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Jian Xu, PhD

Associate Professor

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Phone +1 323 442 4835
Email [email protected]
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Awards

  • American Heart Association National Scientist Development Grant, 2011
     – 2014
  • FASEB Biological Methylation Conference Best Seminar Award, 2012
  • Tokyo Global Center of Excellence Retreat Poster Award, 2011
  • Foundation Independent Postdoctoral Research Fellowship, 2009
     – 2010
  • American Heart Association Postdoctoral Fellowship, 2007
     – 2009
  • University of Cincinnati Graduate Student Poster Forum, Poster Award, 2003
  • American Heart Association Pre-doctoral Fellowship, 2001
     – 2003
  • Peking University Health Science Center Undergraduate Dissertation Award, 2000
  • Peking University Outstanding Student Scholarship, 1995
     – 2000

Research Funding

  • Protein methylation pathways that control genetic susceptibility to environmental pollutants in the occurrence of craniofacial defects
    NIH · R01DE030928 · Jul 1, 2021 – Jun 30, 2026 · Role: Principal Investigator
  • Modulation of Runx2 activity by arginine methylation
    NIH · R21DE028617 · Apr 1, 2019 – Mar 31, 2021 · Role: Principal Investigator
  • Methylation signaling in periodontal health and disease
    NIH · R01DE026468 · Jul 1, 2017 – Jun 30, 2022 · Role: Principal Investigator

Publications

  • Identification of synovial lymphatic system in the temporomandibular joint and their roles in arthritis and pain. Nat Commun. 2026 Apr 25; 17(1).. View in PubMed
  • ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling. Nat Commun. 2024 May 30; 15(1):4614.. View in PubMed
  • Role of Patient Sorting in Avoidable Hospital Stays in Medicare Advantage vs Traditional Medicare. JAMA Health Forum. 2023 11 03; 4(11):e233931.. View in PubMed
  • Cellular pathways influenced by protein arginine methylation: Implications for cancer. Mol Cell. 2021 11 04; 81(21):4357-4368.. View in PubMed
  • Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling. J Biol Chem. 2021 Jan-Jun; 296:100496.. View in PubMed
  • PRMT1-p53 Pathway Controls Epicardial EMT and Invasion. Cell Rep. 2020 06 09; 31(10):107739.. View in PubMed
  • Arginine methylation of SMAD7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem-cell generation. J Biol Chem. 2018 08 24; 293(34):13059-13072.. View in PubMed
  • Prmt1 regulates craniofacial bone formation upstream of Msx1. Mech Dev. 2018 08; 152:13-20.. View in PubMed
  • Transcription Factors in Craniofacial Development: From Receptor Signaling to Transcriptional and Epigenetic Regulation. Curr Top Dev Biol. 2015; 115:377-410.. View in PubMed
  • Does Smad6 methylation control BMP signaling in cancer? Cell Cycle. 2014; 13(8):1209-10. Xu J , Derynck R . . View in PubMed

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