Keck School Faculty

Hidekazu Tsukamoto, PhD
Hidekazu Tsukamoto, PhD
Professor of Pathology
MMR 1333 San Pablo St Health Sciences Campus Los Angeles

Inflammatory pathways in alcoholic steatohepatitis J Hepatol. 2019 Feb; 70(2):249-259. . View in PubMed

Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science J Gastroenterol. 2019 Jan 14. . View in PubMed

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition Hepatology. 2018 Nov; 68(5):1726-1740. . View in PubMed

Publisher Correction: Alcoholic liver disease Nat Rev Dis Primers. 2018 Aug 28; 4(1):18. . View in PubMed

Alcoholic liver disease Nat Rev Dis Primers. 2018 Aug 16; 4(1):16. . View in PubMed

Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition Hepatology. 2018 May 05. . View in PubMed

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients Hepatology. 2018 May; 67(5):1737-1753. . View in PubMed

Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients Hepatology. 2018 05; 67(5):1737-1753. . View in PubMed

Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases Am J Pathol. 2017 Apr; 187(4):781-797. . View in PubMed

Loss of the transforming growth factor-ß effector ß2-Spectrin promotes genomic instability Hepatology. 2017 Feb; 65(2):678-693. . View in PubMed

Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood Hepatology. 2017 02; 65(2):475-490. . View in PubMed

Loss of the transforming growth factor-ß effector ß2-Spectrin promotes genomic instability Hepatology. 2017 02; 65(2):678-693. . View in PubMed

Gender difference in NASH susceptibility: Roles of hepatocyte Ikkß and Sult1e1 PLoS One. 2017; 12(8):e0181052. . View in PubMed

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A Mol Ther. 2017 01 04; 25(1):218-231. . View in PubMed

Alcoholic hepatitis: Translational approaches to develop targeted therapies Hepatology. 2016 10; 64(4):1343-55. . View in PubMed

Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese J Lipid Res. 2016 06; 57(6):1017-28. . View in PubMed

Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe? Gastroenterology. 2016 06; 150(8):1704-9.. View in PubMed

A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution Front Physiol. 2016; 7:579. . View in PubMed

Morphogen-related therapeutic targets for liver fibrosis Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S69-74. . View in PubMed

Notch signaling and M1 macrophage activation in obesity-alcohol synergism Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S24-8. . View in PubMed

ALPD 2015, Preface Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S1. . View in PubMed

Notch, metabolism and macrophages Oncotarget. 2015 Aug 21; 6(24):19942-3. . View in PubMed

Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice J Neuroimmunol. 2015 Aug 15; 285:169-79. . View in PubMed

Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis Pancreas. 2015 Aug; 44(6):882-7. . View in PubMed

Reply: To PMID 25132354 Hepatology. 2015 Jul; 62(1):324. . View in PubMed

Metabolic reprogramming and cell fate regulation in alcoholic liver disease Pancreatology. 2015 Jul; 15(4 Suppl):S61-5. . View in PubMed

NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation J Clin Invest. 2015 Apr; 125(4):1579-90. . View in PubMed

Low intracellular iron increases the stability of matriptase-2 J Biol Chem. 2015 Feb 13; 290(7):4432-46. . View in PubMed

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells J Hepatol. 2015 Feb; 62(2):388-97. . View in PubMed

Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice Hepatology. 2015 Jan; 61(1):129-40. . View in PubMed

New Approaches for Studying Alcoholic Liver Disease Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. . View in PubMed

Alcohol, TLR4-TGF-ß antagonism, and liver cancer Hepatol Int. 2014 Sep; 8 Suppl 2:408-12. . View in PubMed

Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity Hepatol Int. 2014 Jul; 8(3):330-8. . View in PubMed

Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse Alcohol Clin Exp Res. 2014 Jun; 38(6):1540-9. . View in PubMed

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells Hepatology. 2014 Mar; 59(3):1118-29. . View in PubMed

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice Hepatology. 2013 Jul; 58(1):108-19. . View in PubMed

Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells J Clin Invest. 2013 Jul; 123(7):2832-49. . View in PubMed

Kenji Fujiwara, MD, PhD Gastroenterology. 2013 Apr; 144(4):661-3. . View in PubMed

Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway PLoS One. 2013; 8(4):e60534. . View in PubMed

Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations J Biol Chem. 2012 Dec 07; 287(50):42165-79. . View in PubMed

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis J Hepatol. 2012 Oct; 57(4):852-9. . View in PubMed

Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation J Biol Chem. 2012 Sep 14; 287(38):32078-84. . View in PubMed

Epigenetic regulation of miR-34a expression in alcoholic liver injury Am J Pathol. 2012 Sep; 181(3):804-17. . View in PubMed

Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation Hepatology. 2012 Sep; 56(3):1129-39. . View in PubMed

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. . View in PubMed

Hepatology. 2012 Apr; 55(4):1271-81. . View in PubMed

Mouse intragastric infusion (iG) model Nat Protoc. 2012 Mar 29; 7(4):771-81. . View in PubMed

Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration J Biol Chem. 2012 Mar 23; 287(13):10355-67. . View in PubMed

Morphogens and hepatic stellate cell fate regulation in chronic liver disease J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. . View in PubMed

Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. . View in PubMed

Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. . View in PubMed

15th International Symposium on Cells of the Hepatic Sinusoid, 2010 Liver Int. 2011 Jul; 31(6):762-72. . View in PubMed

