Keck School Faculty

Hidekazu Tsukamoto, PhD
Hidekazu Tsukamoto, PhD
Professor of Pathology
Pathology
MMR 1333 San Pablo St Health Sciences Campus Los Angeles

Cell Death and Liver Disease Gut Liver. 2019 Mar 19. . View in PubMed

Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science J Gastroenterol. 2019 Mar; 54(3):218-225. . View in PubMed

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition Hepatology. 2018 11; 68(5):1726-1740. . View in PubMed

Alcoholic liver disease Nat Rev Dis Primers. 2018 08 16; 4(1):16. . View in PubMed

Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases Am J Pathol. 2017 Apr; 187(4):781-797. . View in PubMed

Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood Hepatology. 2017 02; 65(2):475-490. . View in PubMed

Gender difference in NASH susceptibility: Roles of hepatocyte Ikkß and Sult1e1 PLoS One. 2017; 12(8):e0181052. . View in PubMed

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A Mol Ther. 2017 01 04; 25(1):218-231. . View in PubMed

Alcoholic hepatitis: Translational approaches to develop targeted therapies Hepatology. 2016 10; 64(4):1343-55. . View in PubMed

Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-? 1. Cancer Gene Ther. 2016 08; 23(8):266-77.. View in PubMed

Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese J Lipid Res. 2016 06; 57(6):1017-28. . View in PubMed

A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution Front Physiol. 2016; 7:579. . View in PubMed

ALPD 2015, Preface Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S1. . View in PubMed

Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice J Neuroimmunol. 2015 Aug 15; 285:169-79. . View in PubMed

Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis Pancreas. 2015 Aug; 44(6):882-7. . View in PubMed

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells J Hepatol. 2015 Feb; 62(2):388-97. . View in PubMed

Alcohol, TLR4-TGF-ß antagonism, and liver cancer Hepatol Int. 2014 Sep; 8 Suppl 2:408-12. . View in PubMed

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells Hepatology. 2014 Mar; 59(3):1118-29. . View in PubMed

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice Hepatology. 2013 Jul; 58(1):108-19. . View in PubMed

Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations J Biol Chem. 2012 Dec 07; 287(50):42165-79. . View in PubMed

Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation J Biol Chem. 2012 Sep 14; 287(38):32078-84. . View in PubMed

Epigenetic regulation of miR-34a expression in alcoholic liver injury Am J Pathol. 2012 Sep; 181(3):804-17. . View in PubMed

Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. . View in PubMed

Epigenetic cell fate regulation of hepatic stellate cells Hepatol Res. 2011 Jul; 41(7):675-82. . View in PubMed

15th International Symposium on Cells of the Hepatic Sinusoid, 2010 Liver Int. 2011 Jul; 31(6):762-72. . View in PubMed

Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression J Biol Chem. 2011 Jan 28; 286(4):2393-401. . View in PubMed

Enteric dysbiosis associated with a mouse model of alcoholic liver disease Hepatology. 2011 Jan; 53(1):96-105. . View in PubMed

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair Hepatology. 2010 Aug; 52(2):480-92. . View in PubMed

Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport Am J Physiol Renal Physiol. 2010 Jul; 299(1):F28-34. . View in PubMed

Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse Hepatology. 2010 Mar; 51(3):932-41. . View in PubMed

Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation Hepatology. 2010 Mar; 51(3):986-95. . View in PubMed

Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1 J Immunol. 2009 Nov 01; 183(9):5964-76. . View in PubMed

Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199 J Immunol. 2009 Oct 15; 183(8):5232-43. . View in PubMed

"Second hit" models of alcoholic liver disease Semin Liver Dis. 2009 May; 29(2):178-87. . View in PubMed

Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer Pancreas. 2009 Mar; 38(2):e47-52. . View in PubMed

C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene Oncogene. 2008 Dec 04; 27(53):6749-60. . View in PubMed

Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption Alcohol Clin Exp Res. 2008 Nov; 32(11):1947-53. . View in PubMed

Expression of carboxylesterase and lipase genes in rat liver cell-types Biochem Biophys Res Commun. 2008 Sep 26; 374(3):460-4. . View in PubMed

