Nathanael Heckmann, MD

Associate Professor of Orthopaedic Surgery (Clinical Scholar)

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Overview

Dr. Nathanael Heckmann is an Associate Professor of Orthopaedic Surgery and a Clinical Scholar at the Keck School of Medicine of USC, where he also serves as Director of Arthroplasty Research in the Department of Orthopaedic Surgery.

His surgical practice focuses on treating degenerative diseases of the hip and knee, such as osteoarthritis, rheumatoid arthritis, and post-traumatic arthritis. Dr. Heckmann performs a range of advanced procedures, including minimally invasive total hip and knee replacement, partial knee replacement, surgery to fix infected and failed hip and knee replacements, and robotic-assisted and computer-navigated arthroplasty.

Dr. Heckmann’s research focuses on clinical outcomes following hip and knee arthroplasty. His specific areas of inquiry include the diagnosis, treatment, and management of infected hip and knee replacements; perioperative patient optimization, including preoperative risk stratification and postoperative risk mitigation strategies; and exploring the relationship between the human gut microbiome and surgical outcomes.

He holds leadership positions in the American Academy of Orthopaedic Surgeons, the American Association of Hip and Knee Surgeons, and the Western Orthopaedic Association. He is also a member of The Hip Society and The Knee Society. Dr. Heckmann has authored 18 textbook chapters and over 240 peer-reviewed publications. His research has been presented over 350 times at national and international conferences.

Awards

  • Super Doctors: Rising Star, 2021
     – 2025
  • Pasadena Magazine: Top Doctor, 2021
     – 2025
  • Southern California Top Doctor & Rising Star, 2021
     – 2025
  • Los Angeles Magazine: Top Doctor, 2021
     – 2025
  • Western Orthopaedic Association: Young Investigator Award, 2023
     – 2025

Media

Publications

  • Preoperative Inflammatory Biomarkers Identify Dexamethasone Responders in Cardiac Surgery: A Post Hoc Analysis of the DECS Trial. Anesth Analg. 2026 Sep 24.. View in PubMed
  • Sobering Outcomes after Two-Stage Revision for Periprosthetic Joint Infection Among Patients Who Have Revision Total Knee Arthroplasty Components. J Arthroplasty. 2026 Sep 19.. View in PubMed
  • Quantifying the Age-Dependent Risk of Periprosthetic Femoral Fracture Following Cementless Total Hip Arthroplasty: An Analysis using Age as a Continuous Variable. J Arthroplasty. 2026 Sep 15.. View in PubMed
  • Increased Polymicrobial Infection Rates and Associated Mortality in Patients With Chronic Gastrointestinal Disease Undergoing Antibiotic Spacer Placement for Periprosthetic Joint Infection. Arthroplast Today. 2026 Oct; 41:102140.. View in PubMed
  • Cirrhosis is associated with an increased risk of periprosthetic joint infection following total joint arthroplasty. J Clin Orthop Trauma. 2026 Nov; 82:103607.. View in PubMed
  • Response to the Letter To The Editor Risk of Total Hip Arthroplasty After Sacroiliac Joint Fusion Surgery: A Nationwide Study. Global Spine J. 2026 Aug 19; 21925682261480678.. View in PubMed
  • Microbiologic Patterns Found in Periprosthetic Joint Infections Following Total Joint Arthroplasty Differ Across Race and Sex. Arthroplast Today. 2026 Aug; 40:102116.. View in PubMed
  • Tranexamic Acid Use Is Associated With Lower Rates of Transfusion in Patients Undergoing Revision Total Hip Arthroplasty for Periprosthetic Joint Infection. Arthroplast Today. 2026 Aug; 40:102106.. View in PubMed
  • High-Volume Hospitals Are Associated With Lower Rates of Mortality Following Revision Arthroplasty for Periprosthetic Joint Infection. Arthroplast Today. 2026 Aug; 40:102111.. View in PubMed
  • Heterotopic Ossification Following Total Hip Arthroplasty: A Contemporary Approach-Based Review for Surgeons Utilizing the Direct Anterior Approach. Arthroplast Today. 2026 Aug; 40:102110.. View in PubMed