Keck School Faculty

Leslie Ann Saxon, MD
Leslie Ann Saxon, MD
Professor of Medicine (Clinical Scholar);Executive Director, Center for Body Computing (CBC)
HCC 300N Health Sciences Campus Los Angeles
Dr. Leslie Saxon is a professor of clinical medicine (clinical scholar) at the Keck School of Medicine of USC and specializes in the diagnosis and treatment of cardiac arrhythmias and preventing sudden cardiac death. In addition to her work in cardiovascular medicine, Dr. Saxon serves as the executive director of the internationally acclaimed USC Center for Body Computing (CBC) and newly formed USC Virtual Care Clinic (VCC). The CBC is currently a place for all USC schools, including medicine, engineering, business and the cinematic arts, to form interdisciplinary relationships and accelerate the future of fully integrated, “connected” medicine alongside public and private sector partners. She is a well-known authority on the pre-clinical and clinical development and testing of wearable and implanted technology, including networked devices used in medical, wellness and fitness disciplines. With her clinical expertise, she is a valuable strategist in developing device models and software solutions that offer engaging user-feedback based on real-time physiologic data. Her cultivation of critical innovative partnerships to jointly commercialize products within the CBC is essential for furthering and improving the dissemination of medical information, enhancing communication and improving health outcomes. Dr. Saxon has completed over 150 publications in various medical journals, has spoken at various forums, including TEDMED, South by Southwest (SXSW), WIRED Health and CES, and was recently named “Most Tech Friendly Doc” by Rock Health. Known as a digital health guru, Dr. Saxon is frequently interviewed by national media.

Impact of Degree of Left Ventricular Remodeling on Clinical Outcomes From Cardiac Resynchronization Therapy JACC Heart Fail. 2019 Apr; 7(4):281-290. . View in PubMed

Heart Rhythm. 2019 Apr; 16(4):581-587. . View in PubMed

Editorial commentary: Re-inventing chronic disease management as a service - Medication adherence solutions are ground zero Trends Cardiovasc Med. 2019 02; 29(2):118-119. . View in PubMed

Haemodynamic Monitoring Devices in Heart Failure: Maximising Benefit with Digitally Enabled Patient Centric Care Arrhythm Electrophysiol Rev. 2018 Dec; 7(4):294-298. . View in PubMed

Cardiac Resynchronization Therapy Does Not Prevent Atrial Fibrillation But Atrial Fibrillation Prevents Cardiac Resynchronization Therapy and Adversely Impacts Outcomes JACC Clin Electrophysiol. 2018 09; 4(9):1235-1237. . View in PubMed

Baseline diastolic pressure gradient and pressure reduction in chronic heart failure patients implanted with the CardioMEMS™ HF sensor ESC Heart Fail. 2018 06; 5(3):316-321. . View in PubMed

Factors Influencing the Decision to Proceed to Firmware Upgrades to Implanted Pacemakers for Cybersecurity Risk Mitigation Circulation. 2018 09 18; 138(12):1274-1276. . View in PubMed

Pulmonary arterial pressure sensing in a patient with left ventricular assist device during ventricular arrhythmia HeartRhythm Case Rep. 2017 Jul; 3(7):348-351. . View in PubMed

Effects of pressure variation and atrial fibrillation on CardioMEMS™ HF measured pulmonary artery diastolic pressure: comparison of device-averaged and visually inspected waveforms Physiol Meas. 2017 Jun; 38(6):1094-1103. . View in PubMed

2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry Heart Rhythm. 2017 07; 14(7):e55-e96. . View in PubMed

Outcomes of cardiac resynchronization therapy in patients with intermittent atrial fibrillation or atrial flutter in the COMPANION trial Heart Rhythm. 2017 06; 14(6):858-865. . View in PubMed

Coping strategies and mental health outcomes of conflict-affected persons in the Republic of Georgia Epidemiol Psychiatr Sci. 2017 06; 26(3):276-286. . View in PubMed

