Lingyun Ji, PhD

Dr. Lingyun Ji is an Associate Professor of Clinical Population and Public Health Sciences in the Division of Biostatistics at the University of Southern California. Her research interest includes clinical trial design methodology, Bayesian adaptive designs, and statistical methodology in cancer research. She has been actively involved in collaborative work in pediatric and adult oncology. She is a faculty statistician at the Children’s Oncology Group for the COG research effort in acute lymphoblastic leukemia.

• Prognostic markers in pT3 bladder cancer: A study from the international bladder cancer tissue microarray projectUrol Oncol. 2021 05; 39(5):301. e17-301. e28. . View in PubMed
• J Ethnopharmacol. 2024 Mar 26; 328:118000. . View in PubMed
• Outcomes in Children, Adolescents, and Young Adults With Down Syndrome and ALL: A Report From the Children’s Oncology Group J Clin Oncol. 2024 Jan 10; 42(2):218-227. . View in PubMed
• Population-Based Data Linkage Describing Patterns of Cancer Clinical Trial Enrollment Among Children and Adolescents JCO Oncol Pract. 2024 Jan 09; OP2300325. . View in PubMed
• Research progress on the mechanism of traditional Chinese medicine regulating intestinal microbiota to combat influenza a virus infection Virol J. 2023 Nov 13; 20(1):260. . View in PubMed
• Comparison of design methods for a safety run-in phase of a phase II clinical trial Clin Trials. 2023 04; 20(2):181-191. . View in PubMed
• CD22low/Bcl-2high expression identifies poor response to inotuzumab ozogamicin in relapsed/refractory acute lymphoblastic leukemia Blood Adv. 2023 01 24; 7(2):251-255. . View in PubMed
• Loss to follow-up of minorities, adolescents, and young adults on clinical trials: A report from the Children’s Oncology Group Cancer. 2023 05 15; 129(10):1547-1556. . View in PubMed
• Children’s Oncology Group AALL1331: Phase III Trial of Blinatumomab in Children, Adolescents, and Young Adults With Low-Risk B-Cell ALL in First Relapse J Clin Oncol. 2023 09 01; 41(25):4118-4129. . View in PubMed
• Inefficiency of two-stage designs in phase II oncology clinical trials with high proportion of inevaluable patients Contemp Clin Trials. 2022 09; 120:106849. . View in PubMed
• Markers of hypercoagulability in children with newly diagnosed acute lymphoblastic leukemia Pediatr Blood Cancer. 2022 03; 69(3):e29522. . View in PubMed
• Adolescent and young adult (AYA) versus pediatric patients with acute leukemia have a significantly increased risk of acute GVHD following unrelated donor (URD) stem cell transplantation (SCT): the Children’s Oncology Group experience Bone Marrow Transplant. 2022 03; 57(3):445-452. . View in PubMed
• Phase II Trial of Inotuzumab Ozogamicin in Children and Adolescents With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia: Children’s Oncology Group Protocol AALL1621 J Clin Oncol. 2022 03 20; 40(9):956-967. . View in PubMed
• Upregulation of Ferroptosis-Related Fanconi Anemia Group D2 is a Poor Prognostic Factor and an Indicator of Tumor Immune Cell Infiltration in Lung Adenocarcinoma Front Genet. 2022; 13:825685. . View in PubMed
• Pediatric oncology clinician communication about sexual health with adolescents and young adults: A report from the children’s oncology group Cancer Med. 2021 08; 10(15):5110-5119. . View in PubMed
• Development of a Risk Model for Pediatric Hospital-Acquired Thrombosis: A Report from the Children’s Hospital-Acquired Thrombosis ConsortiumJ Pediatr. 2021 01; 228:252-259. e1. . View in PubMed
• Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial JAMA. 2021 03 02; 325(9):833-842. . View in PubMed
• Randomized Phase II Trial of MIBG Versus MIBG, Vincristine, and Irinotecan Versus MIBG and Vorinostat for Patients With Relapsed or Refractory Neuroblastoma: A Report From NANT Consortium J Clin Oncol. 2021 11 01; 39(31):3506-3514. . View in PubMed
• A real-time PCR assay based on a specific mutation of PstS1 gene for detection of Mbovis strains. Biologicals. 2020 Mar; 64:23-27. . View in PubMed
• Preexisting or therapy-induced mutations in relapsed acute lymphoblastic leukemia? Blood. 2020 11 05; 136(19):2233-2235.. View in PubMed
