Mitra K Nadim, MD, FASN

Professor Of Clinical Medicine

Director of Critical Care Nephrology

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Overview

After graduating from UCLA Medical School, Dr. Nadim went to Boston for her internship and residency at the prestigious Beth Israel Hospital, which is affiliated with Harvard University’s School of Medicine. After completing a nephrology fellowship at Brigham and Women’s/Massachusetts General Hospital, Harvard University, Dr. Nadim returned to Southern California and currently serves as Professor of Clinical Medicine and Director of USC’s Hypertension Center. Dr. Nadim served as the Associate Program Director for the Nephrology Fellowship Program from 2003 – 2006.

Dr. Nadim’s major clinical and research interests concerns the diagnosis and management of resistant hypertension. she is currently one of the National Principal Investigators in the Rheos Pivitol Trial, which is a multicenter clinical trial looking at efficacy and safety of the Rheos system, an implantable baroreflex device, in subjects with resistant hypertension.

Dr. Nadim’s clinical areas of expertise:

HYPERTENSION CLINIC

Dr. Nadim is a clinical specialist in hypertension and Director of the USC Hypertension Center. She has been an investigator in several hypertension studies, and her clinical practice has a special emphasis on resistant hypertension.

Awards

  • Keck School of Medicine of USC: Faculty Teaching Award, 2015
  • Keck School of Medicine of USC: Outstanding Year II Course Award, 2013
  • Keck School of Medicine: Faculty Teaching Award, 2012
  • Keck School of Medicine of USC: Master Teacher Award, 2011
  • Keck School of Medicine of USC: Outstanding Year II Teaching Award, 2011
  • Rheos Pivitol Trial : National Principal Investigator, 2008
  • Keck School of Medicine of USC: Outstanding Year II Course Award, 2008
  • Keck School of Medicine of USC: Medical Faculty Women’s Award Research Grant, 2007
  • Keck School of Medicine of USC: Outstanding Year II Teaching Award, 2007
  • Keck School of Medicine of USC: Outstanding Year II Teaching Award, 2004
  • National Institutes of Health: National Research Service Award, 1999
  • National Kidney Foundation: Volunteer/Donor Award, 1999
  • Alpha Omega Alpha: Research Fellowship Award, 1992
  • University of California, Irvine: Cum Laude, 1990
  • University of California, Irvine: Excellence in Research Award, 1990
  • University of California, Irvine: Phi Beta Kappa, 1989
  • Golden Key National Honor Society: Member, 1988