2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry Ann Noninvasive Electrocardiol. 2017 05; 22(3). . View in PubMed

Athletic Performance Monitoring, Pseudo Science and Metaphysics Meet Ethics Am J Bioeth. 2017 01; 17(1):61-62. . View in PubMed

Mobile Health Application Solutions Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e002477. . View in PubMed

Digital monitoring and care: Virtual medicine Trends Cardiovasc Med. 2016 11; 26(8):722-730. . View in PubMed

Implantable Cardioverter Defibrillator Programming Characteristics, Shocked Rhythms, and Survival Among Patients Under Thirty Years of Age J Cardiovasc Electrophysiol. 2016 10; 27(10):1183-1190. . View in PubMed

Lessons Learned and Insights Gained in the Design, Analysis, and Outcomes of the COMPANION Trial JACC Heart Fail. 2016 07; 4(7):521-535. . View in PubMed

Integration of Smartphone Based Monitoring: No Modality is an Island, Entire of Itself J Cardiovasc Electrophysiol. 2016 Jan; 27(1):58-9. . View in PubMed

Rationale and Design of the Left Atrial Pressure Monitoring to Optimize Heart Failure Therapy Study (LAPTOP-HF) J Card Fail. 2015 Jun; 21(6):479-88. . View in PubMed

Incidence of defibrillator shocks after elective generator exchange following uneventful first battery life J Am Heart Assoc. 2014 Nov 10; 3(6):e001289. . View in PubMed

Performance of an automatic arrhythmia classification algorithm: comparison to the ALTITUDE electrophysiologist panel adjudications Pacing Clin Electrophysiol. 2014 Jul; 37(7):889-99. . View in PubMed

Impact of shock energy and ventricular rhythm on the success of first shock therapy: the ALTITUDE first shock study Heart Rhythm. 2013 May; 10(5):702-8. . View in PubMed

Heart Fail Rev. 2012 Nov; 17(6):777-9. . View in PubMed

Guideline adherence after ST-segment elevation versus non-ST segment elevation myocardial infarction Circ Cardiovasc Qual Outcomes. 2012 Sep 01; 5(5):654-61. . View in PubMed

2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management Europace. 2012 Sep; 14(9):1236-86. . View in PubMed

2012 EHRA/HRS expert consensus statement on cardiac resynchronization therapy in heart failure: implant and follow-up recommendations and management Heart Rhythm. 2012 Sep; 9(9):1524-76. . View in PubMed

Noise, artifact, and oversensing related inappropriate ICD shock evaluation: ALTITUDE noise study Pacing Clin Electrophysiol. 2012 Jul; 35(7):863-9. . View in PubMed

Left ventricular versus biventricular for cardiac resynchronization therapy: comparable but not equal Circulation. 2011 Dec 20; 124(25):2803-4. . View in PubMed

Real world evaluation of dual-zone ICD and CRT-D programming compared to single-zone programming: the ALTITUDE REDUCES study J Cardiovasc Electrophysiol. 2011 Sep; 22(9):1023-9. . View in PubMed

Cardiac resynchronization therapy and the relationship of percent biventricular pacing to symptoms and survival Heart Rhythm. 2011 Sep; 8(9):1469-75. . View in PubMed

Implantable cardioverter defibrillator electrogram adjudication for device registries: methodology and observations from ALTITUDE Pacing Clin Electrophysiol. 2011 Aug; 34(8):1003-12. . View in PubMed

Impact of relaxation training on patient-perceived measures of anxiety, pain, and outcomes after interventional electrophysiology procedures Pacing Clin Electrophysiol. 2011 Jul; 34(7):821-6. . View in PubMed

Cardiovascular care and research in the networked era J Cardiovasc Transl Res. 2011 Feb; 4(1):1-2. . View in PubMed

Direct left atrial pressure monitoring in severe heart failure: long-term sensor performance J Cardiovasc Transl Res. 2011 Feb; 4(1):3-13. . View in PubMed

