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Jang-Hyun Youn, PhD

Associate Professor of Physiology & Neuroscience

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Phone +1 323 442 3260
Email youn@usc.edu
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Publications

  • Corrigendum to “Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study” [Phytomedicine 139 (2025) 156510]. Phytomedicine. 2025 Sep; 145:156978.. View in PubMed
  • The polyphenol/caffeine ratio determines the arousal-inducing properties of the green tea ethanol extract. Food Funct. 2025 May 06; 16(9):3694-3706.. View in PubMed
  • Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study. Phytomedicine. 2025 Apr; 139:156510.. View in PubMed
  • Novel neuropharmacological activity of citrus lime (Citrus aurantifolia): A standardized lime peel supplement enhances non-rapid eye movement sleep by activating the GABA type A receptor. Biomed Pharmacother. 2024 Oct; 179:117410.. View in PubMed
  • Kinetic Modeling of In Vivo K+ Distribution and Fluxes with Stable K+ Isotopes: Effects of Dietary K+ Restriction. Int J Mol Sci. 2024 Sep 06; 25(17).. View in PubMed
  • High-Fat Feeding Alters Circulating Triglyceride Composition: Roles of FFA Desaturation and ω-3 Fatty Acid Availability. Int J Mol Sci. 2024 Aug 13; 25(16).. View in PubMed
  • Determinants of Meal-Induced Changes in Circulating FFA Epoxides, Diols, and Diol-to-Epoxide Ratios as Indices of Soluble Epoxide Hydrolase Activity. Int J Mol Sci. 2023 Dec 11; 24(24).. View in PubMed
  • Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity. Int J Mol Sci. 2023 Jun 28; 24(13).. View in PubMed
  • Estimating in vivo potassium distribution and fluxes with stable potassium isotopes. Am J Physiol Cell Physiol. 2022 03 01; 322(3):C410-C420.. View in PubMed
  • Retraction Note to: Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca2+-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells. Apoptosis. 2022 02; 27(1-2):161.. View in PubMed
  • Stable potassium isotopes (41K/39K) track transcellular and paracellular potassium transport in biological systems. Front Physiol. 2022; 13:1016242.. View in PubMed
  • Assessment of soluble epoxide hydrolase activity in vivo: A metabolomic approach. Prostaglandins Other Lipid Mediat. 2020 06; 148:106410.. View in PubMed
  • Interaction of Gut Microbiota and High-Sodium, Low-Potassium Diet in Altering Plasma Triglyceride Profiles Revealed by Lipidomics Analysis. Mol Nutr Food Res. 2019 12; 63(24):e1900752.. View in PubMed
  • Correction to: Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca2+-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells. Apoptosis. 2019 Feb; 24(1-2):200-203.. View in PubMed
  • Effects of Gut Bacteria Depletion and High-Na+ and Low-K+ Intake on Circulating Levels of Biogenic Amines. Mol Nutr Food Res. 2019 02; 63(4):e1801184.. View in PubMed
  • Corrigendum to “Carbonyl reductase 1 protects pancreatic ß-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity” [Free Radic. Biol. Med. 49 (2010):1522-1533]. Free Radic Biol Med. 2018 12; 129:614-617.. View in PubMed
  • Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. J Nutr Biochem. 2017 11; 49:8-14.. View in PubMed
  • Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits. Physiology (Bethesda). 2017 03; 32(2):100-111.. View in PubMed
  • Circulating free fatty acids inhibit food intake in an oleate-specific manner in rats. Physiol Behav. 2016 12 01; 167:194-201.. View in PubMed
  • θ-Defensin RTD-1 improves insulin action and normalizes plasma glucose and FFA levels in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2015 Jul 15; 309(2):E154-60.. View in PubMed
  • Fat sensing and metabolic syndrome. Rev Endocr Metab Disord. 2014 Dec; 15(4):263-75.. View in PubMed
  • Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1059-68.. View in PubMed
  • Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca(2+)-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells. Apoptosis. 2014 Apr; 19(4):682-97.. View in PubMed
  • Regulation of hypothalamic-pituitary-adrenal axis by circulating free fatty acids in male Wistar rats: role of individual free fatty acids. Endocrinology. 2014 Mar; 155(3):923-31.. View in PubMed
  • Role of pituitary in K+ homeostasis: impaired renal responses to altered K+ intake in hypophysectomized rats. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15; 304(12):R1166-74.. View in PubMed
  • Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82.. View in PubMed
