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Jobin Varkey, PhD

Assistant Professor of Research Physiology and Neuroscience

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Phone +1 323 442 0106
Email jvarkey@usc.edu
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Awards

  • Department of Biotechnology, Government of India: DBT Ramalingaswami Fellowship, 2013-2016
  • Council of Scientific and Industrial Research, Government of India: Senior Research Fellowship, 2004-2007
  • Council of Scientific and Industrial Research, Government of India: Junior Research Fellowship, 2002-2004
  • Department of Biotechnology, Government of India: MS Scholarship, 1999-2001

Publications

  • Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2024 Apr 05. . View in PubMed
  • Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1 J Biol Chem. 2024 Jan; 300(1):105585. . View in PubMed
  • Molecular basis of Q-length selectivity for the MW1 antibody-huntingtin interaction J Biol Chem. 2023 04; 299(4):104616. . View in PubMed
  • Structural Model of the Proline-Rich Domain of Huntingtin Exon-1 Fibrils Biophys J. 2020 11 17; 119(10):2019-2028. . View in PubMed
  • An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles Viruses. 2020 12 18; 12(12). . View in PubMed
  • Construction of Parkinson’s disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes Gene. 2019 May 20; 697:67-77. . View in PubMed
  • Gene co-expression network analysis for identifying genetic markers in Parkinson’s disease – a three-way comparative approach Genomics. 2019 07; 111(4):819-830. . View in PubMed
  • E46K-like a-synuclein mutants increase lipid interactions and disrupt membrane selectivity J Biol Chem. 2019 06 21; 294(25):9799-9812. . View in PubMed
  • Membranes as modulators of amyloid protein misfolding and target of toxicity Biochim Biophys Acta Biomembr. 2018 Sep; 1860(9):1863-1875. . View in PubMed
  • Pericyte degeneration causes white matter dysfunction in the mouse central nervous system Nat Med. 2018 03; 24(3):326-337. . View in PubMed
  • Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR J Magn Reson. 2017 07; 280:127-139. . View in PubMed
  • a-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils J Biol Chem. 2016 Jan 29; 291(5):2310-8. . View in PubMed
  • Early sodium dodecyl sulfate induced collapse of a-synuclein correlates with its amyloid formation ACS Chem Neurosci. 2015 Feb 18; 6(2):239-46. . View in PubMed
  • Nonaggregated a-synuclein influences SNARE-dependent vesicle docking via membrane binding Biochemistry. 2014 Jun 24; 53(24):3889-96. . View in PubMed
  • Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16838-43. . View in PubMed
  • a-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles J Biol Chem. 2013 Jun 14; 288(24):17620-30. . View in PubMed
  • Rational design of potent domain antibody inhibitors of amyloid fibril assembly Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):19965-70. . View in PubMed
  • Remodeling of lipid vesicles into cylindrical micelles by a-synuclein in an extended a-helical conformation J Biol Chem. 2012 Aug 24; 287(35):29301-11. . View in PubMed
  • Semisynthetic, site-specific ubiquitin modification of a-synuclein reveals differential effects on aggregation J Am Chem Soc. 2012 Mar 28; 134(12):5468-71. . View in PubMed
  • Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins J Biol Chem. 2010 Oct 15; 285(42):32486-93. . View in PubMed
  • Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins Peptides. 2006 Nov; 27(11):2614-23. . View in PubMed
  • Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines Antimicrob Agents Chemother. 2005 Nov; 49(11):4561-6. . View in PubMed

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