Neil Kaplowitz, MD

Professor of Medicine

USC Associates/Thomas H. Brem Chair in Medicine

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Overview

Dr. Kaplowitz’s research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.

Awards

  • American Liver Foundation: Distinguished Scientific Achievement Award, 2008
  • Western Society of Clinical Investigation: Mayo Soley Award, 2007
  • American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006
  • Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006
  • American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005
  • American Liver Foundation: Greater Los Angeles Medical Honoree, 2000
  • New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994
  • Department of Veterans Affairs : William S. Middleton Award, 1993
  • NIH: Merit Award, 1992
  • Association of American Physicians: Member, 1988
  • Western Gastroenterology : Research Prize, 1986

Publications

  • Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolismCell Host Microbe. 2024 Jan 10; 32(1):48-62. e9. . View in PubMed
  • Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries Liver Int. 2023 Aug; 43(8):1749-1760. . View in PubMed
  • Antioxid Redox Signal. 2023 06; 38(16-18):1071-1081. . View in PubMed
  • Endoplasmic reticulum stress in liver diseases Hepatology. 2023 02 01; 77(2):619-639. . View in PubMed
  • Introducing Laurie DeLeve, MD. , Ph. D. , Our 2022 AASLD President. Hepatology. 2022 03; 75(3):514-517. . View in PubMed
  • The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice Acta Pharm Sin B. 2022 Jan; 12(1):182-196. . View in PubMed
  • Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-ß Front Physiol. 2022; 13:930402. . View in PubMed
  • Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis Hepatology. 2021 12; 74(6):3127-3145. . View in PubMed
  • Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity Hepatology. 2021 12; 74(6):3486-3496. . View in PubMed
  • Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry J Hepatol. 2021 07; 75(1):86-97. . View in PubMed
  • Alcohol, Fasting, and Therapeutic Dosing of Acetaminophen: A Perfect Storm Hepatology. 2021 05; 73(5):1634-1636. . View in PubMed
  • Clinical Characteristics and Outcome of Drug-Induced Liver Injury in the Older Patients: From the Young-Old to the Oldest-Old Clin Pharmacol Ther. 2021 04; 109(4):1147-1158. . View in PubMed
  • IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis Clin Gastroenterol Hepatol. 2021 02; 19(2):397-399. . View in PubMed
  • REPLY Hepatol Commun. 2020 Nov; 4(11):1725. . View in PubMed
  • Markedly Elevated Serum Aspartate Aminotransferase to Alanine Aminotransferase Ratio: A Clue to Hepatic Neoplasia Hepatol Commun. 2020 Jul; 4(7):1099-1101. . View in PubMed
  • Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense Hepatology. 2020 05; 71(5):1530-1532. . View in PubMed
  • Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice Am J Pathol. 2020 01; 190(1):57-67. . View in PubMed
  • Gut Microbiota and Liver Injury (I)-Acute Liver Injury Adv Exp Med Biol. 2020; 1238:23-37. . View in PubMed
  • Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure Gastroenterology. 2019 08; 157(2):552-568. . View in PubMed
  • Drug-induced liver injury Nat Rev Dis Primers. 2019 08 22; 5(1):58. . View in PubMed
  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury J Clin Invest. 2019 12 02; 129(12):5278-5293. . View in PubMed
  • The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects Int J Mol Sci. 2018 Nov 20; 19(11). . View in PubMed
  • Niacin-Induced Anicteric Microvesicular Steatotic Acute Liver Failure Hepatol Commun. 2018 Nov; 2(11):1293-1298. . View in PubMed
  • Herb-Induced Liver Injury: A Global Concern Chin J Integr Med. 2018 Sep; 24(9):643-644. . View in PubMed
  • Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy Br J Pharmacol. 2018 10; 175(19):3747-3757. . View in PubMed
  • Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice J Hepatol. 2018 07; 69(1):51-59. . View in PubMed
