Hidekazu Tsukamoto, PhD

Professor of Pathology

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Publications

  • The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis Redox Biol. 2024 Apr; 70:103052. . View in PubMed
  • NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells Exp Mol Med. 2024 Feb; 56(2):461-477. . View in PubMed
  • Protocol for generation of humanized HCC mouse model and cancer-driver mutations using CRISPR-Cas9 STAR Protoc. 2023 Dec 15; 4(4):102389. . View in PubMed
  • Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal iScience. 2023 Jul 21; 26(7):107035. . View in PubMed
  • LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells iScience. 2023 Mar 17; 26(3):106254. . View in PubMed
  • Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 – ß-catenin cascade to promote liver tumorigenesis Nat Commun. 2023 05 08; 14(1):2651. . View in PubMed
  • miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury Hepatol Commun. 2023 04 01; 7(4). . View in PubMed
  • Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2214829120. . View in PubMed
  • Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis Hepatology. 2023 07 01; 78(1):212-224. . View in PubMed
  • Concomitant genetic defects potentiate the adverse impact of prenatal alcohol exposure on cardiac outflow tract maturation Birth Defects Res. 2022 02; 114(3-4):105-115. . View in PubMed
  • Cell-to-Cell Communications in Alcohol-Associated Liver Disease Front Physiol. 2022; 13:831004. . View in PubMed
  • Acetate reprograms gut microbiota during alcohol consumption Nat Commun. 2022 08 08; 13(1):4630. . View in PubMed
  • Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles Hepatol Commun. 2020 Apr; 4(4):606-626. . View in PubMed
  • Stearoyl-CoA desaturase and tumorigenesis Chem Biol Interact. 2020 Jan 25; 316:108917. . View in PubMed
  • The 14th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ISALPDC) Clin Mol Hepatol. 2020 10; 26(4):584-585. . View in PubMed
  • Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1ß and IL-17 upregulation in alcoholic hepatitis mice J Mol Med (Berl). 2020 07; 98(7):1021-1034. . View in PubMed
  • IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease J Hepatol. 2020 05; 72(5):946-959. . View in PubMed
  • Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease Alcohol Clin Exp Res. 2020 05; 44(5):1061-1074. . View in PubMed
  • Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras Am J Physiol Gastrointest Liver Physiol. 2020 02 01; 318(2):G265-G276. . View in PubMed
  • Fate and functional roles of Prominin 1+ cells in liver injury and cancer Sci Rep. 2020 11 10; 10(1):19412. . View in PubMed
  • Cell Death and Liver Disease Gut Liver. 2020 01 15; 14(1):20-29. . View in PubMed
  • p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs Nat Commun. 2020 06 17; 11(1):3084. . View in PubMed
  • Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis J Clin Invest. 2020 04 01; 130(4):2129-2145. . View in PubMed
  • Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice JCI Insight. 2020 02 13; 5(3). . View in PubMed
  • Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science J Gastroenterol. 2019 Mar; 54(3):218-225. . View in PubMed
  • Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting Alcohol. 2019 06; 77:11-18. . View in PubMed
  • Inflammatory pathways in alcoholic steatohepatitis J Hepatol. 2019 02; 70(2):249-259. . View in PubMed
  • Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition Hepatology. 2018 11; 68(5):1726-1740. . View in PubMed
  • Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients Hepatology. 2018 05; 67(5):1737-1753. . View in PubMed
  • The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading Redox Biol. 2018 04; 14:164-177. . View in PubMed
  • Alcoholic liver disease Nat Rev Dis Primers. 2018 08 16; 4(1):16. . View in PubMed
  • Publisher Correction: Alcoholic liver disease Nat Rev Dis Primers. 2018 08 28; 4(1):18. . View in PubMed
  • Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases Am J Pathol. 2017 Apr; 187(4):781-797. . View in PubMed
  • Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6 Gastroenterology. 2017 05; 152(6):1477-1491. . View in PubMed
  • Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood Hepatology. 2017 02; 65(2):475-490. . View in PubMed
  • Loss of the transforming growth factor-ß effector ß2-Spectrin promotes genomic instability Hepatology. 2017 02; 65(2):678-693. . View in PubMed
