Jian Xu, PhD

Associate Professor

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  • FASEB Biological Methylation Conference Best Seminar Award, 2012
  • American Heart Association National Scientist Development Grant, 2011-2014
  • Tokyo Global Center of Excellence Retreat Poster Award, 2011
  • Foundation Independent Postdoctoral Research Fellowship, 2009-2010
  • American Heart Association Postdoctoral Fellowship, 2007-2009
  • University of Cincinnati Graduate Student Poster Forum, Poster Award, 2003
  • American Heart Association Pre-doctoral Fellowship, 2001-2003
  • Peking University Health Science Center Undergraduate Dissertation Award, 2000
  • Peking University Outstanding Student Scholarship, 1995-2000


  • Role of Patient Sorting in Avoidable Hospital Stays in Medicare Advantage vs Traditional Medicare JAMA Health Forum. 2023 Nov 03; 4(11):e233931. . View in PubMed
  • Cellular pathways influenced by protein arginine methylation: Implications for cancer Mol Cell. 2021 11 04; 81(21):4357-4368. . View in PubMed
  • Molecular mechanisms of epithelial-mesenchymal transition Nat Rev Mol Cell Biol. 2014 Mar; 15(3):178-96. . View in PubMed
  • Does Smad6 methylation control BMP signaling in cancer? Cell Cycle. 2014; 13(8):1209-10.. View in PubMed
  • Arginine Methylation Initiates BMP-Induced Smad Signaling Mol Cell. 2013 Jul 11; 51(1):5-19. . View in PubMed
  • CIB1 is a regulator of pathological cardiac hypertrophy Nat Med. 2010 Aug; 16(8):872-9. . View in PubMed
  • Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure Circulation. 2010 Jan 26; 121(3):419-25. . View in PubMed
  • TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling Mol Cell. 2009 Jul 10; 35(1):26-36. . View in PubMed
  • TGF-beta-induced epithelial to mesenchymal transition Cell Res. 2009 Feb; 19(2):156-72. . View in PubMed
  • Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart J Clin Invest. 2007 Nov; 117(11):3198-210. . View in PubMed
  • Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling Circ Res. 2007 Aug 03; 101(3):313-21. . View in PubMed
  • Re-employment of developmental transcription factors in adult heart disease Semin Cell Dev Biol. 2007 Feb; 18(1):117-31. . View in PubMed
  • Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice J Biol Chem. 2006 Apr 07; 281(14):9152-62. . View in PubMed
  • GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation Circ Res. 2006 Feb 17; 98(3):342-50. . View in PubMed
  • The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury Circ Res. 2006 Feb 17; 98(3):351-60. . View in PubMed
  • The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment Mol Cell Biol. 2005 Nov; 25(22):9936-48. . View in PubMed
  • Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade J Cell Biol. 2005 Jul 04; 170(1):37-47. . View in PubMed
  • Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy Circ Res. 2004 Jan 09; 94(1):110-8. . View in PubMed