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Mark D. Krieger, MD

Professor of Clinical Neurological Surgery

Senior Vice President and Surgeon-in-Chief

Medical Director of Neurological Institute

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Phone +1 323 361 2104
Email mkrieger@chla.usc.edu
CTSI Profile

Publications

  • Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG. Oncogene. 2025 Oct; 44(39):3694-3712.. View in PubMed
  • Racial disparities in hydrocephalus mortality and shunt revision: a study from the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr. 2025 Jun 01; 35(6):554-562.. View in PubMed
  • Lack of classical astroblastoma features in pediatric MN1::BEND2-fused brain tumors. Brain Pathol. 2025 Mar; 35(2):e13297.. View in PubMed
  • Editorial. The risk of a pBIG miss with algorithmic care in pediatric traumatic brain injury. J Neurosurg Pediatr. 2025 Jan 03; 35(3):211-213.. View in PubMed
  • Does machine learning improve prediction accuracy of the Endoscopic Third Ventriculostomy Success Score? A contemporary Hydrocephalus Clinical Research Network cohort study. Childs Nerv Syst. 2024 Dec 10; 41(1):42.. View in PubMed
  • Comparing ventriculoatrial and ventriculopleural shunts in pediatric hydrocephalus: a Hydrocephalus Clinical Research Network study. J Neurosurg Pediatr. 2024 Oct 01; 34(4):305-314.. View in PubMed
  • The role of occipital condyle and atlas anomalies on occipital cervical fusion outcomes in Chiari malformation type I with syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium. J Neurosurg Pediatr. 2024 Jul 01; 34(1):66-74.. View in PubMed
  • Shunt timing in low-weight infants in the treatment of hydrocephalus. J Neurosurg Pediatr. 2024 06 01; 33(6):564-573.. View in PubMed
  • A re-evaluation of the Endoscopic Third Ventriculostomy Success Score: a Hydrocephalus Clinical Research Network study. J Neurosurg Pediatr. 2024 05 01; 33(5):417-427.. View in PubMed
  • Clinical, pathologic, and genomic characteristics of two pediatric glioneuronal tumors with a CLIP2::MET fusion. Acta Neuropathol Commun. 2024 04 22; 12(1):63.. View in PubMed
  • Quantitative noninvasive measurement of cerebrospinal fluid flow in shunted hydrocephalus. J Neurosurg. 2024 04 01; 140(4):1117-1128.. View in PubMed
  • Surgical management of pediatric spinal aneurysmal bone cysts: patient series. J Neurosurg Case Lessons. 2024 Jan 22; 7(4).. View in PubMed
  • Comparison of outcomes in the management of abdominal pseudocyst in children with shunted hydrocephalus: a Hydrocephalus Clinical Research Network study. J Neurosurg Pediatr. 2023 09 01; 32(3):312-323.. View in PubMed
  • Myelomeningocele repair at pediatric hospitals: association with routine discharge and shorter hospital stay. J Neurosurg Pediatr. 2023 09 01; 32(3):376-383.. View in PubMed
  • Pediatric patients with malignant brain tumor treated at children’s hospitals: association with fewer unplanned readmissions. J Neurosurg Pediatr. 2023 09 01; 32(3):324-331.. View in PubMed
  • Interhospital transfer of pediatric patients with malignant brain tumor not associated with increased mortality, but safe routine discharge. J Neurosurg Pediatr. 2023 02 01; 31(2):124-131.. View in PubMed
  • Low-pass whole-genome and targeted sequencing of cell-free DNA from cerebrospinal fluid in pediatric patients with central nervous system tumors. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad077.. View in PubMed
  • Endoscopic third ventriculostomy in previously shunt-treated patients. J Neurosurg Pediatr. 2022 Oct 01; 30(4):428-436.. View in PubMed
  • Hydrocephalus surveillance following CSF diversion: a modified Delphi study. J Neurosurg Pediatr. 2022 Aug 01; 30(2):177-187.. View in PubMed
  • Endoscopic third ventriculostomy revision after failure of initial endoscopic third ventriculostomy and choroid plexus cauterization. J Neurosurg Pediatr. 2022 Jul 01; 30(1):8-17.. View in PubMed
