. Kaslow, PhD
Is this your profile? Click to edit

Overview

More complete information at USC Health Sciences Profiles:
https://profiles.sc-ctsi.org/harvey.kaslow
This URL can be obtained by searching Google for “Harvey Kaslow CTSI.”

Main research interest: Cancer Immunotherapy and Regulation of Immune Responses.
Cytotoxic antibodies and T lymphocytes can be generated that recognize cancer cells, but immunosuppressive factors in solid tumors frequently cause these effectors to fail to control or eliminate the cancer. Compositions are available that overcome these immunosuppressive factors but they produce toxic side-effects which can be life-threatening. There is thus a need for efficacious compositions and methods with reduced toxicity. In collaboration with the laboratory of Alan Epstein (Keck School of Medicine) candidate compositions and methods have been generated and more are under development. Patents covering some compositions and methods have issued and additional patent applications are ongoing and planned. See:
https://onedrive.live.com/view.aspx?resid=8981C17A0B407A86!39098&ithint=file%2cpptx&authkey=!ACYUwJ4HG0p1NRw

Education Efforts:
Dr. Kaslow’s graduate (UCSD) work involved endocrinology and metabolism and his post-doctoral (UCSF) research focused on cell signaling mechanisms. His teaching efforts continue in those areas in graduate, medical, and pharmacy courses. Dr. Kaslow serves as:
Director, MS program in Medical Physiology
Co-chair of the Endocrinology section of the medical student curriculum.
Dr. Kaslow actively participates in the continuing refinement and revision of the medical and graduate student curricula and is developing software for the analysis and management of the curriculum.

Publications

  • A Humanized Lym-1 CAR with Novel DAP10/DAP12 Signaling Domains Demonstrates Reduced Tonic Signaling and Increased Antitumor Activity in B-Cell Lymphoma Models. Clin Cancer Res. 2020 07 15; 26(14):3694-3706.. View in PubMed
  • Lym-1 Chimeric Antigen Receptor T Cells Exhibit Potent Anti-Tumor Effects against B-Cell Lymphoma. Int J Mol Sci. 2017 Dec 20; 18(12).. View in PubMed
  • P2X7 receptor-dependent and -independent T cell death is induced by nicotinamide adenine dinucleotide. J Immunol. 2005 Feb 15; 174(4):1971-9.. View in PubMed
  • Expression of IL-10 and TNF-inhibitor genes in lacrimal gland epithelial cells suppresses their ability to activate lymphocytes. Cornea. 2002 Mar; 21(2):210-4.. View in PubMed
  • Effect of anti-inflammatory cytokines on the activation of lymphocytes by lacrimal gland acinar cells in an autologous mixed cell reaction. Adv Exp Med Biol. 2002; 506(Pt B):789-94.. View in PubMed
  • Autologous lacrimal-lymphoid mixed-cell reactions induce dacryoadenitis in rabbits. Exp Eye Res. 2000 Jul; 71(1):23-31.. View in PubMed
  • Lacrimal gland epithelial cells stimulate proliferation in autologous lymphocyte preparations. Exp Eye Res. 2000 Jul; 71(1):11-22.. View in PubMed
  • A method to study induction of autoimmunity in vitro: co-culture of lacrimal cells and autologous immune system cells. Adv Exp Med Biol. 1998; 438:583-9.. View in PubMed
  • Sjögren’s autoimmunity: how perturbation of recognition in endomembrane traffic may provoke pathological recognition at the cell surface. J Mol Recognit. 1998; 11(1-6):40-8.. View in PubMed
  • Authors and Editors of the world unite. FASEB J. 1995 Feb; 9(2):291.. View in PubMed