Mei Chen
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Association between Self-Reported Survey Measures and Biomarkers of Second-Hand Tobacco Smoke Exposure in Non-Smoking Pregnant Women Int J Environ Res Public Health. 2021 08 31; 18(17). . View in PubMed
Influence of Environmental Tobacco Smoke and Air Pollution on Fetal Growth: A Prospective Study Int J Environ Res Public Health. 2020 07 23; 17(15). . View in PubMed
Suppression of TGFß and Angiogenesis by Type VII Collagen in Cutaneous SCC J Natl Cancer Inst. 2016 Jan; 108(1). . View in PubMed
Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice J Invest Dermatol. 2015 Dec; 135(12):3060-3067. . View in PubMed
A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion Mol Cancer Ther. 2015 Nov; 14(11):2665-73. . View in PubMed
Lentiviral Engineered Fibroblasts Expressing Codon Optimized COL7A1 Restore Anchoring Fibrils in RDEB J Invest Dermatol. 2015 Sep 22. . View in PubMed
Reduced Toxicity Conditioning and Allogeneic Hematopoietic Progenitor Cell Transplantation for Recessive Dystrophic Epidermolysis BullosaJ Pediatr. 2015 Sep; 167(3):765-9. e1. . View in PubMed
Recessive Dystrophic Epidermolysis Bullosa: Advances in the Laboratory Leading to New Therapies J Invest Dermatol. 2015 Jul; 135(7):1705-1707. . View in PubMed
Hsp90a and Hsp90ß together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing J Cell Sci. 2015 Apr 15; 128(8):1475-80. . View in PubMed
Keratinocyte Migration and a Hypothetical New Role for Extracellular Heat Shock Protein 90 Alpha in Orchestrating Skin Wound Healing Adv Wound Care (New Rochelle). 2015 Apr 01; 4(4):203-212. . View in PubMed
Aminoglycosides restore full-length type VII collagen by overcoming premature termination codons: therapeutic implications for dystrophic epidermolysis bullosa Mol Ther. 2014 Oct; 22(10):1741-52. . View in PubMed
De novo anti-type VII collagen antibodies in patients with recessive dystrophic epidermolysis bullosa J Invest Dermatol. 2014 Apr; 134(4):1138-1140. . View in PubMed
Identification of the critical therapeutic entity in secreted Hsp90a that promotes wound healing in newly re-standardized healthy and diabetic pig models PLoS One. 2014; 9(12):e113956. . View in PubMed
Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo Mol Cell Biol. 2013 Dec; 33(24):4947-59. . View in PubMed
Intravenously injected recombinant human type VII collagen homes to skin wounds and restores skin integrity of dystrophic epidermolysis bullosa J Invest Dermatol. 2013 Jul; 133(7):1910-3. . View in PubMed
Topical application of recombinant type VII collagen incorporates into the dermal-epidermal junction and promotes wound closure Mol Ther. 2013 07; 21(7):1335-44. . View in PubMed
Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally Int Rev Cell Mol Biol. 2013; 303:203-35. . View in PubMed
The anti-motility signaling mechanism of TGFß3 that controls cell traffic during skin wound healing Biol Open. 2012 Dec 15; 1(12):1169-77. . View in PubMed
Epidermolysis bullosa acquisita: autoimmunity to anchoring fibril collagen Autoimmunity. 2012 Feb; 45(1):91-101. . View in PubMed
A potentially common peptide target in secreted heat shock protein-90a for hypoxia-inducible factor-1a-positive tumors Mol Biol Cell. 2012 Feb; 23(4):602-13. . View in PubMed
Epidermolysis bullosa acquisita Clin Dermatol. 2012 Jan-Feb; 30(1):60-9. . View in PubMed
A fragment of secreted Hsp90a carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice J Clin Invest. 2011 Nov; 121(11):4348-61. . View in PubMed
Congenital epidermolysis bullosa acquisita: vertical transfer of maternal autoantibody from mother to infant Arch Dermatol. 2011 Mar; 147(3):337-41. . View in PubMed
TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression J Cell Sci. 2011 Jan 01; 124(Pt 1):19-24. . View in PubMed
Bone marrow transplantation for recessive dystrophic epidermolysis bullosa N Engl J Med. 2010 Aug 12; 363(7):629-39. . View in PubMed
Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration J Invest Dermatol. 2009 Aug; 129(8):1909-20. . View in PubMed
Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration J Cell Sci. 2009 May 15; 122(Pt 10):1495-8. . View in PubMed
TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites Cell. 2009 Mar 06; 136(5):891-902. . View in PubMed
Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa Mol Ther. 2009 Jan; 17(1):26-33. . View in PubMed
Familial epidermolysis bullosa acquisita Dermatol Online J. 2008 Dec 15; 14(12):2. . View in PubMed
Duplicating autoimmune bullous diseases by passively transferring autoantibodies into animals J Invest Dermatol. 2008 Oct 06; 128(E3):E25-7. . View in PubMed
Profiling motility signal-specific genes in primary human keratinocytes J Invest Dermatol. 2008 Aug; 128(8):1981-90. . View in PubMed
Characterization of molecular mechanisms underlying mutations in dystrophic epidermolysis bullosa using site-directed mutagenesis J Biol Chem. 2008 Jun 27; 283(26):17838-45. . View in PubMed
Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing Mol Cell Biol. 2008 May; 28(10):3344-58. . View in PubMed
Hypoxia induces epidermal keratinocyte matrix metalloproteinase-9 secretion via the protein kinase C pathway J Cell Physiol. 2008 Jan; 214(1):47-55. . View in PubMed
Autoimmunity to type VII collagen: epidermolysis bullosa acquisita Curr Dir Autoimmun. 2008; 10:195-205. . View in PubMed
Autoimmunity to type VII collagen: epidermolysis bullosa acquisita Clin Rev Allergy Immunol. 2007 Oct; 33(1-2):78-84. . View in PubMed
Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level Mol Cell Biol. 2007 Sep; 27(17):6001-11. . View in PubMed
The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita Am J Pathol. 2007 Jun; 170(6):2009-18. . View in PubMed
Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing EMBO J. 2007 Mar 07; 26(5):1221-33. . View in PubMed
Intravenously injected human fibroblasts home to skin wounds, deliver type VII collagen, and promote wound healing Mol Ther. 2007 Mar; 15(3):628-35. . View in PubMed
Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration J Invest Dermatol. 2006 Sep; 126(9):2096-105. . View in PubMed
Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients J Invest Dermatol. 2006 Jun; 126(6):1323-30. . View in PubMed
PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration J Invest Dermatol. 2006 Jun; 126(6):1233-43. . View in PubMed
Fibroblasts as target cells for DEB gene therapy J Invest Dermatol. 2006 Apr; 126(4):708-10. . View in PubMed
A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing J Cell Biol. 2006 Mar 27; 172(7):1093-105. . View in PubMed
Evidence that anti-type VII collagen antibodies are pathogenic and responsible for the clinical, histological, and immunological features of epidermolysis bullosa acquisita J Invest Dermatol. 2005 May; 124(5):958-64. . View in PubMed
Wound-healing perspectives Dermatol Clin. 2005 Apr; 23(2):181-92. . View in PubMed
Signals that initiate, augment, and provide directionality for human keratinocyte motility J Invest Dermatol. 2004 Oct; 123(4):622-33. . View in PubMed
Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo Mol Ther. 2004 Aug; 10(2):318-26. . View in PubMed
Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa Nat Med. 2004 Jul; 10(7):693-5. . View in PubMed
A patient with both bullous pemphigoid and epidermolysis bullosa acquisita: an example of intermolecular epitope spreading J Am Acad Dermatol. 2004 Jul; 51(1):118-22. . View in PubMed
Epidermolysis bullosa: then and now J Am Acad Dermatol. 2004 Jul; 51(1 Suppl):S55-7. . View in PubMed
Mechanisms of human skin cell motility Histol Histopathol. 2004 10; 19(4):1311-24. . View in PubMed
Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB Mol Biol Cell. 2004 Jan; 15(1):294-309. . View in PubMed
