Lee Ann Baxter-Lowe, PhD

Professor Of Clinical Pathology

Image of Lee Ann Baxter-Lowe, PhD
Is this your profile? Click to edit

Overview

Dr Baxter-Lowe’s research involves characterizing HLA polymorphism and determining its relevance in transplantation and human disease. In recent years she has been investigating the role of HLA antibodies in transplantation of solid organs and hematopoietic stem cells. Her laboratory has supported numerous single and multicenter clinical trials in transplantation and has been a core laboratory for the NIH Immune Tolerance Network. Her research has been reported in more than 125 scientific publications.

Dr. Baxter-Lowe has also served as a clinical histocompatibility laboratory director and in this capacity has been involved in advancing histocompatibility testing and its clinical application. She has had a long-standing commitment to policy development and is currently serving as Chair of the Histocompatibility Committee of the United Network for Organ Sharing (UNOS) and is the facilitator for the Histocompatibility Workgroup for the 2012 National Consensus Conference on Kidney Paired Donation (KPD). She has served as a member or chair of numerous national and international committees in this field.

Publications

  • Evaluation of a rapid flow cytometry assay to assess functional engraftment in CGD patients post-transplant and comparison with molecular chimerism. J Immunol Methods. 2026 Jan; 546:114006.. View in PubMed
  • Novel Scoring System for Ranking Hematopoietic Stem Cell Transplantation. Clin Transplant. 2024 11; 38(11):e15478.. View in PubMed
  • HLA diversity in ethnic populations can affect detection of donor-specific antibodies by single antigen beads. Front Immunol. 2023; 14:1287028.. View in PubMed
  • Next generation multiplexing for digital PCR using a novel melt-based hairpin probe design. Front Genet. 2023; 14:1272964.. View in PubMed
  • Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell disease. Front Immunol. 2022; 13:1055497.. View in PubMed
  • Safety and efficacy of combinatorial therapy utilizing myeloablative conditioning and autologous stem cell transplantation, targeted immunotherapy, and reduced intensity conditioning and allogeneic stem cell transplantation in children, adolescents, and young adults with relapsed/refractory mature B-cell non-Hodgkin lymphoma. Leuk Lymphoma. 2023 01; 64(1):234-237.. View in PubMed
  • Cell-free DNA as a solid-organ transplant biomarker: technologies and approaches. Biomark Med. 2022 04; 16(5):401-415.. View in PubMed
  • Haploidentical vs sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia. Blood Adv. 2022 01 11; 6(1):339-357.. View in PubMed
  • Defining and characterizing HLA diversity. Hum Immunol. 2021 07; 82(7):455-456.. View in PubMed
  • The changing landscape of HLA typing: Understanding how and when HLA typing data can be used with confidence from bench to bedside. Hum Immunol. 2021 Jul; 82(7):466-477.. View in PubMed