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Marcelo Pablo Coba, PhD

Associate Professor of Psychiatry & the Behavioral Sciences

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Phone +1 323 442 4345
Email coba@usc.edu
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Publications

  • Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders Cell Syst. 2025 Apr 16; 16(4):101204. . View in PubMed
  • Human cerebellar organoids with functional Purkinje cellsCell Stem Cell. 2024 01 04; 31(1):39-51. e6. . View in PubMed
  • Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders Front Mol Neurosci. 2024; 17:1359154. . View in PubMed
  • Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis Nat Neurosci. 2023 Dec; 26(12):2090-2103. . View in PubMed
  • Functional and phosphoproteomic analysis of ß-adrenergic receptor signaling at excitatory synapses in the CA1 region of the ventral hippocampus Sci Rep. 2023 05 09; 13(1):7493. . View in PubMed
  • Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity Biol Direct. 2023 05 09; 18(1):22. . View in PubMed
  • A “multi-omics” analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice J Exp Med. 2022 11 07; 219(11). . View in PubMed
  • Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection Elife. 2022 04 08; 11. . View in PubMed
  • Mapping genomic loci implicates genes and synaptic biology in schizophrenia Nature. 2022 04; 604(7906):502-508. . View in PubMed
  • Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer’s Disease Front Aging Neurosci. 2022; 14:894994. . View in PubMed
  • Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders Biol Psychiatry. 2019 02 15; 85(4):305-316. . View in PubMed
  • SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse Neuron. 2019; (103):1-18. . View in PubMed
  • Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons Nat Med. 2018 03; 24(3):313-325. . View in PubMed
  • Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability Sci Rep. 2018 02 02; 8(1):2281. . View in PubMed
  • Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders Nat Neurosci. 2017 Aug; 20(8):1150-1161. . View in PubMed
  • Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling Sci Rep. 2017 07 13; 7(1):5272. . View in PubMed
  • Receptor Tyrosine Kinase MET Interactome and Neurodevelopmental Disorder Partners at the Developing Synapse Biol Psychiatry. 2016 12 15; 80(12):933-942. . View in PubMed
  • Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome Sci Signal. 2016 08 09; 9(440):rs8. . View in PubMed
  • TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function J Neurosci. 2012 Oct 03; 32(40):13987-99. . View in PubMed
  • Neurotransmitters drive combinatorial multistate postsynaptic density networks Sci Signal. 2009 Apr 28; 2(68):ra19. . View in PubMed
  • Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus J Biol Chem. 2008 Dec 05; 283(49):34101-7. . View in PubMed
  • Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies J Neurosci. 2007 Mar 07; 27(10):2673-82. . View in PubMed
  • Proteomic analysis of in vivo phosphorylated synaptic proteins J Biol Chem. 2005 Feb 18; 280(7):5972-82. . View in PubMed

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