Keck School Faculty

INTRAVENOUS N-ACETYLCYSTEINE TO PREVENT CISPLATIN-INDUCED HEARING LOSS IN CHILDREN: A NONRANDOMIZED CONTROLLED PHASE 1 TRIAL Clin Cancer Res. 2023 May 03. . View in PubMed

Variation in Treatment of Pediatric Tuberculosis Infection in Different Provider Settings J Pediatr. 2023 Apr 10; 113419. . View in PubMed

A proof of concept reinforcement learning based tool for non parametric population pharmacokinetics workflow optimization J Pharmacokinet Pharmacodyn. 2023 02; 50(1):33-43. . View in PubMed

Model-Informed Rationale for Early Therapeutic Drug Monitoring of Colistin in Critically Ill Patients J Clin Pharmacol. 2023 01; 63(1):57-65. . View in PubMed

Isavuconazole Pharmacokinetics and Pharmacodynamics in Children Pharmaceutics. 2022 Dec 26; 15(1). . View in PubMed

Interchangeability of generic drugs for subpopulations: Bioequivalence simulation from a nonparametric PK model of gabapentin generic drugs Br J Clin Pharmacol. 2022 Dec 08. . View in PubMed

Assessment of flomoxef combined with amikacin in a hollow-fibre infection model for the treatment of neonatal sepsis in low- and middle-income healthcare settings J Antimicrob Chemother. 2022 Nov 28; 77(12):3349-3357. . View in PubMed

Assessment of Antibiotic Pharmacokinetics, Molecular Biomarkers and Clinical Status in Critically Ill Adults Diagnosed with Community-Acquired Pneumonia and Receiving Intravenous Piperacillin/Tazobactam and Hydrocortisone over the First Five Days of Intensive Care: An Observational Study (STROBE Compliant) J Clin Med. 2022 Jul 16; 11(14). . View in PubMed

Evaluating the effect of clofazimine against Mycobacterium tuberculosis given alone or in combination with pretomanid, bedaquiline or linezolid Int J Antimicrob Agents. 2022 Feb; 59(2):106509. . View in PubMed

Nonparametric Methods in Population Pharmacokinetics J Clin Pharmacol. 2022 02; 62(2):142-157. . View in PubMed

Parametric and Nonparametric Methods in Population Pharmacokinetics: Experts' Discussion on Use, Strengths, and Limitations J Clin Pharmacol. 2022 02; 62(2):158-170. . View in PubMed

Parental Perspectives on Immunizations: Impact of the COVID-19 Pandemic on Childhood Vaccine Hesitancy J Community Health. 2022 02; 47(1):39-52. . View in PubMed

Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia J Antimicrob Chemother. 2022 10 28; 77(11):2956-2959. . View in PubMed

Cefepime Precision Dosing Tool: from Standard to Precise Dose Using Nonparametric Population Pharmacokinetics Antimicrob Agents Chemother. 2022 02 15; 66(2):e0204621. . View in PubMed

Optimal Practice for Vancomycin Therapeutic Drug Monitoring: Position Statement From the Anti-infectives Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Ther Drug Monit. 2022 02 01; 44(1):121-132. . View in PubMed

VP Shunt With Recurrent Malfunction in Two Pediatric Patients: Is the Hydrocephalus Truly Idiopathic? Pediatr Infect Dis J. 2022 04 01; 41(4):358-359.. View in PubMed

Combination Therapy to Kill Mycobacterium tuberculosis in Its Nonreplicating Persister Phenotype Antimicrob Agents Chemother. 2022 10 18; 66(10):e0069522. . View in PubMed

Flomoxef and fosfomycin in combination for the treatment of neonatal sepsis in the setting of highly prevalent antimicrobial resistance J Antimicrob Chemother. 2022 04 27; 77(5):1334-1343. . View in PubMed

Pharmacokinetic modelling of caspofungin to develop an extended dosing regimen in paediatric patients J Antimicrob Chemother. 2022 07 28; 77(8):2209-2216. . View in PubMed

