Keck School Faculty

Host Defense Peptides as Templates for Antifungal Drug Development J Fungi (Basel). 2020 Oct 23; 6(4). . View in PubMed

Antimicrob Agents Chemother. 2018 06; 62(6). . View in PubMed

JCI Insight. 2018 09 20; 3(18). . View in PubMed

J Biol Chem. 2018 02 23; 293(8):2725-2734. . View in PubMed

Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation Antimicrob Agents Chemother. 2017 08; 61(8). . View in PubMed

Innate Immun. 2015 Jan; 21(1):17-29. . View in PubMed

Hydrophobic determinants of a-defensin bactericidal activity Infect Immun. 2014 Jun; 82(6):2195-202. . View in PubMed

Differential Susceptibility of Bacteria to Mouse Paneth Cell a-Defensins under Anaerobic Conditions Antibiotics (Basel). 2014; 3(4):493-508. . View in PubMed

Antibiotics (Basel). 2014; 3(4):617-31. . View in PubMed

ImmunologyHD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. . View in PubMed

Alternative luminal activation mechanisms for paneth cell a-defensins J Biol Chem. 2012 Mar 30; 287(14):11205-12. . View in PubMed

High fidelity processing and activation of the human a-defensin HNP1 precursor by neutrophil elastase and proteinase 3 PLoS One. 2012; 7(3):e32469. . View in PubMed

Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases J Proteome Res. 2011 Oct 07; 10(10):4505-12. . View in PubMed

Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization J Am Chem Soc. 2011 May 04; 133(17):6720-7. . View in PubMed

Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms PLoS One. 2010 Mar 17; 5(3):e9737. . View in PubMed

Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes Infect Immun. 2008 Dec; 76(12):5883-91. . View in PubMed

Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53. . View in PubMed

A pocket guide to explorations of the defensin field Curr Pharm Des. 2007; 13(30):3061-4. . View in PubMed

Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties J Immunol. 2006 Jan 15; 176(2):1154-62. . View in PubMed

Mammalian defensins in the antimicrobial immune response Nat Immunol. 2005 Jun; 6(6):551-7. . View in PubMed

Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes J Leukoc Biol. 2004 Feb; 75(2):332-41. . View in PubMed

alpha-Defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors AIDS. 2003 Sep 26; 17(14):F23-32. . View in PubMed

Antimicrobial properties of the Escherichia coli R1 plasmid host killing peptide J Biotechnol. 2003 Jan 09; 100(1):1-12. . View in PubMed

Antimicrobial peptides from human platelets Infect Immun. 2002 Dec; 70(12):6524-33. . View in PubMed

Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding proteinA microbicidal granule protein of eosinophils and neutrophils. J Biol Chem. 2002 May 31; 277(22):19658-64. . View in PubMed

Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G757-65. . View in PubMed

Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides J Biol Chem. 2002 Feb 01; 277(5):3079-84. . View in PubMed

Cryptdin-3 induces novel apical conductance(s) in Cl- secretory, including cystic fibrosis, epithelia . 2001 Feb; 280(2):C296-302. . View in PubMed

Human neutrophil-mediated nonoxidative antifungal activity against Cryptococcus neoformans Infect Immun. 2000 Nov; 68(11):6257-64. . View in PubMed

Characterization of luminal paneth cell alpha-defensins in mouse small intestineAttenuated antimicrobial activities of peptides with truncated amino termini. J Biol Chem. 2000 Oct 27; 275(43):33969-73. . View in PubMed

Identification of constituents of human neutrophil azurophil granules that mediate fungistasis against Histoplasma capsulatum Infect Immun. 2000 Oct; 68(10):5668-72. . View in PubMed

Formation and characterization of a single Trp-Trp cross-link in indolicidin that confers protease stability without altering antimicrobial activity J Biol Chem. 2000 Apr 21; 275(16):12017-22. . View in PubMed

Isolation, characterization, cDNA cloning, and antimicrobial properties of two distinct subfamilies of alpha-defensins from rhesus macaque leukocytes Infect Immun. 1999 Nov; 67(11):6139-44. . View in PubMed

A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins Science. 1999 Oct 15; 286(5439):498-502. . View in PubMed

CD spectra of indolicidin antimicrobial peptides suggest turns, not polyproline helix Biochemistry. 1999 Sep 21; 38(38):12313-9. . View in PubMed

Cloning and expression of bovine neutrophil beta-defensinsBiosynthetic profile during neutrophilic maturation and localization of mature peptide to novel cytoplasmic dense granules. J Biol Chem. 1999 Sep 10; 274(37):26249-58. . View in PubMed

Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils J Leukoc Biol. 1998 Jan; 63(1):94-100. . View in PubMed

Critical role of lipid composition in membrane permeabilization by rabbit neutrophil defensins J Biol Chem. 1997 Sep 26; 272(39):24224-33. . View in PubMed

Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3 Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8585-9. . View in PubMed

Bilayer interactions of indolicidin, a small antimicrobial peptide rich in tryptophan, proline, and basic amino acids Biophys J. 1997 Feb; 72(2 Pt 1):794-805. . View in PubMed

HPLC methods for purification of antimicrobial peptides Methods Mol Biol. 1997; 78:17-33. . View in PubMed

Cryptdin gene expression in developing mouse small intestine Am J Physiol. 1997 Jan; 272(1 Pt 1):G197-206. . View in PubMed

Interactions of monomeric rabbit neutrophil defensins with bilayers: comparison with dimeric human defensin HNP-2 Biochemistry. 1996 Sep 10; 35(36):11888-94. . View in PubMed

Liposomal entrapment of the neutrophil-derived peptide indolicidin endows it with in vivo antifungal activity Biochim Biophys Acta. 1995 Jul 26; 1237(2):109-14. . View in PubMed

Defensins in granules of phagocytic and non-phagocytic cells Trends Cell Biol. 1995 Mar; 5(3):114-9. . View in PubMed

In vitro activity of naturally occurring peptides (defensins) against Listeria monocytogenes Cad Saude Publica. 1994 Dec; 10(4):440-5. . View in PubMed

Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides Infect Immun. 1994 Dec; 62(12):5397-403. . View in PubMed

Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms Infect Immun. 1994 Nov; 62(11):5040-7. . View in PubMed

Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores Protein Sci. 1994 Sep; 3(9):1362-73. . View in PubMed

Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency Blood. 1994 Apr 01; 83(7):1935-40. . View in PubMed

Fungicidal properties of defensin NP-1 and activity against Cryptococcus neoformans in vitro Antimicrob Agents Chemother. 1993 Dec; 37(12):2628-32. . View in PubMed

Molecular analysis of myeloperoxidase deficiency shows heterogeneous patterns of the complete deficiency state manifested at the genomic, mRNA, and protein levels Blood. 1993 Aug 15; 82(4):1317-22. . View in PubMed

Defensins promote fusion and lysis of negatively charged membranes Protein Sci. 1993 Aug; 2(8):1301-12. . View in PubMed

Defensins are mitogenic for epithelial cells and fibroblasts J Cell Physiol. 1993 May; 155(2):408-13. . View in PubMed

Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils J Biol Chem. 1993 Mar 25; 268(9):6649-53. . View in PubMed

Investigational approaches for studying the structures and biological functions of myeloid antimicrobial peptides Genet Eng (N Y). 1993; 15:131-47. . View in PubMed

Enteric defensins: antibiotic peptide components of intestinal host defense J Cell Biol. 1992 Aug; 118(4):929-36. . View in PubMed

Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils J Biol Chem. 1992 Mar 05; 267(7):4292-5. . View in PubMed

Bactericidal potency and mechanistic specificity of neutrophil defensins against bovine mastitis pathogens Vet Microbiol. 1991 Sep; 29(1):49-58. . View in PubMed

Antimicrobial activity of rabbit leukocyte defensins against Treponema pallidum subsppallidum. Infect Immun. 1991 Apr; 59(4):1359-67. . View in PubMed

Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization Science. 1991 Mar 22; 251(5000):1481-5. . View in PubMed

Defensins: endogenous antibiotic peptides of animal cells Cell. 1991 Jan 25; 64(2):229-30. . View in PubMed

In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins Infect Immun. 1990 Dec; 58(12):3934-40. . View in PubMed

Killing of oral, gram-negative, facultative bacteria by the rabbit defensin, NP-1 Oral Microbiol Immunol. 1990 Dec; 5(6):315-9. . View in PubMed

Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium Infect Immun. 1990 Nov; 58(11):3706-10. . View in PubMed

In vitro antimicrobial activity of defensins against ocular pathogens Arch Ophthalmol. 1990 Jun; 108(6):861-4. . View in PubMed

Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes Proc Natl Acad Sci U S A. 1990 Jan; 87(1):210-4. . View in PubMed