Long-term outcome after ICD and CRT implantation and influence of remote device follow-up: the ALTITUDE survival study Circulation. 2010 Dec 07; 122(23):2359-67. . View in PubMed

Novel use of a vascular plug to anchor an azygous vein ICD lead J Cardiovasc Electrophysiol. 2010 Jan; 21(1):99-102. . View in PubMed

Implant wizardInterview by Gary Baldwin. Health Data Manag. 2010 Jan; 18(1):40. . View in PubMed

Complete heart block and preserved LV function: does right ventricular pacing site matter? J Cardiovasc Electrophysiol. 2009 Aug; 20(8):906-7.. View in PubMed

Influence of left ventricular lead location on outcomes in the COMPANION study J Cardiovasc Electrophysiol. 2009 Jul; 20(7):764-8. . View in PubMed

Impact of cardiac resynchronization therapy on exercise performance, functional capacity, and quality of life in systolic heart failure with QRS prolongation: COMPANION trial sub-study J Card Fail. 2008 Feb; 14(1):9-18. . View in PubMed

Body computing: how networked medical devices can solve problems facing health care today J Cardiovasc Electrophysiol. 2007 Dec; 18(12):1345-7. . View in PubMed

Influence of diabetes on cardiac resynchronization therapy with or without defibrillator in patients with advanced heart failure J Card Fail. 2007 Nov; 13(9):769-73. . View in PubMed

Defining response and defining how we measure response to CRT J Cardiovasc Electrophysiol. 2007 Sep; 18(10):1020-1. . View in PubMed

Does cardiac resynchronization therapy reduce the incidence of atrial fibrillation, and does atrial fibrillation compromise the cardiac resynchronization therapy effect? Heart Rhythm. 2007 Mar; 4(3 Suppl):S31-3.. View in PubMed

Effects of cardiac resynchronization therapy with or without a defibrillator on survival and hospitalizations in patients with New York Heart Association class IV heart failure Circulation. 2007 Jan 16; 115(2):204-12. . View in PubMed

Predictors of sudden cardiac death and appropriate shock in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Trial Circulation. 2006 Dec 19; 114(25):2766-72. . View in PubMed

Recommendations from the Heart Rhythm Society Task Force on Device Performance Policies and Guidelines Endorsed by the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) and the International Coalition of Pacing and Electrophysiology Organizations (COPE) Heart Rhythm. 2006 Oct; 3(10):1250-73. . View in PubMed

More is better with cardiac resynchronization therapy--but is it enough? Eur Heart J. 2006 Aug; 27(16):1891-2.. View in PubMed

Patient selection for primary prevention ICDs--are eps shocking patients into consent? J Card Fail. 2006 Aug; 12(6):413-5.. View in PubMed

Cost effectiveness of cardiac resynchronization therapy in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial J Am Coll Cardiol. 2005 Dec 20; 46(12):2311-21. . View in PubMed

Delayed defibrillation testing after CRT-D implant-weighing competing risks J Cardiovasc Electrophysiol. 2005 Dec; 16(12):1284-5. . View in PubMed

A comparison of cardiac resynchronization by sequential biventricular pacing and left ventricular pacing to simultaneous biventricular pacing: rationale and design of the DECREASE-HF clinical trial J Card Fail. 2005 Apr; 11(3):233-9. . View in PubMed

Effects of resynchronization therapy on cardiac function in pacemaker patients "upgraded" to biventricular devices J Cardiovasc Electrophysiol. 2004 Nov; 15(11):1284-9. . View in PubMed

Improvement in heart rate turbulence as a measure of response to beta-blocker therapy for heart failure J Cardiovasc Electrophysiol. 2004 Jul; 15(7):757-8. . View in PubMed

Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure N Engl J Med. 2004 May 20; 350(21):2140-50. . View in PubMed

