Kai Chen
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Tracking Docetaxel-Induced Cellular Proliferation Changes in Prostate Tumor-Bearing Mice with 18F-FMAU PET Acad Radiol. 2022 Sep 29. . View in PubMed
Radiosynthesis of 20-[18F]fluoroarachidonic acid for PET-MR imaging: Biological evaluation in ApoE4-TR mice Prostaglandins Leukot Essent Fatty Acids. 2022 11; 186:102510. . View in PubMed
Development of a novel radiofluorinated riboflavin probe for riboflavin receptor-targeting PET imaging Pharmacol Res. 2022 09; 183:106395. . View in PubMed
Molecular Imaging of Tumor Microenvironment to Assess the Effects of Locoregional Treatment for Hepatocellular Carcinoma Hepatol Commun. 2022 04; 6(4):652-664. . View in PubMed
Recent advances and applications of microspheres and nanoparticles in transarterial chemoembolization for hepatocellular carcinoma Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 03; 14(2):e1749. . View in PubMed
Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge J Am Chem Soc. 2022 11 09; 144(44):20288-20297. . View in PubMed
A comparison of the monomeric [68Ga]NODAGA-NGR and dimeric [68Ga]NOTA-(NGR)2 as aminopeptidase N ligand for positron emission tomography imaging in tumor-bearing mice Eur J Pharm Sci. 2021 Nov 01; 166:105964. . View in PubMed
Exploring Solvent Effects in the Radiosynthesis of 18F-Labeled Thymidine Analogues toward Clinical Translation for Positron Emission Tomography Imaging ACS Pharmacol Transl Sci. 2021 Feb 12; 4(1):266-275. . View in PubMed
Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases Front Physiol. 2021; 12:700847. . View in PubMed
Supramolecular nanosubstrate-mediated delivery system enables CRISPR-Cas9 knockin of hemoglobin beta gene for hemoglobinopathies Sci Adv. 2020 10; 6(43). . View in PubMed
Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer Med Res Rev. 2020 05; 40(3):909-930. . View in PubMed
Radiofluorinated GPC3-Binding Peptides for PET Imaging of Hepatocellular Carcinoma Mol Imaging Biol. 2020 02; 22(1):134-143. . View in PubMed
Near-Infrared Hybrid Rhodol Dyes with Spiropyran Switches for Sensitive Ratiometric Sensing of pH Changes in Mitochondria and Drosophila melanogaster First-Instar Larvae ACS Appl Bio Mater. 2019 Nov 18; 2(11):4986-4997. . View in PubMed
Preclinical evaluation of a 64Cu-labeled disintegrin for PET imaging of prostate cancer Amino Acids. 2019 Nov; 51(10-12):1569-1575. . View in PubMed
Small molecules as theranostic agents in cancer immunology Theranostics. 2019; 9(25):7849-7871. . View in PubMed
PET Imaging of Adenosine Receptors in Diseases Curr Top Med Chem. 2019; 19(16):1445-1463. . View in PubMed
Polyethyleneimine-Coated Manganese Oxide Nanoparticles for Targeted Tumor PET/MR Imaging ACS Appl Mater Interfaces. 2018 Oct 17; 10(41):34954-34964. . View in PubMed
PET imaging of Hsp90 expression in pancreatic cancer using a new 64Cu-labeled dimeric Sansalvamide A decapeptide Amino Acids. 2018 Jul; 50(7):897-907. . View in PubMed
64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging Nanoscale. 2018 Mar 29; 10(13):6113-6124. . View in PubMed
Cross-Linked Fluorescent Supramolecular Nanoparticles for Intradermal Controlled Release of Antifungal Drug-A Therapeutic Approach for Onychomycosis ACS Nano. 2018 07 24; 12(7):6851-6859. . View in PubMed
Effect of Androgen on Normal Biodistribution of [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in Athymic Non-tumor-bearing Male Mice Anticancer Res. 2017 02; 37(2):475-479. . View in PubMed
Transformative Nanomedicine of an Amphiphilic Camptothecin Prodrug for Long Circulation and High Tumor Uptake in Cancer Therapy ACS Nano. 2017 09 26; 11(9):8838-8848. . View in PubMed
Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times ACS Nano. 2017 01 24; 11(1):153-162. . View in PubMed
Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy Nat Commun. 2017 12 05; 8(1):1954. . View in PubMed
Evaluation of (188)Re-labeled NGR-VEGI protein for radioimaging and radiotherapy in mice bearing human fibrosarcoma HT-1080 xenografts Tumour Biol. 2016 Jul; 37(7):9121-9. . View in PubMed
Pretargeted Positron Emission Tomography Imaging That Employs Supramolecular Nanoparticles with in Vivo Bioorthogonal Chemistry ACS Nano. 2016 Jan 26; 10(1):1417-24. . View in PubMed
In Vivo Tumor Angiogenesis Imaging Using Peptide-Based Near-Infrared Fluorescent Probes Methods Mol Biol. 2016; 1444:73-84. . View in PubMed