Defensins Eur J Haematol. 1990 Jan; 44(1):1-8. . View in PubMed

Monocyte-chemotactic activity of defensins from human neutrophils J Clin Invest. 1989 Dec; 84(6):2017-20. . View in PubMed

Interaction of human defensins with Escherichia coliMechanism of bactericidal activity. J Clin Invest. 1989 Aug; 84(2):553-61. . View in PubMed

Evidence for a pretranslational defect in hereditary and acquired myeloperoxidase deficiency Blood. 1989 May 15; 73(7):1980-6. . View in PubMed

Determination of the disulfide array in the human defensin HNP-2A covalently cyclized peptide. J Biol Chem. 1989 Mar 05; 264(7):4003-7. . View in PubMed

Neutrophils and host defense Ann Intern Med. 1988 Jul 15; 109(2):127-42. . View in PubMed

Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations J Clin Invest. 1988 Jun; 81(6):1829-35. . View in PubMed

Characterization of two crystal forms of human defensin neutrophil cationic peptide 1, a naturally occurring antimicrobial peptide of leukocytes J Biol Chem. 1988 Apr 25; 263(12):5933-5. . View in PubMed

Mechanism of target cytolysis by peptide defensinsTarget cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity. J Immunol. 1988 Apr 15; 140(8):2686-94. . View in PubMed

Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils Biochem Pharmacol. 1988 Mar 01; 37(5):951-6. . View in PubMed

Defensin-rich dense granules of human neutrophils Blood. 1987 Sep; 70(3):757-65. . View in PubMed

Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species Nucleic Acids Res. 1987 Mar 11; 15(5):2013-28. . View in PubMed

Direct inactivation of viruses by human granulocyte defensins J Virol. 1986 Dec; 60(3):1068-74. . View in PubMed

In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes Blood. 1986 Dec; 68(6):1407-10. . View in PubMed

In vitro killing of spores and hyphae of Aspergillus fumigatus and Rhizopus oryzae by rabbit neutrophil cationic peptides and bronchoalveolar macrophages J Infect Dis. 1986 Sep; 154(3):483-9. . View in PubMed

Eosin Y: a reversible stain for detecting electrophoretically resolved protein Anal Biochem. 1986 Jun; 155(2):270-4. . View in PubMed

Antimicrobial activity of phagocyte granule proteins Semin Respir Infect. 1986 Jun; 1(2):107-17. . View in PubMed

DefensinsNatural peptide antibiotics of human neutrophils. J Clin Invest. 1985 Oct; 76(4):1427-35. . View in PubMed

Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2 Am Rev Respir Dis. 1985 Oct; 132(4):901-4. . View in PubMed

Activity of rabbit leukocyte peptides against Candida albicans Infect Immun. 1985 Jul; 49(1):202-6. . View in PubMed

Correlation of binding of rabbit granulocyte peptides to Candida albicans with candidacidal activity Infect Immun. 1985 Jul; 49(1):207-11. . View in PubMed

Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes J Virol. 1985 May; 54(2):467-72. . View in PubMed

In vitro effect of phagocyte cationic peptides on Coccidioides immitis J Infect Dis. 1985 May; 151(5):890-4. . View in PubMed

Divergent expression of cytotoxic and microbicidal functions of rabbit alveolar and peritoneal macrophages: effects of non-specific activation and a natural microbicidal peptide, MCP-1 Aust J Exp Biol Med Sci. 1985 Feb; 63 ( Pt 1):53-63. . View in PubMed

Characterization of two crystal forms of neutrophil cationic protein NP2, a naturally occurring broad-spectrum antimicrobial agent from leukocytes J Mol Biol. 1984 Sep 25; 178(3):783-5. . View in PubMed

Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages Infect Immun. 1983 Oct; 42(1):10-4. . View in PubMed

Isolation and purification of bactericides from human tears Exp Eye Res. 1982 Mar; 34(3):305-18. . View in PubMed

Increased content of microbicidal cationic peptides in rabbit alveolar macrophages elicited by complete Freund adjuvant Infect Immun. 1981 Sep; 33(3):775-8. . View in PubMed

Microbicidal and cytotoxic properties of soluble components from quaternary aminoethyl-sephadex Infect Immun. 1980 Dec; 30(3):887-9. . View in PubMed

A simple and ultrasensitive enzymatic assay for the quantitative determination of lysozyme in the picogram range Anal Biochem. 1980 Nov 15; 109(1):67-70. . View in PubMed

Lysozyme: primary bactericidin in human plasma serum active against Bacillus subtilis Infect Immun. 1978 Jun; 20(3):782-91. . View in PubMed