  • Complications and outcomes of posterior fossa decompression with duraplasty versus without duraplasty for pediatric patients with Chiari malformation type I and syringomyelia: a study from the Park-Reeves Syringomyelia Research Consortium. J Neurosurg Pediatr. 2022 Jul 01; 30(1):39-51.. View in PubMed
  • The Hydrocephalus Clinical Research Network quality improvement initiative: the role of antibiotic-impregnated catheters and vancomycin wound irrigation. J Neurosurg Pediatr. 2022 Jun 01; 29(6):711-718.. View in PubMed
  • Anterior versus posterior entry site for ventriculoperitoneal shunt insertion: a randomized controlled trial by the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr. 2022 Mar 01; 29(3):257-267.. View in PubMed
  • Readmissions after ventricular shunting in pediatric patients with hydrocephalus: a Nationwide Readmissions Database analysis. J Neurosurg Pediatr. 2021 11 01; 28(5):553-562.. View in PubMed
  • Glyco-engineered HEK 293-F cell lines for the production of therapeutic glycoproteins with human N-glycosylation and improved pharmacokinetics. Glycobiology. 2021 08 07; 31(7):859-872.. View in PubMed
  • Extradural decompression versus duraplasty in Chiari malformation type I with syrinx: outcomes on scoliosis from the Park-Reeves Syringomyelia Research Consortium. J Neurosurg Pediatr. 2021 08 01; 28(2):167-175.. View in PubMed
  • Treatment strategies for hydrocephalus related to Dandy-Walker syndrome: evaluating procedure selection and success within the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr. 2021 07 01; 28(1):93-101.. View in PubMed
  • Postoperative facial palsy after pediatric posterior fossa tumor resection. J Neurosurg Pediatr. 2021 05 01; 27(5):566-571.. View in PubMed
  • Dural augmentation approaches and complication rates after posterior fossa decompression for Chiari I malformation and syringomyelia: a Park-Reeves Syringomyelia Research Consortium study. J Neurosurg Pediatr. 2021 04 01; 27(4):459-468.. View in PubMed
  • Predictors of fast and ultrafast shunt failure in pediatric hydrocephalus: a Hydrocephalus Clinical Research Network study. J Neurosurg Pediatr. 2021 03 01; 27(3):277-286.. View in PubMed
  • Occipital-Cervical Fusion and Ventral Decompression in the Surgical Management of Chiari-1 Malformation and Syringomyelia: Analysis of Data From the Park-Reeves Syringomyelia Research Consortium. Neurosurgery. 2021 01 13; 88(2):332-341.. View in PubMed
  • Surgical resource utilization after initial treatment of infant hydrocephalus: comparing ETV, early experience of ETV with choroid plexus cauterization, and shunt insertion in the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr. 2020 10 01; 26(4):337-345.. View in PubMed
  • Resolution of neonatal posthemorrhagic ventricular dilation coincident with patent ductus arteriosus ligation: case report. J Neurosurg Pediatr. 2020 09 01; 26(3):255-261.. View in PubMed
  • Editorial. Early lessons in the management of COVID-19 for the pediatric neurosurgical community from the leadership of the American Society of Pediatric Neurosurgeons. J Neurosurg Pediatr. 2020 07 01; 26(1):1-2.. View in PubMed
  • Pediatric neurosurgery training during residency in the United States: a program director survey. J Neurosurg Pediatr. 2020 07 01; 26(1):6-12.. View in PubMed
  • Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets. Acta Neuropathol Commun. 2020 05 13; 8(1):68.. View in PubMed
  • Radiological and clinical predictors of scoliosis in patients with Chiari malformation type I and spinal cord syrinx from the Park-Reeves Syringomyelia Research Consortium. J Neurosurg Pediatr. 2019 11 01; 24(5):520-527.. View in PubMed
  • Bilateral Congenital Posterior Hemivertebrae and Lumbar Spinal Stenosis Treated With Posterior Spinal Fusion and Instrumentation. J Am Acad Orthop Surg Glob Res Rev. 2019 Oct; 3(10).. View in PubMed
  • Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution. JCO Precis Oncol. 2019; 3.. View in PubMed
  • Imaging Features Predictive of Recurrence in Pediatric Intracranial Germ-Cell Tumors. Pediatr Neurosurg. 2019; 54(3):173-180.. View in PubMed
  • Dynamic MRI in the Evaluation of Atlantoaxial Stability in Pediatric Down Syndrome Patients. Pediatr Neurosurg. 2019; 54(1):12-20.. View in PubMed
  • Risk Factors for Preoperative Developmental Delay in Patients with Nonsyndromic Sagittal Craniosynostosis. Plast Reconstr Surg. 2019 01; 143(1):133e-139e.. View in PubMed
  • Novel Surgical and Radiologic Risk Factors for Progression or Recurrence of Pediatric Pilocytic Astrocytoma. Pediatr Neurosurg. 2019; 54(6):375-385.. View in PubMed
  • Development of best practices to minimize wound complications after complex tethered spinal cord surgery: a modified Delphi study. J Neurosurg Pediatr. 2018 12 01; 22(6):701-709.. View in PubMed
  • Assessing the Benefit-Risk Profile for Pediatric Implantable Auditory Prostheses. Ther Innov Regul Sci. 2018 09; 52(5):669-679.. View in PubMed
  • Seizure outcomes of supratentorial brain tumor resection in pediatric patients. Neuro Oncol. 2018 08 02; 20(9):1272-1281.. View in PubMed
  • The effect of NACHRI children’s hospital designation on outcome in pediatric malignant brain tumors. J Neurosurg Pediatr. 2017 Aug; 20(2):149-157.. View in PubMed
  • Treatment patterns of children with spine and spinal cord tumors: national outcomes and review of the literature. Childs Nerv Syst. 2017 Aug; 33(8):1357-1365.. View in PubMed
  • Return of motor evoked potentials after knee flexion in the setting of high-grade spondylolisthesis. Eur Spine J. 2017 03; 26(3):619-622.. View in PubMed
  • Initial Results of a Safety and Feasibility Study of Auditory Brainstem Implantation in Congenitally Deaf Children. Otol Neurotol. 2017 02; 38(2):212-220.. View in PubMed
  • Parylene MEMS patency sensor for assessment of hydrocephalus shunt obstruction. Biomed Microdevices. 2016 10; 18(5):87.. View in PubMed
  • Infection rate correlated with time to repair of open neural tube defects (myelomeningoceles): an institutional and national study. Childs Nerv Syst. 2016 Sep; 32(9):1675-81.. View in PubMed
  • Re-irradiation of Recurrent Pineal Germ Cell Tumors with Radiosurgery: Report of Two Cases and Review of Literature. Cureus. 2016 Apr 25; 8(4):e585.. View in PubMed
  • Cross-Sectional Analysis on Racial and Economic Disparities Affecting Mortality in Preterm Infants with Posthemorrhagic Hydrocephalus. World Neurosurg. 2016 Apr; 88:399-410.. View in PubMed
  • Surgical management of hydrocephalus secondary to intraventricular hemorrhage in the preterm infant. J Neurosurg Pediatr. 2016 Mar; 17(3):278-84.. View in PubMed
  • Trends in hospitalization of preterm infants with intraventricular hemorrhage and hydrocephalus in the United States, 2000-2010. J Neurosurg Pediatr. 2016 Mar; 17(3):260-9.. View in PubMed
  • Reevaluating the weekend effect on patients with hydrocephalus undergoing operative shunt intervention. J Neurosurg Pediatr. 2016 Feb; 17(2):156-162.. View in PubMed
  • Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy. Neuro Oncol. 2016 Jan; 18(1):126-31.. View in PubMed
  • Regulatory and funding strategies to develop a safety study of an auditory brainstem implant in young children who are deaf. Ther Innov Regul Sci. 2015 Sep; 49(5):659-665.. View in PubMed
  • Differentiating infantile tumors with diffusion imaging. J Neurosurg Pediatr. 2015 Aug; 16(2):117-8.. View in PubMed
  • Racial and socioeconomic disparities in outcomes following pediatric cerebrospinal fluid shunt procedures. J Neurosurg Pediatr. 2015 Jun; 15(6):560-6.. View in PubMed
  • Intracranial hypertension after surgical correction for craniosynostosis: a systematic review. Neurosurg Focus. 2015 May; 38(5):E6.. View in PubMed
