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John Cleveland

Associate Professor of Clinical Surgery, Associate Chief, CT Surgery, Heart Institute CHLA

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Email jcleveland@chla.usc.edu
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Overview

John David Cleveland, MD is an Assistant Professor of Surgery and Pediatrics at the Keck School of Medicine and University of Southern California. He received his medical degree from the University of Alabama School of Medicine. He subsequently completed his residency in Adult Cardiothoracic Surgery at the University of Southern California followed by a fellowship in Congenital Cardiac Surgery at Children’s Hospital of Los Angeles, both under the mentorship of Dr. Vaughn A. Starnes. His clinical and research interests focus on the long-term care of children with congenital heart disease as they progress into adulthood.

Publications

  • Lymphoma accelerates T cell and tissue aging. Cancer Cell. 2025 Oct 13; 43(10):1917-1936.e8.. View in PubMed
  • The complex and hazardous course for heterotaxy-associated congenital heart disease. JTCVS Open. 2025 Aug; 26:196-206.. View in PubMed
  • A Coronary Challenge: Management of Dextro-Transposition With Levo-Malposed Great Vessels. World J Pediatr Congenit Heart Surg. 2025 07; 16(4):549-551.. View in PubMed
  • Graph-based prototype inverse-projection for identifying cortical sulcal pattern abnormalities in congenital heart disease. Med Image Anal. 2025 May; 102:103538.. View in PubMed
  • Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma. Res Sq. 2025 Apr 15.. View in PubMed
  • Early Results of an Infant Model of Orthotopic Cardiac Xenotransplantation. J Heart Lung Transplant. 2025 Apr; 44(4):503-510.. View in PubMed
  • Surgical outcomes of the reinforced Ross procedure in the pediatric population. JTCVS Open. 2025 Apr; 24:341-349.. View in PubMed
  • The landscape of congenital heart disease treated with the Ross procedure. J Thorac Cardiovasc Surg. 2025 Mar; 169(3):974-984.e4.. View in PubMed
  • Treatment of Presumptive Rejection After Orthotopic Pig-to-Baboon Cardiac Xenotransplantation. Xenotransplantation. 2025 Mar-Apr; 32(2):e70044.. View in PubMed
  • Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact. iScience. 2025 Feb 21; 28(2):111707.. View in PubMed
  • Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity. Oncogene. 2025 Jan; 44(2):105-114.. View in PubMed
  • Preservation of Cardiac Xenografts in a Model of Infant Human Cardiac Transplantation. Xenotransplantation. 2025 Jan-Feb; 32(1):e70009.. View in PubMed
  • ECG Features in Orthotopic Cardiac Xenotransplantation: Comparisons With Published Literature. Xenotransplantation. 2024 Nov-Dec; 31(6):e70005.. View in PubMed
  • Pediatric Cardiac Xenotransplantation and Expanded Access: Ethical Considerations. Pediatr Transplant. 2024 Nov; 28(7):e14876.. View in PubMed
  • A Novel Model for Xenograft Right Ventricle to Pulmonary Artery Conduit. ASAIO J. 2024 10 01; 70(10):e139-e141.. View in PubMed
  • Identifying novel data-driven subgroups in congenital heart disease using multi-modal measures of brain structure. Neuroimage. 2024 Aug 15; 297:120721.. View in PubMed
  • Immunisation deferral practices surrounding congenital heart surgery. Cardiol Young. 2024 Jul; 34(7):1550-1553.. View in PubMed
  • Increased endothelial sclerostin caused by elevated DSCAM mediates multiple trisomy 21 phenotypes. J Clin Invest. 2024 Jun 03; 134(11).. View in PubMed
  • Comparing apples to apples: Exploring public reporting of congenital cardiac surgery outcomes based on common congenital heart operations. J Thorac Cardiovasc Surg. 2024 May; 167(5):1570-1580.e3.. View in PubMed
  • Early Wound and Sternal Management Following Pediatric Cardiac Surgery. World J Pediatr Congenit Heart Surg. 2024 05; 15(3):313-318.. View in PubMed
  • Surgical pulmonary arterioplasty at bidirectional cavopulmonary anastomosis leads to favorable pulmonary hemodynamics at final stage palliation. JTCVS Open. 2024 Apr; 18:180-192.. View in PubMed
