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Karen Ting Chang, PhD

Associate Professor of Physiology and Neuroscience

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Phone +1 323 442 1871
Email changkt@usc.edu
CTSI Profile

Publications

  • Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the Drosophila neuromuscular junction. bioRxiv. 2025 Aug 22.. View in PubMed
  • Secretory autophagy – a new paradigm regulating synaptic plasticity. Autophagy. 2024 10; 20(10):2354-2356.. View in PubMed
  • Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodeling. Proc Natl Acad Sci U S A. 2024 Apr 16; 121(16):e2315958121.. View in PubMed
  • Identification of secretory autophagy as a novel mechanism modulating activity-induced synaptic remodeling. bioRxiv. 2023 Oct 06.. View in PubMed
  • Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin. J Cell Biol. 2021 12 06; 220(12).. View in PubMed
  • DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer’s disease. J Pathol. 2021 11; 255(3):296-310.. View in PubMed
  • Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin. J Cell Biol. 2021; 12(220):e202011028.
  • DSCR1‐mediated TET1 splicing regulates miR‐124 expression to control adult hippocampal neurogenesis. EMBO J. 2019; 14(38):e101293.
  • Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. J Neurosci. 2017 03 22; 37(12):3246-3263.. View in PubMed
  • Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools. J Neurosci. 2016 08 24; 36(34):8882-94.. View in PubMed
  • DSCR1 is required for both axonal growth cone extension and steering. J Cell Biol. 2016 05 23; 213(4):451-62.. View in PubMed
  • Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling. PLoS Genet. 2016 05; 12(5):e1006043.. View in PubMed
  • Dynamics of Mitochondrial Transport in Axons. Front Cell Neurosci. 2016; 10:123.. View in PubMed
  • Bidirectional Regulation of Amyloid Precursor Protein-Induced Memory Defects by Nebula/DSCR1: A Protein Upregulated in Alzheimer’s Disease and Down Syndrome. J Neurosci. 2015 Aug 12; 35(32):11374-83.. View in PubMed
  • Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase. Nat Commun. 2014 Jun 30; 5:4246.. View in PubMed
  • Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome. Trends Neurosci. 2013 Dec; 36(12):685-94.. View in PubMed
  • Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons. Front Cell Neurosci. 2013 Sep 10; 7:148.. View in PubMed
  • Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling. PLoS Genet. 2013; 9(9):e1003792.. View in PubMed
  • DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis. EMBO J. 2012 Sep 12; 31(18):3655-66.. View in PubMed
  • Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15456-61.. View in PubMed
  • Progress in molecular biology and translational science. Animal models of human disease. Preface. Prog Mol Biol Transl Sci. 2011; 100:xv.. View in PubMed
  • Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):17117-22.. View in PubMed
  • Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8673-8.. View in PubMed
  • Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. Nat Neurosci. 2005 Nov; 8(11):1577-85.. View in PubMed
  • The Drosophila homolog of Down’s syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15794-9.. View in PubMed
  • Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways. Mol Cell Neurosci. 2002 Dec; 21(4):616-25.. View in PubMed
  • Regulation of lifespan by histone deacetylase. Ageing Res Rev. 2002 Jun; 1(3):313-26.. View in PubMed
  • Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons. Neuron. 2001 Dec 06; 32(5):855-65.. View in PubMed
  • Synaptically driven calcium transients via nicotinic receptors on somatic spines. J Neurosci. 2001 Feb 01; 21(3):771-81.. View in PubMed
  • Nicotinic acetylcholine receptors containing alpha7 subunits are required for reliable synaptic transmission in situ. J Neurosci. 1999 May 15; 19(10):3701-10.. View in PubMed