Publications

  • Acute kidney injury in patients with Cirrhosis: Acute disease quality Initiative (ADQI) and international Club of ascites (ICA) joint multidisciplinary consensus meeting J Hepatol. 2024 Mar 23. . View in PubMed
  • KRT in Patients with AKI and Cirrhosis Clin J Am Soc Nephrol. 2024 Mar 05. . View in PubMed
  • Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US J Hepatol. 2023 12; 79(6):1408-1417. . View in PubMed
  • Fluid resuscitation in patients with cirrhosis and sepsis: A multidisciplinary perspective J Hepatol. 2023 07; 79(1):240-246. . View in PubMed
  • Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup Nat Rev Nephrol. 2023 06; 19(6):401-417. . View in PubMed
  • Acute Kidney Injury in Patients with Cirrhosis N Engl J Med. 2023 02 23; 388(8):733-745. . View in PubMed
  • Management of the kidney transplant recipient in the intensive care unit Curr Opin Crit Care. 2023 12 01; 29(6):587-594. . View in PubMed
  • The Conundrum of Patients With Compensated Cirrhosis Requiring Kidney Transplantation; Kidney Alone or Simultaneous Liver Kidney Transplantation Transplantation. 2023 02 01; 107(2):429-437. . View in PubMed
  • COVID-19 and Acute Kidney Injury Crit Care Clin. 2022 Jul; 38(3):473-489. . View in PubMed
  • Coagulopathy and hemostasis management in patients undergoing liver transplantation: Defining a dynamic spectrum across phases of care Liver Transpl. 2022 10; 28(10):1651-1663. . View in PubMed
  • North American Practice-Based Recommendations for Transjugular Intrahepatic Portosystemic Shunts in Portal HypertensionClin Gastroenterol Hepatol. 2022 08; 20(8):1636-1662. e36. . View in PubMed
  • Impact of medical eligibility criteria and OPTN policy on simultaneous liver kidney allocation and utilization Clin Transplant. 2022 07; 36(7):e14700. . View in PubMed
  • Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward Am J Kidney Dis. 2022 05; 79(5):737-745. . View in PubMed
  • Race Adjustment in eGFR Equations Does Not Improve Estimation of Acute Kidney Injury Events in Patients with Cirrhosis Dig Dis Sci. 2022 04; 67(4):1399-1408. . View in PubMed
  • Role of Novel Kidney Biomarkers in Patients With Cirrhosis and After Liver Transplantation Liver Transpl. 2022 03; 28(3):466-482. . View in PubMed
  • Is Prioritization of Kidney Allografts to Combined Liver-Kidney Recipients Appropriate? PRO. Kidney360. 2022 06 30; 3(6):993-995.. View in PubMed
  • Hepatorenal Syndrome Crit Care Clin. 2021 Apr; 37(2):321-334. . View in PubMed
  • Post-Liver Transplant Acute Kidney Injury Liver Transpl. 2021 11; 27(11):1653-1664. . View in PubMed
  • Estimating Glomerular Filtration Rate in Cirrhosis Using Creatinine-Based and Cystatin C-Based Equations: Systematic Review and Meta-Analysis Liver Transpl. 2021 11; 27(11):1538-1552. . View in PubMed
  • Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative Nat Rev Nephrol. 2021 09; 17(9):605-618. . View in PubMed
  • Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases Hepatology. 2021 08; 74(2):1014-1048. . View in PubMed
  • Chronic Kidney Disease After Simultaneous Liver-Kidney Transplantation: Refining Patient Selection Liver Transpl. 2021 08; 27(8):1092-1094. . View in PubMed
  • Simultaneous heart-kidney transplant: Working together to define when one organ is not enough Am J Transplant. 2021 07; 21(7):2323-2324. . View in PubMed
  • Extrapulmonary manifestations of severe acute respiratory syndrome coronavirus-2 infection J Med Virol. 2021 05; 93(5):2645-2653. . View in PubMed
  • Acute kidney disease and cirrhosis J Hepatol. 2021 03; 74(3):500-501. . View in PubMed
  • Advances in management of hepatorenal syndrome Curr Opin Nephrol Hypertens. 2021 09 01; 30(5):501-506. . View in PubMed
  • Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study Clin Transl Gastroenterol. 2021 05 11; 12(5):e00359. . View in PubMed