  • New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases Hepatology. 2018 05; 67(5):2013-2024. . View in PubMed
  • The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading Redox Biol. 2018 04; 14:164-177. . View in PubMed
  • Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis Int J Mol Sci. 2017 May 09; 18(5). . View in PubMed
  • Prediction of histologic alcoholic hepatitis based on clinical presentation limits the need for liver biopsy Hepatol Commun. 2017 12; 1(10):1070-1084. . View in PubMed
  • Heparan sulfate promotes recovery from acute liver injury: Inhibition of progressive cell death or enhanced regeneration? Hepatology. 2017 11; 66(5):1381-1383.. View in PubMed
  • Death and liver transplantation within 2 years of onset of drug-induced liver injury Hepatology. 2017 10; 66(4):1275-1285. . View in PubMed
  • Protective role of p53 in acetaminophen hepatotoxicity Free Radic Biol Med. 2017 05; 106:111-117. . View in PubMed
  • Mitochondrial remodeling in the liver following chronic alcohol feeding to rats Free Radic Biol Med. 2017 01; 102:100-110. . View in PubMed
  • The role of MAP2 kinases and p38 kinase in acute murine liver injury models Cell Death Dis. 2017 06 29; 8(6):e2903. . View in PubMed
  • Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria Antioxid Redox Signal. 2017 02 10; 26(5):207-220. . View in PubMed
  • Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2862-E2871. . View in PubMed
  • HLA-B*57:01 Confers Susceptibility to Pazopanib-Associated Liver Injury in Patients with Cancer Clin Cancer Res. 2016 Mar 15; 22(6):1371-7. . View in PubMed
  • Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications Liver Int. 2016 Feb; 36(2):158-65. . View in PubMed
  • Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments PLoS Comput Biol. 2016 12; 12(12):e1005253. . View in PubMed
  • The many faces of RIPK3: What about NASH? Hepatology. 2016 11; 64(5):1411-1413.. View in PubMed
  • Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury J Hepatol. 2016 09; 65(3):532-42. . View in PubMed
  • Reply Hepatology. 2016 07; 64(1):312-3. . View in PubMed
  • Reply Hepatology. 2016 07; 64(1):308-9. . View in PubMed
  • Is Sensitivity the Key Measure to Predict Acute Liver Failure in Drug-Induced Liver Injury Patients? Clin Gastroenterol Hepatol. 2016 06; 14(6):918.. View in PubMed
  • c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src Hepatology. 2016 06; 63(6):1987-2003. . View in PubMed
  • A murder mystery in the liver: who done it and how? J Clin Invest. 2016 11 01; 126(11):4068-4071.. View in PubMed
  • Questions and controversies: the role of necroptosis in liver disease Cell Death Discov. 2016; 2:16089. . View in PubMed
  • Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-? B. J Immunol. 2016 10 15; 197(8):3120-3129.. View in PubMed
  • Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy Sci Rep. 2015 Dec 11; 5:18017. . View in PubMed
  • Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis Hepatology. 2015 Dec; 62(6):1847-57. . View in PubMed
  • Alcoholic foamy degeneration and alcoholic fatty liver with jaundice: Often overlooked causes of jaundice and hepatic decompensation that can mimic alcoholic hepatitis Clin Liver Dis (Hoboken). 2015 Dec; 6(6):145-148. . View in PubMed
  • Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database Drug Saf. 2015 Nov; 38(11):1103-13. . View in PubMed
  • Inhibition of immune tolerance unmasks drug-induced allergic hepatitis Hepatology. 2015 Aug; 62(2):346-8. . View in PubMed
  • Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: a systematic review and meta-analysis of clinical trials in advanced cancer patients Eur J Cancer. 2015 Jul; 51(10):1293-302. . View in PubMed
  • Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity J Hepatol. 2015 Jul; 63(1):5-7. . View in PubMed
  • Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity J Hepatol. 2015 Jun; 62(6):1367-74. . View in PubMed
