James B. Dewey, PhD

Assistant Professor of Otolaryngology-Head and Neck Surgery

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Overview

The Dewey Lab studies the mechanical processes that underlie normal hearing and how these processes are affected in hearing-impaired ears. Current topics of investigation include (1) how sound causes the structures within the cochlear spiral to vibrate, (2) how these vibrations are amplified by the sensory outer hair cells, and (3) how this amplification process leads to the emission of sound by the ear.

#Courses

OHNS 500, Neuroanatomy and Neurophysiology in Speech, Language and Hearing (Y1, Fall Semester)

Research Funding

  • Mechanisms of amplification and nonlinearity in the mouse cochlea
    NIH · R01DC021006 · Dec 1, 2023 – Nov 30, 2028 · Role: Principal Investigator
  • Role of tonic outer hair cell motility in cochlear amplification
    NIH · R21DC019209 · Sep 23, 2020 – Aug 31, 2023 · Role: Principal Investigator
  • Influence of hair bundle properties on cochlear mechanics
    NIH · F32DC016211 · Apr 1, 2017 – Mar 31, 2020 · Role: Principal Investigator
  • Auditory Function at the Base of the Human Cochlea
    NIH · F31DC013710 · Jun 1, 2014 – May 31, 2016 · Role: Principal Investigator

Publications

  • Broadband amplification of organ of Corti vibrations in the mouse cochlear apex. bioRxiv. 2026 Jun 06.. View in PubMed
  • Multimodal microscope for optical coherence microscopy, tomography, vibrometry, and two-photon microscopy in the living mouse cochlea. J Biomed Opt. 2025 Oct; 30(10):106005.. View in PubMed
  • Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects. Proc Natl Acad Sci U S A. 2025 Jul 29; 122(30):e2505176122.. View in PubMed
  • The Medial Olivocochlear Efferent Pathway Potentiates Cochlear Amplification in Response to Hearing Loss. J Neurosci. 2025 04 09; 45(15).. View in PubMed
  • Sources of Microstructure in Mammalian Cochlear Responses. J Assoc Res Otolaryngol. 2025 Feb; 26(1):1-15.. View in PubMed
  • Tonic sound-evoked motility of cochlear outer hair cells in mice with impaired mechanotransduction. bioRxiv. 2024 Dec 20.. View in PubMed
  • Visualizing motions within the cochlea’s organ of Corti and illuminating cochlear mechanics with optical coherence tomography. Hear Res. 2025 01; 455:109154.. View in PubMed
  • Similar Tuning of Distortion-Product Otoacoustic Emission Ratio Functions and Cochlear Vibrations in Mice. AIP Conf Proc. 2024 Feb 27; 3062(1).. View in PubMed
  • Bandpass Shape of Distortion-Product Otoacoustic Emission Ratio Functions Reflects Cochlear Frequency Tuning in Normal-Hearing Mice. J Assoc Res Otolaryngol. 2023 06; 24(3):305-324.. View in PubMed
  • The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell. J Assoc Res Otolaryngol. 2023 04; 24(2):117-127.. View in PubMed