Lee M Zuckerman, MD

Associate Professor of Clinical Orthopaedic Surgery

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Lee Zuckerman, MD is an orthopaedic surgeon who specializes in treating both benign and malignant tumors in the arms, legs, and pelvis in both adults and children, including primary tumors and metastatic disease. His clinical focus is to not only help cure patients, but to help facilitate multidisciplinary care and treat the long-term musculoskeletal effects caused by their disease. By focusing on individual goals and customizing care, Dr. Zuckerman works with each patient to maximize their function both during and after their cancer treatment is complete.

Dr. Zuckerman’s research focuses on improving treatments and outcomes for patients with musculoskeletal tumors. He has pioneered the use of magnetic lengthening nails for bone reconstruction in cancer patients and specializes in joint-preservation surgery and limb-lengthening in addition to limb-salvage surgery. He is the author of multiple articles and book chapters regarding the use of these nails and is an international expert on the topic, giving lectures throughout the United States and abroad.

Beyond his work at USC, he has performed limb-salvage surgery in Haiti, the Dominican Republic and Guyana, and has published both videos and articles of the topic of performing these complex surgeries in underserved countries.

Dr. Zuckerman also works to raise awareness in the treatment of sarcomas and other cancers and has completed multiple Ironman distance triathlons for this purpose.


  • Clinical compatibility of magnetic resonance imaging with magnetic intramedullary nails: a feasibility study Arch Orthop Trauma Surg. 2024 Apr; 144(4):1503-1509. . View in PubMed
  • Reconstruction of Bony Defects With Motorized Intramedullary Nails After Tumor Resection Instr Course Lect. 2024; 73:369-385. . View in PubMed
  • Role of immunotherapy in chondrosarcoma: A case report and review of the literature Ther Adv Med Oncol. 2023; 15:17588359231199877. . View in PubMed
  • Outpatient Opioid Prescribing Habits in Pediatric Patients With Bone Sarcomas After Undergoing Primary Tumor Resection J Pediatr Orthop. 2022 May-Jun 01; 42(5):e501-e506. . View in PubMed
  • Technical considerations for the management of segmental osseous defects with an internal bone transport nail Expert Rev Med Devices. 2022 Mar; 19(3):203-211. . View in PubMed
  • All-Internal Limb Lengthening with Simultaneous Corrective Osteotomy After Internal Hemipelvectomy: A Case Report JBJS Case Connect. 2022 04 01; 12(2). . View in PubMed
  • Biologic Reconstruction With a Motorized Intramedullary Bone Transport Nail After Tumor Resection J Orthop Trauma. 2021 Oct 01; 35(Suppl 4):S25-S30. . View in PubMed
  • Ultrasound-Assisted Posterior Knee Arthroscopy: A Description of the Technique J Ultrasound Med. 2021 Sep; 40(9):1949-1953. . View in PubMed
  • Unusual presentation in Haiti of a recurrent giant cell tumor of bone affecting the distal radius: A case report Int J Surg Case Rep. 2021 Mar; 80:105686. . View in PubMed
  • Comparison of forces generated using compression plating versus a magnetic lengthening nail in a sawbones femur model Clin Biomech (BristolAvon). 2021 12; 90:105508. . View in PubMed
  • Bupivacaine and Lidocaine Induce Apoptosis in Osteosarcoma Tumor Cells Clin Orthop Relat Res. 2021 01 01; 479(1):180-194. . View in PubMed
  • Antiproliferative effect of bupivacaine on patient-derived sarcoma cells Mol Clin Oncol. 2020 Sep; 13(3):7. . View in PubMed
  • Secondary Chondrosarcoma Arising from the Proximal Fibula Presenting as Sciatica J Orthop Case Rep. 2020 Aug-Sep; 10(5):53-56. . View in PubMed
  • Limb Salvage for Musculoskeletal Tumors in the Austere Environment: Review of the Literature With Illustrative Cases Regarding Considerations and PitfallsJ Am Acad Orthop Surg Glob Res Rev. 2020 10 01; 4(10):e19. 00172. . View in PubMed
  • Inhibitory Effects of Indomethacin in Human MNNG/HOS Osteosarcoma Cell Line In Vitro Cancer Invest. 2020 Jan; 38(1):23-36. . View in PubMed
  • Successful treatment of a dedifferentiated chondrosarcoma of the proximal humerus with a hemicortical articular surface sparing allograft: A case report Int J Surg Case Rep. 2020; 72:590-595. . View in PubMed
  • Development of multifocal extra-abdominal desmoid fibromatosis after surgical resection Clin Case Rep. 2019 Dec; 7(12):2515-2519. . View in PubMed
  • Short tau inversion recovery magnetic resonance imaging for staging and screening in myxoid liposarcoma J Orthop. 2019 May-Jun; 16(3):206-210. . View in PubMed
  • The In Vitro Effects of Bupivacaine on Cartilage-forming Tumor Cells J Am Acad Orthop Surg. 2019 Apr 01; 27(7):e337-e345. . View in PubMed
  • The effect of non-steroidal anti-inflammatory drugs on osteosarcoma cells Eur Rev Med Pharmacol Sci. 2019 Mar; 23(6):2681-2690. . View in PubMed
  • Use of Magnetic Growing Intramedullary Nails in Compression During Intercalary Allograft Reconstruction Orthopedics. 2018 Nov 01; 41(6):330-335. . View in PubMed
  • A biomechanical comparison of the two- and four-hole side-plate dynamic hip screw in an osteoporotic composite femur model J Orthop Surg (Hong Kong). 2017 May-Aug; 25(2):2309499017717199. . View in PubMed
  • Heat Generation During Bone Drilling: A Comparison Between Industrial and Orthopaedic Drill Bits J Orthop Trauma. 2017 Feb; 31(2):e55-e59. . View in PubMed
  • Metastatic biomarkers in synovial sarcoma Biomark Res. 2017; 5:4. . View in PubMed
  • Thumb Reconstruction with Arthrodesis to the Second Metacarpal following Sarcoma Excision Case Rep Orthop. 2016; 2016:8061036. . View in PubMed
  • Management of Pelvic Chondroblastic Osteosarcoma after Urgent Spinal Decompression – A Report of 2 Cases J Orthop Case Rep. 2016 Jan-Mar; 6(1):72-5. . View in PubMed
  • Conversion of a surgical elbow arthrodesis to total elbow arthroplasty Case Rep Orthop. 2015; 2015:578189. . View in PubMed
  • Pigmented villonodular synovitis: extrasynovial recurrence Arthroscopy. 2011 Oct; 27(10):1449-51. . View in PubMed
  • Parkinson’s disease and the orthopaedic patient J Am Acad Orthop Surg. 2009 Jan; 17(1):48-55. . View in PubMed
  • Thrombosis prophylaxis using external compression Surg Gynecol Obstet. 1983 May; 156(5):599-604. . View in PubMed