  • Introduction: craniosynostosis: modern treatment strategies. Neurosurg Focus. 2015 May; 38(5):E1.. View in PubMed
  • Risk factors for hydrocephalus and neurological deficit in children born with an encephalocele. J Neurosurg Pediatr. 2015 Apr; 15(4):392-8.. View in PubMed
  • Tumor-associated macrophages in SHH subgroup of medulloblastomas. Clin Cancer Res. 2015 Mar 15; 21(6):1457-65.. View in PubMed
  • Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia. Front Oncol. 2015; 5:191.. View in PubMed
  • The association between dental health and procedures and developing shunt infections in pediatric patients. J Neurosurg Pediatr. 2014 Nov; 14(5):508-13.. View in PubMed
  • What is the risk of infecting a cerebrospinal fluid-diverting shunt with percutaneous tapping? J Neurosurg Pediatr. 2014 Oct; 14(4):336-9.. View in PubMed
  • Deep brain stimulation evoked potentials may relate to clinical benefit in childhood dystonia. Brain Stimul. 2014 Sep-Oct; 7(5):718-26.. View in PubMed
  • PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas. Clin Cancer Res. 2014 Feb 15; 20(4):827-36.. View in PubMed
  • Deep brain stimulation in children and young adults with secondary dystonia: the Children’s Hospital Los Angeles experience. Neurosurg Focus. 2013 Nov; 35(5):E7.. View in PubMed
  • Positional plagiocephaly: an analysis of the literature on the effectiveness of current guidelines. Neurosurg Focus. 2013 Oct; 35(4):E1.. View in PubMed
  • Management of plagiocephaly. Neurosurg Focus. 2013 Oct; 35(4):Introduction.. View in PubMed
  • Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children’s Hospital Los Angeles (CHLA) experience, 1991-2010. Pediatr Blood Cancer. 2012 Jun; 58(6):905-9.. View in PubMed
  • Spinal arachnoid cysts in the pediatric population: report of 31 cases and a review of the literature. J Neurosurg Pediatr. 2012 Apr; 9(4):432-41.. View in PubMed
  • Microdeletion del(22)(q12.2) encompassing the facial development-associated gene, MN1 (meningioma 1) in a child with Pierre-Robin sequence (including cleft palate) and neurofibromatosis 2 (NF2): a case report and review of the literature. BMC Med Genet. 2012 Mar 22; 13:19.. View in PubMed
  • Supratentorial ependymoma in children: to observe or to treat following gross total resection? Pediatr Blood Cancer. 2012 Mar; 58(3):380-3.. View in PubMed
  • Symptoms before and after posterior fossa surgery in pediatric patients. Pediatr Neurosurg. 2012; 48(1):21-5.. View in PubMed
  • Elevated citrate in pediatric astrocytomas with malignant progression. Neuro Oncol. 2011 Oct; 13(10):1107-17.. View in PubMed
  • Posterior interhemispheric retrocallosal approach to pineal region and posterior fossa lesions in a pediatric population. J Neurosurg Pediatr. 2011 May; 7(5):527-33.. View in PubMed
  • Incidence of venous infarction after sacrificing middle-third superior sagittal sinus cortical bridging veins in a pediatric population. J Neurosurg Pediatr. 2011 Mar; 7(3):224-8.. View in PubMed
  • Scoliosis and Chiari malformation Type I in children. J Neurosurg Pediatr. 2011 Jan; 7(1):25-9.. View in PubMed
  • Normally shaped heads with no sutures, normally shaped heads with abnormal sutures, and abnormally shaped heads with normal sutures. J Craniofac Surg. 2011 Jan; 22(1):173-7.. View in PubMed
  • Surgical management of primary central nervous system germ cell tumors: proceedings from the Second International Symposium on Central Nervous System Germ Cell Tumors. J Neurosurg Pediatr. 2010 Aug; 6(2):125-30.. View in PubMed
  • Evaluation of intracranial cerebrospinal fluid cytology in staging pediatric medulloblastomas, supratentorial primitive neuroectodermal tumors, and ependymomas. J Neurosurg Pediatr. 2010 Aug; 6(2):131-6.. View in PubMed
  • The role of stereotactic radiotherapy in the management of ependymomas. Childs Nerv Syst. 2009 Oct; 25(10):1269-73.. View in PubMed