• Comparative prognostic implication of treatment response assessments in mCRPC: PERCIST 10, RECIST 1. 1, and PSA response criteria. Theranostics. 2020; 10(7):3254-3262. . View in PubMed
• Peripherally inserted central catheters lead to a high risk of venous thromboembolism in children Blood. 2020 01 16; 135(3):220-226. . View in PubMed
• Excellent outcome of young children with nodular desmoplastic medulloblastoma treated on “Head Start” III: a multi-institutional, prospective clinical trial Neuro Oncol. 2020 12 18; 22(12):1862-1872. . View in PubMed
• Clinical findings and outcomes of MRI staging of breast cancer in a diverse population Breast Cancer Res Treat. 2019 Apr; 174(2):315-324. . View in PubMed
• Bias in retrospective analyses of biomarker effect using data from an outcome-adaptive randomized trial Clin Trials. 2019 12; 16(6):599-609. . View in PubMed
• Rejoinder Clin Trials. 2019 12; 16(6):613-615. . View in PubMed
• Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method Pharm Stat. 2019 11; 18(6):659-670. . View in PubMed
• Prediction of Time to Hormonal Treatment Failure in Metastatic Castration-Sensitive Prostate Cancer with 18F-FDG PET/CT J Nucl Med. 2019 11; 60(11):1524-1530. . View in PubMed
• Treatment of higher risk acute lymphoblastic leukemia in young people (CCG-1961), long-term follow-up: a report from the Children’s Oncology Group Leukemia. 2019 09; 33(9):2144-2154. . View in PubMed
• Transplantation. 2019 04; 103(4):747-754. . View in PubMed
• Trial Design Challenges and Approaches for Precision Oncology in Rare Tumors: Experiences of the Children’s Oncology Group JCO Precis Oncol. 2019; 3. . View in PubMed
• Excellent long-term survival of children with Down syndrome and standard-risk ALL: a report from the Children’s Oncology Group Blood Adv. 2019 06 11; 3(11):1647-1656. . View in PubMed
• Adv Radiat Oncol. 2019 Jan-Mar; 4(1):96-102. . View in PubMed
• Impact of timing of administration of bone supportive therapy on pain palliation from radium-223 Cancer Treat Res Commun. 2019; 18:100114. . View in PubMed
• Pre-irradiation intensive induction and marrow-ablative consolidation chemotherapy in young children with newly diagnosed high-grade brainstem gliomas: report of the “head-start” I and II clinical trials J Neurooncol. 2018 Dec; 140(3):717-725. . View in PubMed
• Predictive Value of FDG PET/CT to Detect Lymph Node Metastases in Cervical Cancer Clin Nucl Med. 2018 Nov; 43(11):793-801. . View in PubMed
• Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study BMC Cancer. 2018 Oct 11; 18(1):970. . View in PubMed
• Active Surveillance for Prostate Cancer: Are We Failing Latino Patients at a Large Safety Net Hospital? Clin Genitourin Cancer. 2018 08; 16(4):e719-e727.. View in PubMed
• Obesity and risk for venous thromboembolism from contemporary therapy for pediatric acute lymphoblastic leukemia Thromb Res. 2018 05; 165:44-50. . View in PubMed
• Predictors of response, progression-free survival, and overall survival using NANT Response Criteria (v10) in relapsed and refractory high-risk neuroblastoma. Pediatr Blood Cancer. 2018 05; 65(5):e26940. . View in PubMed
• A multi-institutional registry of pediatric hospital-acquired thrombosis cases: The Children’s Hospital-Acquired Thrombosis (CHAT) project Thromb Res. 2018 01; 161:67-72. . View in PubMed
• Baseline Glomerular Filtration Rate and Cisplatin- Induced Renal Toxicity in Urothelial Cancer Patients Clin Genitourin Cancer. 2017 Sep 06. . View in PubMed
• Accuracy of Contrast-Enhanced Ultrasound Compared With Magnetic Resonance Imaging in Assessing the Tumor Response After Neoadjuvant Chemotherapy for Breast Cancer J Ultrasound Med. 2017 May; 36(5):901-911. . View in PubMed
• Attitudes and barriers to the use of donation after cardiac death livers: Comparison of a United States transplant center survey to the united network for organ sharing data Liver Transpl. 2017 11; 23(11):1372-1383. . View in PubMed
• No Acute Changes in LVEF Observed With Concurrent Trastuzumab and Breast Radiation With Low Heart Doses Clin Breast Cancer. 2017 11; 17(7):510-515. . View in PubMed
