Mark Lee Barr, MD

Associate Professor of Surgery

Chair for the Department's Appointments, Promotion and Tenure Committee

Director of Cardiac Surgery Clearkship

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Overview

Dr. Mark L. Barr obtained his medical degree from Mount Sinai School of Medicine in New York and completed 10 years of postgraduate residency at New York University and Columbia University, including a 2-year NIH-sponsored research fellowship in transplan-tation immunology. He is currently Co-Director of the USC Transplantation Institute in the Department of Surgery, Chair of the Department of Surgery Appointments, Promo-tions, and Tenure Committee, and Director of the Cardiothoracic Surgery Medical Stu-dent 4 Clerkship. He has served as Chair of the UNOS Thoracic Transplantation Commit-tee, as President of the International Society for Heart and Lung Transplantation (ISHLT), as Chair of the Thoracic Committee of the American Society of Transplant Surgeons (ASTS), and on the Board of Directors of the ISHLT, the ASTS, and the American Society of Transplantation. Dr. Barr was the Chair of the Advisory Committee on Transplantation (ACOT) under the auspices of the Secretary of the Department of Health and Human Ser-vices during the 8 years of the Obama administration. He is an author / co-author on more than 150 peer-reviewed publications and book chapters in the fields of cardiotho-racic surgery and heart and lung transplantation, has served on multiple scientific review boards for NIAID, NHLBI, and NCRR of the National Institutes of Health, and was a Deputy Editor of the American Journal of Transplantation for 15 years. He will serve on the Board of Directors of the OPTN / UNOS beginning in 2022.

Publications

  • Commentary: Lungs across borders: American lungs in Canadian patients J Thorac Cardiovasc Surg. 2022 12; 164(6):1669-1670. . View in PubMed
  • Pediatric Living Lung Donor Transplant Candidates: Psychiatric Status of Utilized and Non-Utilized Donors J Clin Psychol Med Settings. 2022 03; 29(1):62-70. . View in PubMed
  • Early onset of deep sternal wound infection after cardiac surgery is associated with decreased survival: A propensity weighted analysis J Card Surg. 2021 Dec; 36(12):4509-4518. . View in PubMed
  • Equivalent outcomes with minimally invasive and sternotomy mitral valve repair for degenerative mitral valve disease J Card Surg. 2021 Aug; 36(8):2636-2643. . View in PubMed
  • Use of a Bluetooth tablet-based technology to improve outcomes in lung transplantation: A pilot study Am J Transplant. 2020 12; 20(12):3649-3657. . View in PubMed
  • Selective Aortic Arch and Root Replacement in Repair of Acute Type A Aortic Dissection Ann Thorac Surg. 2018 Feb; 105(2):505-512. . View in PubMed
  • Invited Commentary Ann Thorac Surg. 2018 04; 105(4):1157-1159. . View in PubMed
  • The Utility of Nurse-Managed Extracorporeal Life Support in an Adult Cardiac Intensive Care Unit Ann Thorac Surg. 2017 Aug; 104(2):510-514. . View in PubMed
  • Outcomes after mitral valve repair: A single-center 16-year experienceJ Thorac Cardiovasc Surg. 2017 09; 154(3):822-830. e2. . View in PubMed
  • Assessment of segmental myocardial blood flow and myocardial perfusion reserve by adenosine-stress myocardial arterial spin labeling perfusion imaging J Magn Reson Imaging. 2017 08; 46(2):413-420. . View in PubMed
  • Double-gated myocardial ASL perfusion imaging is robust to heart rate variation Magn Reson Med. 2017 05; 77(5):1975-1980. . View in PubMed
  • A comparison of aortic valve replacement via an anterior right minithoracotomy with standard sternotomy: a propensity score analysis of 492 patients Eur J Cardiothorac Surg. 2016 Feb; 49(2):456-63. . View in PubMed
  • Changes in donor heart allocation in the United States without fundamental changes in the system: rearranging deck chairs and elephants in the room Am J Transplant. 2015 Jan; 15(1):7-9. . View in PubMed
  • Outcomes after pregnancy in living lobar lung transplantation Transplantation. 2014 Oct 15; 98(7):692-4. . View in PubMed
  • Morbidity and mortality of live lung donation: results from the RELIVE study Am J Transplant. 2014 Aug; 14(8):1846-52. . View in PubMed
