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Leonardo Morsut

Associate Professor of Stem Cell Biology and Regenerative Medicine

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Phone +1 323 442 4363
Email [email protected]
CTSI Profile

Overview

Morsut Lab Website

Research Funding

  • Engineering Therapeutic Monocytes to Immunomodulate Infarcted Human Myocardium on a Chip
    NIH · R21HL186766 · Aug 1, 2026 – Jun 30, 2028 · Role: Principal Investigator
  • Technologies to study and control patterning and differentiation in multicellular development, a case study for multilayered arterial wall of controlled thickness
    NIH · R35GM162013 · Apr 1, 2026 – Jan 31, 2031 · Role: Principal Investigator
  • Synthetic development: dissection of morphogenetic programs via reconstructive and perturbative approaches
    NIH · R35GM138256 · Sep 15, 2020 – Jun 30, 2025 · Role: Principal Investigator
  • Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact
    NIH · R00EB021030 · Aug 1, 2017 – Apr 30, 2021 · Role: Principal Investigator
  • Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact Signals
    NIH · K99EB021030 · Aug 5, 2015 – Jul 31, 2017 · Role: Principal Investigator

Publications

  • Patterning human kidney organoids with synthetic Wnt-secreting organizers. Science. 2026 Jul 02; 393(6806):eadu9122.. View in PubMed
  • Mapping and engineering the human cell-cell interactome. Nat Biotechnol. 2026 Aug; 44(8):1292-1303.. View in PubMed
  • A novel reaction-diffusion architecture for engineering self-organized patterns in mammalian cells. bioRxiv. 2026 May 25.. View in PubMed
  • What do you most hope we will achieve with mammalian synthetic biology within the next decade? Cell Syst. 2025 Dec 17; 16(12):101485. Fussenegger M, Chen YY , Wong W, Borth N, Rosser S, Morsut L , Di . View in PubMed
  • Derivation of cardiomyocyte-propelled motile aggregates from stem cells. bioRxiv. 2025 Jul 09.. View in PubMed
  • Programming the elongation of mammalian cell aggregates with synthetic gene circuits. bioRxiv. 2024 Dec 11.. View in PubMed
  • Control of spatio-temporal patterning via cell growth in a multicellular synthetic gene circuit. Nat Commun. 2024 11 19; 15(1):9867.. View in PubMed
  • Author Correction: Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs. Nat Commun. 2024 Aug 01; 15(1):6490.. View in PubMed
  • Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs. Nat Commun. 2024 07 13; 15(1):5891.. View in PubMed
  • Parsing patterns: Emerging roles of tissue self-organization in health and disease. Cell. 2024 Jun 20; 187(13):3165-3186.. View in PubMed

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