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Jian Xu, PhD

Associate Professor

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Phone +1 323 442 4835
Email [email protected]
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Awards

  • FASEB Biological Methylation Conference Best Seminar Award, 2012
  • American Heart Association National Scientist Development Grant, 2011-2014
  • Tokyo Global Center of Excellence Retreat Poster Award, 2011
  • Foundation Independent Postdoctoral Research Fellowship, 2009-2010
  • American Heart Association Postdoctoral Fellowship, 2007-2009
  • University of Cincinnati Graduate Student Poster Forum, Poster Award, 2003
  • American Heart Association Pre-doctoral Fellowship, 2001-2003
  • Peking University Health Science Center Undergraduate Dissertation Award, 2000
  • Peking University Outstanding Student Scholarship, 1995-2000

Publications

  • Role of Patient Sorting in Avoidable Hospital Stays in Medicare Advantage vs Traditional Medicare. JAMA Health Forum. 2023 11 03; 4(11):e233931.. View in PubMed
  • Cellular pathways influenced by protein arginine methylation: Implications for cancer. Mol Cell. 2021 11 04; 81(21):4357-4368.. View in PubMed
  • Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling. J Biol Chem. 2021 Jan-Jun; 296:100496.. View in PubMed
  • PRMT1-p53 Pathway Controls Epicardial EMT and Invasion. Cell Rep. 2020 06 09; 31(10):107739.. View in PubMed
  • Arginine methylation of SMAD7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem-cell generation. J Biol Chem. 2018 08 24; 293(34):13059-13072.. View in PubMed
  • Prmt1 regulates craniofacial bone formation upstream of Msx1. Mech Dev. 2018 08; 152:13-20.. View in PubMed
  • Transcription Factors in Craniofacial Development: From Receptor Signaling to Transcriptional and Epigenetic Regulation. Curr Top Dev Biol. 2015; 115:377-410.. View in PubMed
  • Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014 Mar; 15(3):178-96.. View in PubMed
  • Does Smad6 methylation control BMP signaling in cancer? Cell Cycle. 2014; 13(8):1209-10.. View in PubMed
  • Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013 Jul 11; 51(1):5-19.. View in PubMed
  • CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med. 2010 Aug; 16(8):872-9.. View in PubMed
  • Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation. 2010 Jan 26; 121(3):419-25.. View in PubMed
  • TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Mol Cell. 2009 Jul 10; 35(1):26-36.. View in PubMed
  • TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009 Feb; 19(2):156-72.. View in PubMed
  • Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest. 2007 Nov; 117(11):3198-210.. View in PubMed
  • Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res. 2007 Aug 03; 101(3):313-21.. View in PubMed
  • Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol. 2007 Feb; 18(1):117-31.. View in PubMed
  • Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem. 2006 Apr 07; 281(14):9152-62.. View in PubMed
  • The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res. 2006 Feb 17; 98(3):351-60.. View in PubMed
  • GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res. 2006 Feb 17; 98(3):342-50.. View in PubMed
  • The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol. 2005 Nov; 25(22):9936-48.. View in PubMed
  • Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J Cell Biol. 2005 Jul 04; 170(1):37-47.. View in PubMed
  • Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res. 2004 Jan 09; 94(1):110-8.. View in PubMed

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