Parametric and Nonparametric Population Pharmacokinetic Models to Assess Probability of Target Attainment of Imipenem Concentrations in Critically Ill Patients Pharmaceutics. 2021 Dec 16; 13(12). . View in PubMed

Growth medium and nitric oxide alter Mycobacterium abscessus morphotype and virulence Microbiol Res. 2021 Dec; 253:126887. . View in PubMed

A pharmacokinetics-based approach to the monitoring of patient adherence to atorvastatin therapy Pharmacol Res Perspect. 2021 10; 9(5):e00856. . View in PubMed

'Cost-benefit analysis comparing trough, two-level AUC, and Bayesian AUC dosing for vancomycin': authors' reply Clin Microbiol Infect. 2021 06; 27(6):929-930. . View in PubMed

Effect of Body Fat on Population Pharmacokinetics of High-Dose Methotrexate in Pediatric Patients With Acute Lymphoblastic Leukemia J Clin Pharmacol. 2021 06; 61(6):755-762. . View in PubMed

Supporting Precision Dosing in Drug Labeling Clin Pharmacol Ther. 2021 01; 109(1):37-41. . View in PubMed

Roger WJelliffe, MD, FCP, FAAPS: A World Leader in Population Pharmacokinetic and Pharmacodynamic Modeling and Model-Based Target Controlled Individualized Dosing. Clin Pharmacol Ther. 2021 01; 109(1):22-24. . View in PubMed

Ther Drug Monit. 2021 08 01; 43(4):461-471. . View in PubMed

Safety, Tolerability, and Population Pharmacokinetics of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients Antimicrob Agents Chemother. 2021 07 16; 65(8):e0029021. . View in PubMed

Amikacin Combined with Fosfomycin for Treatment of Neonatal Sepsis in the Setting of Highly Prevalent Antimicrobial Resistance Antimicrob Agents Chemother. 2021 06 17; 65(7):e0029321. . View in PubMed

Editorial: In Memory of Roger Jelliffe, MD Ther Drug Monit. 2021 08 01; 43(4):459-460. . View in PubMed

The case for precision dosing: medical conservatism does not justify inaction J Antimicrob Chemother. 2021 06 18; 76(7):1661-1665. . View in PubMed

Dosage Individualization of Linezolid: Precision Dosing of Linezolid To Optimize Efficacy and Minimize Toxicity Antimicrob Agents Chemother. 2021 05 18; 65(6). . View in PubMed

Dose Fractionation of Moxifloxacin for Treatment of Tuberculosis: Impact of Dosing Interval and Elimination Half-Life on Microbial Kill and Resistance Suppression Antimicrob Agents Chemother. 2021 03 18; 65(4). . View in PubMed

The Pharmacodynamic-Toxicodynamic Relationship of AUC and Cmax in Vancomycin-Induced Kidney Injury in an Animal Model Antimicrob Agents Chemother. 2021 02 17; 65(3). . View in PubMed

The Funnel: a Screening Technique for Identifying Optimal Two-Drug Combination Chemotherapy Regimens Antimicrob Agents Chemother. 2021 01 20; 65(2). . View in PubMed

Comment on: AUCs and 123s: a critical appraisal of vancomycin therapeutic drug monitoring in paediatrics J Antimicrob Chemother. 2021 08 12; 76(9):2486-2488. . View in PubMed

Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships Antimicrob Agents Chemother. 2021 09 17; 65(10):e0106021. . View in PubMed

Building Optimal Three-Drug Combination Chemotherapy Regimens To Eradicate Mycobacterium tuberculosis in Its Slow-Growth Acid Phase Antimicrob Agents Chemother. 2021 09 17; 65(10):e0069321. . View in PubMed

An Algorithm for Nonparametric Estimation of a Multivariate Mixing Distribution with Applications to Population Pharmacokinetics Pharmaceutics. 2020 Dec 30; 13(1). . View in PubMed