  • Pediatric lung allocation: the rest of the story Am J Transplant. 2014 Jan; 14(1):11-2. . View in PubMed
  • Call it BOS, call it CLAD–the need for prospective clinical trials and elucidating the mechanism of extracorporeal photopheresis Am J Transplant. 2013 Apr; 13(4):833-834. . View in PubMed
  • Identifying the barriers and facilitators to participation in physical activity for children with Down syndrome J Intellect Disabil Res. 2011 Nov; 55(11):1020-33. . View in PubMed
  • Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling Antioxid Redox Signal. 2011 Sep 01; 15(5):1379-88. . View in PubMed
  • Electrochemical impedance spectroscopy to assess vascular oxidative stress Ann Biomed Eng. 2011 Jan; 39(1):287-96. . View in PubMed
  • Alveolar inflammation in cystic fibrosis J Cyst Fibros. 2010 May; 9(3):217-27. . View in PubMed
  • Lung transplantation in the United States, 1999-2008 Am J Transplant. 2010 Apr; 10(4 Pt 2):1047-68. . View in PubMed
  • Lung transplantation for cystic fibrosis Proc Am Thorac Soc. 2009 Dec; 6(8):619-33. . View in PubMed
  • Extracorporeal photopheresis: past, present, and future J Am Acad Dermatol. 2009 Oct; 61(4):652-65. . View in PubMed
  • CT-guided tube pericardiostomy: a safe and effective technique in the management of postsurgical pericardial effusion AJR Am J Roentgenol. 2009 Oct; 193(4):W314-20. . View in PubMed
  • Genetic modulation of CD44 expression by intragraft fibroblasts J Biochem. 2008 Nov; 144(5):571-80. . View in PubMed
  • Outcomes after lung retransplantation in the modern era Am J Respir Crit Care Med. 2008 Jan 01; 177(1):114-20. . View in PubMed
  • Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration Free Radic Biol Med. 2007 Feb 15; 42(4):519-29. . View in PubMed
  • Rat chemokine CXCL11: structure, tissue distribution, function and expression in cardiac transplantation models Mol Cell Biochem. 2007 Feb; 296(1-2):1-9. . View in PubMed
  • Repeat organ transplantation in the United States, 1996-2005 Am J Transplant. 2007; 7(5 Pt 2):1424-33. . View in PubMed
  • Pediatric transplantation in the United States, 1996-2005 Am J Transplant. 2007; 7(5 Pt 2):1339-58. . View in PubMed
  • Multicenter retrospective analysis of cardiovascular risk factors affecting long-term outcome of de novo cardiac transplant recipients J Heart Lung Transplant. 2006 Sep; 25(9):1063-9. . View in PubMed
  • A report of the Vancouver Forum on the care of the live organ donor: lung, liver, pancreas, and intestine data and medical guidelines Transplantation. 2006 May 27; 81(10):1373-85. . View in PubMed
  • The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix Stem Cells. 2006 Apr; 24(4):928-35. . View in PubMed
  • Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient Int Immunol. 2006 Feb; 18(2):279-89. . View in PubMed
  • Report of a National Conference on Donation after cardiac death Am J Transplant. 2006 Feb; 6(2):281-91. . View in PubMed
  • Pleural space problems after living lobar transplantation J Heart Lung Transplant. 2005 Dec; 24(12):2086-90. . View in PubMed
  • Contribution of mesenchymal progenitor cells to tissue repair in rat cardiac allografts undergoing chronic rejection J Heart Lung Transplant. 2005 Dec; 24(12):2160-9. . View in PubMed
  • Transforming growth factor-beta/interleukin-2-induced regulatory CD4+ T cells prolong cardiac allograft survival in rats J Heart Lung Transplant. 2005 Dec; 24(12):2153-9. . View in PubMed
  • The ethics of living donor lung transplantation Thorac Surg Clin. 2005 Nov; 15(4):519-25. . View in PubMed
  • Living donor lobar lung transplantation: current status and future directions Transplant Proc. 2005 Nov; 37(9):3983-6. . View in PubMed
  • Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part IV: recipient-related risk factors and markers J Heart Lung Transplant. 2005 Oct; 24(10):1468-82. . View in PubMed
  • Thoracic organ transplantation in the United States, 1994-2003 Am J Transplant. 2005 Apr; 5(4 Pt 2):934-49. . View in PubMed
  • Long-term pulmonary function after living-donor lobar lung transplantation in adults Ann Thorac Surg. 2005 Feb; 79(2):418-25. . View in PubMed
  • Living lobar lung transplantation Respir Care Clin N Am. 2004 Dec; 10(4):563-79. . View in PubMed