Normal and gene-corrected dystrophic epidermolysis bullosa fibroblasts alone can produce type VII collagen at the basement membrane zone J Invest Dermatol. 2003 Nov; 121(5):1021-8. . View in PubMed
An efficient gene transduction system for studying gene function in primary human dermal fibroblasts and epidermal keratinocytes Clin Exp Dermatol. 2003 Mar; 28(2):193-9. . View in PubMed
Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa Nat Genet. 2002 Dec; 32(4):670-5. . View in PubMed
The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn's disease have autoantibodies to type VII collagen J Invest Dermatol. 2002 Jun; 118(6):1059-64. . View in PubMed
Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen J Am Acad Dermatol. 2002 May; 46(5 Suppl):S161-4. . View in PubMed
An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen Exp Cell Res. 2002 Feb 15; 273(2):219-28. . View in PubMed
The recombinant expression of full-length type VII collagen and characterization of molecular mechanisms underlying dystrophic epidermolysis bullosa J Biol Chem. 2002 Jan 18; 277(3):2118-24. . View in PubMed
The p38-MAPK/SAPK pathway is required for human keratinocyte migration on dermal collagen J Invest Dermatol. 2001 Dec; 117(6):1601-11. . View in PubMed
Epidermolysis bullosa acquisita: update and review Clin Dermatol. 2001 Nov-Dec; 19(6):712-8. . View in PubMed
The carboxyl terminus of type VII collagen mediates antiparallel dimer formation and constitutes a new antigenic epitope for epidermolysis Bullosa acquisita autoantibodies J Biol Chem. 2001 Jun 15; 276(24):21649-55. . View in PubMed
Autoantibodies to type VII collagen have heterogeneous subclass and light chain compositions and their complement-activating capacities do not correlate with the inflammatory clinical phenotype J Clin Immunol. 2000 Nov; 20(6):416-23. . View in PubMed
Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb Mol Cell Biol. 2000 Nov; 20(21):7867-80. . View in PubMed
Development and characterization of a recombinant truncated type VII collagen "minigene"Implication for gene therapy of dystrophic epidermolysis bullosa. J Biol Chem. 2000 Aug 11; 275(32):24429-35. . View in PubMed
Alpha 2 beta 1 integrin mediates dermal fibroblast attachment to type VII collagen via a 158-amino-acid segment of the NC1 domain Exp Cell Res. 1999 Jun 15; 249(2):231-9. . View in PubMed
Bullous systemic lupus erythematosus with autoantibodies recognizing multiple skin basement membrane components, bullous pemphigoid antigen 1, laminin-5, laminin-6, and type VII collagen Arch Dermatol. 1999 May; 135(5):569-73. . View in PubMed
NC1 domain of type VII collagen binds to the beta3 chain of laminin 5 via a unique subdomain within the fibronectin-like repeats J Invest Dermatol. 1999 Feb; 112(2):177-83. . View in PubMed
Molecular cloning and characterization of a cDNA encoding canine type VII collagen non-collagenous (NC1) domain, the target antigen of autoimmune disease epidermolysis bullosa acquisita (EBA) Biochim Biophys Acta. 1998 Oct 22; 1408(1):25-34. . View in PubMed
Epitope spreading: lessons from autoimmune skin diseases J Invest Dermatol. 1998 Feb; 110(2):103-9. . View in PubMed
Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix componentsA potential role in epidermal-dermal adherence in human skin. J Biol Chem. 1997 Jun 06; 272(23):14516-22. . View in PubMed
Laminin-6 and laminin-5 are recognized by autoantibodies in a subset of cicatricial pemphigoid J Invest Dermatol. 1997 Jun; 108(6):848-53. . View in PubMed
Modulation of type VII collagen (anchoring fibril) expression by retinoids in human skin cells Biochim Biophys Acta. 1997 Apr 10; 1351(3):333-40. . View in PubMed
Ultraviolet A irradiation upregulates type VII collagen expression in human dermal fibroblasts J Invest Dermatol. 1997 Feb; 108(2):125-8. . View in PubMed
Development of an ELISA for rapid detection of anti-type VII collagen autoantibodies in epidermolysis bullosa acquisita J Invest Dermatol. 1997 Jan; 108(1):68-72. . View in PubMed