How to design a study to evaluate therapeutic drug monitoring in infectious diseases? Clin Microbiol Infect. 2020 Aug; 26(8):1008-1016.. View in PubMed

Intra-individual Pharmacokinetic Variability of Intravenous Busulfan in Hematopoietic Stem Cell-Transplanted Children Clin Pharmacokinet. 2020 08; 59(8):1049-1061. . View in PubMed

Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime Clin Pharmacokinet. 2020 08; 59(8):1027-1036. . View in PubMed

Population Pharmacokinetics of Imipenem in Critically Ill Patients: A Parametric and Nonparametric Model Converge on CKD-EPI Estimated Glomerular Filtration Rate as an Impactful Covariate Clin Pharmacokinet. 2020 07; 59(7):885-898. . View in PubMed

Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper Intensive Care Med. 2020 06; 46(6):1127-1153. . View in PubMed

Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics Ther Drug Monit. 2020 02; 42(1):83-92. . View in PubMed

Development and Implementation of Electronic Health Record-Integrated Model-Informed Clinical Decision Support Tools for the Precision Dosing of Drugs Clin Pharmacol Ther. 2020 01; 107(1):129-135. . View in PubMed

Pharmacodynamic Evaluation of Plasma and Epithelial Lining Fluid Exposures of Amikacin against Pseudomonas aeruginosa in a Dynamic In Vitro Hollow-Fiber Infection Model Antimicrob Agents Chemother. 2020 08 20; 64(9). . View in PubMed

Development of a methodology to make individual estimates of the precision of liquid chromatography-tandem mass spectrometry drug assay results for use in population pharmacokinetic modeling and the optimization of dosage regimens PLoS One. 2020; 15(3):e0229873. . View in PubMed

Building Optimal Three-Drug Combination Chemotherapy Regimens Antimicrob Agents Chemother. 2020 10 20; 64(11). . View in PubMed

Caspofungin Weight-Based Dosing Supported by a Population Pharmacokinetic Model in Critically Ill Patients Antimicrob Agents Chemother. 2020 08 20; 64(9). . View in PubMed

Developing New Drugs for Mycobacterium tuberculosis Therapy: What Information Do We Get from Preclinical Animal Models? Antimicrob Agents Chemother. 2020 11 17; 64(12).. View in PubMed

Use of Simulation Strategies to Predict Subtherapeutic Meropenem Exposure Caused by Augmented Renal Clearance in Critically Ill Pediatric Patients With Sepsis J Pediatr Pharmacol Ther. 2020; 25(5):413-422. . View in PubMed

Population Pharmacokinetics and Target Attainment of Cefepime in Critically Ill Patients and Guidance for Initial Dosing Antimicrob Agents Chemother. 2020 08 20; 64(9). . View in PubMed

In Memoriam: Roger Jelliffe, MD, FCP, FAAPS Ther Drug Monit. 2020 10 01; 42(5):658-659. . View in PubMed

Nonparametric Population Pharmacokinetic Modeling of Isoniazid in Colombian Patients With Tuberculosis Ther Drug Monit. 2019 12; 41(6):719-725. . View in PubMed

Update in antibiotic therapy in intensive care unit: report from the 2019 Nîmes International Symposium Anaesth Crit Care Pain Med. 2019 12; 38(6):647-656. . View in PubMed

Development of Chronic Pseudomonas aeruginosa-Positive Respiratory Cultures in Children with Tracheostomy Lung. 2019 12; 197(6):811-817. . View in PubMed

Optimizing Gentamicin Dosing in Pediatrics Using Monte Carlo Simulations Pediatr Infect Dis J. 2019 04; 38(4):390-395. . View in PubMed

Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study Antimicrob Agents Chemother. 2019 04; 63(4). . View in PubMed

