Keck School Faculty

Justin Ichida

Justin Ichida

Associate Professor of Stem Cell Biology and Regenerative Medicine
John Douglas French Alzheimer's Endowed Professor in Regenerative Medicine
Stem Cell Biology & Regenerative Medicine
BCC 307 1425 San Pablo Street Health Sciences Campus Los Angeles

The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease Neurobiol Dis. 2020 Dec 24; 149:105228. . View in PubMed

Protocol for Differentiation of Human iPSCs into Pulmonary Neuroendocrine Cells STAR Protoc. 2020 Sep 18; 1(2):100068. . View in PubMed

Efficient Generation and Transcriptomic Profiling of Human iPSC-Derived Pulmonary Neuroendocrine Cells iScience. 2020 May 22; 23(5):101083. . View in PubMed

Generation of inner ear hair cells by direct lineage conversion of primary somatic cells Elife. 2020 06 30; 9. . View in PubMed

Organoids Develop Motor Skills: 3D Human Neuromuscular Junctions Cell Stem Cell. 2020 02 06; 26(2):131-133. . View in PubMed

Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD Acta Neuropathol. 2019 Nov; 138(5):883-884. . View in PubMed

RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats Nat Neurosci. 2019 09; 22(9):1383-1388. . View in PubMed

ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD Acta Neuropathol. 2019 07; 138(1):49-65. . View in PubMed

C9ORF72 protein function and immune dysregulation in amyotrophic lateral sclerosis Neurosci Lett. 2019 11 20; 713:134523. . View in PubMed

Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders Biol Psychiatry. 2019 02 15; 85(4):305-316. . View in PubMed

Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons JCI Insight. 2019 07 16; 5. . View in PubMed

Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular ReprogrammingCell Stem Cell. 2019 10 03; 25(4):486-500. e9. . View in PubMed

Directly Reprogrammed Neurons Still Have Some Growing Up to Do Cell Stem Cell. 2019 07 03; 25(1):1-2. . View in PubMed

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies Stem Cell Reports. 2019 11 12; 13(5):939-955. . View in PubMed

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity Nat Genet. 2018 04; 50(4):603-612. . View in PubMed

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons Nat Med. 2018 03; 24(3):313-325. . View in PubMed

Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons Development. 2018 11 21; 145(22). . View in PubMed

Human Induced Pluripotent Stem Cell-Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury JAMA Facial Plast Surg. 2017 May 01; 19(3):197-205. . View in PubMed

Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis JCI Insight. 2017 11 16; 2(22). . View in PubMed

New approaches for direct conversion of patient fibroblasts into neural cells Brain Res. 2017 02 01; 1656:2-13. . View in PubMed

Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State Dev Cell. 2015 Nov 09; 35(3):358-65. . View in PubMed

Small Molecules Take a Big Step by Converting Fibroblasts into Neurons Cell Stem Cell. 2015 Aug 06; 17(2):127-9. . View in PubMed

Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance Nat Neurosci. 2015 Jul; 18(7):978-87. . View in PubMed

Probing disorders of the nervous system using reprogramming approaches EMBO J. 2015 Jun 03; 34(11):1456-77. . View in PubMed

Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons J Neurosci. 2015 Jan 21; 35(3):1291-306. . View in PubMed

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts Nat Neurosci. 2015 Jan; 18(1):17-24. . View in PubMed

Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death Neuron. 2014 Dec 17; 84(6):1213-25. . View in PubMed

Notch inhibition allows oncogene-independent generation of iPS cells Nat Chem Biol. 2014 Aug; 10(8):632-639. . View in PubMed

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1 Cell Stem Cell. 2014 Jun 05; 14(6):781-95. . View in PubMed

Ketamine exposure in early development impairs specification of the primary germ cell layers Neurotoxicol Teratol. 2014 May-Jun; 43:59-68. . View in PubMed

Nanog-independent reprogramming to iPSCs with canonical factors Stem Cell Reports. 2014 Feb 11; 2(2):119-26. . View in PubMed

Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies Cell Reprogram. 2013 Dec; 15(6):495-502. . View in PubMed

CLP1 links tRNA metabolism to progressive motor-neuron loss Nature. 2013 Mar 28; 495(7442):474-80. . View in PubMed

ß-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells PLoS One. 2013; 8(5):e63265. . View in PubMed

Reprogramming within hours following nuclear transfer into mouse but not human zygotes Nat Commun. 2011 Oct 04; 2:488. . View in PubMed

Conversion of mouse and human fibroblasts into functional spinal motor neurons Cell Stem Cell. 2011 Sep 02; 9(3):205-18. . View in PubMed

Shushing down the epigenetic landscape towards stem cell differentiation Development. 2010 Aug 01; 137(15):2455-60. . View in PubMed

Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication J Am Chem Soc. 2010 Apr 28; 132(16):5880-5. . View in PubMed

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog Cell Stem Cell. 2009 Nov 06; 5(5):491-503. . View in PubMed

Elucidating nuclear reprogramming mechanisms: taking a synergistic approach Reprod Biomed Online. 2008 Jan; 16(1):41-50. . View in PubMed

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