Keck School Faculty

Hussein Yassine

Hussein Yassine

Associate Professor of Medicine
CSC 210 Health Sciences Campus Los Angeles

: Presidential Poster Award, Endocrine Society , 2009

: Department of Veterans Affairs VISN 18 Outstanding Research Award , 2009

Case Western Reserve University, Cleveland, OH : Resident Teacher of the Year Award, 2007

Beirut Arab University, Beirut, Lebanon : Dean's Honor List on graduation, 2003

Beirut Arab University, Beirut, Lebanon : Dean's Distinguished Student Medicine Day Award, 2002

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial EBioMedicine. 2020 Sep; 59:102883. . View in PubMed

Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes: Exploratory Analyses From the Action for Health in Diabetes Brain Magnetic Resonance Imaging Study J Gerontol A Biol Sci Med Sci. 2020 Mar 09; 75(4):771-778. . View in PubMed

Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus? Neurobiol Aging. 2020 08; 92:61-72.. View in PubMed

Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer's Disease Cooperative Study-Sponsored DHA Clinical Trial J Alzheimers Dis. 2020; 74(3):975-990. . View in PubMed

Simple and Fast Assay for Apolipoprotein E Phenotyping and Glycotyping: Discovering Isoform-Specific Glycosylation in Plasma and Cerebrospinal Fluid J Alzheimers Dis. 2020; 76(3):883-893. . View in PubMed

APOE Alleles and Diet in Brain Aging and Alzheimer's Disease Front Aging Neurosci. 2020; 12:150. . View in PubMed

ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors Arterioscler Thromb Vasc Biol. 2019 10; 39(10):2145-2156. . View in PubMed

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes J Neurosci. 2019 11 27; 39(48):9611-9622. . View in PubMed

Low-Density Lipoprotein Particle Size Subfractions and Cerebral Amyloidosis J Alzheimers Dis. 2019; 68(3):983-990. . View in PubMed

Development of a delayed-release nutrient for appetite control in adults with obesity and type 2 diabetes and initial clinical testing in a single dose randomized controlled trial Nutr Diabetes. 2019 07 15; 9(1):20. . View in PubMed

DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA Alzheimers Res Ther. 2017 Mar 23; 9(1):23. . View in PubMed

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review JAMA Neurol. 2017 Mar 01; 74(3):339-347. . View in PubMed

Targeting prodromal Alzheimer's disease: too late for prevention? Lancet Neurol. 2017 12; 16(12):946-947.. View in PubMed

Lessons from the Multidomain Alzheimer Preventive Trial Lancet Neurol. 2017 08; 16(8):585-586. . View in PubMed

Changes in low-density lipoprotein size phenotypes associate with changes in apolipoprotein C-III glycoforms after dietary interventionsJ Clin Lipidol. 2017 Jan - Feb; 11(1):224-233. e2. . View in PubMed

Ex vivo instability of glycated albumin: A role for autoxidative glycation Arch Biochem Biophys. 2017 09 01; 629:36-42. . View in PubMed

Development of quantitative mass spectrometric immunoassay for serum amyloid A Biomarkers. 2016 Dec; 21(8):743-751. . View in PubMed

Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis JAMA Neurol. 2016 Oct 01; 73(10):1208-1216. . View in PubMed

Posttranslational modifications of apolipoprotein A-II proteoforms in type 2 diabetes J Clin Lipidol. 2016 Jul-Aug; 10(4):808-815. . View in PubMed

ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease J Am Heart Assoc. 2016 Feb 12; 5(2). . View in PubMed

Disialylated apolipoprotein C-III proteoform is associated with improved lipids in prediabetes and type 2 diabetes J Lipid Res. 2016 05; 57(5):894-905. . View in PubMed

The association of plasma cystatin C proteoforms with diabetic chronic kidney disease Proteome Sci. 2016; 14:7. . View in PubMed

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease Alzheimers Res Ther. 2016 06 30; 8:25. . View in PubMed

Site specific modification of the human plasma proteome by methylglyoxal Toxicol Appl Pharmacol. 2015 Dec 01; 289(2):155-62. . View in PubMed

Serum amyloid a truncations in type 2 diabetes mellitus PLoS One. 2015; 10(1):e0115320. . View in PubMed

The Association of Human Apolipoprotein C-III Sialylation Proteoforms with Plasma Triglycerides PLoS One. 2015; 10(12):e0144138. . View in PubMed

The Application of Multiple Reaction Monitoring to Assess Apo A-I Methionine Oxidations in Diabetes and Cardiovascular Disease Transl Proteom. 2014 Dec 01; 4-5:18-24. . View in PubMed

Elevated plasma albumin and apolipoprotein A-I oxidation under suboptimal specimen storage conditions Mol Cell Proteomics. 2014 Jul; 13(7):1890-9. . View in PubMed

Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes Metabolism. 2014 May; 63(5):727-34. . View in PubMed

The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins Lipids Health Dis. 2014 Jan 08; 13:8. . View in PubMed

Mass spectrometric immunoassay and MRM as targeted MS-based quantitative approaches in biomarker development: potential applications to cardiovascular disease and diabetes Proteomics Clin Appl. 2013 Aug; 7(7-8):528-40. . View in PubMed

Erlotinib-associated exacerbation of hypothyroidism with pericardial tamponade Endocr Pract. 2012 Sep-Oct; 18(5):e111-3. . View in PubMed

Adjusting for Urinary Creatinine Overestimates Arsenic Concentrations in Diabetics Cardiorenal Med. 2012 Feb; 2(1):26-32. . View in PubMed

New site(s) of methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism Chem Biol Interact. 2011 Jun 30; 192(1-2):122-8. . View in PubMed

Clinical determinants of aspirin resistance in diabetes Diabetes Res Clin Pract. 2010 Oct; 90(1):e19-21. . View in PubMed

Effect of glucose or fat challenge on aspirin resistance in diabetes Int J Endocrinol. 2010; 2010:820876. . View in PubMed

Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial J Gerontol A Biol Sci Med Sci. 2009 Jan; 64(1):90-5. . View in PubMed

Dr. Yassine is an Associate Professor in the Department of Medicine, Keck School of Medicine of USC.

The Yassine lab ( specializes in how changes in lipid metabolism and nutrition affect cognition and the risk of developing Alzheimer's disease (AD). The lab has an interest in studying how carrying the APOE4 allele, strongest genetic risk factors for developing AD, affects lipid metabolism, the response to the diet; combining basic science, clinical trials and brain imaging studies.

Dr. Yassine directs the Roybal AD Research program focused on understanding how obesity, diabetes and vascular risk factors in Los Angeles’s Latinx population affect cognition and AD risk using longitudinal studies with cerebrospinal fluid and brain imaging biomarkers.

Dr. Yassine runs the Lipid Clinic at Roybal Healthcare Center in East LA, providing care for a large population of complex lipid and diabetes disorders that are referred from all LA county clinics.
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