Maximal concentration of intravenous busulfan as a determinant of veno-occlusive disease: a pharmacokinetic-pharmacodynamic analysis in 293 hematopoietic stem cell transplanted children Bone Marrow Transplant. 2019 03; 54(3):448-457. . View in PubMed

Early Use of Anti-influenza Medications in Hospitalized Children With Tracheostomy Pediatrics. 2019 03; 143(3). . View in PubMed

In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae J Antimicrob Chemother. 2019 12 01; 74(12):3521-3529. . View in PubMed

Length of Stay and Hospital Revisit After Bacterial Tracheostomy-Associated Respiratory Tract Infection Hospitalizations Hosp Pediatr. 2018 Jan 16. . View in PubMed

Activity of Moxifloxacin against Mycobacterium tuberculosis in Acid Phase and Nonreplicative-Persister Phenotype Phase in a Hollow-Fiber Infection Model Antimicrob Agents Chemother. 2018 12; 62(12). . View in PubMed

The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model Antimicrob Agents Chemother. 2018 12; 62(12). . View in PubMed

Interchangeability of Generic Drugs: A Nonparametric Pharmacokinetic Model of Gabapentin Generic Drugs Clin Pharmacol Ther. 2018 11; 104(5):966-973. . View in PubMed

Pharmacometric Modeling and Simulation Is Essential to Pediatric Clinical Pharmacology J Clin Pharmacol. 2018 10; 58 Suppl 10:S73-S85. . View in PubMed

Linezolid Kills Acid-Phase and Nonreplicative-Persister-Phase Mycobacterium tuberculosis in a Hollow-Fiber Infection Model Antimicrob Agents Chemother. 2018 08; 62(8). . View in PubMed

Risk factors for hospitalizations due to bacterial respiratory tract infections after tracheotomy Pediatr Pulmonol. 2018 03; 53(3):349-357. . View in PubMed

Pharmacokinetic/Pharmacodynamic Determinants of Vancomycin Efficacy in Enterococcal Bacteremia Antimicrob Agents Chemother. 2018 03; 62(3). . View in PubMed

Prospective Trial on the Use of Trough Concentration versus Area under the Curve To Determine Therapeutic Vancomycin Dosing Antimicrob Agents Chemother. 2018 02; 62(2). . View in PubMed

Pharmacodynamics of teicoplanin against MRSA J Antimicrob Chemother. 2017 Dec 01; 72(12):3382-3389. . View in PubMed

Pharmacodynamics of Isavuconazole for Invasive Mold Disease: Role of Galactomannan for Real-Time Monitoring of Therapeutic Response Clin Infect Dis. 2017 Jun 01; 64(11):1557-1563. . View in PubMed

Clin Pharmacol Ther. 2017 May; 101(5):646-656. . View in PubMed

Is continuous infusion of imipenem always the best choice? Int J Antimicrob Agents. 2017 Mar; 49(3):348-354.. View in PubMed

Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin Mol Cancer Res. 2017 12; 15(12):1704-1713. . View in PubMed

Tools for the Individualized Therapy of Teicoplanin for Neonates and Children Antimicrob Agents Chemother. 2017 10; 61(10). . View in PubMed

Pseudomonas aeruginosa and post-tracheotomy bacterial respiratory tract infection readmissions Pediatr Pulmonol. 2017 09; 52(9):1212-1218. . View in PubMed

Correction for Rhodes et al, Evaluation of Vancomycin Exposures Associated with Elevations in Novel Urinary Biomarkers of Acute Kidney Injury in Vancomycin-Treated Rats. Antimicrob Agents Chemother. 2017 04; 61(4). . View in PubMed

A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics Clin Pharmacokinet. 2017 04; 56(4):435-447. . View in PubMed

Experiment design for nonparametric models based on minimizing Bayes Risk: application to voriconazole¹ J Pharmacokinet Pharmacodyn. 2017 04; 44(2):95-111. . View in PubMed

