Hussein Yassine, MD

Dr. Yassine is the Volke Endowed Professor of Neurology at Keck School of Medicine of USC.

The Yassine lab specializes in how lipid metabolism and nutrition changes affect cognition and the risk of developing late-onset Alzheimer’s disease (AD). The lab is interested in studying how carrying the APOE4 allele, the strongest genetic risk factor for developing AD, affects lipid metabolism, neuroinflammation, and the response to the diet; combining basic science, clinical trials, and brain imaging studies.

Dr. Yassine directs the USC Center for Personalized Brain Health (https://keck.usc.edu/cpbh/) focused on understanding mechanisms and risk factors of dementia in patients carrying the APOE4 allele.

• Beirut Arab University, Beirut, Lebanon: Dean’s Distinguished Student Medicine Day Award, 2002
• Beirut Arab University, Beirut, Lebanon: Dean’s Honor List on graduation, 2003
• Case Western Reserve University, Cleveland, OH: Resident Teacher of the Year Award, 2007
• Department of Veterans Affairs VISN 18 Outstanding Research Award, 2009
• Presidential Poster Award, Endocrine Society, 2009

• Drug Development for Alzheimer's neuroinflammation
  NIH · U01AG094622 · Aug 1, 2025 – Jul 31, 2030 · Role: Principal Investigator
• Effect of diabetes and AD pathology on brain imaging and cognition in Latino adults
  NIH · R01AG078362 · Sep 30, 2022 – Aug 31, 2027 · Role: Principal Investigator
• Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4
  NIH · R01AG076124 · May 15, 2022 – Apr 30, 2027 · Role: Principal Investigator
• Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4 Diversity Supplement
  NIH · RF1AG076124 · May 15, 2022 – Apr 30, 2025 · Role: Principal Investigator
• A Symposium on Nutrition State of Science for Dementia Prevention
  NIH · R13AG069386 · Aug 15, 2020 – Jul 31, 2021 · Role: Principal Investigator
• ApoE, ABCA1 and endosomal dysregulation in AD
  NIH · R01AG067063 · May 15, 2020 – Feb 28, 2025 · Role: Principal Investigator
• DHA brain delivery by APOE genotype
  NIH · R21AG056518 · May 15, 2018 – Jan 31, 2021 · Role: Principal Investigator
• The delivery of essential fatty acids to the Brain in Alzheimer's disease
  NIH · R01AG054434 · Sep 1, 2017 – Apr 30, 2022 · Role: Principal Investigator
• Biomarkers of ABCA1 mediated functions in Alzheimers disease
  NIH · R01AG055770 · Jun 1, 2017 – May 31, 2022 · Role: Principal Investigator
• The Effect of Saturated Fat Ingestion on the HDL Proteome
  NIH · K23HL107389 · May 15, 2012 – Apr 30, 2018 · Role: Principal Investigator
• Alzheimer's Abeta, Tau, Apolipoproteins and Blood-brain barrier
  NIH · R01NS034467 · Sep 1, 1995 – Feb 28, 2025 · Role: Principal Investigator

• Alzheimer's disease
• APOE
• Lipids

• CPBH News

• Aisen, Paul
• Thompson, Paul
• Zlokovic, Berislav
• Schneider, Lon
• Toga, Arthur
• Chui, Helena