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Hidekazu Tsukamoto, PhD

Professor of Pathology

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Phone +1 323 442 5107
Email [email protected]
CTSI Profile

Research Funding

  • "CYP1B1+PRRX1+NR4A2+ hepatic stellate cells in alcohol-associated hepatitis"
    NIH · R01AA031670 · Aug 20, 2024 – Jun 30, 2029 · Role: Principal Investigator
  • Hepatocyte-derived extracellular vesicles in alcoholic liver disease
    NIH · R01AA028134 · Jul 1, 2020 – Mar 31, 2025 · Role: Co-Principal Investigator
  • Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH · U01AA027681 · Sep 25, 2018 – Aug 31, 2023 · Role: Co-Principal Investigator
  • BLR&D Research Career Scientist Award Application
    NIH · IK6BX004205 · Apr 1, 2018 – Mar 31, 2030 · Role: Principal Investigator
  • Molecular Mechanisms of Stellate Cell Activation in Liver Fibrosis
    NIH · I01BX001991 · Oct 1, 2013 – Sep 30, 2026 · Role: Principal Investigator
  • The dynamics and mechanisms of autophagy in ethanol – induced liver pathogenesis
    NIH · R01AA021751 · Aug 15, 2013 – Jul 31, 2019 · Role: Co-Principal Investigator
  • International Symposium of ALPD and Cirrhosis
    NIH · R13AA020691 · Aug 5, 2011 – Jul 31, 2021 · Role: Principal Investigator
  • Epigenetic Regulation of Alcoholic Liver Fibrosis
    NIH · U01AA018663 · Sep 1, 2010 – Aug 31, 2021 · Role: Principal Investigator
  • 15th International Symposium on Cells of the Hepatic Sinusoid
    NIH · R13AA019890 · Jul 1, 2010 – Jun 30, 2011 · Role: Principal Investigator
  • TLR4 and TGF-beta interactions in HCC induced by HCV and alcohol
    NIH · RC2AA019392 · Sep 30, 2009 – Aug 31, 2012 · Role: Principal Investigator
  • Epigenetic mechanism of HSC transdifferentiation in alcoholic liver fibrosis
    NIH · R21AA016682 · Sep 30, 2006 – Aug 31, 2009 · Role: Principal Investigator
  • Iron Signaling/Monocytes/Alcoholic Hepatitis Patients
    NIH · R21AA015162 · Sep 10, 2004 – Aug 31, 2007 · Role: Principal Investigator
  • Integrative Liver Cell Core
    NIH · R24AA012885 · Jun 1, 2001 – May 31, 2026 · Role: Principal Investigator
  • NON-PARENCHYMAL LIVER CELL CORE
    NIH · R01AA012885 · Jun 1, 2001 – May 31, 2006 · Role: Principal Investigator
  • Training Program in Alcoholic Liver&Pancreatic Diseases
    NIH · T32AA007578 · May 1, 2000 – Apr 30, 2011 · Role: Principal Investigator
  • Southern California Research Center for ALPD and Cirrhosis
    NIH · P50AA011999 · Dec 31, 1998 – Apr 30, 2029 · Role: Principal Investigator
  • PATHOGENESIS OF ALCOHOL LIVER INJURY
    NIH · R37AA006603 · Sep 1, 1991 – Nov 30, 2004 · Role: Principal Investigator
  • PATHOGENESIS OF ALCOHOL LIVER INJURY
    NIH · R01AA006603 · Jun 1, 1984 – Nov 30, 1998 · Role: Principal Investigator