  • Reply: To PMID 24704526 Gastroenterology. 2015 Feb; 148(2):452-3. . View in PubMed
  • Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways J Hepatol. 2015 Jan; 62(1):219-33. . View in PubMed
  • Reply: To PMID 24704526 Gastroenterology. 2014 Dec; 147(6):1442. . View in PubMed
  • In vitro assays of mitochondrial function/dysfunction Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. . View in PubMed
  • Liver safety assessment in special populations (hepatitis B, C, and oncology trials) Drug Saf. 2014 Nov; 37 Suppl 1:S57-62. . View in PubMed
  • ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis J Hepatol. 2014 Nov; 61(5):1126-34. . View in PubMed
  • The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future Drug Saf. 2014 Nov; 37 Suppl 1:S1-7. . View in PubMed
  • Cell death and cell death responses in liver disease: mechanisms and clinical relevanceGastroenterology. 2014 Oct; 147(4):765-783. e4. . View in PubMed
  • Use of Hy’s law and a new composite algorithm to predict acute liver failure in patients with drug-induced liver injuryGastroenterology. 2014 Jul; 147(1):109-118. e5. . View in PubMed
  • Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway Chem Res Toxicol. 2014 May 19; 27(5):794-804. . View in PubMed
  • Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways Hepatology. 2014 Apr; 59(4):1543-1554. . View in PubMed
  • JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death Cell Death Dis. 2014 Jan 09; 5:e989. . View in PubMed
  • Mechanisms of drug-induced liver injury Clin Liver Dis. 2013 Nov; 17(4):507-18vii. . View in PubMed
  • ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading J Hepatol. 2013 Oct; 59(4):805-13. . View in PubMed
  • Role of Mitochondria in Alcoholic Liver Disease Curr Pathobiol Rep. 2013 Sep 01; 1(3):159-168. . View in PubMed
  • Avoiding idiosyncratic DILI: two is better than one Hepatology. 2013 Jul; 58(1):15-7. . View in PubMed
  • Mitochondrial glutathione: features, regulation and role in disease Biochim Biophys Acta. 2013 May; 1830(5):3317-28. . View in PubMed
  • Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. . View in PubMed
  • Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations J Biol Chem. 2012 Dec 07; 287(50):42165-79. . View in PubMed
  • Current challenges and controversies in drug-induced liver injury Drug Saf. 2012 Dec 01; 35(12):1099-117. . View in PubMed
  • Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography-mass spectrometry based metabolite profiling J Chromatogr A. 2012 Oct 12; 1259:128-37. . View in PubMed
  • Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis J Hepatol. 2012 Oct; 57(4):852-9. . View in PubMed
  • Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice Hepatology. 2012 Jul; 56(1):130-9. . View in PubMed
  • Dealing with stress Hepatology. 2012 Jan; 55(1):3-13. . View in PubMed
  • c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice J Biol Chem. 2011 Oct 07; 286(40):35071-8. . View in PubMed
  • Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis J Hepatol. 2011 Oct; 55(4):820-7. . View in PubMed
  • Differential effect of gender on hepatic fat Pediatr Radiol. 2011 Sep; 41(9):1146-53. . View in PubMed
  • Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice Hepatology. 2011 Jul; 54(1):229-39. . View in PubMed
  • Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab Pharmacogenet Genomics. 2011 Jul; 21(7):365-74. . View in PubMed
  • Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells J Biol Chem. 2011 Jun 24; 286(25):22047-54. . View in PubMed
  • Case definition and phenotype standardization in drug-induced liver injury Clin Pharmacol Ther. 2011 Jun; 89(6):806-15. . View in PubMed
  • The contribution of endoplasmic reticulum stress to liver diseases Hepatology. 2011 May; 53(5):1752-63. . View in PubMed
  • Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis J Proteome Res. 2011 Feb 04; 10(2):705-13. . View in PubMed
  • Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates J Biol Chem. 2010 Dec 17; 285(51):39646-54. . View in PubMed
  • Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria Mol Interv. 2010 Apr; 10(2):98-111. . View in PubMed
  • Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1 J Biol Chem. 2010 Mar 12; 285(11):8244-55. . View in PubMed
  • Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats Hepatology. 2010 Mar; 51(3):796-805. . View in PubMed
  • Signal transduction pathways involved in drug-induced liver injury Handb Exp Pharmacol. 2010; (196):267-310. . View in PubMed
  • Diagnosis, management and prevention of drug-induced liver injury Gut. 2009 Nov; 58(11):1555-64. . View in PubMed
  • Redox regulation of tumor necrosis factor signaling Antioxid Redox Signal. 2009 Sep; 11(9):2245-63. . View in PubMed
  • Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex Hepatology. 2009 Jun; 49(6):2001-9. . View in PubMed
  • Genetic risk factors for portopulmonary hypertension in patients with advanced liver disease Am J Respir Crit Care Med. 2009 May 01; 179(9):835-42. . View in PubMed
  • Glutathione in liver diseases and hepatotoxicity Mol Aspects Med. 2009 Feb-Apr; 30(1-2):29-41. . View in PubMed
  • Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates Gastroenterology. 2008 Oct; 135(4):1168-75. . View in PubMed
  • How to protect against acetaminophen: don’t ask for JUNK Gastroenterology. 2008 Oct; 135(4):1047-51. . View in PubMed
  • Clinical risk factors for portopulmonary hypertension Hepatology. 2008 Jul; 48(1):196-203. . View in PubMed
  • Regulation of H(2)O(2)-induced necrosis by PKC and AMP-activated kinase signaling in primary cultured hepatocytes Am J Physiol Cell Physiol. 2008 Jul; 295(1):C50-63. . View in PubMed
  • Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. . View in PubMed
  • Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury J Biol Chem. 2008 May 16; 283(20):13565-77. . View in PubMed
  • Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes Hepatology. 2007 Nov; 46(5):1586-96. . View in PubMed
  • Endoplasmic reticulum stress and liver injury Semin Liver Dis. 2007 Nov; 27(4):367-77. . View in PubMed
  • Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms J Biol Chem. 2007 Oct 05; 282(40):29470-81. . View in PubMed
  • Mechanisms of drug-induced liver disease Clin Liver Dis. 2007 Aug; 11(3):459-75v. . View in PubMed
  • Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium Am J Clin Nutr. 2007 Jul; 86(1):14-24. . View in PubMed
  • Drug-induced liver injury Drug Saf. 2007; 30(4):277-94. . View in PubMed
  • Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry Hepatology. 2006 Dec; 44(6):1581-8. . View in PubMed
  • Current concepts and controversies in the treatment of alcoholic hepatitis World J Gastroenterol. 2006 Nov 21; 12(43):6909-21. . View in PubMed
  • Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model J Hepatol. 2006 Nov; 45(5):717-24. . View in PubMed
  • Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S7-9. . View in PubMed
  • Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis Free Radic Biol Med. 2006 Aug 15; 41(4):627-39. . View in PubMed
  • Role of innate immunity in acetaminophen-induced hepatotoxicity Expert Opin Drug Metab Toxicol. 2006 Aug; 2(4):493-503. . View in PubMed
  • ER stress: can the liver cope? J Hepatol. 2006 Aug; 45(2):321-33.. View in PubMed
  • Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial JAMA. 2006 Jul 05; 296(1):87-93. . View in PubMed
  • Mechanisms of liver injuryIII. Role of glutathione redox status in liver injury. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G1-7. . View in PubMed
  • c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity Gastroenterology. 2006 Jul; 131(1):165-78. . View in PubMed
  • Neutrophil depletion protects against murine acetaminophen hepatotoxicity Hepatology. 2006 Jun; 43(6):1220-30. . View in PubMed
  • Drug hepatotoxicity Clin Liver Dis. 2006 May; 10(2):207-17vii. . View in PubMed