Boramino acid as a marker for amino acid transporters Sci Adv. 2015 Sep; 1(8):e1500694. . View in PubMed
Targeted Prostate Gland Biopsy With Combined Transrectal Ultrasound, mpMRI, and 18F-FMAU PET/CT Clin Nucl Med. 2015 Aug; 40(8):e426-8. . View in PubMed
Development of PET probes for cancer imaging Curr Top Med Chem. 2015; 15(8):795-819. . View in PubMed
In vivo NIRF imaging-guided delivery of a novel NGR-VEGI fusion protein for targeting tumor vasculature Amino Acids. 2014 Dec; 46(12):2721-32. . View in PubMed
MicroPET imaging of CD13 expression using a (64)Cu-labeled dimeric NGR peptide based on sarcophagine cage Mol Pharm. 2014 Nov 03; 11(11):3938-46. . View in PubMed
A direct comparison of tumor angiogenesis with 68Ga-labeled NGR and RGD peptides in HT-1080 tumor xenografts using microPET imaging Amino Acids. 2014 Oct; 46(10):2355-64. . View in PubMed
68Ga-labeled cyclic NGR peptide for microPET imaging of CD13 receptor expression Molecules. 2014 Aug 05; 19(8):11600-12. . View in PubMed
Near-infrared fluorescence imaging of CD13 receptor expression using a novel Cy55-labeled dimeric NGR peptide. Amino Acids. 2014 Jun; 46(6):1547-56. . View in PubMed
Radiolabeled nanoparticles for multimodality tumor imaging Theranostics. 2014; 4(3):290-306. . View in PubMed
Recent advances in diagnosis and treatment of gliomas using chlorotoxin-based bioconjugates Am J Nucl Med Mol Imaging. 2014; 4(5):385-405. . View in PubMed
(99m)Tc-labeled monomeric and dimeric NGR peptides for SPECT imaging of CD13 receptor in tumor-bearing mice Amino Acids. 2013 May; 44(5):1337-45. . View in PubMed
Synthesis and evaluation of 64Cu-labeled monomeric and dimeric NGR peptides for MicroPET imaging of CD13 receptor expression Mol Pharm. 2013 Jan 07; 10(1):417-27. . View in PubMed
Strain-Promoted Catalyst-Free Click Chemistry for Rapid Construction of (64)Cu-Labeled PET Imaging Probes ACS Med Chem Lett. 2012 Dec 13; 3(12):1019-23. . View in PubMed
Microwave-assisted one-pot radiosynthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-ß-d-arabinofuranosyluracil ([18F]-FMAU) Nucl Med Biol. 2012 Oct; 39(7):1019-25. . View in PubMed
[18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in prostate cancer: initial preclinical observations Mol Imaging. 2012 Sep-Oct; 11(5):426-32. . View in PubMed
A Cy55-labeled phage-displayed peptide probe for near-infrared fluorescence imaging of tumor vasculature in living mice. Amino Acids. 2012 Apr; 42(4):1329-37. . View in PubMed
Evaluation of 64Cu labeled GX1: a phage display peptide probe for PET imaging of tumor vasculature Mol Imaging Biol. 2012 Feb; 14(1):96-105. . View in PubMed
Efficient multicistronic co-expression of hNIS and hTPO in prostate cancer cells for nonthyroidal tumor radioiodine therapy Am J Nucl Med Mol Imaging. 2012; 2(4):483-98. . View in PubMed
Design, synthesis and validation of integrin a2ß1-targeted probe for microPET imaging of prostate cancer Eur J Nucl Med Mol Imaging. 2011 Jul; 38(7):1313-22. . View in PubMed
Integrin targeted delivery of chemotherapeutics Theranostics. 2011 Feb 17; 1:189-200. . View in PubMed
Positron emission tomography imaging of cancer biology: current status and future prospects Semin Oncol. 2011 Feb; 38(1):70-86. . View in PubMed
Target-specific delivery of peptide-based probes for PET imaging Adv Drug Deliv Rev. 2010 Aug 30; 62(11):1005-22. . View in PubMed
Phage display-derived peptides for osteosarcoma imaging Clin Cancer Res. 2010 Aug 15; 16(16):4268-77. . View in PubMed
Design of targeted cardiovascular molecular imaging probes J Nucl Med. 2010 May 01; 51 Suppl 1:3S-17S. . View in PubMed
Design and development of molecular imaging probes Curr Top Med Chem. 2010; 10(12):1227-36. . View in PubMed
The research interests in Dr. Chen’s laboratory focus on the development of novel theranostic agents for disease diagnosis and treatment. Dr. Chen has published over 70 peer-reviewed articles, and he is a co-inventor of 20 International and US patents. He has served as a reviewer for a number of funding agencies. Dr. Chen has also served as an active reviewer for over 70 research journals. In addition, he sits on the Editorial Board of 7 peer-reviewed international journals. Dr. Chen has been elected as the member of Board of Directors for the Radiopharmaceutical Sciences Council of Society of Nuclear Medicine and Molecular Imaging (SNMMI).