  • Anatomic considerations in the management of complete atrioventricular canal. Cardiol Young. 2024 Apr; 34(4):754-758.. View in PubMed
  • Association of genetic and sulcal traits with executive function in congenital heart disease. Ann Clin Transl Neurol. 2024 02; 11(2):278-290.. View in PubMed
  • The potential of cardiac xenotransplantation for management of infants with complex congenital heart disease. Transl Pediatr. 2023 Dec 26; 12(12):2247-2255.. View in PubMed
  • Severe Ebstein’s anomaly in a premature, low-weight neonate. J Thorac Cardiovasc Surg. 2023 12; 166(6):1739-1743.. View in PubMed
  • Associations between prediagnostic aspirin use and ovarian tumor gene expression. Cancer Med. 2023 09; 12(17):18405-18417.. View in PubMed
  • Novel Use of the ŌNŌ Retrieval System for Intracardiac Thrombectomy in a High-Risk Pediatric Patient. J Soc Cardiovasc Angiogr Interv. 2023 Jul-Aug; 2(4):100976.. View in PubMed
  • Validity Properties of a Self-reported Modified Frailty Phenotype Among People With HIV in Clinical Care in the United States. J Assoc Nurses AIDS Care. 2023 Mar-Apr 01; 34(2):158-170.. View in PubMed
  • Association of Potentially Damaging De Novo Gene Variants With Neurologic Outcomes in Congenital Heart Disease. JAMA Netw Open. 2023 01 03; 6(1):e2253191.. View in PubMed
  • Ross procedure in neonates and infants: A valuable operation with defined limits. J Thorac Cardiovasc Surg. 2023 01; 165(1):262-272.e3.. View in PubMed
  • Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription. Proc Natl Acad Sci U S A. 2022 Nov 08; 119(45):e2214900119.. View in PubMed
  • Commentary: Palliation pit stop. J Thorac Cardiovasc Surg. 2022 11; 164(5):1304-1305.. View in PubMed
  • Commentary: In analytics we trust? J Thorac Cardiovasc Surg. 2022 07; 164(1):224-226.. View in PubMed
  • Novel Transcriptomic Interactions Between Immune Content and Genomic Classifier Predict Lethal Outcomes in High-grade Prostate Cancer. Eur Urol. 2022 04; 81(4):325-330.. View in PubMed
  • Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy. Cancer Res. 2022 04 01; 82(7):1234-1250.. View in PubMed
  • The Right Heart for Delayed Sternal Closure? Ann Thorac Surg. 2022 04; 113(4):1237-1238.. View in PubMed
  • The Surgical Approach to Pulmonary Valve Replacement. Semin Thorac Cardiovasc Surg. 2022; 34(4):1256-1261.. View in PubMed
  • Resident education in congenital heart surgery does not compromise outcomes. J Thorac Cardiovasc Surg. 2022 01; 163(1):251-260.. View in PubMed
  • Non-invasive biomarkers of Fontan-associated liver disease. JHEP Rep. 2021 Dec; 3(6):100362.. View in PubMed
  • Prevalence and impact of comorbid chronic pain and cigarette smoking among people living with HIV. AIDS Care. 2021 12; 33(12):1534-1542.. View in PubMed
  • Simple, reproducible, and consistent physiology: The argument for single-ventricle repair in critically ill neonates with Ebstein anomaly. JTCVS Tech. 2021 Dec; 10:428-432.. View in PubMed
  • Commentary: The heart of symptomatic neonatal Ebstein anomaly: Negative interventricular interaction and ventricular myopathy. JTCVS Tech. 2021 Oct; 9:135-136.. View in PubMed
  • Serious Infections in Patients With Gout in the US: A National Study of Incidence, Time Trends, and Outcomes. Arthritis Care Res (Hoboken). 2021 06; 73(6):898-908.. View in PubMed
  • Current opinion in pediatric heart transplantation. Curr Opin Organ Transplant. 2021 06 01; 26(3):290-295.. View in PubMed
  • KLK3 SNP-SNP interactions for prediction of prostate cancer aggressiveness. Sci Rep. 2021 04 29; 11(1):9264.. View in PubMed
  • Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma. Cell Rep. 2021 03 16; 34(11):108870.. View in PubMed
  • TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia. Blood Cancer Discov. 2021 03; 2(2):162-185.. View in PubMed
  • Commentary: In pursuit of the perfect pulmonary valve…. J Thorac Cardiovasc Surg. 2021 02; 161(2):365-367.. View in PubMed
  • Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer. Clin Cancer Res. 2021 01 01; 27(1):320-329.. View in PubMed
  • TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype. Blood. 2020 12 10; 136(24):2812-2823.. View in PubMed
  • Impact of prior diaphragm plication on subsequent stages of single ventricle palliation. J Thorac Cardiovasc Surg. 2020 Nov; 160(5):1291-1296.e1.. View in PubMed
  • Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia. J Neuroinflammation. 2020 Oct 14; 17(1):301.. View in PubMed
  • The Sound of One Hand Clapping… World J Pediatr Congenit Heart Surg. 2020 09; 11(5):625-626.. View in PubMed
  • Commentary: Getting circulations crossed! JTCVS Tech. 2020 Sep; 3:305-306.. View in PubMed
  • Spondyloarthritis is associated with higher healthcare utilization and complication rates after primary total knee or total hip arthroplasty. Clin Rheumatol. 2020 Aug; 39(8):2345-2353.. View in PubMed
  • Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity. JCI Insight. 2020 05 07; 5(9).. View in PubMed
  • Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. Oncogene. 2020 05; 39(22):4465-4474.. View in PubMed
  • Socioeconomic status and healthcare access are associated with healthcare utilization after knee arthroplasty: A U.S. national cohort study. Joint Bone Spine. 2020 Mar; 87(2):157-162.. View in PubMed
  • Total knee arthroplasty outcomes in lupus: a study using the US National Inpatient Sample. Rheumatology (Oxford). 2019 12 01; 58(12):2130-2136.. View in PubMed
  • An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma. Cell Rep. 2019 11 05; 29(6):1660-1674.e7.. View in PubMed
  • Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy. Cell Rep. 2019 10 01; 29(1):135-150.e9.. View in PubMed
  • The risk of Sjogren’s syndrome in the older adults with gout: A medicare claims study. Joint Bone Spine. 2019 Oct; 86(5):615-619.. View in PubMed
  • African American Specific Gene Panel Predictive of Poor Prostate Cancer Outcome. J Urol. 2019 08; 202(2):247-255.. View in PubMed
  • BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Cancer Cell. 2019 05 13; 35(5):752-766.e9.. View in PubMed
  • Distinct transcriptional repertoire of the androgen receptor in ETS fusion-negative prostate cancer. Prostate Cancer Prostatic Dis. 2019 05; 22(2):292-302.. View in PubMed
  • PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomas. J Clin Invest. 2018 12 03; 128(12):5517-5530.. View in PubMed
  • Elevated Pulmonary Artery Pressure, Not Pulmonary Vascular Resistance, is an Independent Predictor of Short-Term Morbidity Following Bidirectional Cavopulmonary Connection. Pediatr Cardiol. 2018 Dec; 39(8):1572-1580.. View in PubMed
  • Systems analysis of intracellular pH vulnerabilities for cancer therapy. Nat Commun. 2018 07 31; 9(1):2997.. View in PubMed
  • Need for Pulmonary Arterioplasty During Glenn Independently Predicts Inferior Surgical Outcome. Ann Thorac Surg. 2018 07; 106(1):156-164.. View in PubMed
  • “Milestones” are not “tombstones”! J Thorac Cardiovasc Surg. 2018 06; 155(6):2790-2791.. View in PubMed
  • Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery (ALCAPA): CCTA Demonstration of Anatomy Relevant to Adult Ischemic Cardiomyopathy Presentation and Utilization of Images for Virtual Surgical Planning. World J Pediatr Congenit Heart Surg. 2018 05; 9(3):347-349.. View in PubMed
  • Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. Front Immunol. 2018; 9:1242.. View in PubMed
  • Evaluation of Hemodynamic Performance of Aortic Valve Bioprostheses in a Model of Oversizing. Ann Thorac Surg. 2017 Jun; 103(6):1866-1876.. View in PubMed
  • A comparison of aortic valve replacement via an anterior right minithoracotomy with standard sternotomy: a propensity score analysis of 492 patients. Eur J Cardiothorac Surg. 2016 Feb; 49(2):456-63.. View in PubMed
  • Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma. Blood. 2014 Sep 25; 124(13):2081-90.. View in PubMed
  • Impending paradoxical embolism presenting as myocardial infarction. J Cardiol Cases. 2013 May 01; 7(5):e145-e148.. View in PubMed
  • Arrested bullet embolus to the aortic root. Ann Thorac Surg. 2013 Jan; 95(1):356.. View in PubMed

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