Jonathan S Lopresti, MD

Associate Professor of Clinical Medicine

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A native of Los Angeles, Dr. LoPresti received both his medical degree and his Ph.D. in physiology from the University of Southern California. He first joined the Trojan family in 1974 as a biology undergraduate and finished his residency at the LAC+USC Medical Center ten years later. Dr. LoPresti has contributed to over fifty presentations, recently lecturing on a case of an aggressive Papillary Thyroid Cancer arising in the third trimester of pregnancy. In addition, he has had leadership roles in the American Thyroid Association and has been published in numerous journals, abstracts and book chapters.


  • Keck School of Medicine of USC: Faculty Teaching Award, Year II, 2015
  • Keck School of Medicine of USC: Faculty Teaching Award, Year IV, 2015
  • Keck School of Medicine of USC: Professor of the Year for Fourth Year Students, 1998
  • Department of Medicine, USC: Attending of the Year for Internal Medicine, 1997


  • Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies: (IMA, LC-MS/MS and RIA) J Clin Endocrinol Metab. 2024 Apr 30. . View in PubMed
  • Thyroid. 2018 07; 28(7):842-848. . View in PubMed
  • Clinical features and hospital outcomes in thyroid storm: a retrospective cohort study J Clin Endocrinol Metab. 2015 Feb; 100(2):451-9. . View in PubMed
  • MHC class I loss is a frequent mechanism of immune escape in papillary thyroid cancer that is reversed by interferon and selumetinib treatment in vitro Clin Cancer Res. 2014 Dec 01; 20(23):6034-44. . View in PubMed
  • Serum thyroglobulin (Tg) monitoring of patients with differentiated thyroid cancer using sensitive (second-generation) immunometric assays can be disrupted by false-negative and false-positive serum thyroglobulin autoantibody misclassifications J Clin Endocrinol Metab. 2014 Dec; 99(12):4589-99. . View in PubMed
  • Is an isolated TSH elevation in chronic nonthyroidal illness “subclinical hypothyroidism”? J Clin Endocrinol Metab. 2014 Nov; 99(11):4015-26.. View in PubMed
  • How sensitive (second-generation) thyroglobulin measurement is changing paradigms for monitoring patients with differentiated thyroid cancer, in the absence or presence of thyroglobulin autoantibodies Curr Opin Endocrinol Diabetes Obes. 2014 Oct; 21(5):394-404. . View in PubMed
  • BRAF V600E in papillary thyroid carcinoma is associated with increased programmed death ligand 1 expression and suppressive immune cell infiltration Thyroid. 2014 Sep; 24(9):1385-93. . View in PubMed
  • In search of an unstimulated thyroglobulin baseline value in low-risk papillary thyroid carcinoma patients not receiving radioactive iodine ablation Thyroid. 2014 Jul; 24(7):1127-33. . View in PubMed
  • Serum Basal thyroglobulin measured by a second-generation assay correlates with the recombinant human thyrotropin-stimulated thyroglobulin response in patients treated for differentiated thyroid cancer Thyroid. 2010 Jun; 20(6):587-95. . View in PubMed
  • Measuring thyroglobulin and thyroglobulin autoantibody in patients with differentiated thyroid cancer Nat Clin Pract Endocrinol Metab. 2008 Apr; 4(4):223-33. . View in PubMed
  • Clinical impact of thyroglobulin (Tg) and Tg autoantibody method differences on the management of patients with differentiated thyroid carcinomas J Clin Endocrinol Metab. 2005 Oct; 90(10):5566-75. . View in PubMed
  • A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma J Clin Endocrinol Metab. 2003 Sep; 88(9):4507-8; author reply 4508-10. . View in PubMed
  • Follicular lesions of thyroid: a 5-year fine-needle aspiration experience Cancer. 2000 Dec 25; 90(6):335-41. . View in PubMed
  • Detection of residual and recurrent differentiated thyroid carcinoma by serum thyroglobulin measurement Thyroid. 1999 May; 9(5):435-41. . View in PubMed
  • Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma J Clin Endocrinol Metab. 1998 Apr; 83(4):1121-7. . View in PubMed
  • Laboratory tests for thyroid disorders Otolaryngol Clin North Am. 1996 Aug; 29(4):557-75. . View in PubMed
  • Multiphasic thyrotropin responses to thyroid hormone administration in man J Clin Endocrinol Metab. 1995 Mar; 80(3):854-9. . View in PubMed
  • 3,5,3′-Triiodothyronine (T3) sulfate: a major metabolite in T3 metabolism in man J Clin Endocrinol Metab. 1994 Mar; 78(3):688-92. . View in PubMed
  • Myxedema comaA form of decompensated hypothyroidism. Endocrinol Metab Clin North Am. 1993 Jun; 22(2):279-90. . View in PubMed
  • Thyrotropin (TSH)-releasing hormone stimulation test responses employing third and fourth generation TSH assays J Clin Endocrinol Metab. 1993 Feb; 76(2):494-8. . View in PubMed
  • Amiodarone-induced hyperthyroidism: thyroidectomy under local anesthesia Am Heart J. 1991 Oct; 122(4 Pt 1):1160-1. . View in PubMed
  • Characteristics of 3,5,3′-triiodothyronine sulfate metabolism in euthyroid man J Clin Endocrinol Metab. 1991 Oct; 73(4):703-9. . View in PubMed
  • Influence of fasting and refeeding on 3,3′,5′-triiodothyronine metabolism in man J Clin Endocrinol Metab. 1991 Jan; 72(1):130-6. . View in PubMed
  • Does a hidden pool of reverse triiodothyronine (rT3) production contribute to total thyroxine (T4) disposal in high T4 states in man J Clin Endocrinol Metab. 1990 May; 70(5):1479-84. . View in PubMed
  • Applications of a new chemiluminometric thyrotropin assay to subnormal measurement J Clin Endocrinol Metab. 1990 Feb; 70(2):453-60. . View in PubMed
  • Serum triiodothyronine valuesPrognostic indicators of acute mortality due to Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome. Arch Intern Med. 1990 Feb; 150(2):406-9. . View in PubMed
  • Alterations in 3,3’5′-triiodothyronine metabolism in response to propylthiouracil, dexamethasone, and thyroxine administration in man J Clin Invest. 1989 Nov; 84(5):1650-6. . View in PubMed
  • Unique alterations of thyroid hormone indices in the acquired immunodeficiency syndrome (AIDS) Ann Intern Med 1989 Jun 15; 110(12):970-5. . View in PubMed
  • Effect of carbohydrate refeeding on free fatty acids after a fast in obese diabetic and obese non-diabetic females Metabolism. 1989 Mar; 38(3):208-14. . View in PubMed
  • Thyrotropin secretion in thyrotoxic and thyroxine-treated patients: assessment by a sensitive immunoenzymometric assay J Clin Endocrinol Metab. 1986 Aug; 63(2):349-55. . View in PubMed
  • Urinary immunoprecipitation method for estimation of thyroxine to triiodothyronine conversion in altered thyroid states J Clin Endocrinol Metab. 1982 Oct; 55(4):666-70. . View in PubMed
  • A new method for measurement of the conversion ratio of thyroxine to triiodothyronine in euthyroid man J Clin Endocrinol Metab. 1981 Dec; 53(6):1218-22. . View in PubMed