Keck School Faculty

Neil Kaplowitz, MD
Neil Kaplowitz, MD
Professor of Medicine;USC Associates/Thomas H. Brem Chair in Medicine;Chief, Division of Gastroenterology and Liver Diseases
HMR 101 Health Sciences Campus Los Angeles
Dr. Kaplowtiz's research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.

American Liver Foundation: Distinguished Scientific Achievement Award, 2008

Western Society of Clinical Investigation: Mayo Soley Award, 2007

Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006

American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006

American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005

American Liver Foundation: Greater Los Angeles Medical Honoree, 2000

New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994

Department of Veterans Affairs : William S. Middleton Award, 1993

NIH: Merit Award, 1992

Association of American Physicians: Member, 1988

Western Gastroenterology : Research Prize, 1986

Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy Br J Pharmacol. 2018 Jul 19. . View in PubMed

Herb-Induced Liver Injury: A Global Concern Chin J Integr Med. 2018 May 03. . View in PubMed

New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases Hepatology. 2018 May; 67(5):2013-2024. . View in PubMed

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading Redox Biol. 2018 Apr; 14:164-177. . View in PubMed

Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice J Hepatol. 2018 Mar 08. . View in PubMed

Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy Hepatol Commun. 2017 Dec; 1(10):1070-1084. . View in PubMed

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis Int J Mol Sci. 2017 May 09; 18(5). . View in PubMed

Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria Antioxid Redox Signal. 2017 Feb 10; 26(5):207-220. . View in PubMed

Heparan sulfate promotes recovery from acute liver injury: Inhibition of progressive cell death or enhanced regeneration? Hepatology. 2017 11; 66(5):1381-1383.. View in PubMed

Death and liver transplantation within 2 years of onset of drug-induced liver injury Hepatology. 2017 10; 66(4):1275-1285. . View in PubMed

Protective role of p53 in acetaminophen hepatotoxicity Free Radic Biol Med. 2017 05; 106:111-117. . View in PubMed

Mitochondrial remodeling in the liver following chronic alcohol feeding to rats Free Radic Biol Med. 2017 01; 102:100-110. . View in PubMed

The role of MAP2 kinases and p38 kinase in acute murine liver injury models Cell Death Dis. 2017 06 29; 8(6):e2903. . View in PubMed

Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2862-E2871. . View in PubMed

Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments PLoS Comput Biol. 2016 Dec; 12(12):e1005253. . View in PubMed

A murder mystery in the liver: who done it and how? J Clin Invest. 2016 Nov 01; 126(11):4068-4071.. View in PubMed

Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury J Hepatol. 2016 Sep; 65(3):532-42. . View in PubMed

HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer Clin Cancer Res. 2016 Mar 15; 22(6):1371-7. . View in PubMed

Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications Liver Int. 2016 Feb; 36(2):158-65. . View in PubMed

The many faces of RIPK3: What about NASH? Hepatology. 2016 11; 64(5):1411-1413.. View in PubMed

Reply Hepatology. 2016 07; 64(1):308-9. . View in PubMed

Reply Hepatology. 2016 07; 64(1):312-3. . View in PubMed

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src Hepatology. 2016 06; 63(6):1987-2003. . View in PubMed

Questions and controversies: the role of necroptosis in liver disease Cell Death Discov. 2016; 2:16089. . View in PubMed

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-? B. J Immunol. 2016 10 15; 197(8):3120-3129.. View in PubMed

Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy Sci Rep. 2015 Dec 11; 5:18017. . View in PubMed

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis Hepatology. 2015 Dec; 62(6):1847-57. . View in PubMed

Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database Drug Saf. 2015 Nov; 38(11):1103-13. . View in PubMed

Inhibition of immune tolerance unmasks drug-induced allergic hepatitis Hepatology. 2015 Aug; 62(2):346-8. . View in PubMed

Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: a systematic review and meta-analysis of clinical trials in advanced cancer patients Eur J Cancer. 2015 Jul; 51(10):1293-302. . View in PubMed

Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity J Hepatol. 2015 Jul; 63(1):5-7. . View in PubMed

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity J Hepatol. 2015 Jun; 62(6):1367-74. . View in PubMed

Reply: To PMID 24704526 Gastroenterology. 2015 Feb; 148(2):452-3. . View in PubMed

Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways J Hepatol. 2015 Jan; 62(1):219-33. . View in PubMed

Reply: To PMID 24704526 Gastroenterology. 2014 Dec; 147(6):1442. . View in PubMed

Liver safety assessment in special populations (hepatitis B, C, and oncology trials) Drug Saf. 2014 Nov; 37 Suppl 1:S57-62. . View in PubMed

