James B. Dewey, PhD

Assistant Professor of Otolaryngology-Head and Neck Surgery

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Overview

The Dewey Lab studies the mechanical processes that underlie normal hearing and how these processes are affected in hearing-impaired ears. Current topics of investigation include (1) how sound causes the structures within the cochlear spiral to vibrate, (2) how these vibrations are amplified by the sensory outer hair cells, and (3) how this amplification process leads to the emission of sound by the ear.

Courses Taught

    OHNS 500, Neuroanatomy and Neurophysiology in Speech, Language and Hearing (Y1, Fall Semester)

Publications

  • Bandpass Shape of Distortion-Product Otoacoustic Emission Ratio Functions Reflects Cochlear Frequency Tuning in Normal-Hearing Mice J Assoc Res Otolaryngol. 2023 06; 24(3):305-324. . View in PubMed
  • The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of WE. Brownell. J Assoc Res Otolaryngol. 2023 04; 24(2):117-127. . View in PubMed
  • Cubic and quadratic distortion products in vibrations of the mouse cochlear apex JASA Express Lett. 2022 11; 2(11):114402. . View in PubMed
  • Overturning the mechanisms of cochlear amplification via area deformations of the organ of Corti J Acoust Soc Am. 2022 10; 152(4):2227. . View in PubMed
  • In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device Biomed Opt Express. 2021 Aug 01; 12(8):5196-5213. . View in PubMed
  • The Elusive Cochlear Filter: Wave Origin of Cochlear Cross-Frequency Masking J Assoc Res Otolaryngol. 2021 12; 22(6):623-640. . View in PubMed
  • Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo Proc Natl Acad Sci U S A. 2021 10 26; 118(43). . View in PubMed
  • LMO7 deficiency reveals the significance of the cuticular plate for hearing function Nat Commun. 2019 03 08; 10(1):1117. . View in PubMed
  • Amplification and Suppression of Traveling Waves along the Mouse Organ of Corti: Evidence for Spatial Variation in the Longitudinal Coupling of Outer Hair Cell-Generated Forces J Neurosci. 2019 03 06; 39(10):1805-1816. . View in PubMed
  • Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea Cell Rep. 2018 06 05; 23(10):2915-2927. . View in PubMed
  • Profiles of Stimulus-Frequency Otoacoustic Emissions from 05 to 20 kHz in Humans. J Assoc Res Otolaryngol. 2017 Feb; 18(1):89-110. . View in PubMed
  • A common microstructure in behavioral hearing thresholds and stimulus-frequency otoacoustic emissions J Acoust Soc Am. 2017 11; 142(5):3069. . View in PubMed
  • Neuroplastin Isoform Np55 Is Expressed in the Stereocilia of Outer Hair Cells and Required for Normal Outer Hair Cell Function J Neurosci. 2016 08 31; 36(35):9201-16. . View in PubMed
  • Efferent Modulation of Stimulus Frequency Otoacoustic Emission Fine Structure Front Syst Neurosci. 2015; 9:168. . View in PubMed
  • Effects of contralateral acoustic stimulation on spontaneous otoacoustic emissions and hearing threshold fine structure J Assoc Res Otolaryngol. 2014 Dec; 15(6):897-914. . View in PubMed
  • Effects of fundamental frequency and vocal-tract length cues on sentence segregation by listeners with hearing loss J Acoust Soc Am. 2011 Aug; 130(2):1006-19. . View in PubMed