  • Management of acute kidney injury associated with Covid-19: what have we learned? Curr Opin Nephrol Hypertens. 2021 11 01; 30(6):563-570.. View in PubMed
  • Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup Nat Rev Nephrol. 2020 Dec; 16(12):765. . View in PubMed
  • Sepsis-associated acute kidney injury: is COVID-19 different? Kidney Int. 2020 12; 98(6):1370-1372.. View in PubMed
  • COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup Nat Rev Nephrol. 2020 12; 16(12):747-764. . View in PubMed
  • MELD-GRAIL-Na: Glomerular Filtration Rate and Mortality on Liver-Transplant Waiting List Hepatology. 2020 05; 71(5):1766-1774. . View in PubMed
  • Community Health Care Quality Standards to Prevent Acute Kidney Injury and Its ConsequencesAm J Med. 2020 05; 133(5):552-560. e3. . View in PubMed
  • Reply to: “Lack of evidence for a continuum between hepatorenal syndrome and acute tubular necrosis” J Hepatol. 2020 03; 72(3):582-583. . View in PubMed
  • Outcomes of Liver Transplantation in Patients on Renal Replacement Therapy: Considerations for Simultaneous Liver Kidney Transplantation Versus Safety Net Transplant Direct. 2019 Oct; 5(10):e490. . View in PubMed
  • News in pathophysiology, definition and classification of hepatorenal syndrome: A step beyond the International Club of Ascites (ICA) consensus document J Hepatol. 2019 10; 71(4):811-822. . View in PubMed
  • Acute kidney injury in cirrhosis: implications for liver transplantation Curr Opin Crit Care. 2019 04; 25(2):171-178. . View in PubMed
  • A Model for Glomerular Filtration Rate Assessment in Liver Disease (GRAIL) in the Presence of Renal Dysfunction Hepatology. 2019 03; 69(3):1219-1230. . View in PubMed
  • Quality Improvement Goals for Acute Kidney Injury Clin J Am Soc Nephrol. 2019 06 07; 14(6):941-953. . View in PubMed
  • Hepatorenal Syndrome Clin J Am Soc Nephrol. 2019 05 07; 14(5):774-781. . View in PubMed
  • Author Correction: Hepatorenal syndrome Nat Rev Dis Primers. 2018 Oct 15; 4(1):33. . View in PubMed
  • Acute Kidney Injury After Liver Transplantation Transplantation. 2018 10; 102(10):1636-1649. . View in PubMed
  • Hepatorenal syndrome Nat Rev Dis Primers. 2018 09 13; 4(1):23. . View in PubMed
  • Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group J Am Heart Assoc. 2018 06 01; 7(11). . View in PubMed
  • Renal dysfunction and cirrhosis Curr Opin Crit Care. 2017 Dec; 23(6):457-462. . View in PubMed
  • Proenkephalin (PENK) as a Novel Biomarker for Kidney Function J Appl Lab Med. 2017 Nov 01; 2(3):400-412. . View in PubMed
  • Sustained Reduction of Blood Pressure With Baroreceptor Activation Therapy: Results of the 6-Year Open Follow-Up Hypertension. 2017 May; 69(5):836-843. . View in PubMed
  • Intensive care unit management: Renal replacement therapy, ventilator management, volume assessment, and optimal management of hypotension Clin Liver Dis (Hoboken). 2017 Mar; 9(3):69-72. . View in PubMed
  • Inequity in organ allocation for patients awaiting liver transplantation: Rationale for uncapping the model for end-stage liver disease J Hepatol. 2017 09; 67(3):517-525. . View in PubMed
  • What endpoints should be used for clinical studies in acute kidney injury? Intensive Care Med. 2017 06; 43(6):901-903.. View in PubMed
  • Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup Nat Rev Nephrol. 2017 04; 13(4):241-257. . View in PubMed
  • An exploratory propensity score matched comparison of second-generation and first-generation baroreflex activation therapy systems J Am Soc Hypertens. 2017 02; 11(2):81-91. . View in PubMed
  • Perioperative Renal Replacement Therapy in Liver Transplantation Int Anesthesiol Clin. 2017; 55(2):81-91. . View in PubMed
  • Corrigendum to “Management of the critically ill patients with cirrhosis: A multidisciplinary perspective” J Hepatol. 2016 May 27. . View in PubMed