  • Rules and laws of drug hepatotoxicity Pharmacoepidemiol Drug Saf. 2006 Apr; 15(4):231-3. . View in PubMed
  • Liver biology and pathobiology Hepatology. 2006 Feb; 43(2 Suppl 1):S235-8. . View in PubMed
  • Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding Alcohol Clin Exp Res. 2005 Aug; 29(8):1496-503. . View in PubMed
  • Idiosyncratic drug hepatotoxicity Nat Rev Drug Discov. 2005 Jun; 4(6):489-99. . View in PubMed
  • Hepatic mitochondrial glutathione: transport and role in disease and toxicity Toxicol Appl Pharmacol. 2005 May 01; 204(3):263-73. . View in PubMed
  • Serum alanine aminotransferase in skeletal muscle diseases Hepatology. 2005 Feb; 41(2):380-2. . View in PubMed
  • Marked elevation in serum transaminases: an atypical presentation of choledocholithiasis Am J Gastroenterol. 2005 Feb; 100(2):295-8. . View in PubMed
  • Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity Gastroenterology. 2004 Dec; 127(6):1760-74. . View in PubMed
  • Severe hepatotoxicity associated with the use of weight loss diet supplements containing ma huang or usnic acid J Hepatol. 2004 Dec; 41(6):1062-4. . View in PubMed
  • Statin-induced hepatotoxicity Gastroenterology. 2004 Oct; 127(4):1278; author reply 1278-9. . View in PubMed
  • Liver injury associated with the beta-interferons for MS Neurology. 2004 Sep 28; 63(6):1142-3; author reply 1142-3. . View in PubMed
  • Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury Hepatology. 2004 Aug; 40(2):442-51. . View in PubMed
  • Acetaminophen hepatoxicity: what do we know, what don’t we know, and what do we do next? Hepatology. 2004 Jul; 40(1):23-6.. View in PubMed
  • Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury World J Gastroenterol. 2004 Jun 15; 10(12):1699-708. . View in PubMed
  • Clinical perspectives on xenobiotic-induced hepatotoxicity Drug Metab Rev. 2004 May; 36(2):301-12. . View in PubMed
  • Drug-induced liver injury Clin Infect Dis. 2004 Mar 01; 38 Suppl 2:S44-8. . View in PubMed
  • Usnic acid-induced necrosis of cultured mouse hepatocytes: inhibition of mitochondrial function and oxidative stress Biochem Pharmacol. 2004 Feb 01; 67(3):439-51. . View in PubMed
  • Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1335-44. . View in PubMed
  • Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria Mol Pharmacol. 2003 Nov; 64(5):1136-44. . View in PubMed
  • Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion Hepatology. 2003 Sep; 38(3):692-702. . View in PubMed
  • Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes Hepatology. 2003 Jun; 37(6):1425-34. . View in PubMed
  • Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice Gastroenterology. 2003 May; 124(5):1488-99. . View in PubMed
  • Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress Gastroenterology. 2003 Mar; 124(3):708-24. . View in PubMed
  • 2003 Jan 21; 138(2):159-60; author reply 159-60. . View in PubMed
  • Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance Drug Saf. 2003; 26(11):815-27. . View in PubMed
  • Immune-mediated drug-induced liver disease Clin Liver Dis. 2002 Aug; 6(3):755-74. . View in PubMed
  • Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes Hepatology. 2002 Jul; 36(1):55-64. . View in PubMed
  • The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane Mol Pharmacol. 2002 Feb; 61(2):425-35. . View in PubMed
  • Biochemical and cellular mechanisms of toxic liver injury Semin Liver Dis. 2002; 22(2):137-44. . View in PubMed
  • Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses Invest Ophthalmol Vis Sci. 2001 Feb; 42(2):409-16. . View in PubMed
  • Causality assessment versus guilt-by-association in drug hepatotoxicity Hepatology. 2001 Jan; 33(1):308-10. . View in PubMed
  • Drug-induced liver disorders: implications for drug development and regulation Drug Saf. 2001; 24(7):483-90. . View in PubMed
