Michael Bienkowski, PhD

Assistant Professor of Physiology and Neuroscience and Biomedical Engineering

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Overview

Dr. Bienkowski is interested in characterizing brain cell types and understanding their susceptibility to neurodegenerative diseases like Alhzeimer’s disease and retinal degenerative diseases. His translational research laboratory (USC Center for Integrative Connectomics) uses state-of-the-art connectomics and transcriptomics approaches to investigate cell type-specific progressive changes to gene expression and connectivity in rodent and human brain tissue. A major goal of the lab is to build translational cell type atlases to guide clinical drug development and enhance the effectiveness of treatment plans at progressive disease stages.

Research Funding

  • Multiscale Modeling of Hippocampus Vulnerability to Alzheimer's Disease Neurodegeneration.
    NIH · R01AG092662 · Jan 1, 2026 – Dec 31, 2030 · Role: Principal Investigator
  • A Translational 3D Map of Hippocampal Cell Types To Drive Investigations of Alzheimer's Disease
    NIH · K01AG066847 · Aug 1, 2021 – Jul 31, 2026 · Role: Principal Investigator
  • Alzheimer's Disease Research Centers
    NIH · P30AG066530 · Sep 1, 2020 – Mar 31, 2030 · Role: Co-Principal Investigator
  • Structural and Functional Neural Network Mediating Fear Memory and PTSD
    NIH · F32MH107071 · Sep 16, 2015 – Sep 15, 2017 · Role: Principal Investigator

Publications

  • Differential vulnerability of CA1 pyramidal neuron cell types in the 5xFAD Alzheimer’s disease mouse model. bioRxiv. 2026 Jun 02.. View in PubMed
  • Comparing Gallyas and AT8 staining for quantification of tau pathology in subregions of the human hippocampus. J Neuropathol Exp Neurol. 2026 May 01; 85(5):433-445.. View in PubMed
  • Mapping Projectome Heterogeneity of Subiculum Neuron Cell Types. bioRxiv. 2026 Apr 04.. View in PubMed
  • Laminar organization of pyramidal neuron cell types defines distinct CA1 hippocampal subregions. Nat Commun. 2025 Dec 03; 16(1):10604.. View in PubMed
  • Electric field stimulation directs target-specific axon regeneration and partial restoration of vision after optic nerve crush injury. PLoS One. 2025; 20(1):e0315562.. View in PubMed
  • Machine Learning Classification of Alzheimer’s Disease Pathology Reveals Diffuse Amyloid as a Major Predictor of Cognitive Impairment in Human Hippocampal Subregions. bioRxiv. 2023 Jun 05.. View in PubMed
  • Further refining the boundaries of the hippocampus CA2 with gene expression and connectivity: Potential subregions and heterogeneous cell types. Hippocampus. 2023 03; 33(3):150-160.. View in PubMed
  • Cellular anatomy of the mouse primary motor cortex. Nature. 2021 10; 598(7879):159-166.. View in PubMed
  • The mouse cortico-basal ganglia-thalamic network. Nature. 2021 10; 598(7879):188-194.. View in PubMed
  • Organization of the inputs and outputs of the mouse superior colliculus. Nat Commun. 2021 06 28; 12(1):4004.. View in PubMed