  • A decade of living lobar lung transplantation: perioperative complications after 253 donor lobectomies Am J Transplant. 2004 Aug; 4(8):1283-8. . View in PubMed
  • Surrogate markers and risk factors for chronic lung allograft dysfunction Am J Transplant. 2004 Jul; 4(7):1171-8. . View in PubMed
  • Neochordal repair of the posterior mitral leaflet J Thorac Cardiovasc Surg. 2004 Feb; 127(2):440-7. . View in PubMed
  • Potential role for antiangiogenic proteins in the myocardial infarction repair process J Surg Res. 2004 Jan; 116(1):156-64. . View in PubMed
  • Thoracic organ transplantation Am J Transplant. 2004; 4 Suppl 9:93-105. . View in PubMed
  • A decade of living lobar lung transplantation: recipient outcomes J Thorac Cardiovasc Surg. 2004 Jan; 127(1):114-22. . View in PubMed
  • Determinants of quality of life changes among long-term cardiac transplant survivors: results from longitudinal data J Heart Lung Transplant. 2003 Oct; 22(10):1157-67. . View in PubMed
  • Evidence for recipient derived fibroblast recruitment and activation during the development of chronic cardiac allograft rejection Transplantation. 2003 Aug 15; 76(3):609-14. . View in PubMed
  • Living lobar transplantation Chest Surg Clin N Am. 2003 Aug; 13(3):505-24. . View in PubMed
  • Depopulated vena caval homograft: a new venous conduit J Thorac Cardiovasc Surg. 2003 Aug; 126(2):498-503. . View in PubMed
  • Photopheresis for the prevention and treatment of transplant rejection J Cutan Med Surg. 2003 Jul-Aug; 7(4 Suppl):18-9. . View in PubMed
  • The PORTEL registry: overview and selected findings Prog Transplant. 2003 Jun; Suppl:3-13; quiz 16-7. . View in PubMed
  • Migration of mesenchymal stem cells to heart allografts during chronic rejection Transplantation. 2003 Mar 15; 75(5):679-85. . View in PubMed
  • Thoracic transplantation Am J Transplant. 2003; 3 Suppl 4:91-102. . View in PubMed
  • Does lung growth occur when mature lobes are transplanted into children? Pediatr Transplant. 2002 Dec; 6(6):500-4.. View in PubMed
  • Hyperinflation resulting in hemodynamic collapse following living donor lobar transplantation Anesthesiology. 2002 Nov; 97(5):1315-7. . View in PubMed
  • Vascular endothelial cell apoptosis induced by anti-donor non-MHC antibodies: a possible injury pathway contributing to chronic allograft rejection J Heart Lung Transplant. 2002 Nov; 21(11):1174-87. . View in PubMed
  • Life satisfaction and adverse effects in renal transplant recipients: a longitudinal analysis Clin Transplant. 2002 Apr; 16(2):113-21. . View in PubMed
  • Dyspnea lusoria: compression of the pulmonary artery by a Kommerell’s diverticulum Ann Thorac Surg. 2002 Jan; 73(1):312-3. . View in PubMed
  • The effect of pleural adhesions on pediatric cystic fibrosis patients undergoing lung transplantation Am Surg. 2001 Dec; 67(12):1136-9. . View in PubMed
  • Living donor lung transplantation: selection, technique, and outcome Transplant Proc. 2001 Nov-Dec; 33(7-8):3527-32. . View in PubMed
  • Current status of heart and lung transplantation Transplant Proc. 2001 Nov-Dec; 33(7-8):3564-5. . View in PubMed
  • Regional topical hypothermia of the beating heart: preservation of function and tissue Ann Thorac Surg. 2001 Sep; 72(3):804-9. . View in PubMed
  • Suggested guidelines for the use of tacrolimus in cardiac transplant recipients J Heart Lung Transplant. 2001 Jul; 20(7):734-8. . View in PubMed
  • A novel paracorporeal method for isolated rodent lung reperfusion Transplantation. 2001 May 15; 71(9):1244-8. . View in PubMed
  • Bronchiolitis obliterans is not the primary cause of death in pediatric living donor lobar lung transplant recipients J Heart Lung Transplant. 2001 May; 20(5):491-6. . View in PubMed
  • Building a clinical cardiothoracic surgical program: a multi-institutional model J Thorac Cardiovasc Surg. 2001 Apr; 121(4 Suppl):S8-11. . View in PubMed
  • Mechanical cardiac support 2000: current applications and future trial designJune 15-16, 2000 Bethesda, Maryland. J Am Coll Cardiol. 2001 Jan; 37(1):340-70. . View in PubMed
  • Consensus statement on the live organ donor JAMA. 2000 Dec 13; 284(22):2919-26. . View in PubMed