  • A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A Mol Ther. 2017 01 04; 25(1):218-231. . View in PubMed
  • The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury J Biol Chem. 2017 07 07; 292(27):11336-11347. . View in PubMed
  • Gender difference in NASH susceptibility: Roles of hepatocyte Ikkß and Sult1e1 PLoS One. 2017; 12(8):e0181052. . View in PubMed
  • Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-? 1. Cancer Gene Ther. 2016 Aug; 23(8):266-77.. View in PubMed
  • Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus-the ‘D-shuttle’ project J Radiol Prot. 2016 Mar; 36(1):49-66. . View in PubMed
  • The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. . View in PubMed
  • TGF-ß/ß2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome J Clin Invest. 2016 Feb; 126(2):527-42. . View in PubMed
  • Alcoholic hepatitis: Translational approaches to develop targeted therapies Hepatology. 2016 10; 64(4):1343-55. . View in PubMed
  • Uncovering the liver’s role in immunity through RNA co-expression networks Mamm Genome. 2016 10; 27(9-10):469-84. . View in PubMed
  • Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe? Gastroenterology. 2016 06; 150(8):1704-9.. View in PubMed
  • Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese J Lipid Res. 2016 06; 57(6):1017-28. . View in PubMed
  • PLoS One. 2016; 11(5):e0156111. . View in PubMed
  • Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models Front Physiol. 2016; 7:498. . View in PubMed
  • A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution Front Physiol. 2016; 7:579. . View in PubMed
  • ALPD 2015, Preface Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S1. . View in PubMed
  • Morphogen-related therapeutic targets for liver fibrosis Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S69-74. . View in PubMed
  • Notch signaling and M1 macrophage activation in obesity-alcohol synergism Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S24-8. . View in PubMed
  • Notch, metabolism and macrophages Oncotarget. 2015 Aug 21; 6(24):19942-3. . View in PubMed
  • Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice J Neuroimmunol. 2015 Aug 15; 285:169-79. . View in PubMed
  • Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis Pancreas. 2015 Aug; 44(6):882-7. . View in PubMed
  • Reply: To PMID 25132354 Hepatology. 2015 Jul; 62(1):324. . View in PubMed
  • Metabolic reprogramming and cell fate regulation in alcoholic liver disease Pancreatology. 2015 Jul; 15(4 Suppl):S61-5. . View in PubMed
  • NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation J Clin Invest. 2015 Apr; 125(4):1579-90. . View in PubMed
  • Low intracellular iron increases the stability of matriptase-2 J Biol Chem. 2015 Feb 13; 290(7):4432-46. . View in PubMed
  • Alcohol directly stimulates epigenetic modifications in hepatic stellate cells J Hepatol. 2015 Feb; 62(2):388-97. . View in PubMed
  • TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis Adv Exp Med Biol. 2015; 815:131-44. . View in PubMed
  • Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice Hepatology. 2015 Jan; 61(1):129-40. . View in PubMed
  • Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in miceGastroenterology. 2015 Jan; 148(1):203-214. e16. . View in PubMed
  • New Approaches for Studying Alcoholic Liver Disease Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. . View in PubMed
  • Alcohol, TLR4-TGF-ß antagonism, and liver cancer Hepatol Int. 2014 Sep; 8 Suppl 2:408-12. . View in PubMed
  • Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity Hepatol Int. 2014 Jul; 8(3):330-8. . View in PubMed
  • Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse Alcohol Clin Exp Res. 2014 Jun; 38(6):1540-9. . View in PubMed
  • Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells J Gastroenterol. 2014 May; 49(5):890-9. . View in PubMed
  • Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells Hepatology. 2014 Mar; 59(3):1118-29. . View in PubMed
  • Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells J Clin Invest. 2013 Jul; 123(7):2832-49. . View in PubMed
  • Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice Hepatology. 2013 Jul; 58(1):108-19. . View in PubMed
  • Kenji Fujiwara, MD, PhD Gastroenterology. 2013 Apr; 144(4):661-3. . View in PubMed
  • Phenotypes of CCAAT/enhancer-binding protein beta deficiency: hyperdontia and elongated coronoid process Oral Dis. 2013 Mar; 19(2):144-50. . View in PubMed
  • Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway PLoS One. 2013; 8(4):e60534. . View in PubMed
  • Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations J Biol Chem. 2012 Dec 07; 287(50):42165-79. . View in PubMed
  • Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis J Hepatol. 2012 Oct; 57(4):852-9. . View in PubMed
  • Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation J Biol Chem. 2012 Sep 14; 287(38):32078-84. . View in PubMed
  • Epigenetic regulation of miR-34a expression in alcoholic liver injury Am J Pathol. 2012 Sep; 181(3):804-17. . View in PubMed
  • Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation Hepatology. 2012 Sep; 56(3):1129-39. . View in PubMed
  • Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. . View in PubMed
  • Hepatology. 2012 Apr; 55(4):1271-81. . View in PubMed
  • Mouse intragastric infusion (iG) model Nat Protoc. 2012 Mar 29; 7(4):771-81. . View in PubMed
  • Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration J Biol Chem. 2012 Mar 23; 287(13):10355-10367. . View in PubMed
  • Morphogens and hepatic stellate cell fate regulation in chronic liver disease J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. . View in PubMed
  • Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. . View in PubMed
  • StellaTUM: current consensus and discussion on pancreatic stellate cell research Gut. 2012 Feb; 61(2):172-8. . View in PubMed
  • Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. . View in PubMed
  • Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK J Hepatol. 2011 Sep; 55(3):673-682. . View in PubMed
  • Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. . View in PubMed
  • 15th International Symposium on Cells of the Hepatic Sinusoid, 2010 Liver Int. 2011 Jul; 31(6):762-72. . View in PubMed
  • Epigenetic cell fate regulation of hepatic stellate cells Hepatol Res. 2011 Jul; 41(7):675-82. . View in PubMed
  • Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease Gastroenterology. 2011 Mar; 140(3):1052-62. . View in PubMed
  • Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver Hepatology. 2011 Mar; 53(3):983-95. . View in PubMed
  • Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein Blood. 2011 Feb 03; 117(5):1687-99. . View in PubMed
  • Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression J Biol Chem. 2011 Jan 28; 286(4):2393-401. . View in PubMed
  • Enteric dysbiosis associated with a mouse model of alcoholic liver disease Hepatology. 2011 Jan; 53(1):96-105. . View in PubMed
  • The Necdin-Wnt pathway causes epigenetic peroxisome proliferator-activated receptor gamma repression in hepatic stellate cells J Biol Chem. 2010 Oct 01; 285(40):30463-71. . View in PubMed
  • c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair Hepatology. 2010 Aug; 52(2):480-92. . View in PubMed
  • Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport Am J Physiol Renal Physiol. 2010 Jul; 299(1):F28-34. . View in PubMed
  • TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I J Hepatol. 2010 Mar; 52(3):407-16. . View in PubMed
  • Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation Hepatology. 2010 Mar; 51(3):986-95. . View in PubMed
  • Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse Hepatology. 2010 Mar; 51(3):932-41. . View in PubMed
  • MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosisGastroenterology. 2010 Feb; 138(2):705-14714. e1-4. . View in PubMed
  • Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1 J Immunol. 2009 Nov 01; 183(9):5964-76. . View in PubMed
  • Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199 J Immunol. 2009 Oct 15; 183(8):5232-43. . View in PubMed
  • Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression J Biol Chem. 2009 Aug 21; 284(34):22580-9. . View in PubMed
  • S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model Hepatology. 2009 Aug; 50(2):462-71. . View in PubMed
  • “Second hit” models of alcoholic liver disease Semin Liver Dis. 2009 May; 29(2):178-87. . View in PubMed
  • Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1Gastroenterology. 2009 May; 136(5):1783-95. e10. . View in PubMed
  • Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer Pancreas. 2009 Mar; 38(2):e47-52. . View in PubMed
  • Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development Hepatology. 2009 Mar; 49(3):998-1011. . View in PubMed
  • Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression Cell Metab. 2009 Mar; 9(3):217-27. . View in PubMed
  • Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. . View in PubMed