Epigenetic cell fate regulation of hepatic stellate cells Hepatol Res. 2011 Jul; 41(7):675-82. . View in PubMed

Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease Gastroenterology. 2011 Mar; 140(3):1052-62. . View in PubMed

Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression J Biol Chem. 2011 Jan 28; 286(4):2393-401. . View in PubMed

Enteric dysbiosis associated with a mouse model of alcoholic liver disease Hepatology. 2011 Jan; 53(1):96-105. . View in PubMed

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair Hepatology. 2010 Aug; 52(2):480-92. . View in PubMed

Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport Am J Physiol Renal Physiol. 2010 Jul; 299(1):F28-34. . View in PubMed

Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse Hepatology. 2010 Mar; 51(3):932-41. . View in PubMed

Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation Hepatology. 2010 Mar; 51(3):986-95. . View in PubMed

MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosisGastroenterology. 2010 Feb; 138(2):705-14, 714. e1-4. . View in PubMed

Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1 J Immunol. 2009 Nov 01; 183(9):5964-76. . View in PubMed

Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199 J Immunol. 2009 Oct 15; 183(8):5232-43. . View in PubMed

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression J Biol Chem. 2009 Aug 21; 284(34):22580-9. . View in PubMed

Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1Gastroenterology. 2009 May; 136(5):1783-95. e10. . View in PubMed

"Second hit" models of alcoholic liver disease Semin Liver Dis. 2009 May; 29(2):178-87. . View in PubMed

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression Cell Metab. 2009 Mar; 9(3):217-27. . View in PubMed

Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer Pancreas. 2009 Mar; 38(2):e47-52. . View in PubMed

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development Hepatology. 2009 Mar; 49(3):998-1011. . View in PubMed

Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption Alcohol Clin Exp Res. 2008 Nov; 32(11):1947-53. . View in PubMed

Expression of carboxylesterase and lipase genes in rat liver cell-types Biochem Biophys Res Commun. 2008 Sep 26; 374(3):460-4. . View in PubMed

Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G512-21. . View in PubMed

Fat paradox of steatohepatitis J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S104-7. . View in PubMed

Intragastric ethanol infusion model in rodents Methods Mol Biol. 2008; 447:33-48. . View in PubMed

A rat model reproducing key pathological responses of alcoholic chronic pancreatitis Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G68-79. . View in PubMed

Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation Hepatology. 2007 Oct; 46(4):1187-97. . View in PubMed

Conceptual importance of identifying alcoholic liver disease as a lifestyle disease J Gastroenterol. 2007 Aug; 42(8):603-9. . View in PubMed

A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix J Biol Chem. 2007 Apr 27; 282(17):12928-39. . View in PubMed

Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages J Biol Chem. 2007 Feb 23; 282(8):5582-8. . View in PubMed

Epigenetic mechanism of stellate cell trans-differentiation J Hepatol. 2007 Feb; 46(2):352-3. . View in PubMed

Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S109-10. . View in PubMed

Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S102-5. . View in PubMed

Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells J Biol Chem. 2005 Dec 09; 280(49):40650-9. . View in PubMed

Fat paradox in liver disease Keio J Med. 2005 Dec; 54(4):190-2. . View in PubMed

Adipogenic phenotype of hepatic stellate cells Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):132S-133S. . View in PubMed

Hepatoprotective mechanisms of Yan-gan-wan Hepatol Res. 2005 Aug; 32(4):202-12. . View in PubMed

A pilot study of an alcoholic liver disease recurrence prevention education program in hospitalized patients with advanced liver disease Addict Behav. 2005 Mar; 30(3):465-73. . View in PubMed

Adipogenic transcriptional regulation of hepatic stellate cells J Biol Chem. 2005 Feb 11; 280(6):4959-67. . View in PubMed

Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. . View in PubMed

Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption Gastroenterology. 2004 May; 126(5):1387-99. . View in PubMed

Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells J Biol Chem. 2004 Mar 19; 279(12):11392-401. . View in PubMed

Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes Blood. 2004 Feb 15; 103(4):1509-14. . View in PubMed

Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen J Biol Chem. 2004 Feb 06; 279(6):4820-8. . View in PubMed

PPAR Gamma and Hepatic Stellate Cells Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S7. . View in PubMed

Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county Alcohol Clin Exp Res. 2003 Nov; 27(11):1798-804. . View in PubMed

Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease Alcohol. 2003 Jun; 30(2):107-13. . View in PubMed

Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001 Alcohol. 2002 Oct; 28(2):117-28. . View in PubMed

Redox regulation of cytokine expression in Kupffer cells Antioxid Redox Signal. 2002 Oct; 4(5):741-8. . View in PubMed

Iron activates NF-kappaB in Kupffer cells Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G719-26. . View in PubMed

Role of abnormal methionine metabolism in alcoholic liver injury Alcohol. 2002 Jul; 27(3):155-62. . View in PubMed

IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells Am J Physiol Gastrointest Liver Physiol. 2002 Jun; 282(6):G981-90. . View in PubMed

Iron regulation of hepatic macrophage TNFalpha expression Free Radic Biol Med. 2002 Feb 15; 32(4):309-13. . View in PubMed

Alcoholic liver disease (ALD): a new domain for prevention efforts Subst Use Misuse. 2002; 37(14):1887-904. . View in PubMed

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