Keck School Faculty

Kai Chen, PhD
Kai Chen, PhD
Associate Professor Of Research Radiology
CSC 103 Health Sciences Campus Los Angeles

Radiofluorinated GPC3-Binding Peptides for PET Imaging of Hepatocellular Carcinoma Mol Imaging Biol. 2020 Feb; 22(1):134-143. . View in PubMed

Preclinical evaluation of a 64Cu-labeled disintegrin for PET imaging of prostate cancer Amino Acids. 2019 Nov; 51(10-12):1569-1575. . View in PubMed

Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer Med Res Rev. 2019 Oct 25. . View in PubMed

PET Imaging of Adenosine Receptors in Diseases Curr Top Med Chem. 2019; 19(16):1445-1463. . View in PubMed

Small molecules as theranostic agents in cancer immunology Theranostics. 2019; 9(25):7849-7871. . View in PubMed

Polyethyleneimine-Coated Manganese Oxide Nanoparticles for Targeted Tumor PET/MR Imaging ACS Appl Mater Interfaces. 2018 Oct 17; 10(41):34954-34964. . View in PubMed

PET imaging of Hsp90 expression in pancreatic cancer using a new 64Cu-labeled dimeric Sansalvamide A decapeptide Amino Acids. 2018 Jul; 50(7):897-907. . View in PubMed

64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging Nanoscale. 2018 Mar 29; 10(13):6113-6124. . View in PubMed

Cross-Linked Fluorescent Supramolecular Nanoparticles for Intradermal Controlled Release of Antifungal Drug-A Therapeutic Approach for Onychomycosis ACS Nano. 2018 07 24; 12(7):6851-6859. . View in PubMed

Effect of Androgen on Normal Biodistribution of [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in Athymic Non-tumor-bearing Male Mice Anticancer Res. 2017 02; 37(2):475-479. . View in PubMed

Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times ACS Nano. 2017 01 24; 11(1):153-162. . View in PubMed

Transformative Nanomedicine of an Amphiphilic Camptothecin Prodrug for Long Circulation and High Tumor Uptake in Cancer Therapy ACS Nano. 2017 09 26; 11(9):8838-8848. . View in PubMed

Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy Nat Commun. 2017 12 05; 8(1):1954. . View in PubMed

Evaluation of (188)Re-labeled NGR-VEGI protein for radioimaging and radiotherapy in mice bearing human fibrosarcoma HT-1080 xenografts Tumour Biol. 2016 Jul; 37(7):9121-9. . View in PubMed

Pretargeted Positron Emission Tomography Imaging That Employs Supramolecular Nanoparticles with in Vivo Bioorthogonal Chemistry ACS Nano. 2016 Jan 26; 10(1):1417-24. . View in PubMed

In Vivo Tumor Angiogenesis Imaging Using Peptide-Based Near-Infrared Fluorescent Probes Methods Mol Biol. 2016; 1444:73-84. . View in PubMed

Boramino acid as a marker for amino acid transporters Sci Adv. 2015 Sep; 1(8):e1500694. . View in PubMed

Targeted Prostate Gland Biopsy With Combined Transrectal Ultrasound, mpMRI, and 18F-FMAU PET/CT Clin Nucl Med. 2015 Aug; 40(8):e426-8. . View in PubMed

Development of PET probes for cancer imaging Curr Top Med Chem. 2015; 15(8):795-819. . View in PubMed

In vivo NIRF imaging-guided delivery of a novel NGR-VEGI fusion protein for targeting tumor vasculature Amino Acids. 2014 Dec; 46(12):2721-32. . View in PubMed

MicroPET imaging of CD13 expression using a (64)Cu-labeled dimeric NGR peptide based on sarcophagine cage Mol Pharm. 2014 Nov 03; 11(11):3938-46. . View in PubMed

A direct comparison of tumor angiogenesis with 68Ga-labeled NGR and RGD peptides in HT-1080 tumor xenografts using microPET imaging Amino Acids. 2014 Oct; 46(10):2355-64. . View in PubMed

68Ga-labeled cyclic NGR peptide for microPET imaging of CD13 receptor expression Molecules. 2014 Aug 05; 19(8):11600-12. . View in PubMed

Near-infrared fluorescence imaging of CD13 receptor expression using a novel Cy55-labeled dimeric NGR peptide. Amino Acids. 2014 Jun; 46(6):1547-56. . View in PubMed

Recent advances in diagnosis and treatment of gliomas using chlorotoxin-based bioconjugates Am J Nucl Med Mol Imaging. 2014; 4(5):385-405. . View in PubMed

Radiolabeled nanoparticles for multimodality tumor imaging Theranostics. 2014; 4(3):290-306. . View in PubMed

(99m)Tc-labeled monomeric and dimeric NGR peptides for SPECT imaging of CD13 receptor in tumor-bearing mice Amino Acids. 2013 May; 44(5):1337-45. . View in PubMed

Synthesis and evaluation of 64Cu-labeled monomeric and dimeric NGR peptides for MicroPET imaging of CD13 receptor expression Mol Pharm. 2013 Jan 07; 10(1):417-27. . View in PubMed

Strain-Promoted Catalyst-Free Click Chemistry for Rapid Construction of (64)Cu-Labeled PET Imaging Probes ACS Med Chem Lett. 2012 Dec 13; 3(12):1019-23. . View in PubMed

Microwave-assisted one-pot radiosynthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-ß-d-arabinofuranosyluracil ([18F]-FMAU) Nucl Med Biol. 2012 Oct; 39(7):1019-25. . View in PubMed

[18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in prostate cancer: initial preclinical observations Mol Imaging. 2012 Sep-Oct; 11(5):426-32. . View in PubMed

A Cy55-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice. Amino Acids. 2012 Apr; 42(4):1329-37. . View in PubMed

Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature Mol Imaging Biol. 2012 Feb; 14(1):96-105. . View in PubMed

Efficient multicistronic co-expression of hNIS and hTPO in prostate cancer cells for nonthyroidal tumor radioiodine therapy Am J Nucl Med Mol Imaging. 2012; 2(4):483-98. . View in PubMed

Design, synthesis and validation of integrin a2ß1-targeted probe for microPET imaging of prostate cancer Eur J Nucl Med Mol Imaging. 2011 Jul; 38(7):1313-22. . View in PubMed

Integrin targeted delivery of chemotherapeutics Theranostics. 2011 Feb 17; 1:189-200. . View in PubMed

Positron emission tomography imaging of cancer biology: current status and future prospects Semin Oncol. 2011 Feb; 38(1):70-86. . View in PubMed

Target-specific delivery of peptide-based probes for PET imaging Adv Drug Deliv Rev. 2010 Aug 30; 62(11):1005-22. . View in PubMed

Phage display-derived peptides for osteosarcoma imaging Clin Cancer Res. 2010 Aug 15; 16(16):4268-77. . View in PubMed

Design of targeted cardiovascular molecular imaging probes J Nucl Med. 2010 May 01; 51 Suppl 1:3S-17S. . View in PubMed

Design and development of molecular imaging probes Curr Top Med Chem. 2010; 10(12):1227-36. . View in PubMed

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