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Jianfu Chen

Professor of Biomedical Sciences

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Email [email protected]
CTSI Profile

Research Funding

  • Broader Evaluation of TMD Treatment Efficacy and Response (BETTER TMD)
    NIH · U01DE036113 · Sep 11, 2025 – Jun 30, 2030 · Role: Principal Investigator
  • Multiplex meningeal lymphatic activation for Alzheimer?s disease
    NIH · R21AG089268 · Aug 15, 2024 – May 31, 2026 · Role: Principal Investigator
  • Mapping temporomandibular joint (TMJ) degeneration and pain
    NIH · R01DE033511 · Jul 1, 2024 – Apr 30, 2029 · Role: Principal Investigator
  • MSC implantation as a treatment for developmental brain defects in craniosynostosis
    NIH · R01NS136377 · Jun 1, 2024 – May 31, 2029 · Role: Principal Investigator
  • Brain lymphatic activation for craniosynostosis and Alzheimer?s disease
    NIH · RF1NS137467 · Jun 1, 2024 – May 31, 2027 · Role: Principal Investigator
  • Center for TMD IMPACT
    NIH · R34DE033572 · Sep 19, 2023 – Sep 18, 2024 · Role: Co-Principal Investigator
  • Mechanisms and rescue of craniosynostosis associated with gene-environment interaction
    NIH · R01DE030901 · Jul 1, 2021 – Apr 30, 2026 · Role: Principal Investigator
  • Mechanisms regulating neural progenitor expansion in the developing brain
    NIH · R01NS097231 · Sep 1, 2016 – Aug 31, 2021 · Role: Principal Investigator
  • Genetic analysis of a microRNA pathway regulating neural tube closure
    NIH · R01NS096176 · Apr 1, 2016 – Jan 31, 2021 · Role: Principal Investigator
  • Wdr62 in neural development and malformations of cortical development disease
    NIH · R00HD073269 · Aug 1, 2012 – Dec 31, 2017 · Role: Principal Investigator
  • Wdr62 in neural development and malformations of cortical development disease
    NIH · K99HD073269 · Aug 1, 2012 – Jul 31, 2014 · Role: Principal Investigator

Publications

  • Identification of synovial lymphatic system in the temporomandibular joint and their roles in arthritis and pain. Nat Commun. 2026 Apr 25; 17(1).. View in PubMed
  • Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast-Immune Microenvironment Driving Arthritis Pain. Adv Sci (Weinh). 2026 Mar; 13(18):e19816.. View in PubMed
  • Identification of lymphatic vessels in skull periosteum but not bone marrow reveals skull channel heterogeneity. J Exp Med. 2025 Dec 01; 222(12).. View in PubMed
  • Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future. J Pain. 2025 11; 36:105560.. View in PubMed
  • Mapping cell diversity and dynamics in inflammatory temporomandibular joint osteoarthritis with pain at single-cell resolution. JCI Insight. 2025 02 10; 10(3).. View in PubMed
  • Atp13a5 Marker Reveals Pericyte Specification in the Mouse Central Nervous System. J Neurosci. 2024 10 23; 44(43).. View in PubMed
  • Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice. J Vis Exp. 2024 09 13.. View in PubMed
  • HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV. Brain Behav Immun. 2025 Jan; 123:108-122.. View in PubMed
  • Impaired phase separation and nucleolar functions in hiPSC models of SNORD118-related ribosomopathies. iScience. 2024 Aug 16; 27(8):110430.. View in PubMed
  • Recapitulating and reversing human brain ribosomopathy defects via the maladaptive integrated stress response. Sci Adv. 2024 02 02; 10(5):eadk1034.. View in PubMed

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