  • Metabolism of orthotopic mouse brain tumor models. Mol Imaging. 2009 Jul-Aug; 8(4):199-208.. View in PubMed
  • Surgical treatment of rathke cleft cysts in children. Neurosurgery. 2009 Jun; 64(6):1132-7; author reply 1037-8.. View in PubMed
  • Use of cranial fixation pins in pediatric neurosurgery. Neurosurgery. 2008 Apr; 62(4):913-8; discussion 918-9.. View in PubMed
  • Craniospinal Langerhans cell histiocytosis in children: 30 years’ experience at a single institution. J Neurosurg Pediatr. 2008 Mar; 1(3):187-95.. View in PubMed
  • Metabolism of diffuse intrinsic brainstem gliomas in children. Neuro Oncol. 2008 Feb; 10(1):32-44.. View in PubMed
  • Pediatric shunt malfunction without ventricular dilatation. Pediatr Neurosurg. 2008; 44(2):128-32.. View in PubMed
  • Pathogenesis and treatment of intracranial arachnoid cysts in pediatric patients younger than 2 years of age. Neurosurg Focus. 2007; 22(2):E1.. View in PubMed
  • Quantitative short echo time 1H-MR spectroscopy of untreated pediatric brain tumors: preoperative diagnosis and characterization. AJNR Am J Neuroradiol. 2006 Mar; 27(3):560-72.. View in PubMed
  • Craniopharyngioma in childhood. Adv Pediatr. 2006; 53:183-209.. View in PubMed
  • Chemical analysis of fluid obtained from intracranial arachnoid cysts in pediatric patients. J Neurosurg. 2005 Nov; 103(5 Suppl):427-32.. View in PubMed
  • Untreated pediatric primitive neuroectodermal tumor in vivo: quantitation of taurine with MR spectroscopy. Radiology. 2005 Sep; 236(3):1020-5.. View in PubMed
  • Craniopharyngiomas of childhood: the CHLA experience. Childs Nerv Syst. 2005 Aug; 21(8-9):785-9.. View in PubMed
  • Craniotomy for fenestration of multiloculated hydrocephalus in pediatric patients. Neurosurgery. 2005 Jul; 57(1 Suppl):100-6; discussion 100-6.. View in PubMed
  • Effects of surgical resection and adjuvant therapy on pediatric intracranial ependymomas. Expert Rev Neurother. 2005 Jul; 5(4):465-71.. View in PubMed
  • Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy. Neurosurg Focus. 2005 Jun 15; 18(6A):E4.. View in PubMed
  • Atypical teratoid/rhabdoid tumors of the central nervous system: management and outcomes. Neurosurg Focus. 2005 Jun 15; 18(6A):E8.. View in PubMed
  • Proton-decoupled 31P MRS in untreated pediatric brain tumors. Magn Reson Med. 2005 Jan; 53(1):22-9.. View in PubMed
  • Atypical teratoid/rhabdoid tumor: an unusual presentation. Neuroradiology. 2004 Oct; 46(10):834-7.. View in PubMed
  • Iatrogenic intraspinal epidermoid tumor: two cases and a review of the literature. Spine (Phila Pa 1976). 2004 Jan 01; 29(1):E15-8.. View in PubMed
  • Magnetic resonance spectroscopy of atypical diffuse pontine masses. Neurosurg Focus. 2003 Jul 15; 15(1):E5.. View in PubMed
  • Assessment of long-term remission of acromegaly following surgery. J Neurosurg. 2003 Apr; 98(4):719-24.. View in PubMed
  • Invasive pituitary adenomas: significance of proliferation parameters. Pituitary. 1999 Aug; 2(2):117-22.. View in PubMed
  • Toward a simpler surgical management of Chiari I malformation in a pediatric population. Pediatr Neurosurg. 1999 Mar; 30(3):113-21.. View in PubMed
  • Role of stereotactic biopsy in the diagnosis and management of brain tumors. Semin Surg Oncol. 1998 Jan-Feb; 14(1):13-25.. View in PubMed
  • Recurrence patterns and anaplastic change in a long-term study of pilocytic astrocytomas. Pediatr Neurosurg. 1997 Jul; 27(1):1-11.. View in PubMed
  • Spinal extradural leiomyoma in a pediatric patient with acquired immunodeficiency syndrome: case report. Neurosurgery. 1997 May; 40(5):1080-2.. View in PubMed
  • Septic cavernous sinus thrombosis following transsphenoidal craniotomy. Case report. J Neurosurg. 1996 Nov; 85(5):949-52.. View in PubMed
  • Gunshot wounds to the head in an urban setting. Neurosurg Clin N Am. 1995 Oct; 6(4):605-10.. View in PubMed

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