Lee M. Zuckerman, MD

Associate Professor of Clinical Orthopaedic Surgery

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Overview

Lee Zuckerman, MD is an orthopaedic surgeon who specializes in treating both benign and malignant tumors in the arms, legs, and pelvis in both adults and children, including primary tumors and metastatic disease. His clinical focus is to not only help cure patients, but to help facilitate multidisciplinary care and treat the long-term musculoskeletal effects caused by their disease. By focusing on individual goals and customizing care, Dr. Zuckerman works with each patient to maximize their function both during and after their cancer treatment is complete.

Dr. Zuckerman’s research focuses on improving treatments and outcomes for patients with musculoskeletal tumors. He has pioneered the use of magnetic lengthening nails for bone reconstruction in cancer patients and specializes in joint-preservation surgery and limb-lengthening in addition to limb-salvage surgery. He is the author of multiple articles and book chapters regarding the use of these nails and is an international expert on the topic, giving lectures throughout the United States and abroad.

Beyond his work at USC, he has performed limb-salvage surgery in Haiti, the Dominican Republic and Guyana, and has published both videos and articles of the topic of performing these complex surgeries in underserved countries.

Dr. Zuckerman also works to raise awareness in the treatment of sarcomas and other cancers and has completed multiple Ironman distance triathlons for this purpose.

Publications

  • A modified Delphi consensus on tenosynovial giant cell tumour and giant cell tumour of bone : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM). Bone Joint J. 2026 Jun 09; 108.. View in PubMed
  • Complications of PI to PIII hemipelvic resections for intermediate and malignant tumours : a systematic review and meta-analysis. Bone Jt Open. 2026 Jun 01; 7(6):713-723.. View in PubMed
  • Rate and Type of Surgery and Prevalence of Malignancy in Patients With Ollier’s Disease and Maffucci Syndrome. Am J Med Genet A. 2026 Sep; 200(9):2025-2035.. View in PubMed
  • Extramedullary Lengthening After a Distal Femoral Replacement to Improve Bone Stock and Restore Leg Length: A Case Report. JBJS Case Connect. 2026 Apr 01; 16(2).. View in PubMed
  • Chondrosarcoma: Clinical behavior, molecular mechanisms, and emerging therapeutic strategies. Crit Rev Oncol Hematol. 2026 Feb; 218:105075.. View in PubMed
  • Clinical compatibility of magnetic resonance imaging with magnetic intramedullary nails: a feasibility study. Arch Orthop Trauma Surg. 2024 Apr; 144(4):1503-1509.. View in PubMed
  • Reconstruction of Bony Defects With Motorized Intramedullary Nails After Tumor Resection. Instr Course Lect. 2024; 73:369-385.. View in PubMed
  • Role of immunotherapy in chondrosarcoma: A case report and review of the literature. Ther Adv Med Oncol. 2023; 15:17588359231199877.. View in PubMed
  • Outpatient Opioid Prescribing Habits in Pediatric Patients With Bone Sarcomas After Undergoing Primary Tumor Resection. J Pediatr Orthop. 2022 May-Jun 01; 42(5):e501-e506.. View in PubMed
  • All-Internal Limb Lengthening with Simultaneous Corrective Osteotomy After Internal Hemipelvectomy: A Case Report. JBJS Case Connect. 2022 Apr 01; 12(2).. View in PubMed