Publications

  • Characterizing Kupffer Cell Production of CD5 Antigen-Like and Its Function on Regulating Migration of Natural Killer T Cells. Am J Pathol. 2025 10; 195(10):1839-1853.. View in PubMed
  • Retraction: C-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2025 06 01; 81(6):E181.. View in PubMed
  • Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease. J Clin Invest. 2025 Jul 01; 135(13).. View in PubMed
  • Retraction Notice to: LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells. iScience. 2025 Mar 21; 28(3):112032.. View in PubMed
  • Retraction Notice to: Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal. iScience. 2024 Dec 20; 27(12):111489.. View in PubMed
  • Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. J Clin Invest. 2024 10 01; 134(19).. View in PubMed
  • Author Correction: NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. Exp Mol Med. 2024 Oct; 56(10):2323.. View in PubMed
  • NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. Exp Mol Med. 2024 02; 56(2):461-477.. View in PubMed
  • The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis. Redox Biol. 2024 04; 70:103052.. View in PubMed
  • Protocol for generation of humanized HCC mouse model and cancer-driver mutations using CRISPR-Cas9. STAR Protoc. 2023 12 15; 4(4):102389.. View in PubMed
  • Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal. iScience. 2023 Jul 21; 26(7):107035.. View in PubMed
  • Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 – β-catenin cascade to promote liver tumorigenesis. Nat Commun. 2023 05 08; 14(1):2651.. View in PubMed
  • miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury. Hepatol Commun. 2023 04 01; 7(4).. View in PubMed
  • LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells. iScience. 2023 Mar 17; 26(3):106254.. View in PubMed
  • Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle. Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2214829120.. View in PubMed
  • Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis. Hepatology. 2023 07 01; 78(1):212-224.. View in PubMed
  • Acetate reprograms gut microbiota during alcohol consumption. Nat Commun. 2022 08 08; 13(1):4630.. View in PubMed
  • Cell-to-Cell Communications in Alcohol-Associated Liver Disease. Front Physiol. 2022; 13:831004.. View in PubMed
  • Concomitant genetic defects potentiate the adverse impact of prenatal alcohol exposure on cardiac outflow tract maturation. Birth Defects Res. 2022 02; 114(3-4):105-115.. View in PubMed
  • Fate and functional roles of Prominin 1+ cells in liver injury and cancer. Sci Rep. 2020 11 10; 10(1):19412.. View in PubMed
  • The 14th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ISALPDC). Clin Mol Hepatol. 2020 10; 26(4):584-585.. View in PubMed
  • Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice. J Mol Med (Berl). 2020 07; 98(7):1021-1034.. View in PubMed
  • p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs. Nat Commun. 2020 06 17; 11(1):3084.. View in PubMed
  • Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease. Alcohol Clin Exp Res. 2020 05; 44(5):1061-1074.. View in PubMed
  • Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. J Clin Invest. 2020 04 01; 130(4):2129-2145.. View in PubMed
  • Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3).. View in PubMed
  • Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Hepatol Commun. 2020 Apr; 4(4):606-626.. View in PubMed
  • Cell Death and Liver Disease. Gut Liver. 2020 01 15; 14(1):20-29.. View in PubMed
  • IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959.. View in PubMed
  • Stearoyl-CoA desaturase and tumorigenesis. Chem Biol Interact. 2020 Jan 25; 316:108917.. View in PubMed
  • Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras. Am J Physiol Gastrointest Liver Physiol. 2020 02 01; 318(2):G265-G276.. View in PubMed
  • Inflammatory pathways in alcoholic steatohepatitis. J Hepatol. 2019 02; 70(2):249-259.. View in PubMed
  • Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science. J Gastroenterol. 2019 Mar; 54(3):218-225.. View in PubMed
  • Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition. Hepatology. 2018 11; 68(5):1726-1740.. View in PubMed
  • Publisher Correction: Alcoholic liver disease. Nat Rev Dis Primers. 2018 08 28; 4(1):18.. View in PubMed
  • Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2019 06; 77:11-18.. View in PubMed
  • Alcoholic liver disease. Nat Rev Dis Primers. 2018 08 16; 4(1):16.. View in PubMed
  • Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology. 2018 05; 67(5):1737-1753.. View in PubMed
  • The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. Redox Biol. 2018 04; 14:164-177.. View in PubMed
  • Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1. PLoS One. 2017; 12(8):e0181052.. View in PubMed
  • The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury. J Biol Chem. 2017 07 07; 292(27):11336-11347.. View in PubMed
  • Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases. Am J Pathol. 2017 Apr; 187(4):781-797.. View in PubMed
  • Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017 05; 152(6):1477-1491.. View in PubMed
  • A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Mol Ther. 2017 01 04; 25(1):218-231.. View in PubMed
  • Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability. Hepatology. 2017 02; 65(2):678-693.. View in PubMed
  • A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution. Front Physiol. 2016; 7:579.. View in PubMed
  • Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. Front Physiol. 2016; 7:498.. View in PubMed
  • Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology. 2017 02; 65(2):475-490.. View in PubMed
  • Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-λ2 or IL-29/IFN-λ1. Cancer Gene Ther. 2016 Aug; 23(8):266-77.. View in PubMed
  • Uncovering the liver’s role in immunity through RNA co-expression networks. Mamm Genome. 2016 10; 27(9-10):469-84.. View in PubMed
  • Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. PLoS One. 2016; 11(5):e0156111.. View in PubMed
  • Alcoholic hepatitis: Translational approaches to develop targeted therapies. Hepatology. 2016 10; 64(4):1343-55.. View in PubMed
  • Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese. J Lipid Res. 2016 06; 57(6):1017-28.. View in PubMed
  • The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35.. View in PubMed
  • Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe? Gastroenterology. 2016 06; 150(8):1704-9. Gao B, Tsukamoto H . . View in PubMed
  • TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. J Clin Invest. 2016 Feb; 126(2):527-42.. View in PubMed
  • Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus-the ‘D-shuttle’ project. J Radiol Prot. 2016 Mar; 36(1):49-66.. View in PubMed
  • Notch, metabolism and macrophages. Oncotarget. 2015 Aug 21; 6(24):19942-3.. View in PubMed
  • Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis. Pancreas. 2015 Aug; 44(6):882-7.. View in PubMed
  • Morphogen-related therapeutic targets for liver fibrosis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39.. View in PubMed
  • ALPD 2015, Preface. Clin Res Hepatol Gastroenterol. 2015 Sep; 39.. View in PubMed
  • Notch signaling and M1 macrophage activation in obesity-alcohol synergism. Clin Res Hepatol Gastroenterol. 2015 Sep; 39.. View in PubMed
  • Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice. J Neuroimmunol. 2015 Aug 15; 285:169-79.. View in PubMed
  • Reply: To Hepatology. 2015 Jul; 62(1):324. Lazaro R, Wu R, Tsukamoto H . View in PubMed
  • NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest. 2015 Apr; 125(4):1579-90.. View in PubMed
  • Metabolic reprogramming and cell fate regulation in alcoholic liver disease. Pancreatology. 2015 Jul; 15(4 Suppl):S61-5.. View in PubMed
  • TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis. Adv Exp Med Biol. 2015; 815:131-44.. View in PubMed
  • Low intracellular iron increases the stability of matriptase-2. J Biol Chem. 2015 Feb 13; 290(7):4432-46.. View in PubMed
  • Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. Hepatology. 2015 Jan; 61(1):129-40.. View in PubMed
  • Alcohol directly stimulates epigenetic modifications in hepatic stellate cells. J Hepatol. 2015 Feb; 62(2):388-97.. View in PubMed
  • Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology. 2015 Jan; 148(1):203-214.e16.. View in PubMed
  • New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183.. View in PubMed
  • Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. Hepatol Int. 2014 Jul; 8(3):330-8.. View in PubMed
  • Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. Alcohol Clin Exp Res. 2014 Jun; 38(6):1540-9.. View in PubMed
  • Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology. 2014 Mar; 59(3):1118-29.. View in PubMed
  • Alcohol, TLR4-TGF-β antagonism, and liver cancer. Hepatol Int. 2014 Sep; 8.. View in PubMed
  • Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. J Clin Invest. 2013 Jul; 123(7):2832-49.. View in PubMed
  • Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells. J Gastroenterol. 2014 May; 49(5):890-9.. View in PubMed
  • Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice. Hepatology. 2013 Jul; 58(1):108-19.. View in PubMed
  • Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. PLoS One. 2013; 8(4):e60534.. View in PubMed
  • Kenji Fujiwara, MD, PhD. Gastroenterology. 2013 Apr; 144(4):661-3.. View in PubMed
  • Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem. 2012 Dec 07; 287(50):42165-79.. View in PubMed
  • Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation. Hepatology. 2012 Sep; 56(3):1129-39.. View in PubMed
  • Phenotypes of CCAAT/enhancer-binding protein beta deficiency: hyperdontia and elongated coronoid process. Oral Dis. 2013 Mar; 19(2):144-50.. View in PubMed
  • Epigenetic regulation of miR-34a expression in alcoholic liver injury. Am J Pathol. 2012 Sep; 181(3):804-17.. View in PubMed
  • Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation. J Biol Chem. 2012 Sep 14; 287(38):32078-84.. View in PubMed
  • Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol. 2012 Oct; 57(4):852-9.. View in PubMed
  • Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53.. View in PubMed
  • Mouse intragastric infusion (iG) model. Nat Protoc. 2012 Mar 29; 7(4):771-81.. View in PubMed
  • Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol. 2012 Mar; 27.. View in PubMed
  • Morphogens and hepatic stellate cell fate regulation in chronic liver disease. J Gastroenterol Hepatol. 2012 Mar; 27.. View in PubMed
  • Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect. Hepatology. 2012 Apr; 55(4):1271-81.. View in PubMed
  • Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration. J Biol Chem. 2012 Mar 23; 287(13):10355-10367.. View in PubMed
  • Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34.. View in PubMed
  • StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 2012 Feb; 61(2):172-8.. View in PubMed
  • 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72.. View in PubMed
  • Epigenetic cell fate regulation of hepatic stellate cells. Hepatol Res. 2011 Jul; 41(7):675-82.. View in PubMed
  • Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18.. View in PubMed
  • Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar; 53(3):983-95.. View in PubMed
  • Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol. 2011 Sep; 55(3):673-682.. View in PubMed

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