  • Management of the critically ill patient with cirrhosis: A multidisciplinary perspective J Hepatol. 2016 Mar; 64(3):717-35. . View in PubMed
  • Pathogenesis of Hepatorenal Syndrome: Implications for Therapy Am J Kidney Dis. 2016 Feb; 67(2):318-28. . View in PubMed
  • Kidney biomarkers in cirrhosis J Hepatol. 2016 10; 65(4):809-824. . View in PubMed
  • Protecting the Kidney in Liver Transplant Candidates: Practice-Based Recommendations From the American Society of Transplantation Liver and Intestine Community of Practice Am J Transplant. 2016 09; 16(9):2516-31. . View in PubMed
  • Management of Acute-on-Chronic Liver Failure Semin Liver Dis. 2016 05; 36(2):141-52. . View in PubMed
  • Acute Kidney Injury in Cirrhosis Crit Care Clin. 2015 Oct; 31(4):737-50. . View in PubMed
  • Hepatorenal Disorders Chest. 2015 Aug; 148(2):550-558. . View in PubMed
  • Renal Denervation in Heart Failure Curr Hypertens Rep. 2015 Mar; 17(3):17. . View in PubMed
  • Resistant hypertension: medical management and alternative therapies Cardiol Clin. 2015 Feb; 33(1):75-87. . View in PubMed
  • Intraoperative hemodialysis during liver transplantation: a decade of experience Liver Transpl. 2014 Jul; 20(7):756-64. . View in PubMed
  • Glomerular filtration rate equations for liver-kidney transplantation in patients with cirrhosis: validation of current recommendations Hepatology. 2014 Apr; 59(4):1514-21. . View in PubMed
  • Simultaneous liver-kidney transplantation summit: current state and future directions Am J Transplant. 2012 Nov; 12(11):2901-8. . View in PubMed
  • Simultaneous liver-kidney transplantation: a survey of US transplant centers Am J Transplant. 2012 Nov; 12(11):3119-27. . View in PubMed
  • Liver Transpl. 2012 Oct; 18(10):1138-9. . View in PubMed
  • Impact of the etiology of acute kidney injury on outcomes following liver transplantation: acute tubular necrosis versus hepatorenal syndrome Liver Transpl. 2012 May; 18(5):539-48. . View in PubMed
  • Baroreflex activation therapy provides durable benefit in patients with resistant hypertension: results of long-term follow-up in the Rheos Pivotal Trial J Am Soc Hypertens. 2012 Mar-Apr; 6(2):152-8. . View in PubMed
  • Hepatorenal syndrome: the 8th International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group Crit Care. 2012 Feb 09; 16(1):R23. . View in PubMed
  • Medical management of hepatorenal syndrome Nephrol Dial Transplant. 2012 Jan; 27(1):34-41. . View in PubMed
  • Baroreflex activation therapy lowers blood pressure in patients with resistant hypertension: results from the double-blind, randomized, placebo-controlled rheos pivotal trial J Am Coll Cardiol. 2011 Aug 09; 58(7):765-73. . View in PubMed
  • Working Party proposal for a revised classification system of renal dysfunction in patients with cirrhosis Gut. 2011 May; 60(5):702-9. . View in PubMed
  • Blood-management programs: a clinical and administrative model with program implementation strategies Perm J. 2009; 13(1):18-28. . View in PubMed
  • An overview of drug-induced acute kidney injury Crit Care Med. 2008 Apr; 36(4 Suppl):S216-23. . View in PubMed
  • Fluids for prevention and management of acute kidney injury Int J Artif Organs. 2008 Feb; 31(2):96-110. . View in PubMed
  • Are 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors renoprotective? J Am Soc Nephrol. 2005 Mar; 16 Suppl 1:S11-7.. View in PubMed
  • Antihypertensive drugs and the kidney Curr Cardiol Rep. 2004 Nov; 6(6):403-8. . View in PubMed
  • Cellular and molecular mediators in common pathway mechanisms of chronic renal disease progression Curr Opin Nephrol Hypertens. 2000 Jul; 9(4):323-31. . View in PubMed
  • Glomerular normalcy and pathosis: a “fin de millénaire” perspective J Nephrol. 1999 Jul-Aug; 12 Suppl 2:S16-28. . View in PubMed
  • Angiotensin receptor blockers in chronic renal disease: the promise of a bright clinical future J Am Soc Nephrol. 1999 Apr; 10 Suppl 12:S283-6. . View in PubMed