Scalpels not hammers: The way forward for precision drug prescription Clin Pharmacol Ther. 2017 03; 101(3):368-372. . View in PubMed

Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation Front Pharmacol. 2017; 8:358. . View in PubMed

Sofosbuvir (SOF) Suppresses Ledipasvir (LDV)-resistant Mutants during SOF/LDV Combination Therapy against Genotype 1b Hepatitis C Virus (HCV) Sci Rep. 2017 10 31; 7(1):14421. . View in PubMed

The effect of medication nonadherence on progression-free survival among patients with renal cell carcinoma Cancer Manag Res. 2017; 9:731-739. . View in PubMed

Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones Expert Opin Drug Metab Toxicol. 2016 May; 12(5):533-44. . View in PubMed

Pharmacodynamics of Voriconazole in Children: Further Steps along the Path to True Individualized Therapy Antimicrob Agents Chemother. 2016 Apr; 60(4):2336-42. . View in PubMed

Plasma and intracellular exposure to ganciclovir in adult renal transplant recipients: is there an association with haematological toxicity? J Antimicrob Chemother. 2016 Feb; 71(2):484-9.. View in PubMed

An exploratory analysis of the ability of a cefepime trough concentration greater than 22 mg/L to predict neurotoxicity J Infect Chemother. 2016 Feb; 22(2):78-83. . View in PubMed

The Brief Case: Neonatal Meningitis Caused by Listeria monocytogenes Diagnosed by Multiplex Molecular Panel J Clin Microbiol. 2016 12; 54(12):2846-2849. . View in PubMed

Closing the Brief Case: Neonatal Meningitis Caused by Listeria monocytogenes Diagnosed by Multiplex Molecular Panel J Clin Microbiol. 2016 12; 54(12):3075. . View in PubMed

Dosage Adjustments Related to Young or Old Age and Organ Impairment J Clin Pharmacol. 2016 12; 56(12):1461-1473. . View in PubMed

Population pharmacokinetics and pharmacodynamics of teicoplanin in neonates: making better use of C-reactive protein to deliver individualized therapy J Antimicrob Chemother. 2016 11; 71(11):3168-3178. . View in PubMed

A Nonparametric Pharmacokinetic Approach to Determine the Optimal Dosing Regimen for 30-Minute and 3-Hour Meropenem Infusions in Critically Ill Patients Ther Drug Monit. 2016 10; 38(5):593-9. . View in PubMed

Evaluation of Vancomycin Exposures Associated with Elevations in Novel Urinary Biomarkers of Acute Kidney Injury in Vancomycin-Treated Rats Antimicrob Agents Chemother. 2016 10; 60(10):5742-51. . View in PubMed

Voriconazole pharmacokinetics following HSCT: results from the BMT CTN 0101 trial J Antimicrob Chemother. 2016 08; 71(8):2234-40. . View in PubMed

Accurately Achieving Target Busulfan Exposure in Children and Adolescents With Very Limited Sampling and the BestDose Software Ther Drug Monit. 2016 06; 38(3):332-42. . View in PubMed

Defining Clinical Exposures of Cefepime for Gram-Negative Bloodstream Infections That Are Associated with Improved Survival Antimicrob Agents Chemother. 2015 Dec 14; 60(3):1401-10. . View in PubMed

Characterisation of a multidrug-resistant meningitic Escherichia coli strain (O75:K1:H5) isolated from an infant that is sensitive to memantine, a newly identified host-directed antimicrobial drug Int J Antimicrob Agents. 2015 Nov; 46(5):598-600. . View in PubMed

Improved Tacrolimus Target Concentration Achievement Using Computerized Dosing in Renal Transplant Recipients--A Prospective, Randomized Study Transplantation. 2015 Oct; 99(10):2158-66. . View in PubMed

Population modeling and simulation study of the pharmacokinetics and antituberculosis pharmacodynamics of isoniazid in lungs Antimicrob Agents Chemother. 2015 Sep; 59(9):5181-9. . View in PubMed