• Inequity in organ allocation for patients awaiting liver transplantation: Rationale for uncapping the model for end-stage liver disease J Hepatol. 2017 09; 67(3):517-525. . View in PubMed
• Endoplasmic reticulum stress in complex atypical hyperplasia as a possible predictor of occult carcinoma and progestin response Gynecol Oncol. 2016 Dec; 143(3):650-654. . View in PubMed
• Value of routine staging imaging studies for patients with stage III breast cancer J Surg Oncol. 2016 Dec; 114(8):917-921. . View in PubMed
• Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response Oncotarget. 2016 Nov 08; 7(45):73147-73159. . View in PubMed
• Outcome of young children with high-grade glioma treated with irradiation-avoiding intensive chemotherapy regimens: Final report of the Head Start II and III trials Pediatr Blood Cancer. 2016 10; 63(10):1806-13. . View in PubMed
• Comparative Toxicity by Sex Among Children Treated for Acute Lymphoblastic Leukemia: A Report From the Children’s Oncology Group Pediatr Blood Cancer. 2015 Dec; 62(12):2140-9. . View in PubMed
• Liver transplantation for metastatic neuroendocrine tumors: Outcomes and prognostic variables J Surg Oncol. 2015 Aug; 112(2):125-32. . View in PubMed
• A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan Cell Metab. 2015 Jul 07; 22(1):86-99. . View in PubMed
• Preservation of high glycolytic phenotype by establishing new acute lymphoblastic leukemia cell lines at physiologic oxygen concentration Exp Cell Res. 2015 May 15; 334(1):78-89. . View in PubMed
• Escalation of oncologic services at the end of life among patients with gynecologic cancer at an urban, public hospital J Oncol Pract. 2015 Mar; 11(2):e163-9. . View in PubMed
• Thyroid lesions visualized on CT: sonographic and pathologic correlation Acad Radiol. 2015 Feb; 22(2):203-9. . View in PubMed
• Stereotactic radiosurgery to the resection cavity for brain metastases: prognostic factors and outcomes J Radiosurg SBRT. 2015; 3(3):179-186. . View in PubMed
• Phosphorylated ribosomal S6 (p-rpS6) as a post-treatment indicator of HER2 signalling targeted drug resistance Biomarkers. 2015; 20(5):313-22. . View in PubMed
• Phase I clinical trial of temsirolimus and vinorelbine in advanced solid tumors Cancer Chemother Pharmacol. 2014 Dec; 74(6):1227-34. . View in PubMed
• Intraoperative hemodialysis during liver transplantation: a decade of experience Liver Transpl. 2014 Jul; 20(7):756-64. . View in PubMed
• p53 expression is a strong marker of inferior survival in de novo diffuse large B-cell lymphoma and may have enhanced negative effect with MYC coexpression: a single institutional clinicopathologic study Am J Clin Pathol. 2014 Apr; 141(4):593-604. . View in PubMed
• Infectious morbidity by catheter type in neutropenic children with cancer Pediatr Infect Dis J. 2014 Mar; 33(3):263-6. . View in PubMed
• PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas Clin Cancer Res. 2014 Feb 15; 20(4):827-36. . View in PubMed
• Intensive induction chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic progenitor cell rescue for young children newly-diagnosed with central nervous system atypical teratoid/rhabdoid tumors: the Head Start III experience Pediatr Blood Cancer. 2014 Jan; 61(1):95-101. . View in PubMed
• The combination of fludarabine, cytarabine and etoposide is an active and well-tolerated regimen in relapsed/refractory acute myeloid leukemia Acta Haematol. 2014; 131(4):202-7. . View in PubMed
• Comparative performance of PET tracers in biochemical recurrence of prostate cancer: a critical analysis of literature Am J Nucl Med Mol Imaging. 2014; 4(6):580-601. . View in PubMed
• Early cardiac outcomes following contemporary treatment for childhood acute myeloid leukemia: a North American perspective Pediatr Blood Cancer. 2013 Sep; 60(9):1528-33. . View in PubMed
• Baseline 18F-FDG PET/CT parameters as imaging biomarkers of overall survival in castrate-resistant metastatic prostate cancer J Nucl Med. 2013 Aug; 54(8):1195-201. . View in PubMed
• Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma Cancer Res. 2013 Jul 01; 73(13):3852-64. . View in PubMed