Noninvasive assessment of the biventricular pacing system Ann Noninvasive Electrocardiol. 2004 Jan; 9(1):58-70. . View in PubMed

Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias J Am Coll Cardiol. 2003 Oct 15; 42(8):1454-9. . View in PubMed

NASPE training requirements for cardiac implantable electronic devices: selection, implantation, and follow-up Pacing Clin Electrophysiol. 2003 Jul; 26(7 Pt 1):1556-62. . View in PubMed

Isolated bundle branch block and left ventricular dysfunction J Card Fail. 2003 Apr; 9(2):87-92. . View in PubMed

Heart failure and Implantable Cardioverter Defibrillator (ICD) therapy: Update and perspective on current primary prevention trials J Card Fail. 2002 Jun; 8(3):161-6. . View in PubMed

Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling Circulation. 2002 Mar 19; 105(11):1304-10. . View in PubMed

Arrhythmias associated with dilated cardiomyopathy Card Electrophysiol Rev. 2002 Feb; 6(1-2):18-25. . View in PubMed

Cardiac resynchronization: a cornerstone in the foundation of device therapy for heart failure J Am Coll Cardiol. 2001 Dec; 38(7):1971-3. . View in PubMed

Atypical right atrial flutter patterns Circulation. 2001 Jun 26; 103(25):3092-8. . View in PubMed

Heart failure management using implantable devices for ventricular resynchronization: Comparison of Medical Therapy, Pacing, and Defibrillation in Chronic Heart Failure (COMPANION) trialCOMPANION Steering Committee and COMPANION Clinical Investigators. J Card Fail. 2000 Sep; 6(3):276-85. . View in PubMed

Body surface mapping of counterclockwise and clockwise typical atrial flutter: a comparative analysis with endocardial activation sequence mapping J Am Coll Cardiol. 2000 Apr; 35(5):1276-87. . View in PubMed

Long-term His-bundle pacing and cardiac function Circulation. 2000 Feb 29; 101(8):836-7. . View in PubMed

Biventricular pacing in patients with congestive heart failure: two prospective randomized trialsThe VIGOR CHF and VENTAK CHF Investigators. Am J Cardiol. 1999 Mar 11; 83(5B):120D-123D. . View in PubMed

Electrophysiologic effects of adenosine in patients with supraventricular tachycardia Circulation. 1999 Mar 02; 99(8):1034-40. . View in PubMed

Radiofrequency catheter ablation of ventricular tachycardia after myocardial infarction Circulation. 1998 Jul 28; 98(4):308-14. . View in PubMed

Narrow complex tachycardia with VA block: diagnostic and therapeutic implications Pacing Clin Electrophysiol. 1998 Jun; 21(6):1196-206. . View in PubMed

Acute effects of intraoperative multisite ventricular pacing on left ventricular function and activation/contraction sequence in patients with depressed ventricular function J Cardiovasc Electrophysiol. 1998 Jan; 9(1):13-21. . View in PubMed

Anatomic and electrophysiologic relation between the coronary sinus and mitral annulus: implications for ablation of left-sided accessory pathways Am Heart J. 1998 Jan; 135(1):93-8. . View in PubMed

Electrophysiology of "incisional" reentrant atrial tachycardia complicating surgery for congenital heart disease Pacing Clin Electrophysiol. 1997 Aug; 20(8 Pt 2):2107-11. . View in PubMed

Exploring postinfarction reentrant ventricular tachycardia with entrainment mapping J Am Coll Cardiol. 1997 May; 29(6):1180-9. . View in PubMed

Preferential locations for critical reentry circuit sites causing ventricular tachycardia after inferior wall myocardial infarction J Cardiovasc Electrophysiol. 1997 Apr; 8(4):363-70. . View in PubMed

Atrial fibrillation and dilated cardiomyopathy: therapeutic strategies when sinus rhythm cannot be maintained Pacing Clin Electrophysiol. 1997 Mar; 20(3 Pt 1):720-5. . View in PubMed