Simultaneous plasma and genital pharmacokinetics and pharmacodynamics of atazanavir and efavirenz in HIV-infected women starting therapy J Clin Pharmacol. 2015 Jul; 55(7):798-808. . View in PubMed

Optimal timing of oral fosfomycin administration for pre-prostate biopsy prophylaxis J Antimicrob Chemother. 2015 Jul; 70(7):2068-73. . View in PubMed

Describing Assay Precision-Reciprocal of Variance Is Correct, Not CV Percent: Its Use Should Significantly Improve Laboratory Performance Ther Drug Monit. 2015 Jun; 37(3):389-94. . View in PubMed

Combination treatment with meropenem plus levofloxacin is synergistic against Pseudomonas aeruginosa infection in a murine model of pneumonia J Infect Dis. 2015 Apr 15; 211(8):1326-33. . View in PubMed

Achieving target voriconazole concentrations more accurately in children and adolescents Antimicrob Agents Chemother. 2015; 59(6):3090-7. . View in PubMed

Influence of renal function estimation on pharmacokinetic modeling of vancomycin in elderly patients Antimicrob Agents Chemother. 2015; 59(6):2986-94. . View in PubMed

Innovative approaches to optimizing the delivery of vancomycin in individual patients Adv Drug Deliv Rev. 2014 Nov 20; 77:50-7. . View in PubMed

A population pharmacokinetic modeling approach shows that serum penicillin G concentrations are below inhibitory concentrations by two weeks after benzathine penicillin G injection in the majority of young adults Antimicrob Agents Chemother. 2014 Nov; 58(11):6735-41. . View in PubMed

Population pharmacokinetics of a single intramuscular administration of tulathromycin in adult desert tortoises (Gopherus agassizii) J Vet Pharmacol Ther. 2014 Oct; 37(5):500-7. . View in PubMed

Pharmacokinetic tools for the dose adjustment of ciclosporin in haematopoietic stem cell transplant patients Br J Clin Pharmacol. 2014 Oct; 78(4):836-46. . View in PubMed

Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans Neuroreport. 2014 Sep 10; 25(13):1018-23. . View in PubMed

Individualization of piperacillin dosing for critically ill patients: dosing software to optimize antimicrobial therapy Antimicrob Agents Chemother. 2014 Jul; 58(7):4094-102. . View in PubMed

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions Lancet Infect Dis. 2014 Jun; 14(6):498-509. . View in PubMed

New algorithm for valganciclovir dosing in pediatric solid organ transplant recipients Pediatr Transplant. 2014 Feb; 18(1):103-11. . View in PubMed

Analysis of combination drug therapy to develop regimens with shortened duration of treatment for tuberculosis PLoS One. 2014; 9(7):e101311. . View in PubMed

Are vancomycin trough concentrations adequate for optimal dosing? Antimicrob Agents Chemother. 2014; 58(1):309-16.. View in PubMed

The Case for Using Higher Doses of First Line Anti-Tuberculosis Drugs to Optimize Efficacy Curr Pharm Des. 2014; 20(39):6191-206. . View in PubMed

Effect of protease inhibitors on steady-state pharmacokinetics of oral norethindrone contraception in HIV-infected women J Acquir Immune Defic Syndr. 2014 Jan 01; 65(1):72-7. . View in PubMed

Inclusion of CYP3A5 genotyping in a nonparametric population model improves dosing of tacrolimus early after transplantation Transpl Int. 2013 Dec; 26(12):1198-207. . View in PubMed

Impact of Bolus dosing versus continuous infusion of Piperacillin and Tazobactam on the development of antimicrobial resistance in Pseudomonas aeruginosa Antimicrob Agents Chemother. 2013 Dec; 57(12):5811-9. . View in PubMed

Pharmacodynamic target attainment for various ceftazidime dosing schemes in high-flux hemodialysis Antimicrob Agents Chemother. 2013 Dec; 57(12):5854-9. . View in PubMed