• Outcome of infants and young children with newly diagnosed ependymoma treated on the “Head Start” III prospective clinical trial J Neurooncol. 2013 Jun; 113(2):285-91. . View in PubMed
• Membrane-bound TRAIL supplements natural killer cell cytotoxicity against neuroblastoma cells J Immunother. 2013 Jun; 36(5):319-29. . View in PubMed
• A novel approach for detecting hypercoagulability utilizing thromboelastography Thromb Res. 2013 Apr; 131(4):352-6. . View in PubMed
• The genetic landscape of high-risk neuroblastoma Nat Genet. 2013 Mar; 45(3):279-84. . View in PubMed
• Characterization and drug resistance patterns of Ewing’s sarcoma family tumor cell lines PLoS One. 2013; 8(12):e80060. . View in PubMed
• Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma J Clin Oncol. 2012 Oct 01; 30(28):3525-32. . View in PubMed
• Prospective evaluation of 18F-NaF and 18F-FDG PET/CT in detection of occult metastatic disease in biochemical recurrence of prostate cancer Clin Nucl Med. 2012 Jul; 37(7):637-43. . View in PubMed
• Accuracy of predicting axillary lymph node positivity by physical examination, mammography, ultrasonography, and magnetic resonance imaging Ann Surg Oncol. 2012 Jun; 19(6):1825-30. . View in PubMed
• Hearing loss among survivors of childhood brain tumors treated with an irradiation-sparing approach Pediatr Blood Cancer. 2012 Jun; 58(6):953-8. . View in PubMed
• Novel pathways to erythropoiesis induced by dimerization of intracellular C-Mpl in human hematopoietic progenitors Stem Cells. 2012 Apr; 30(4):697-708. . View in PubMed
• Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation Pediatr Blood Cancer. 2011 Oct; 57(4):669-73. . View in PubMed
• Thyroid and hepatic function after high-dose 131 I-metaiodobenzylguanidine (131 I-MIBG) therapy for neuroblastoma Pediatr Blood Cancer. 2011 Feb; 56(2):191-201. . View in PubMed
• Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children’s Oncology Group Clin Cancer Res. 2011 Jan 01; 17(1):56-66. . View in PubMed
• Combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant neuroblastoma cell lines with mutant TP53 Mol Cancer Ther. 2010 Dec; 9(12):3289-301. . View in PubMed
• Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models Cancer Prev Res (Phila). 2010 Oct; 3(10):1259-64. . View in PubMed
• Outcome for children treated for relapsed or refractory acute myelogenous leukemia (rAML): a Therapeutic Advances in Childhood Leukemia (TACL) Consortium study Pediatr Blood Cancer. 2010 Sep; 55(3):421-9. . View in PubMed
• Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children’s Oncology Group J Clin Oncol. 2010 Apr 20; 28(12):1989-94. . View in PubMed
• Outcome of patients treated for relapsed or refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium study J Clin Oncol. 2010 Feb 01; 28(4):648-54. . View in PubMed
• The prognostic value of tumor markers in newly diagnosed patients with primary central nervous system germ cell tumors Pediatr Blood Cancer. 2008 Dec; 51(6):768-73. . View in PubMed
• Outcome of children less than three years old at diagnosis with non-metastatic medulloblastoma treated with chemotherapy on the “Head Start” I and II protocols Pediatr Blood Cancer. 2008 Jun; 50(6):1169-75. . View in PubMed
• Metastatic ependymoma: a multi-institutional retrospective analysis of prognostic factors Pediatr Blood Cancer. 2008 Feb; 50(2):231-5. . View in PubMed
• Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): report of the Head Start I and II experience Pediatr Blood Cancer. 2008 Feb; 50(2):312-8. . View in PubMed
• Sodium thiosulfate administered six hours after cisplatin does not compromise antineuroblastoma activity Clin Cancer Res. 2008 Jan 15; 14(2):533-40. . View in PubMed
• Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide J Natl Cancer Inst. 2007 Jul 18; 99(14):1107-19. . View in PubMed
• Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue Pediatr Blood Cancer. 2007 Jul; 49(1):34-40. . View in PubMed

• Wiemels, Joseph
• Lenz, Heinz-Josef
• Gaynon, Paul
• Matsuo, Koji
• Orgel, Etan
• Daneshmand, Siamak
• Alonzo, Todd
• Freyer, David
• Ulaner, Gary