  • Modulation of pulmonary NA+ pump gene expression during cold storage and reperfusion Transplantation. 2000 Oct 15; 70(7):1016-20. . View in PubMed
  • Platelet activating factor acetylhydrolase decreases lung reperfusion injury Ann Thorac Surg. 2000 Aug; 70(2):423-8. . View in PubMed
  • Prophylactic photopheresis and chronic rejection: effects on graft intimal hyperplasia in cardiac transplantation Clin Transplant. 2000 Apr; 14(2):162-6. . View in PubMed
  • Comparison of outcomes between living donor and cadaveric lung transplantation in children Ann Thorac Surg. 1999 Dec; 68(6):2279-83; discussion 2283-4. . View in PubMed
  • Addition of a water-soluble alpha-tocopherol analogue to University of Wisconsin solution improves endothelial viability and decreases lung reperfusion injury J Surg Res. 1999 Sep; 86(1):145-9. . View in PubMed
  • A randomized, multicenter comparison of tacrolimus and cyclosporine immunosuppressive regimens in cardiac transplantation: decreased hyperlipidemia and hypertension with tacrolimus J Heart Lung Transplant. 1999 Apr; 18(4):336-45. . View in PubMed
  • Sirolimus (rapamycin) potentiates cyclosporine in prevention of acute lung rejection J Thorac Cardiovasc Surg. 1999 Apr; 117(4):714-8. . View in PubMed
  • A comparison of the new preservation solution Celsior to Euro-Collins and University of Wisconsin solutions in lung reperfusion injury Transplantation. 1999 Jan 15; 67(1):152-5. . View in PubMed
  • Photopheresis for the prevention of rejection in cardiac transplantationPhotopheresis Transplantation Study Group. N Engl J Med. 1998 Dec 10; 339(24):1744-51. . View in PubMed
  • Photopheresis in transplantation: future research and directions Transplant Proc. 1998 Aug; 30(5):2248-50. . View in PubMed
  • Recipient and donor outcomes in living related and unrelated lobar transplantation Transplant Proc. 1998 Aug; 30(5):2261-3. . View in PubMed
  • Living donor lobar lung transplantation: the pediatric experience Pediatr Transplant. 1998 Aug; 2(3):185-90. . View in PubMed
  • Addition of aprotinin to organ preservation solutions decreases lung reperfusion injury Ann Thorac Surg. 1998 Jul; 66(1):225-30. . View in PubMed
  • Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury J Thorac Cardiovasc Surg. 1998 Mar; 115(3):631-6; discussion 636-7. . View in PubMed
  • Experience with living-donor lobar transplantation for indications other than cystic fibrosis J Thorac Cardiovasc Surg. 1997 Dec; 114(6):917-21; discussion 921-2. . View in PubMed
  • Living donor lobar lung transplants and HLA matching: a preliminary report Transplant Proc. 1997 Feb-Mar; 29(1-2):1418-9. . View in PubMed
  • A new organ preservation solution, Celsior, is superior to Euro-Collins and University of Wisconsin solutions in decreasing lung reperfusion injury Transplant Proc. 1997 Feb-Mar; 29(1-2):1357-8. . View in PubMed
  • Living-donor lobar lung transplantation experience: intermediate results J Thorac Cardiovasc Surg. 1996 Nov; 112(5):1284-90; discussion 1290-1. . View in PubMed
  • Bilateral lobar transplantation utilizing living related donors Artif Organs. 1996 Oct; 20(10):1110-1. . View in PubMed
  • Immunomodulation in transplantation with photopheresis Artif Organs. 1996 Aug; 20(8):971-3. . View in PubMed
  • Safe application of diagnostic laparoscopy during biventricular assistance Ann Thorac Surg. 1996 Feb; 61(2):735-7. . View in PubMed
  • Living-related lobar transplantation: recipient outcome and early rejection patterns Transplant Proc. 1995 Jun; 27(3):1995-6. . View in PubMed
  • Prophylactic photopheresis and effect on graft atherosclerosis in cardiac transplantation Transplant Proc. 1995 Jun; 27(3):1993-4. . View in PubMed
  • Surgical management of cardiac pheochromocytomaResection versus transplantation. Ann Surg. 1995 Apr; 221(4):415-9. . View in PubMed
  • Increased early mortality in women undergoing cardiac transplantation Circulation. 1995 Feb 15; 91(4):1029-35. . View in PubMed
  • Lobar transplantationIndications, technique, and outcome. J Thorac Cardiovasc Surg. 1994 Sep; 108(3):403-10; discussion 410-1. . View in PubMed
  • Influence of HLA mismatch on rejection after heart transplantation: a multiinstitutional studyThe Cardiac Transplant Research Database Group. J Heart Lung Transplant. 1994 Jul-Aug; 13(4):583-95; discussion 595-6. . View in PubMed
