Justin Ichida
John Douglas French Alzheimer's Endowed Professor in Regenerative Medicine
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The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease Neurobiol Dis. 2020 Dec 24; 149:105228. . View in PubMed
Protocol for Differentiation of Human iPSCs into Pulmonary Neuroendocrine Cells STAR Protoc. 2020 Sep 18; 1(2):100068. . View in PubMed
Efficient Generation and Transcriptomic Profiling of Human iPSC-Derived Pulmonary Neuroendocrine Cells iScience. 2020 May 22; 23(5):101083. . View in PubMed
Generation of inner ear hair cells by direct lineage conversion of primary somatic cells Elife. 2020 06 30; 9. . View in PubMed
Organoids Develop Motor Skills: 3D Human Neuromuscular Junctions Cell Stem Cell. 2020 02 06; 26(2):131-133. . View in PubMed
Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD Acta Neuropathol. 2019 Nov; 138(5):883-884. . View in PubMed
RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats Nat Neurosci. 2019 09; 22(9):1383-1388. . View in PubMed
ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD Acta Neuropathol. 2019 07; 138(1):49-65. . View in PubMed
C9ORF72 protein function and immune dysregulation in amyotrophic lateral sclerosis Neurosci Lett. 2019 11 20; 713:134523. . View in PubMed
Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders Biol Psychiatry. 2019 02 15; 85(4):305-316. . View in PubMed
Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons JCI Insight. 2019 07 16; 5. . View in PubMed
Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular ReprogrammingCell Stem Cell. 2019 10 03; 25(4):486-500. e9. . View in PubMed
Directly Reprogrammed Neurons Still Have Some Growing Up to Do Cell Stem Cell. 2019 07 03; 25(1):1-2. . View in PubMed
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies Stem Cell Reports. 2019 11 12; 13(5):939-955. . View in PubMed
CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity Nat Genet. 2018 04; 50(4):603-612. . View in PubMed
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons Nat Med. 2018 03; 24(3):313-325. . View in PubMed
Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons Development. 2018 11 21; 145(22). . View in PubMed
Human Induced Pluripotent Stem Cell-Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury JAMA Facial Plast Surg. 2017 May 01; 19(3):197-205. . View in PubMed
Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis JCI Insight. 2017 11 16; 2(22). . View in PubMed
New approaches for direct conversion of patient fibroblasts into neural cells Brain Res. 2017 02 01; 1656:2-13. . View in PubMed
Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State Dev Cell. 2015 Nov 09; 35(3):358-65. . View in PubMed
Small Molecules Take a Big Step by Converting Fibroblasts into Neurons Cell Stem Cell. 2015 Aug 06; 17(2):127-9. . View in PubMed
Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance Nat Neurosci. 2015 Jul; 18(7):978-87. . View in PubMed
Probing disorders of the nervous system using reprogramming approaches EMBO J. 2015 Jun 03; 34(11):1456-77. . View in PubMed
Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons J Neurosci. 2015 Jan 21; 35(3):1291-306. . View in PubMed
Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts Nat Neurosci. 2015 Jan; 18(1):17-24. . View in PubMed
Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death Neuron. 2014 Dec 17; 84(6):1213-25. . View in PubMed
Notch inhibition allows oncogene-independent generation of iPS cells Nat Chem Biol. 2014 Aug; 10(8):632-639. . View in PubMed
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1 Cell Stem Cell. 2014 Jun 05; 14(6):781-95. . View in PubMed
Ketamine exposure in early development impairs specification of the primary germ cell layers Neurotoxicol Teratol. 2014 May-Jun; 43:59-68. . View in PubMed
Nanog-independent reprogramming to iPSCs with canonical factors Stem Cell Reports. 2014 Feb 11; 2(2):119-26. . View in PubMed
Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies Cell Reprogram. 2013 Dec; 15(6):495-502. . View in PubMed
CLP1 links tRNA metabolism to progressive motor-neuron loss Nature. 2013 Mar 28; 495(7442):474-80. . View in PubMed
ß-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells PLoS One. 2013; 8(5):e63265. . View in PubMed
Reprogramming within hours following nuclear transfer into mouse but not human zygotes Nat Commun. 2011 Oct 04; 2:488. . View in PubMed
Conversion of mouse and human fibroblasts into functional spinal motor neurons Cell Stem Cell. 2011 Sep 02; 9(3):205-18. . View in PubMed
Shushing down the epigenetic landscape towards stem cell differentiation Development. 2010 Aug 01; 137(15):2455-60. . View in PubMed
Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication J Am Chem Soc. 2010 Apr 28; 132(16):5880-5. . View in PubMed
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog Cell Stem Cell. 2009 Nov 06; 5(5):491-503. . View in PubMed
Elucidating nuclear reprogramming mechanisms: taking a synergistic approach Reprod Biomed Online. 2008 Jan; 16(1):41-50. . View in PubMed