Neil Kaplowitz, MD

Professor of Medicine

USC Associates/Thomas H. Brem Chair in Medicine

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Overview

Dr. Kaplowitz’s research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.

Awards

  • Western Gastroenterology: Research Prize, 1986
  • Association of American Physicians: Member, 1988
  • NIH: Merit Award, 1992
  • Department of Veterans Affairs: William S. Middleton Award, 1993
  • New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994
  • American Liver Foundation: Greater Los Angeles Medical Honoree, 2000
  • American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005
  • Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006
  • American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006
  • Western Society of Clinical Investigation: Mayo Soley Award, 2007
  • American Liver Foundation: Distinguished Scientific Achievement Award, 2008

Research Funding

  • Targets of JNK in acute hepatotoxicity.
    NIH · R01DK126866 · Sep 18, 2020 – May 31, 2025 · Role: Principal Investigator
  • Retrograde Signaling in Alcohol-Induced Mitochondrial Stress and Biogenesis.
    NIH · R21AA017746 · Sep 15, 2008 – Aug 31, 2010 · Role: Principal Investigator
  • Cellular Mechanisms of Hepatotoxicity.
    NIH · R01DK067215 · Apr 1, 2004 – Feb 28, 2021 · Role: Principal Investigator
  • Homocysteine, ER Stress and Alcoholic Liver Injury.
    NIH · R01AA014428 · Jul 1, 2003 – Mar 31, 2015 · Role: Principal Investigator
  • USC Research Center for Liver Disease
    NIH · P30DK048522 · Mar 1, 1995 – Feb 28, 2021 · Role: Principal Investigator
  • EFFECT OF ETHANOL ON HEPATIC GSH HOMEOSTASIS
    NIH · R01AA009526 · Apr 1, 1993 – Mar 31, 2001 · Role: Principal Investigator
  • ROLE OF CYTOKINE INFLAMMATION
    NIH · R13DK044465 · Sep 30, 1991 – Aug 31, 1992 · Role: Principal Investigator
  • PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R01DK030312 · Feb 1, 1982 – May 31, 2005 · Role: Principal Investigator
  • PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R37DK030312 · Feb 1, 1982 – May 31, 2000 · Role: Principal Investigator
  • THE PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R01AM030312 · Feb 1, 1982 – Jan 31, 1987 · Role: Principal Investigator

Research Keywords

  • Models of acute and chronic liver disease

Publications

  • Bile acids in liver and gastrointestinal cancer. Semin Cancer Biol. 2025 11; 116:45-58.. View in PubMed
  • Early oxidative protein modifications and gut damage/leakiness contribute to drug-induced acute liver failure. Clin Mol Hepatol. 2026 Jan; 32(1):e29-e33.. View in PubMed
  • Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer’s disease mice: Potential role in chronic heavy alcohol feeding. Neurobiol Dis. 2024 09; 199:106570.. View in PubMed
  • Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death. Front Cell Dev Biol. 2024; 12:1359152.. View in PubMed
  • Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism. Cell Host Microbe. 2024 01 10; 32(1):48-62.e9.. View in PubMed
  • Clinical presentation, causative drugs and outcome of patients with autoimmune features in two prospective DILI registries. Liver Int. 2023 08; 43(8):1749-1760.. View in PubMed
  • c-Jun-N Terminal Kinase-Mediated Degradation of γ-Glutamylcysteine Ligase Catalytic Subunit Inhibits GSH Recovery After Acetaminophen Treatment: Role in Sustaining JNK Activation and Liver Injury. Antioxid Redox Signal. 2023 06; 38(16-18):1071-1081.. View in PubMed
  • Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-β. Front Physiol. 2022; 13:930402.. View in PubMed
  • Endoplasmic reticulum stress in liver diseases. Hepatology. 2023 02 01; 77(2):619-639.. View in PubMed
  • Introducing Laurie DeLeve, M.D., Ph.D., Our 2022 AASLD President. Hepatology. 2022 03; 75(3):514-517.. View in PubMed