NPEST: a nonparametric method and a database for transcription start site prediction Quant Biol. 2013 Dec; 1(4):261-271. . View in PubMed

Use of nucleoside reverse transcriptase inhibitor-only regimens in HIV-infected children and adolescents Pediatr Infect Dis J. 2013 Sep; 32(9):e370-6. . View in PubMed

Pharmacodynamics of liposomal amphotericin B and flucytosine for cryptococcal meningoencephalitis: safe and effective regimens for immunocompromised patients J Infect Dis. 2013 Jul 15; 208(2):351-61. . View in PubMed

Two general methods for population pharmacokinetic modeling: non-parametric adaptive grid and non-parametric Bayesian J Pharmacokinet Pharmacodyn. 2013 Apr; 40(2):189-99. . View in PubMed

Software for dosage individualization of voriconazole for immunocompromised patients Antimicrob Agents Chemother. 2013 Apr; 57(4):1888-94. . View in PubMed

Population pharmacokinetic and pharmacodynamic modeling for assessing risk of bisphosphonate-related osteonecrosis of the jaw Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Feb; 115(2):224-32. . View in PubMed

From pediatric covariate model to semiphysiological function for maturation: part I-extrapolation of a covariate model from morphine to Zidovudine CPT Pharmacometrics Syst Pharmacol. 2012 Oct 03; 1:e9. . View in PubMed

Quantification by energy dispersive x-ray spectroscopy of alendronate in the diseased jaw bone of patients with bisphosphonate-related jaw osteonecrosis Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Oct; 114(4):480-6. . View in PubMed

Antiviral therapy of two patients with chromosomally-integrated human herpesvirus-6A presenting with cognitive dysfunction J Clin Virol. 2012 Sep; 55(1):40-5. . View in PubMed

Accurate detection of outliers and subpopulations with Pmetrics, a nonparametric and parametric pharmacometric modeling and simulation package for R Ther Drug Monit. 2012 Aug; 34(4):467-76. . View in PubMed

Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals Antimicrob Agents Chemother. 2012 Jun; 56(6):2959-66. . View in PubMed

High dose of darunavir in treatment-experienced HIV-infected adolescent results in virologic suppression and improved CD4 cell count Ther Drug Monit. 2012 Jun; 34(3):237-41. . View in PubMed

More codeine fatalities after tonsillectomy in North American children Pediatrics. 2012 May; 129(5):e1343-7. . View in PubMed

Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients Biol Blood Marrow Transplant. 2012 May; 18(5):731-8. . View in PubMed

Comparison of four renal function estimation equations for pharmacokinetic modeling of gentamicin in geriatric patients Antimicrob Agents Chemother. 2012 Apr; 56(4):1862-9. . View in PubMed

Relevance of pharmacokinetic and pharmacodynamic modeling to clinical care of critically ill patients Curr Pharm Biotechnol. 2011 Dec; 12(12):2044-61. . View in PubMed

Obesity and its impact on drug therapy: are we ready for this change? Clin Pharmacokinet. 2011 Dec 01; 50(12):825-6.. View in PubMed

Posaconazole for chronic refractory coccidioidal meningitis Clin Infect Dis. 2011 Dec; 53(12):1252-4. . View in PubMed

Nonparametric population modeling and Bayesian analysis Pharmacol Res. 2011 Oct; 64(4):426. . View in PubMed

Comment: assessment of vancomycin dosing and subsequent serum concentrations in pediatric patients Ann Pharmacother. 2011 Sep; 45(9):1171-2. . View in PubMed

CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected children Ther Drug Monit. 2011 Aug; 33(4):417-24. . View in PubMed

Psychological factors, beliefs about medication, and adherence of youth with human immunodeficiency virus in a multisite directly observed therapy pilot study J Adolesc Health. 2011 Jun; 48(6):637-40. . View in PubMed

