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Jon A. Detterich, MD

Professor of Clinical Pediatrics and Physiology and Biophysics

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Phone +1 323 361 5473
Email jdetterich@chla.usc.edu
CTSI Profile

Publications

  • Revisiting the Effect of Udenafil on Exercise Performance in Patients With Fontan Circulation: Results of a Post Hoc Analysis of the FUEL Trial. J Am Heart Assoc. 2025 Aug 19; 14(16):e041348.. View in PubMed
  • Modelling right and left ventricular adaptation over time after tetralogy of Fallot repair and the need for pulmonary valve replacement in adolescence. Cardiol Young. 2025 Jul; 35(7):1319-1328.. View in PubMed
  • The impact of measurement techniques and common effectors on red blood cell aggregation. Biorheology. 2025 May; 60(1-2):19-22.. View in PubMed
  • Methylated Arginine Metabolites as Biomarkers for Clinical Status and Response to Type 5 Phosphodiesterase Inhibition in Patients With Fontan Circulation. J Am Heart Assoc. 2025 Apr; 14(7):e038061.. View in PubMed
  • Multiresolution comparison of fetal real-time and cine magnetic resonance imaging at 0.55T. J Cardiovasc Magn Reson. 2025; 27(1):101856.. View in PubMed
  • Feasibility of fetal cardiac function and anatomy assessment by real-time spiral balanced steady-state free precession magnetic resonance imaging at 0.55T. J Cardiovasc Magn Reson. 2025; 27(1):101130.. View in PubMed
  • Nitrosyl hemoglobin formation from nitrite in normal and sickle blood. Free Radic Biol Med. 2024 Nov 20; 225:316-322.. View in PubMed
  • The impact of blood viscosity modeling on computational fluid dynamic simulations of pediatric patients with Fontan circulation. Phys Fluids (1994). 2024 Nov; 36(11):111911.. View in PubMed
  • Myocardial Scarring and Sudden Cardiac Death in Young Patients With Hypertrophic Cardiomyopathy: A Multicenter Cohort Study. JAMA Cardiol. 2024 Nov 01; 9(11):1001-1008.. View in PubMed
  • Exercise Performance: A Fontan Phenotype Predictive of Long-Term Survival. JACC Adv. 2024 Oct; 3(10):101253.. View in PubMed
  • Blood Rheology and Hemodynamics: Still Illuminating after 20 Years. Semin Thromb Hemost. 2024 Sep; 50(6):916-918.. View in PubMed
  • Non-invasive in-utero quantification of vascular reactivity in human placenta. Ultrasound Obstet Gynecol. 2024 04; 63(4):481-488.. View in PubMed
  • Decreased erythrocyte aggregation in Glenn and Fontan: univentricular circulation as a rheologic disease model. Pediatr Res. 2024 Apr; 95(5):1335-1345.. View in PubMed
  • The Effect of Udenafil on Heart Rate and Blood Pressure in Adolescents With the Fontan Circulation. Am J Cardiol. 2024 01 01; 210:183-187.. View in PubMed
  • The prevalence of abnormal spirometry in children with CHD. Cardiol Young. 2023 Dec; 33(12):2548-2552.. View in PubMed
  • The Fontan Udenafil Exercise Longitudinal Trial: Subgroup Analysis. Pediatr Cardiol. 2023 Dec; 44(8):1691-1701.. View in PubMed
  • Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study. Circulation. 2023 10 24; 148(17):1330-1339.. View in PubMed
  • Cardiac Magnetic Resonance Imaging to Determine Single Ventricle Function in a Pediatric Population is Feasible in a Large Trial Setting: Experience from the Single Ventricle Reconstruction Trial Longitudinal Follow up. Pediatr Cardiol. 2023 Oct; 44(7):1454-1461.. View in PubMed
  • Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study. Diagnostics (Basel). 2023 Apr 30; 13(9).. View in PubMed
  • Single Ventricle Reconstruction III: Brain Connectome and Neurodevelopmental Outcomes: Design, Recruitment, and Technical Challenges of a Multicenter, Observational Neuroimaging Study. medRxiv. 2023 Apr 17.. View in PubMed
  • The pediatric heart network’s study on long-term outcomes of children with HLHS and the impact of Norwood Shunt type in the single ventricle reconstruction trial cohort (SVRIII): Design and adaptations. Am Heart J. 2022 Dec; 254:216-227.. View in PubMed