  • Living-related donor lobectomy for bilateral lobar transplantation in patients with cystic fibrosis Ann Thorac Surg. 1994 Jun; 57(6):1423-7; discussion 1428. . View in PubMed
  • Myocardial perfusion scintigraphy in heart transplant recipients with and without allograft atherosclerosis: a comparison of thallium-201 and technetium 99m sestamibi J Heart Lung Transplant. 1994 Mar-Apr; 13(2):173-80. . View in PubMed
  • Pediatric lung transplantation Semin Pediatr Surg. 1993 Nov; 2(4):279-88. . View in PubMed
  • Posttransplantation lymphoproliferative disorders treated with cyclophosphamide-doxorubicin-vincristine-prednisone chemotherapy Cancer. 1993 Nov 01; 72(9):2782-5. . View in PubMed
  • Clinical experience with cardiac retransplantation J Thorac Cardiovasc Surg. 1993 Oct; 106(4):622-9; discussion 629-31. . View in PubMed
  • Management of lymphoproliferative disorders after cardiac transplantation Ann Thorac Surg. 1993 Sep; 56(3):527-38. . View in PubMed
  • Effect of anti-HLA antibodies on the long-term survival of heart and kidney allografts Transplant Proc. 1993 Feb; 25(1 Pt 1):262-4. . View in PubMed
  • Effect of recipient gender and race on heart and kidney allograft survival Transplant Proc. 1992 Dec; 24(6):2670-1. . View in PubMed
  • Effect of anti-HLA and anti-idiotypic antibodies on the long-term survival of heart and kidney allografts Transplant Proc. 1992 Dec; 24(6):2494-5. . View in PubMed
  • Photochemotherapy in human heart transplant recipients at high risk for fatal rejection J Heart Lung Transplant. 1992 Jul-Aug; 11(4 Pt 1):746-50. . View in PubMed
  • Effect of complete cardiac denervation on atrial natriuretic factor release in baboons J Surg Res. 1992 Jul; 53(1):43-7. . View in PubMed
  • Predictors of survival after repeat heart transplantationThe Registry of the International Society for Heart and Lung Transplantation, and Contributing Investigators. J Heart Lung Transplant. 1992 May-Jun; 11(3 Pt 2):S142-58. . View in PubMed
  • Relation of HLA antibodies and graft atherosclerosis in human cardiac allograft recipients J Heart Lung Transplant. 1992 May-Jun; 11(3 Pt 2):S120-3. . View in PubMed
  • Alternative splicing of the mRNA encoding the human cholesteryl ester transfer protein Biochemistry. 1992 Mar 03; 31(8):2352-8. . View in PubMed
  • University of Wisconsin solution versus crystalloid cardioplegia for human donor heart preservationA randomized blinded prospective clinical trial. J Thorac Cardiovasc Surg. 1992 Feb; 103(2):194-8; discussion 198-9. . View in PubMed
  • Beta-adrenergic receptor sensitivity and guanine nucleotide regulatory proteins in transplanted human hearts and autotransplanted baboons Transplantation. 1991 Dec; 52(6):960-6. . View in PubMed
  • University of Wisconsin solution for human donor heart preservation: initial clinical experience Ann Thorac Surg. 1991 Dec; 52(6):1213-6. . View in PubMed
  • Improved heart preservation with University of Wisconsin solution: experimental and preliminary human experience Circulation. 1991 Nov; 84(5 Suppl):III324-8. . View in PubMed
  • Anti-CD3 monoclonal antibody induction therapyImmunological equivalency with triple-drug therapy in heart transplantation. Circulation. 1990 Nov; 82(5 Suppl):IV291-4. . View in PubMed
  • Humoral immune responses after cardiac transplantation: correlation with fatal rejection and graft atherosclerosis Surgery. 1989 Aug; 106(2):203-7; discussion 207-8. . View in PubMed
  • LTC4, thromboxane B2 and 6-keto PGF1 in syngeneic and allogenic heterotopic cardiac transplant in rats Transplant Proc. 1989 Feb; 21(1 Pt 1):442. . View in PubMed
  • Acute reoxygenation injury in the isolated rat heart: role of resident cardiac mast cells Circ Res. 1988 Dec; 63(6):1044-52. . View in PubMed
  • Very rapid lactate measurement in ischemic perfused hearts using 1H MRS continuous negative echo acquisition during steady-state frequency selective excitation Magn Reson Med. 1988 May; 7(1):65-78. . View in PubMed
  • Pediatric aspects of the Michigan polybrominated biphenyl contamination Environ Res. 1980 Apr; 21(2):255-74. . View in PubMed

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