  • C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene Oncogene. 2008 Dec 04; 27(53):6749-60. . View in PubMed
  • Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption Alcohol Clin Exp Res. 2008 Nov; 32(11):1947-53. . View in PubMed
  • Expression of carboxylesterase and lipase genes in rat liver cell-types Biochem Biophys Res Commun. 2008 Sep 26; 374(3):460-4. . View in PubMed
  • Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G512-21. . View in PubMed
  • Fat paradox of steatohepatitis J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S104-7. . View in PubMed
  • Intragastric ethanol infusion model in rodents Methods Mol Biol. 2008; 447:33-48. . View in PubMed
  • Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G39-49. . View in PubMed
  • A rat model reproducing key pathological responses of alcoholic chronic pancreatitis Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G68-79. . View in PubMed
  • Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation Hepatology. 2007 Oct; 46(4):1187-97. . View in PubMed
  • Conceptual importance of identifying alcoholic liver disease as a lifestyle disease J Gastroenterol. 2007 Aug; 42(8):603-9. . View in PubMed
  • A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix J Biol Chem. 2007 Apr 27; 282(17):12928-39. . View in PubMed
  • Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages J Biol Chem. 2007 Feb 23; 282(8):5582-8. . View in PubMed
  • Epigenetic mechanism of stellate cell trans-differentiation J Hepatol. 2007 Feb; 46(2):352-3. . View in PubMed
  • Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S109-10. . View in PubMed
  • Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S102-5. . View in PubMed
  • A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease Ann Rheum Dis. 2006 Apr; 65(4):508-14. . View in PubMed
  • Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells J Biol Chem. 2005 Dec 09; 280(49):40650-9. . View in PubMed
  • Fat paradox in liver disease Keio J Med. 2005 Dec; 54(4):190-2. . View in PubMed
  • Adipogenic phenotype of hepatic stellate cells Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):132S-133S. . View in PubMed
  • Steatohepatitis induced by intragastric overfeeding in mice Hepatology. 2005 Oct; 42(4):905-14. . View in PubMed
  • Hepatoprotective mechanisms of Yan-gan-wan Hepatol Res. 2005 Aug; 32(4):202-12. . View in PubMed
  • A pilot study of an alcoholic liver disease recurrence prevention education program in hospitalized patients with advanced liver disease Addict Behav. 2005 Mar; 30(3):465-73. . View in PubMed
  • Adipogenic transcriptional regulation of hepatic stellate cells J Biol Chem. 2005 Feb 11; 280(6):4959-67. . View in PubMed
  • Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5′-methylthioadenosine Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. . View in PubMed
  • Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G722-9. . View in PubMed
  • Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption Gastroenterology. 2004 May; 126(5):1387-99. . View in PubMed
  • Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells J Biol Chem. 2004 Mar 19; 279(12):11392-401. . View in PubMed
  • Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes Blood. 2004 Feb 15; 103(4):1509-14. . View in PubMed
  • Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen J Biol Chem. 2004 Feb 06; 279(6):4820-8. . View in PubMed
  • Signaling role of iron in NF-kappa B activation in hepatic macrophages Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S36. . View in PubMed
  • PPAR Gamma and Hepatic Stellate Cells Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S7. . View in PubMed
  • Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county Alcohol Clin Exp Res. 2003 Nov; 27(11):1798-804. . View in PubMed
  • A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus Rheumatology (Oxford). 2003 Aug; 42(8):980-5. . View in PubMed
  • Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease Alcohol. 2003 Jun; 30(2):107-13. . View in PubMed
  • Signaling role of intracellular iron in NF-kappaB activation J Biol Chem. 2003 May 16; 278(20):17646-54. . View in PubMed
  • Aberrant HS1 molecule in a patient with systemic lupus erythematosus Genes Immun. 2003 Mar; 4(2):122-31. . View in PubMed
  • Redox regulation of cytokine expression in Kupffer cells Antioxid Redox Signal. 2002 Oct; 4(5):741-8. . View in PubMed