The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future Drug Saf. 2014 Nov; 37 Suppl 1:S1-7. . View in PubMed

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis J Hepatol. 2014 Nov; 61(5):1126-34. . View in PubMed

Cell death and cell death responses in liver disease: mechanisms and clinical relevanceGastroenterology. 2014 Oct; 147(4):765-783. e4. . View in PubMed

Use of Hy's law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injuryGastroenterology. 2014 Jul; 147(1):109-118. e5. . View in PubMed

Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway Chem Res Toxicol. 2014 May 19; 27(5):794-804. . View in PubMed

Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways Hepatology. 2014 Apr; 59(4):1543-1554. . View in PubMed

Mechanisms of drug-induced liver injury Clin Liver Dis. 2013 Nov; 17(4):507-18, vii. . View in PubMed

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading J Hepatol. 2013 Oct; 59(4):805-13. . View in PubMed

Role of Mitochondria in Alcoholic Liver Disease Curr Pathobiol Rep. 2013 Sep 01; 1(3):159-168. . View in PubMed

Avoiding idiosyncratic DILI: two is better than one Hepatology. 2013 Jul; 58(1):15-7. . View in PubMed

Mitochondrial glutathione: features, regulation and role in disease Biochim Biophys Acta. 2013 May; 1830(5):3317-28. . View in PubMed

Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. . View in PubMed

Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations J Biol Chem. 2012 Dec 07; 287(50):42165-79. . View in PubMed

Current challenges and controversies in drug-induced liver injury Drug Saf. 2012 Dec 01; 35(12):1099-117. . View in PubMed

Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling J Chromatogr A. 2012 Oct 12; 1259:128-37. . View in PubMed

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis J Hepatol. 2012 Oct; 57(4):852-9. . View in PubMed

Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice Hepatology. 2012 Jul; 56(1):130-9. . View in PubMed

Dealing with stress Hepatology. 2012 Jan; 55(1):3-13. . View in PubMed

c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice J Biol Chem. 2011 Oct 07; 286(40):35071-8. . View in PubMed

Differential effect of gender on hepatic fat Pediatr Radiol. 2011 Sep; 41(9):1146-53. . View in PubMed

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice Hepatology. 2011 Jul; 54(1):229-39. . View in PubMed

Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab Pharmacogenet Genomics. 2011 Jul; 21(7):365-74. . View in PubMed

Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells J Biol Chem. 2011 Jun 24; 286(25):22047-54. . View in PubMed

The contribution of endoplasmic reticulum stress to liver diseases Hepatology. 2011 May; 53(5):1752-63. . View in PubMed

Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis J Proteome Res. 2011 Feb 04; 10(2):705-13. . View in PubMed

Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates J Biol Chem. 2010 Dec 17; 285(51):39646-54. . View in PubMed

Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria Mol Interv. 2010 Apr; 10(2):98-111. . View in PubMed

Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1 J Biol Chem. 2010 Mar 12; 285(11):8244-55. . View in PubMed

Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats Hepatology. 2010 Mar; 51(3):796-805. . View in PubMed

Signal transduction pathways involved in drug-induced liver injury Handb Exp Pharmacol. 2010; (196):267-310. . View in PubMed

Redox regulation of tumor necrosis factor signaling Antioxid Redox Signal. 2009 Sep; 11(9):2245-63. . View in PubMed

Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex Hepatology. 2009 Jun; 49(6):2001-9. . View in PubMed

Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease Am J Respir Crit Care Med. 2009 May 01; 179(9):835-42. . View in PubMed

Glutathione in liver diseases and hepatotoxicity Mol Aspects Med. 2009 Feb-Apr; 30(1-2):29-41. . View in PubMed

How to protect against acetaminophen: don't ask for JUNK Gastroenterology. 2008 Oct; 135(4):1047-51. . View in PubMed

Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates Gastroenterology. 2008 Oct; 135(4):1168-75. . View in PubMed

Clinical risk factors for portopulmonary hypertension Hepatology. 2008 Jul; 48(1):196-203. . View in PubMed

Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes Am J Physiol Cell Physiol. 2008 Jul; 295(1):C50-63. . View in PubMed

Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. . View in PubMed

Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury J Biol Chem. 2008 May 16; 283(20):13565-77. . View in PubMed

Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes Hepatology. 2007 Nov; 46(5):1586-96. . View in PubMed

Endoplasmic reticulum stress and liver injury Semin Liver Dis. 2007 Nov; 27(4):367-77. . View in PubMed

Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms J Biol Chem. 2007 Oct 05; 282(40):29470-81. . View in PubMed

Mechanisms of drug-induced liver disease Clin Liver Dis. 2007 Aug; 11(3):459-75, v. . View in PubMed

Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium Am J Clin Nutr. 2007 Jul; 86(1):14-24. . View in PubMed

Drug-induced liver injury Drug Saf. 2007; 30(4):277-94. . View in PubMed

Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry Hepatology. 2006 Dec; 44(6):1581-8. . View in PubMed

Current concepts and controversies in the treatment of alcoholic hepatitis World J Gastroenterol. 2006 Nov 21; 12(43):6909-21. . View in PubMed

Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model J Hepatol. 2006 Nov; 45(5):717-24. . View in PubMed

Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S7-9. . View in PubMed

Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis Free Radic Biol Med. 2006 Aug 15; 41(4):627-39. . View in PubMed

ER stress: can the liver cope? J Hepatol. 2006 Aug; 45(2):321-33.. View in PubMed

Role of innate immunity in acetaminophen-induced hepatotoxicity Expert Opin Drug Metab Toxicol. 2006 Aug; 2(4):493-503. . View in PubMed

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial JAMA. 2006 Jul 05; 296(1):87-93. . View in PubMed

Mechanisms of liver injuryIII. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G1-7. . View in PubMed

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity Gastroenterology. 2006 Jul; 131(1):165-78. . View in PubMed

Neutrophil depletion protects against murine acetaminophen hepatotoxicity Hepatology. 2006 Jun; 43(6):1220-30. . View in PubMed

Drug hepatotoxicity Clin Liver Dis. 2006 May; 10(2):207-17, vii. . View in PubMed

Rules and laws of drug hepatotoxicity Pharmacoepidemiol Drug Saf. 2006 Apr; 15(4):231-3. . View in PubMed

Liver biology and pathobiology Hepatology. 2006 Feb; 43(2 Suppl 1):S235-8. . View in PubMed

Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding Alcohol Clin Exp Res. 2005 Aug; 29(8):1496-503. . View in PubMed

Idiosyncratic drug hepatotoxicity Nat Rev Drug Discov. 2005 Jun; 4(6):489-99. . View in PubMed

Hepatic mitochondrial glutathione: transport and role in disease and toxicity Toxicol Appl Pharmacol. 2005 May 01; 204(3):263-73. . View in PubMed

Serum alanine aminotransferase in skeletal muscle diseases Hepatology. 2005 Feb; 41(2):380-2. . View in PubMed

Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis Am J Gastroenterol. 2005 Feb; 100(2):295-8. . View in PubMed

Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity Gastroenterology. 2004 Dec; 127(6):1760-74. . View in PubMed

Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid J Hepatol. 2004 Dec; 41(6):1062-4. . View in PubMed

Statin-induced hepatotoxicity Gastroenterology. 2004 Oct; 127(4):1278; author reply 1278-9. . View in PubMed

Liver injury associated with the beta-interferons for MS Neurology. 2004 Sep 28; 63(6):1142-3; author reply 1142-3. . View in PubMed

Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury Hepatology. 2004 Aug; 40(2):442-51. . View in PubMed

Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology. 2004 Jul; 40(1):23-6.. View in PubMed

Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury World J Gastroenterol. 2004 Jun 15; 10(12):1699-708. . View in PubMed

Clinical perspectives on xenobiotic-induced hepatotoxicity Drug Metab Rev. 2004 May; 36(2):301-12. . View in PubMed

Drug-induced liver injury Clin Infect Dis. 2004 Mar 01; 38 Suppl 2:S44-8. . View in PubMed

Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress Biochem Pharmacol. 2004 Feb 01; 67(3):439-51. . View in PubMed

Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1335-44. . View in PubMed

Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria Mol Pharmacol. 2003 Nov; 64(5):1136-44. . View in PubMed

Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion Hepatology. 2003 Sep; 38(3):692-702. . View in PubMed

Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes Hepatology. 2003 Jun; 37(6):1425-34. . View in PubMed

Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice Gastroenterology. 2003 May; 124(5):1488-99. . View in PubMed

Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress Gastroenterology. 2003 Mar; 124(3):708-24. . View in PubMed

2003 Jan 21; 138(2):159-60; author reply 159-60. . View in PubMed

Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance Drug Saf. 2003; 26(11):815-27. . View in PubMed

Immune-mediated drug-induced liver disease Clin Liver Dis. 2002 Aug; 6(3):755-74. . View in PubMed

Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes Hepatology. 2002 Jul; 36(1):55-64. . View in PubMed

Mechanism of staurosporine-induced apoptosis in murine hepatocytes Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G825-34. . View in PubMed

The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane Mol Pharmacol. 2002 Feb; 61(2):425-35. . View in PubMed

Biochemical and cellular mechanisms of toxic liver injury Semin Liver Dis. 2002; 22(2):137-44. . View in PubMed

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