Marlena Fejzo

Clinical Assistant Professor of Population and Public Health Sciences in the Center for Genetic Epidemiology

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Overview

Marlena Schoenberg Fejzo, Ph.D. is a medical scientist whose research focuses on conditions and diseases that primarily affect women. She received a Ph.D. in Genetics from Harvard University in 1995. Currently she works in the Center for Genetic Epidemiology at the University of Southern California and Materna Biosciences, Inc. She has published peer-reviewed scientific articles on ovarian cancer, breast cancer, multiple sclerosis, and discovered the first genes associated with uterine fibroids, nausea and vomiting of pregnancy, and hyperemesis gravidarum. She is a science advisor and board member for the Hyperemesis Education and Research Foundation.

Publications

  • GDF15 linked to maternal risk of nausea and vomiting during pregnancy Nature. 2023 Dec 13. . View in PubMed
  • Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy bioRxiv. 2023 Jun 04. . View in PubMed
  • Pregnant, miserable, and starving in 21st century America AJOG Glob Rep. 2023 Feb; 3(1):100141. . View in PubMed
  • Author’s reply BJOG. 2023 06; 130(7):843-844. . View in PubMed
  • Inaccuracies in “Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis” Am J Obstet Gynecol. 2022 Nov; 227(5):792. . View in PubMed
  • Patterns of Use and Self-reported Effectiveness of Cannabis for Hyperemesis Gravidarum Geburtshilfe Frauenheilkd. 2022 May; 82(5):517-527. . View in PubMed
  • Whole-exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum BJOG. 2022 10; 129(11):1845-1852. . View in PubMed
  • Analysis in epithelial ovarian cancer identifies KANSL1 as a biomarker and target gene for immune response and HDAC inhibition Gynecol Oncol. 2021 02; 160(2):539-546. . View in PubMed
  • HyperEmesis Level Prediction (HELP Score) Identifies Patients with Indicators of Severe Disease: a Validation Study Geburtshilfe Frauenheilkd. 2021 Jan; 81(1):90-98. . View in PubMed
  • A core outcome set for hyperemesis gravidarum studies is a small step in the right direction BJOG. 2020 07; 127(8):993. . View in PubMed
  • Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality Geburtshilfe Frauenheilkd. 2019 Apr; 79(4):382-388. . View in PubMed
  • Analysis of neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum reveals increased reporting of autism spectrum disorder Reprod Toxicol. 2019 03; 84:59-64. . View in PubMed
  • Nausea and vomiting of pregnancy and hyperemesis gravidarum Nat Rev Dis Primers. 2019 09 12; 5(1):62. . View in PubMed
  • Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum Geburtshilfe Frauenheilkd. 2018 Sep; 78(9):866-870. . View in PubMed
  • Critique of inaccurate reporting in Edlavitch article on “Publishing negative findings and the challenge of avoiding type II errors in studies of suspect teratogens: Example of a recent ondansetron publication” Reprod Toxicol. 2018 01; 75:144-145. . View in PubMed
  • Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum Nat Commun. 2018 03 21; 9(1):1178. . View in PubMed
  • Proteasome ubiquitin receptor PSMD4 is an amplification target in breast cancer and may predict sensitivity to PARPi Genes Chromosomes Cancer. 2017 08; 56(8):589-597. . View in PubMed
  • Measures of depression and anxiety in women with hyperemesis gravidarum are flawed Evid Based Nurs. 2017 07; 20(3):78-79. . View in PubMed
  • Analysis of pre- and post-pregnancy issues in women with hyperemesis gravidarum Auton Neurosci. 2017 01; 202:73-78. . View in PubMed
  • Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2) Mol Cell Endocrinol. 2017 01 05; 439:308-316. . View in PubMed
  • Response to the questions submitted by MrReichmann. Reprod Toxicol. 2016 12; 66:123. . View in PubMed
  • Ondansetron in pregnancy and risk of adverse fetal outcomes in the United States Reprod Toxicol. 2016 07; 62:87-91. . View in PubMed
  • Intestinal obstruction is a rare complication of ondansetron exposure in hyperemesis gravidarum Reprod Toxicol. 2015 Nov; 57:207. . View in PubMed
  • ADRM1-amplified metastasis gene in gastric cancer Genes Chromosomes Cancer. 2015 Aug; 54(8):506-515. . View in PubMed
  • Neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum Eur J Obstet Gynecol Reprod Biol. 2015 Jun; 189:79-84. . View in PubMed
  • Psychiatric factors do not affect recurrence risk of hyperemesis gravidarum J Obstet Gynaecol Res. 2015 Apr; 41(4):512-6. . View in PubMed
  • KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition Br J Cancer. 2014 Oct 28; 111(9):1788-801. . View in PubMed
  • POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer Gynecol Oncol. 2014 Feb; 132(2):334-42. . View in PubMed
  • Antihistamines and other prognostic factors for adverse outcome in hyperemesis gravidarum Eur J Obstet Gynecol Reprod Biol. 2013 Sep; 170(1):71-6. . View in PubMed
  • Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer Int J Mol Sci. 2013 Feb 01; 14(2):3094-109. . View in PubMed
  • Dacomitinib, an irreversible Pan-ErbB inhibitor significantly abrogates growth in head and neck cancer models that exhibit low response to cetuximab PLoS One. 2013; 8(2):e56112. . View in PubMed
  • Hyperemesis gravidarum: it is time to put an end to the misguided theory of a psychiatric etiology Gen Hosp Psychiatry. 2012 Nov-Dec; 34(6):699-700; author reply 700-1. . View in PubMed
  • No increased risk of psychological/behavioral disorders in siblings of women with hyperemesis gravidarum (HG) unless their mother had HG J Dev Orig Health Dis. 2012 Oct; 3(5):375-9. . View in PubMed
  • Change in paternity and recurrence of hyperemesis gravidarum J Matern Fetal Neonatal Med. 2012 Aug; 25(8):1241-5. . View in PubMed
  • Risk factors, treatments, and outcomes associated with prolonged hyperemesis gravidarum J Matern Fetal Neonatal Med. 2012 Jun; 25(6):632-6. . View in PubMed
  • Posttraumatic stress symptoms following pregnancy complicated by hyperemesis gravidarum J Matern Fetal Neonatal Med. 2011 Nov; 24(11):1307-11. . View in PubMed
  • Prenatal exposure to hyperemesis gravidarum linked to increased risk of psychological and behavioral disorders in adulthood J Dev Orig Health Dis. 2011 Aug; 2(4):200-4. . View in PubMed
  • Knockdown of ovarian cancer amplification target ADRM1 leads to downregulation of GIPC1 and upregulation of RECK Genes Chromosomes Cancer. 2011 Jun; 50(6):434-41. . View in PubMed
  • Familial aggregation of hyperemesis gravidarumAm J Obstet Gynecol. 2011 Mar; 204(3):230. e1-7. . View in PubMed
  • Recurrence risk of hyperemesis gravidarum J Midwifery Womens Health. 2011 Mar-Apr; 56(2):132-6. . View in PubMed
  • Periostin promotes ovarian cancer angiogenesis and metastasis Gynecol Oncol. 2010 Nov; 119(2):337-44. . View in PubMed
  • Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo Clin Cancer Res. 2010 Mar 01; 16(5):1509-19. . View in PubMed
  • Tissue microarrays from frozen tissues-OCT technique Methods Mol Biol. 2010; 664:73-80. . View in PubMed
  • Patients with a history of hyperemesis gravidarum have similar symptoms during egg stimulation and develop ovarian hyperstimulation syndrome: case seriesFertil Steril. 2010 Jan; 93(1):267. e9-11. . View in PubMed
  • Symptoms and pregnancy outcomes associated with extreme weight loss among women with hyperemesis gravidarum J Womens Health (Larchmt). 2009 Dec; 18(12):1981-7. . View in PubMed
  • High prevalence of severe nausea and vomiting of pregnancy and hyperemesis gravidarum among relatives of affected individuals Eur J Obstet Gynecol Reprod Biol. 2008 Nov; 141(1):13-7. . View in PubMed
  • Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target Genes Chromosomes Cancer. 2008 Oct; 47(10):873-83. . View in PubMed
  • Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells Br J Cancer. 2008 Mar 25; 98(6):1076-84. . View in PubMed
  • The psychosocial burden of hyperemesis gravidarum J Perinatol. 2008 Mar; 28(3):176-81. . View in PubMed
  • Secular trends in the treatment of hyperemesis gravidarum Am J Perinatol. 2008 Mar; 25(3):141-7. . View in PubMed
  • RIN1 is a breast tumor suppressor gene Cancer Res. 2007 Dec 15; 67(24):11510-6. . View in PubMed
  • Elective pregnancy termination in a large cohort of women with hyperemesis gravidarum Contraception. 2007 Dec; 76(6):451-5. . View in PubMed