  • Mediastinal infantile hemangioma with spinal canal extension and extensive gastrointestinal involvement complicated by respiratory failure. Pediatr Blood Cancer. 2022 11; 69(11):e29934.. View in PubMed
  • Impaired Neurovascular Function Underlies Poor Neurocognitive Outcomes and Is Associated with Nitric Oxide Bioavailability in Congenital Heart Disease. Metabolites. 2022 Sep 19; 12(9).. View in PubMed
  • Early initiation of disease-modifying therapy can impede or prevent diffuse myocardial fibrosis in sickle cell anemia. Blood. 2022 09 15; 140(11):1322-1324.. View in PubMed
  • Myocardial Iron Overload Causes Subclinical Myocardial Dysfunction in Sickle Cell Disease. JACC Cardiovasc Imaging. 2022 08; 15(8):1510-1512.. View in PubMed
  • Reduced Forced Vital Capacity and the Number of Chest Wall Surgeries are Associated with Decreased Exercise Capacity in Children with Congenital Heart Disease. Pediatr Cardiol. 2022 Jan; 43(1):54-61.. View in PubMed
  • Physical Properties of Blood and their Relationship to Clinical Conditions. Front Physiol. 2022; 13:906768.. View in PubMed
  • Considerations for Biventricular Conversion of Fontan Circulation. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2022; 25:11-18.. View in PubMed
  • Non-invasive biomarkers of Fontan-associated liver disease. JHEP Rep. 2021 Dec; 3(6):100362.. View in PubMed
  • Individual red blood cell nitric oxide production in sickle cell anemia: Nitric oxide production is increased and sickle shaped cells have unique morphologic change compared to discoid cells. Free Radic Biol Med. 2021 08 01; 171:143-155.. View in PubMed
  • Kidney iron deposition by R2* is associated with haemolysis and urinary iron. Br J Haematol. 2021 05; 193(3):633-636.. View in PubMed
  • Loss of alpha-globin genes in human subjects is associated with improved nitric oxide-mediated vascular perfusion. Am J Hematol. 2021 03 01; 96(3):277-281.. View in PubMed
  • Extracardiac Doppler indices predict perinatal mortality in fetuses with Ebstein anomaly and tricuspid valve dysplasia. Prenat Diagn. 2021 02; 41(3):332-340.. View in PubMed
  • Tricuspid regurgitant jet velocity and myocardial tissue Doppler parameters predict mortality in a cohort of patients with sickle cell disease spanning from pediatric to adult age groups – revisiting this controversial concept after 16 years of additional evidence. Am J Hematol. 2021 01; 96(1):31-39.. View in PubMed
  • Progressive vasoconstriction with sequential thermal stimulation indicates vascular dysautonomia in sickle cell disease. Blood. 2020 09 03; 136(10):1191-1200.. View in PubMed
  • Procedural, pregnancy, and short-term outcomes after fetal aortic valvuloplasty. Catheter Cardiovasc Interv. 2020 09 01; 96(3):626-632.. View in PubMed
  • Mental stress causes vasoconstriction in subjects with sickle cell disease and in normal controls. Haematologica. 2020 01; 105(1):83-90.. View in PubMed
  • Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents. Free Radic Biol Med. 2019 09; 141:408-415.. View in PubMed
  • Sickle cell microvascular paradox-oxygen supply-demand mismatch. Am J Hematol. 2019 06; 94(6):678-688.. View in PubMed
  • Differences in Right Ventricular Physiologic Response to Chronic Volume Load in Patients with Repaired Pulmonary Atresia Intact Ventricular Septum/Critical Pulmonary Stenosis Versus Tetralogy of Fallot. Pediatr Cardiol. 2019 Mar; 40(3):526-536.. View in PubMed
  • Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt. Front Physiol. 2019; 10:381.. View in PubMed
  • Red blood cell mechanical sensitivity improves in patients with sickle cell disease undergoing chronic transfusion after prolonged, subhemolytic shear exposure. Transfusion. 2018 12; 58(12):2788-2796.. View in PubMed
  • Accuracy of a Novel Handheld Wireless Platform for Detection of Cardiac Dysfunction in Anthracycline-Exposed Survivors of Childhood Cancer. Clin Cancer Res. 2018 07 01; 24(13):3119-3125.. View in PubMed
  • A novel cross-correlation methodology for assessing biophysical responses associated with pain. J Pain Res. 2018; 11:2207-2219.. View in PubMed
  • Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: What should be our goals for transfusion therapy? Clin Hemorheol Microcirc. 2018; 68(2-3):173-186.. View in PubMed
  • Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain. Am J Hematol. 2017 Nov; 92(11):1137-1145.. View in PubMed
  • Myocardial fibrosis: the heart of diastole? Blood. 2017 07 13; 130(2):104-105.. View in PubMed
  • Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease. PLoS One. 2017; 12(5):e0178353.. View in PubMed
  • Elevated Low-Shear Blood Viscosity is Associated with Decreased Pulmonary Blood Flow in Children with Univentricular Heart Defects. Pediatr Cardiol. 2016 Apr; 37(4):789-801.. View in PubMed
  • The role of blood rheology in sickle cell disease. Blood Rev. 2016 Mar; 30(2):111-8.. View in PubMed
  • Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease. Blood. 2015 Aug 06; 126(6):703-10.. View in PubMed
  • Giant Pseudoaneurysm of Reconstructed Right Ventricular Outflow Tract. Ann Thorac Surg. 2015 Aug; 100(2):734.. View in PubMed
  • Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis. Physiol Rep. 2015 Jul 14; 3(7).. View in PubMed
  • Pulmonary hypertension in well-transfused thalassemia major patients. Blood Cells Mol Dis. 2015 Feb; 54(2):189-94.. View in PubMed
  • Outcomes of critical congenital heart disease requiring emergent neonatal cardiac intervention. Prenat Diagn. 2014 Dec; 34(12):1127-32.. View in PubMed
  • Nitric oxide, vasodilation and the red blood cell. Biorheology. 2014; 51(2-3):121-34.. View in PubMed
  • Effects of ethanol on red blood cell rheological behavior. Clin Hemorheol Microcirc. 2014; 56(2):87-99.. View in PubMed
  • Deformability analysis of sickle blood using ektacytometry. Biorheology. 2014; 51(2-3):159-70.. View in PubMed
  • Abnormal cerebral microstructure in premature neonates with congenital heart disease. AJNR Am J Neuroradiol. 2013 Oct; 34(10):2026-33.. View in PubMed
  • Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion. Transfusion. 2013 May; 53(5):1059-68.. View in PubMed
  • Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron. Am J Hematol. 2013 Mar; 88(3):213-8.. View in PubMed
  • Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. Transfusion. 2013 Feb; 53(2):297-305.. View in PubMed
  • Prenatal diagnosis of congenital heart disease: impact of mode of delivery on neonatal outcome. Prenat Diagn. 2012 Dec; 32(13):1250-5.. View in PubMed
  • Color M-mode sonography for evaluation of fetal arrhythmias. J Ultrasound Med. 2012 Oct; 31(10):1681-8.. View in PubMed
  • Systemic endothelial dysfunction in children with idiopathic pulmonary arterial hypertension correlates with disease severity. J Heart Lung Transplant. 2012 Jun; 31(6):642-7.. View in PubMed
  • Electrocardiographic consequences of cardiac iron overload in thalassemia major. Am J Hematol. 2012 Feb; 87(2):139-44.. View in PubMed
  • Analysis of light scattering by red blood cells in ektacytometry using global pattern fitting. Biorheology. 2012; 49(5-6):317-28.. View in PubMed
  • Fetoscopic laser photocoagulation of feeding vessels to a large placental chorioangioma following fetal deterioration after amnioreduction. Fetal Diagn Ther. 2012; 31(3):191-5.. View in PubMed
  • Twin-twin transfusion syndrome treated with laser surgery: postnatal prevalence of congenital heart disease in surviving recipients and donors. Prenat Diagn. 2011 Oct; 31(10):973-7.. View in PubMed
  • Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81.. View in PubMed
  • Prenatal diagnosis of cor triatriatum sinister in association with hypoplastic left heart syndrome. Pediatr Cardiol. 2011 Aug; 32(6):818-21.. View in PubMed
  • Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:1626-9.. View in PubMed
  • Integrin subunit gene expression is regionally differentiated in adult brain. J Neurosci. 1999 Mar 01; 19(5):1541-56.. View in PubMed

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