Fat paradox of steatohepatitis J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S104-7. . View in PubMed

A rat model reproducing key pathological responses of alcoholic chronic pancreatitis Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G68-79. . View in PubMed

Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation Hepatology. 2007 Oct; 46(4):1187-97. . View in PubMed

Conceptual importance of identifying alcoholic liver disease as a lifestyle disease J Gastroenterol. 2007 Aug; 42(8):603-9. . View in PubMed

A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix J Biol Chem. 2007 Apr 27; 282(17):12928-39. . View in PubMed

Epigenetic mechanism of stellate cell trans-differentiation J Hepatol. 2007 Feb; 46(2):352-3. . View in PubMed

Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S109-10. . View in PubMed

Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S102-5. . View in PubMed

A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease Ann Rheum Dis. 2006 Apr; 65(4):508-14. . View in PubMed

Fat paradox in liver disease Keio J Med. 2005 Dec; 54(4):190-2. . View in PubMed

Adipogenic phenotype of hepatic stellate cells Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):132S-133S. . View in PubMed

A pilot study of an alcoholic liver disease recurrence prevention education program in hospitalized patients with advanced liver disease Addict Behav. 2005 Mar; 30(3):465-73. . View in PubMed

Adipogenic transcriptional regulation of hepatic stellate cells J Biol Chem. 2005 Feb 11; 280(6):4959-67. . View in PubMed

Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption Gastroenterology. 2004 May; 126(5):1387-99. . View in PubMed

Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen J Biol Chem. 2004 Feb 06; 279(6):4820-8. . View in PubMed

Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county Alcohol Clin Exp Res. 2003 Nov; 27(11):1798-804. . View in PubMed

Aberrant HS1 molecule in a patient with systemic lupus erythematosus Genes Immun. 2003 Mar; 4(2):122-31. . View in PubMed

Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001 Alcohol. 2002 Oct; 28(2):117-28. . View in PubMed

Alcoholic liver disease (ALD): a new domain for prevention efforts Subst Use Misuse. 2002; 37(14):1887-904. . View in PubMed

Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis Arthritis Rheum. 2001 Dec; 44(12):2819-27. . View in PubMed

Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease Am J Physiol Endocrinol Metab. 2001 Sep; 281(3):E420-9. . View in PubMed

Current concepts in the pathogenesis of alcoholic liver injury FASEB J. 2001 Jun; 15(8):1335-49. . View in PubMed

Defect of lck in a patient with common variable immunodeficiency Int J Mol Med. 2001 Jun; 7(6):609-14. . View in PubMed

Alcohol and retinoids Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):207S-217S. . View in PubMed

Gadolinium chloride-induced hepatocyte proliferation is prevented by antibodies to tumor necrosis factor alpha Toxicol Appl Pharmacol. 2001 Jan 01; 170(1):39-45. . View in PubMed

Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1333-42. . View in PubMed

Exacerbation of alcoholic liver injury by enteral endotoxin in rats Hepatology. 2000 Nov; 32(5):1008-17. . View in PubMed

Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver Am J Physiol Gastrointest Liver Physiol. 2000 Jul; 279(1):G178-85. . View in PubMed

Cyp2e1 and ALD Hepatology. 2000 Jul; 32(1):154-6. . View in PubMed

Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes Biochem Biophys Res Commun. 2000 Jun 16; 272(3):877-81. . View in PubMed

Effect of thioacetamide on the hepatic expression of gamma-glutamylcysteine synthetase subunits in the Rat Toxicol Appl Pharmacol. 1999 Sep 15; 159(3):161-8. . View in PubMed

Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide Gastroenterology. 1999 Sep; 117(3):706-16. . View in PubMed

Effect of ethanol and high-fat feeding on hepatic gamma-glutamylcysteine synthetase subunit expression in the rat Hepatology. 1999 Jul; 30(1):209-14. . View in PubMed

Cytokine regulation of hepatic stellate cells in liver fibrosis Alcohol Clin Exp Res. 1999 May; 23(5):911-6. . View in PubMed

Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS J Pharm Sci. 1998 Nov; 87(11):1308-15. . View in PubMed