  • Radiation inactivation studies of hepatic sinusoidal reduced glutathione transport system Biochim Biophys Acta. 2000 Apr 05; 1464(2):207-18. . View in PubMed
  • Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody J Clin Invest. 2000 Feb; 105(3):329-39. . View in PubMed
  • Cell death at the millenniumImplications for liver diseases. Clin Liver Dis. 2000 Feb; 4(1):1-23v. . View in PubMed
  • GSH transport in human cerebrovascular endothelial cells and human astrocytes: evidence for luminal localization of Na+-dependent GSH transport in HCEC Brain Res. 2000 Jan 10; 852(2):374-82. . View in PubMed
  • Mechanisms of liver cell injury J Hepatol. 2000; 32(1 Suppl):39-47. . View in PubMed
  • Avoiding hepatic injury from drugs Gastroenterology. 1999 Oct; 117(4):759. . View in PubMed
  • GSH transport in immortalized mouse brain endothelial cells: evidence for apical localization of a sodium-dependent GSH transporter J Neurochem. 1999 Jul; 73(1):390-9. . View in PubMed
  • Protection from oxidant injury by sodium-dependent GSH uptake in retinal Müller cells Exp Eye Res. 1999 May; 68(5):609-16. . View in PubMed
  • Hepatotoxicity of psychotropic drugs Hepatology. 1999 May; 29(5):1347-51. . View in PubMed
  • Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor Gastroenterology. 1998 Dec; 115(6):1541-51. . View in PubMed
  • Glutathione transport in immortalized HLE cells and expression of transport in HLE cell poly(A)+ RNA-injected Xenopus laevis oocytes Invest Ophthalmol Vis Sci. 1998 Jul; 39(8):1379-86. . View in PubMed
  • Novel properties of hepatic canalicular reduced glutathione transport revealed by radiation inactivation Am J Physiol. 1998 05; 274(5):G923-30. . View in PubMed
  • Role of the liver in interorgan homeostasis of glutathione and cyst(e)ine Semin Liver Dis. 1998; 18(4):313-29. . View in PubMed
  • Changes in glutathione homeostasis during liver regeneration in the rat Hepatology. 1998 Jan; 27(1):147-53. . View in PubMed
  • Mitochondrial glutathione: importance and transport Semin Liver Dis. 1998; 18(4):389-401. . View in PubMed
  • Hepatotoxicity of herbal remedies: insights into the intricacies of plant-animal warfare and cell death Gastroenterology. 1997 Oct; 113(4):1408-12. . View in PubMed
  • Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine Hepatology. 1997 Sep; 26(3):699-708. . View in PubMed
  • GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect Am J Physiol. 1997 Jul; 273(1 Pt 1):G7-17. . View in PubMed
  • Sinusoidal endothelial cells as a target for acetaminophen toxicityDirect action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 1997 May 09; 53(9):1339-45. . View in PubMed
  • Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium Exp Eye Res. 1997 Apr; 64(4):615-26. . View in PubMed
  • Progressive defect in biliary GSH secretion in streptozotocin-induced diabetic rats Am J Physiol. 1997 Feb; 272(2 Pt 1):G374-82. . View in PubMed
  • Oxidative stress and alcoholic liver disease Alcohol Health Res World. 1997; 21(4):321-4. . View in PubMed
  • Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. . View in PubMed
  • Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats Hepatology. 1996 Jul; 24(1):253-8. . View in PubMed
  • Evidence that interference with binding to hepatic cytosol binders can inhibit bile acid excretion in rats Hepatology. 1996 Jun; 23(6):1642-9. . View in PubMed
  • Inhibition of rat sinusoidal GSH transporter by thioethers: specificity, sidedness, and kinetics Am J Physiol. 1996 Jun; 270(6 Pt 1):G969-75. . View in PubMed
  • GSH transporters: molecular characterization and role in GSH homeostasis Biol Chem Hoppe Seyler. 1996 May; 377(5):267-73. . View in PubMed
  • Plasma membrane and mitochondrial transport of hepatic reduced glutathione Semin Liver Dis. 1996 May; 16(2):147-58. . View in PubMed
  • Evidence for the existence of a sodium-dependent glutathione (GSH) transporterExpression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. . View in PubMed
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