Lon Schneider, MD

Lon S. Schneider, MD, MS, is professor of psychiatry, neurology, and gerontology at the Keck School of Medicine and Leonard Davis School of Gerontology of the University of Southern California; and holds the Della Martin Chair in Psychiatry and Neuroscience. He directs the USC California Alzheimer’s Disease Center (California Department of Health Services), the Geriatric Studies Center, and co-directs the clinical core of the USC NIA Alzheimer’s Disease Research Center. He holds a master’s degree in applied biometry and epidemiology. His work involves treatment development with novel metabolic and neuroregenerative compounds, outcomes assessment, and approaches to modelling, clinical trials methods and simulations, and, recently, in silico screening of medications for slowing Alzheimer’s disease. He is an associate editor or editorial board member of several publications, and serves on The Lancet Commission on dementia prevention, intervention, and care. He is a Fellow of the American College of Neuropsychopharmacology, and a Distinguished Life Fellow of the American Psychiatric Association.

• First Annual Dorothy Kirsten French Memorial Lecture: First Annual Dorothy Kirsten French Memorial Lecture
• Los Angeles/Brentwood VA Medical Center: Tsai Memorial Lecture
• Los Angeles Alzheimer’ Association: 11th and 21st Annual Research Awards
• American Association for Geriatric Psychiatry: Senior Investigator Award
• Clinical Research, Alzheimer’s Association: Senator Mark Hatfield Award
• University of Pittsburgh School of Public Health: Jay L. Foster Memorial Lecture
• Clinical Research, Alzheimer’s Association: Senator Mark Hatfield Award
• Los Angeles Magazine: Best Doctors in Los Angeles
• Good Housekeeping: The 327 Best Mental Health Experts
• Woodward/White, Inc.: The Best Doctors in America, 1992
   – 2009

• FDA approved IND 29644: Multicenter Phase 1 Trial to Evaluate Safety and Immunogenicity of Preventive Tau Vaccine, AV-1980R/A, in cognitively unimpaired preclinical AD participants.
  NIH · R01AG092949 · Aug 1, 2025 – Jul 31, 2030 · Role: Co-Principal Investigator
• Safety/Tolerability/Immunogenicity of first-in-human A? DNA vaccine, AV-1959D Phase 1 trials in early-stage AD subjects: based on IND18953 cleared by FDA.
  NIH · R01AG074983 · Feb 15, 2022 – Jan 31, 2027 · Role: Co-Principal Investigator
• Alzheimer's Disease Research Centers
  NIH · P30AG066530 · Sep 1, 2020 – Mar 31, 2030 · Role: Co-Principal Investigator
• Allopregnanolone as Regenerative Therapeutic for Alzheimer's: Phase 2 Clinical Trial
  NIH · R01AG063826 · Aug 15, 2019 – Apr 30, 2026 · Role: Co-Principal Investigator
• (-)-Phenserine inhibition of neuronal death in Alzheimer?s disease and developing brain-labeled plasma exosomes assays as biomarkers for a phenserine phase 1b ascending dose trial
  NIH · R01AG062687 · May 1, 2019 – Feb 28, 2025 · Role: Principal Investigator
• Novel Cognitive and Functional Measure for Alzheimer's Disease Prevention Trials
  NIH · R01AG051346 · Sep 1, 2018 – May 31, 2024 · Role: Co-Principal Investigator
• In Silico Screening of Medications for Slowing Alzheimer's Disease Progression.
  NIH · R01AG057684 · Sep 15, 2017 – Mar 31, 2022 · Role: Co-Principal Investigator
• Allopregnanolone Regenerative Therapeutic for MCI/AD: Dose Finding Phase I
  NIH · UF1AG046148 · Sep 20, 2013 – Aug 31, 2017 · Role: Co-Principal Investigator
• Synthesis of Longer-Term Alzheimer Disease Studies in Order to Model and Improve
  NIH · R01AG037561 · Apr 1, 2011 – Mar 31, 2016 · Role: Principal Investigator
• Estrogen Receptor-beta phytoSERMs for Management of Menopause and Memory Decline
  NIH · R01AG033288 · Jun 1, 2010 – Nov 30, 2015 · Role: Principal Investigator
• Depression in Alzheimer's Disease Study 2 (DIADS-2)
  NIH · U01MH066175 · Jun 10, 2003 – Feb 28, 2009 · Role: Principal Investigator
• CARBAMAZEPINE TRIAL IN AGITATED ALZHEIMERS OUTPATIENTS
  NIH · R01MH048759 · Sep 30, 1992 – Aug 31, 1997 · Role: Principal Investigator
• GERIATRIC PSYCHIATRIC FELLOWSHIP PROGRAM
  NIH · T01MH019213 · Sep 1, 1990 – Jun 30, 1993 · Role: Principal Investigator
• FACULTY SCHOLAR AWARD IN GERIATRIC MENTAL HEALTH
  NIH · T01MH019074 · Sep 30, 1988 – Feb 28, 1993 · Role: Principal Investigator
• NIMH CLINICAL TRAINING
  NIH · T01MH017392 · Jul 15, 1983 – Jun 30, 1990 · Role: Principal Investigator

• Antipsychotic Drugs for Dementia Have Adverse Effects (04/20/2009)
• NEJM letter retracted over authorship (04/12/2007)

• Aisen, Paul
• Thompson, Paul
• Ringman, John
• Toga, Arthur
• Rissman, Robert
• Zlokovic, Berislav