Electrocardiographic and electrophysiologic characterization of atypical atrial flutter in man: use of activation and entrainment mapping and implications for catheter ablation J Cardiovasc Electrophysiol. 1997 Feb; 8(2):121-44. . View in PubMed

Mechanism of initiation of atrial flutter in humans: site of unidirectional block and direction of rotation J Am Coll Cardiol. 1997 Feb; 29(2):376-84. . View in PubMed

Improving survival for patients with atrial fibrillation and advanced heart failure J Am Coll Cardiol. 1996 Nov 15; 28(6):1458-63. . View in PubMed

Mode of onset of torsade de pointes in congenital long QT syndrome J Am Coll Cardiol. 1996 Nov 01; 28(5):1262-8. . View in PubMed

ICD use as a bridge to cardiac transplantation Circulation. 1996 Nov 01; 94(9):2308-10. . View in PubMed

Activation and entrainment mapping defines the tricuspid annulus as the anterior barrier in typical atrial flutter Circulation. 1996 Aug 01; 94(3):398-406. . View in PubMed

Familial long QT syndrome: electrical storm and implantable cardioverter device therapy Am Heart J. 1996 May; 131(5):1037-9. . View in PubMed

Ablation of 'incisional' reentrant atrial tachycardia complicating surgery for congenital heart diseaseUse of entrainment to define a critical isthmus of conduction. Circulation. 1996 Feb 01; 93(3):502-12. . View in PubMed

Improving survival for patients with advanced heart failure: a study of 737 consecutive patients J Am Coll Cardiol. 1995 Nov 15; 26(6):1417-23. . View in PubMed

Amiodarone and torsades de pointes in patients with advanced heart failure Am J Cardiol. 1995 Sep 01; 76(7):499-502. . View in PubMed

Implantable defibrillators for high-risk patients with heart failure who are awaiting cardiac transplantation Am Heart J. 1995 Sep; 130(3 Pt 1):501-6. . View in PubMed

Relation of pace mapping QRS configuration and conduction delay to ventricular tachycardia reentry circuits in human infarct scars J Am Coll Cardiol. 1995 Aug; 26(2):481-8. . View in PubMed

Monomorphic versus polymorphic ventricular tachycardia after coronary artery bypass grafting Am J Cardiol. 1995 Feb 15; 75(5):403-5. . View in PubMed

Identification of reentry circuit sites during catheter mapping and radiofrequency ablation of ventricular tachycardia late after myocardial infarction Circulation. 1993 Oct; 88(4 Pt 1):1647-70. . View in PubMed

Predicting death from progressive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy Am J Cardiol. 1993 Jul 01; 72(1):62-5. . View in PubMed

Increased risk of progressive hemodynamic deterioration in advanced heart failure patients requiring permanent pacemakers Am Heart J. 1993 May; 125(5 Pt 1):1306-10. . View in PubMed

Biplanar transesophageal echocardiographic direction of radiofrequency catheter ablation in children and adolescents with the Wolff-Parkinson-White syndrome Am J Cardiol. 1993 Apr 01; 71(10):872-4. . View in PubMed

Prognosis after syncope: impact of left ventricular function Am Heart J. 1993 Jan; 125(1):121-7. . View in PubMed

Amiodarone therapy does not compromise subsequent heart transplantation J Am Coll Cardiol. 1992 Dec; 20(7):1556-61. . View in PubMed

Identifying sites for catheter ablation of ventricular tachycardia Herz. 1992 Jun; 17(3):158-70. . View in PubMed

Permanent pacemaker placement in chronic atrial fibrillation associated with intermittent AV block and cerebral symptoms Pacing Clin Electrophysiol. 1990 Jun; 13(6):724-9. . View in PubMed

Abdominal pain occurring during the rapid administration of fructose solutions N Engl J Med. 1957 Jan 17; 256(3):132-3. . View in PubMed

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