GLUT1 glucose transporter: differential gene transcription and mRNA binding to cytosolic and polysome proteins in brain and peripheral tissues Brain Res Mol Brain Res. 1998 Jul 15; 58(1-2):170-7. . View in PubMed

Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells J Biol Chem. 1998 Jan 02; 273(1):302-8. . View in PubMed

Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis Am J Physiol. 1997 Mar; 272(3 Pt 1):G589-96. . View in PubMed

A new type of major aminopeptidase in bovine brain Biochem Mol Med. 1996 Dec; 59(2):161-8. . View in PubMed

Evidence for translational control elements within the 5'-untranslated region of GLUT1 glucose transporter mRNA J Neurochem. 1996 Oct; 67(4):1335-43. . View in PubMed

Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells Hepatology. 1996 Sep; 24(3):670-6. . View in PubMed

Down-regulation of secretion of human complement component C2 by the product of an alternatively spliced C2 messenger RNA J Immunol. 1996 Jun 15; 156(12):4901-8. . View in PubMed

Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA J Clin Invest. 1996 Jun 15; 97(12):2823-32. . View in PubMed

Giant mitochondria induced in rat pancreatic exocrine cells by ethanol and iron Anat Rec. 1996 May; 245(1):65-75. . View in PubMed

Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart Free Radic Res. 1996 May; 24(5):361-7. . View in PubMed

Effects of dietary polyunsaturated fat on ethanol-induced Ito cell activation Am J Physiol. 1996 Apr; 270(4 Pt 1):G581-6. . View in PubMed

Glutathione peroxidase activity in endometrium: effects of sex hormones and cancer Gynecol Oncol. 1996 Feb; 60(2):277-82. . View in PubMed

Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease Hepatology. 1995 Oct; 22(4 Pt 1):1304-9. . View in PubMed

Experimental liver cirrhosis induced by alcohol and iron J Clin Invest. 1995 Jul; 96(1):620-30. . View in PubMed

Bispecific antibody-mediated cytotoxicity by CD4+ and CD8(+)-activated T cells generated from leukemia patients after allogeneic bone marrow transplantation Bone Marrow Transplant. 1995 Feb; 15(2):193-8. . View in PubMed

[A case of nodular regenerative hyperplasia (NRH) of the liver associated with recurrent hepatic encephalopathy due to splenorenal shunt] Nihon Shokakibyo Gakkai Zasshi. 1994 Jun; 91(6):1136-40. . View in PubMed

Dietary modulation of alcohol-induced pancreatic injury Alcohol. 1993 Nov-Dec; 10(6):481-4. . View in PubMed

Evolution of intragastric ethanol infusion model Alcohol. 1993 Nov-Dec; 10(6):437-41. . View in PubMed

Experimental models of hepatic fibrosis: a review Semin Liver Dis. 1990 Feb; 10(1):56-65. . View in PubMed

Animal models for alcoholic liver disease Hepatology. 1989 Nov; 10(5):898-9. . View in PubMed

Differential effects of interleukin-1 alpha, tumor necrosis factor alpha, and transforming growth factor beta 1 on cell proliferation and collagen formation by cultured fat-storing cells Liver. 1989 Apr; 9(2):71-8. . View in PubMed

[Abnormal cholecystokinin-acinar function coupling in atrophied pancreatic acini from rats fed ethanol and a high-fat diet] Arukoru Kenkyuto Yakubutsu Ison. 1988 Dec; 23(4):332-50. . View in PubMed

Ethanol-induced liver fibrosis in rats fed high fat diet Hepatology. 1986 Sep-Oct; 6(5):814-22. . View in PubMed

Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat Alcohol Clin Exp Res. 1986; 10(6 Suppl):13S-19S. . View in PubMed

Comparison of tyrosine phosphorylation of proteins by membrane fractions from mouse liver, Ehrlich ascites tumor and MH134 hepatoma FEBS Lett. 1985 May 06; 184(1):60-4. . View in PubMed

Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats Alcohol Clin Exp Res. 1985 Jan-Feb; 9(1):31-7. . View in PubMed

[Studies on the direct extraction method for determination of lead in blood by atomic absorption spectrophotometry (author's transl)] Rinsho Byori. 1978 Jul; 26(7):611-4. . View in PubMed

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