  • Gut sensing of potassium intake and its role in potassium homeostasis. Semin Nephrol. 2013 May; 33(3):248-56.. View in PubMed
  • A Fall in plasma free fatty acid (FFA) level activates the hypothalamic-pituitary-adrenal axis independent of plasma glucose: evidence for brain sensing of circulating FFA. Endocrinology. 2012 Aug; 153(8):3587-92.. View in PubMed
  • Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care. 2012 May; 35(5):1015-20.. View in PubMed
  • Effects of nicotinic acid on gene expression: potential mechanisms and implications for wanted and unwanted effects of the lipid-lowering drug. J Clin Endocrinol Metab. 2011 Oct; 96(10):3048-55.. View in PubMed
  • Gut sensing of dietary K⁺ intake increases renal K⁺excretion. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R421-9.. View in PubMed
  • Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue. Am J Physiol Endocrinol Metab. 2011 Jun; 300(6):E1012-21.. View in PubMed
  • Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: implications for unwanted effects of nicotinic acid treatment. Metabolism. 2011 Jan; 60(1):134-44.. View in PubMed
  • Carbonyl reductase 1 protects pancreatic β-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity. Free Radic Biol Med. 2010 Nov 30; 49(10):1522-33.. View in PubMed
  • eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E846-53.. View in PubMed
  • Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. Arterioscler Thromb Vasc Biol. 2010 Feb; 30(2):290-7.. View in PubMed
  • Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med. 2009 May 05; 150(9):619-25.. View in PubMed
  • Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol. 2009; 71:381-401.. View in PubMed
  • AMPK activation with AICAR provokes an acute fall in plasma [K+]. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35.. View in PubMed
  • Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes. 2007 Dec; 56(12):2973-81.. View in PubMed
  • Evidence for gut factor in K+ homeostasis. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7.. View in PubMed
  • Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Diabetes. 2006 Aug; 55(8):2311-7.. View in PubMed
  • Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration. Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63.. View in PubMed
  • Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2488-94.. View in PubMed
  • Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005 Sep; 25(5):335-42.. View in PubMed
  • alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem Biophys Res Commun. 2005 Jan 07; 326(1):197-202.. View in PubMed
  • Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37.. View in PubMed
  • Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med. 2004 Jul; 10(7):727-33.. View in PubMed
  • Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E69-74.. View in PubMed
  • Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation. Diabetes. 2003 Sep; 52(9):2331-7.. View in PubMed
  • Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E233-40.. View in PubMed
  • Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74.. View in PubMed
  • Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content. Diabetes. 2002 Apr; 51(4):915-20.. View in PubMed
  • Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats. Am J Physiol Endocrinol Metab. 2000 Jun; 278(6):E977-84.. View in PubMed
  • Glucose transporters and glucose transport in skeletal muscles of 1- to 25-mo-old rats. Am J Physiol. 1993 Mar; 264(3 Pt 1):E319-27.. View in PubMed
  • Effects of alkaline pH on the stimulation of glucose transport in rat skeletal muscle. Biochim Biophys Acta. 1993 Feb 09; 1145(2):199-204.. View in PubMed
  • Glucose transporters and maximal transport are increased in endurance-trained rat soleus. J Appl Physiol (1985). 1992 Aug; 73(2):486-92.. View in PubMed
  • Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction. Am J Physiol. 1991 Mar; 260(3 Pt 1):C555-61.. View in PubMed
  • Prolonged incubation of skeletal muscle increases system A amino acid transport. Am J Physiol. 1991 Jan; 260(1 Pt 1):C88-95.. View in PubMed
  • Fructose effect to suppress hepatic glycogen degradation. J Biol Chem. 1987 Aug 25; 262(24):11470-7.. View in PubMed
  • Synergism of glucose and fructose in net glycogen synthesis in perfused rat livers. J Biol Chem. 1986 Dec 05; 261(34):15960-9.. View in PubMed
  • Computed insulin profiles for normalization of glycemia in diabetic patients. Bull Math Biol. 1983; 45(5):739-48.. View in PubMed

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