  • Iron activates NF-kappaB in Kupffer cells Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G719-26. . View in PubMed
  • Role of abnormal methionine metabolism in alcoholic liver injury Alcohol. 2002 Jul; 27(3):155-62. . View in PubMed
  • IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells Am J Physiol Gastrointest Liver Physiol. 2002 Jun; 282(6):G981-90. . View in PubMed
  • Alcoholic liver disease (ALD): a new domain for prevention efforts Subst Use Misuse. 2002; 37(14):1887-904. . View in PubMed
  • Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis Arthritis Rheum. 2001 Dec; 44(12):2819-27. . View in PubMed
  • Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications Prostaglandins Leukot Essent Fatty Acids. 2001 Oct; 65(4):191-6. . View in PubMed
  • Wnt signaling regulates hemopoiesis through stromal cells J Immunol. 2001 Jul 15; 167(2):765-72. . View in PubMed
  • Defect of lck in a patient with common variable immunodeficiency Int J Mol Med. 2001 Jun; 7(6):609-14. . View in PubMed
  • Outside-to-inside signal through the membrane TNF-alpha induces E-selectin (CD62E) expression on activated human CD4+ T cells J Immunol. 2001 Jan 01; 166(1):130-6. . View in PubMed
  • Gadolinium chloride-induced hepatocyte proliferation is prevented by antibodies to tumor necrosis factor alpha Toxicol Appl Pharmacol. 2001 Jan 01; 170(1):39-45. . View in PubMed
  • Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1333-42. . View in PubMed
  • Peroxisome proliferator-activated receptors and hepatic stellate cell activation J Biol Chem. 2000 Nov 17; 275(46):35715-22. . View in PubMed
  • Exacerbation of alcoholic liver injury by enteral endotoxin in rats Hepatology. 2000 Nov; 32(5):1008-17. . View in PubMed
  • Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver Am J Physiol Gastrointest Liver Physiol. 2000 Jul; 279(1):G178-85. . View in PubMed
  • Cyp2e1 and ALD Hepatology. 2000 Jul; 32(1):154-6. . View in PubMed
  • Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes Biochem Biophys Res Commun. 2000 Jun 16; 272(3):877-81. . View in PubMed
  • Meningitis carcinomatosa originating from an alpha fetoprotein-producing gastric cancer Intern Med. 2000 Mar; 39(3):223-7. . View in PubMed
  • RAR and RXR expression by Kupffer cells Exp Mol Pathol. 2000 Feb; 68(1):13-20. . View in PubMed
  • Effect of thioacetamide on the hepatic expression of gamma-glutamylcysteine synthetase subunits in the Rat Toxicol Appl Pharmacol. 1999 Sep 15; 159(3):161-8. . View in PubMed
  • Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide Gastroenterology. 1999 Sep; 117(3):706-16. . View in PubMed
  • Effect of ethanol and high-fat feeding on hepatic gamma-glutamylcysteine synthetase subunit expression in the rat Hepatology. 1999 Jul; 30(1):209-14. . View in PubMed
  • Cytokine regulation of hepatic stellate cells in liver fibrosis Alcohol Clin Exp Res. 1999 May; 23(5):911-6. . View in PubMed
  • Relationship between serum levels of anti-low-density lipoprotein-acetaldehyde-adduct antibody and aldehyde dehydrogenase 2 heterozygotes in patients with alcoholic liver injury Alcohol Clin Exp Res. 1999 Apr; 23(4 Suppl):24S-28S. . View in PubMed
  • Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury Am J Physiol. 1999 12; 277(6):G1240-50. . View in PubMed
  • Is interleukin-10 antifibrogenic in chronic liver injury? Hepatology. 1998 Dec; 28(6):1707-9.. View in PubMed
  • Drug delivery of antisense molecules to the brain for treatment of Alzheimer’s disease and cerebral AIDS J Pharm Sci. 1998 Nov; 87(11):1308-15. . View in PubMed
  • Molecular mechanism of induced hepatic macrophage cytokine gene expression in experimental alcoholic liver injury Alcohol Clin Exp Res. 1998 Aug; 22(5 Suppl):253S-254S. . View in PubMed
  • Identification of the 150-kDa surface antigen of Entamoeba histolytica as a galactose- and N-acetyl-D-galactosamine-inhibitable lectin Parasitol Res. 1998 Aug; 84(8):632-9. . View in PubMed
  • GLUT1 glucose transporter: differential gene transcription and mRNA binding to cytosolic and polysome proteins in brain and peripheral tissues Brain Res Mol Brain Res. 1998 Jul 15; 58(1-2):170-7. . View in PubMed
  • WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes Carcinogenesis. 1998 Jul; 19(7):1217-22. . View in PubMed
  • Polymorphism in the Ialpha1 germ-line transcript regulatory region and IgA productivity in patients with IgA nephropathy J Immunol. 1998 May 15; 160(10):4936-42. . View in PubMed
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