Increased clearance of morphine in sickle cell disease: implications for pain management J Pain. 2011 May; 12(5):531-8. . View in PubMed

Incidence and predictors of invasive candidiasis associated with candidaemia in children Mycoses. 2011 Mar; 54(2):146-53. . View in PubMed

Pharmacokinetic optimization of antiretroviral therapy in children and adolescents Clin Pharmacokinet. 2011 Mar; 50(3):143-89. . View in PubMed

Pharmacokinetics and pharmacogenomics of once-daily raltegravir and atazanavir in healthy volunteers Antimicrob Agents Chemother. 2010 Nov; 54(11):4619-25. . View in PubMed

Directly observed therapy (DOT) for nonadherent HIV-infected youth: lessons learned, challenges ahead AIDS Res Hum Retroviruses. 2010 Sep; 26(9):947-53. . View in PubMed

Practical, individualized dosing: 21st century therapeutics and the clinical pharmacometrician J Clin Pharmacol. 2010 Jul; 50(7):842-7. . View in PubMed

Can therapeutic drug monitoring improve pharmacotherapy of HIV infection in adolescents? Ther Drug Monit. 2010 Jun; 32(3):273-81.. View in PubMed

Comment on: Pharmacokinetics and 48 week efficacy of low-dose lopinavir/ritonavir in HIV-infected children J Antimicrob Chemother. 2010 Apr; 65(4):808-9; author reply 809-10. . View in PubMed

Voriconazole pharmacokinetics and pharmacodynamics in children Clin Infect Dis. 2010 Jan 01; 50(1):27-36. . View in PubMed

Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir Ther Clin Risk Manag. 2009 Jun; 5(3):595-615. . View in PubMed

Population pharmacokinetics of lopinavir predict suboptimal therapeutic concentrations in treatment-experienced human immunodeficiency virus-infected children Antimicrob Agents Chemother. 2009 Jun; 53(6):2532-8. . View in PubMed

Pharmacokinetics and safety of caspofungin in older infants and toddlers Antimicrob Agents Chemother. 2009 Apr; 53(4):1450-6. . View in PubMed

Practical therapeutic drug management in HIV-infected patients: use of population pharmacokinetic models supplemented by individualized Bayesian dose optimization J Clin Pharmacol. 2008 Sep; 48(9):1081-91. . View in PubMed

Cervical shedding of HIV-1 RNA among women with low levels of viremia while receiving highly active antiretroviral therapy J Acquir Immune Defic Syndr. 2007 Jan 01; 44(1):38-42. . View in PubMed

Pharmacokinetics, safety, and tolerability of caspofungin in children and adolescents Antimicrob Agents Chemother. 2005 Nov; 49(11):4536-45. . View in PubMed

Management of antiretroviral therapy in neonates, children, and adolescents Curr HIV/AIDS Rep. 2004 Jun; 1(2):97-104. . View in PubMed

Management of Antiretroviral Therapy in Neonates, Children, and Adolescents Curr Infect Dis Rep. 2003 Dec; 5(6):521-530. . View in PubMed

Effect of chloroquine on human immunodeficiency virus (HIV) vertical transmission Afr Health Sci. 2003 Aug; 3(2):61-7. . View in PubMed

Pharmacokinetic characteristics of caspofungin in two pediatric liver transplant patients Curr Ther Res Clin Exp. 2003 Feb; 64(2):127-36. . View in PubMed

Organ heavy-metal accumulation during parenteral nutrition is associated with pathologic abnormalities in rats Nutrition. 2001 Jul-Aug; 17(7-8):600-6. . View in PubMed

Fluconazole prophylaxis in the very low birth weight infant: not ready for prime time Pediatrics. 2001 Feb; 107(2):404-5. . View in PubMed

Cost-benefit analysis comparing trough, two-level AUC and Bayesian AUC dosing for vancomycinClin Microbiol Infect. 2021 Sep; 27(9):1346. e1-1346. e7. . View in PubMed