Keck School Faculty

Neil Kaplowitz, MD
Neil Kaplowitz, MD
Professor of Medicine;USC Associates/Thomas H. Brem Chair in Medicine;Chief, Division of Gastroenterology and Liver Diseases
Medicine
HMR 101 Health Sciences Campus Los Angeles
Dr. Kaplowtiz's research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.

American Liver Foundation: Distinguished Scientific Achievement Award, 2008

Western Society of Clinical Investigation: Mayo Soley Award, 2007

Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006

American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006

American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005

American Liver Foundation: Greater Los Angeles Medical Honoree, 2000

New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994

Department of Veterans Affairs : William S. Middleton Award, 1993

NIH: Merit Award, 1992

Association of American Physicians: Member, 1988

Western Gastroenterology : Research Prize, 1986

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis Int J Mol Sci. 2017 May 09; 18(5). . View in PubMed

Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria Antioxid Redox Signal. 2017 Feb 10; 26(5):207-220. . View in PubMed

Death and liver transplantation within 2 years of onset of drug-induced liver injury Hepatology. 2017 10; 66(4):1275-1285. . View in PubMed

Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria Antioxid Redox Signal. 2017 02 10; 26(5):207-220. . View in PubMed

Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments PLoS Comput Biol. 2016 Dec; 12(12):e1005253. . View in PubMed

A murder mystery in the liver: who done it and how? J Clin Invest. 2016 Nov 01; 126(11):4068-4071.. View in PubMed

Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury J Hepatol. 2016 Sep; 65(3):532-42. . View in PubMed

Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments PLoS Comput Biol. 2016 12; 12(12):e1005253. . View in PubMed

Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury J Hepatol. 2016 09; 65(3):532-42. . View in PubMed

c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src Hepatology. 2016 06; 63(6):1987-2003. . View in PubMed

A murder mystery in the liver: who done it and how? J Clin Invest. 2016 11 01; 126(11):4068-4071.. View in PubMed

Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database Drug Saf. 2015 Nov; 38(11):1103-13. . View in PubMed

Characterisation of liver chemistry abnormalities associated with pazopanib monotherapy: a systematic review and meta-analysis of clinical trials in advanced cancer patients Eur J Cancer. 2015 Jul; 51(10):1293-302. . View in PubMed

Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways J Hepatol. 2015 Jan; 62(1):219-33. . View in PubMed

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis J Hepatol. 2014 Nov; 61(5):1126-34. . View in PubMed

Cell death and cell death responses in liver disease: mechanisms and clinical relevanceGastroenterology. 2014 Oct; 147(4):765-783. e4. . View in PubMed

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading J Hepatol. 2013 Oct; 59(4):805-13. . View in PubMed

Avoiding idiosyncratic DILI: two is better than one Hepatology. 2013 Jul; 58(1):15-7. . View in PubMed

Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations J Biol Chem. 2012 Dec 07; 287(50):42165-79. . View in PubMed

Current challenges and controversies in drug-induced liver injury Drug Saf. 2012 Dec 01; 35(12):1099-117. . View in PubMed

Dealing with stress Hepatology. 2012 Jan; 55(1):3-13. . View in PubMed

c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice J Biol Chem. 2011 Oct 07; 286(40):35071-8. . View in PubMed

Differential effect of gender on hepatic fat Pediatr Radiol. 2011 Sep; 41(9):1146-53. . View in PubMed

Case definition and phenotype standardization in drug-induced liver injury Clin Pharmacol Ther. 2011 Jun; 89(6):806-15. . View in PubMed

Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats Hepatology. 2010 Mar; 51(3):796-805. . View in PubMed

Diagnosis, management and prevention of drug-induced liver injury Gut. 2009 Nov; 58(11):1555-64. . View in PubMed

Clinical risk factors for portopulmonary hypertension Hepatology. 2008 Jul; 48(1):196-203. . View in PubMed

Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. . View in PubMed

Endoplasmic reticulum stress and liver injury Semin Liver Dis. 2007 Nov; 27(4):367-77. . View in PubMed

Drug-induced liver injury Drug Saf. 2007; 30(4):277-94. . View in PubMed

Current concepts and controversies in the treatment of alcoholic hepatitis World J Gastroenterol. 2006 Nov 21; 12(43):6909-21. . View in PubMed

ER stress: can the liver cope? J Hepatol. 2006 Aug; 45(2):321-33.. View in PubMed

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial JAMA. 2006 Jul 05; 296(1):87-93. . View in PubMed

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity Gastroenterology. 2006 Jul; 131(1):165-78. . View in PubMed

Drug hepatotoxicity Clin Liver Dis. 2006 May; 10(2):207-17, vii. . View in PubMed

Acetaminophen hepatoxicity: what do we know, what don't we know, and what do we do next? Hepatology. 2004 Jul; 40(1):23-6.. View in PubMed

Clinical perspectives on xenobiotic-induced hepatotoxicity Drug Metab Rev. 2004 May; 36(2):301-12. . View in PubMed

Drug-induced liver injury Clin Infect Dis. 2004 Mar 01; 38 Suppl 2:S44-8. . View in PubMed

Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells Am J Physiol Gastrointest Liver Physiol. 2003 Dec; 285(6):G1335-44. . View in PubMed

Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria Mol Pharmacol. 2003 Nov; 64(5):1136-44. . View in PubMed

Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice Gastroenterology. 2003 May; 124(5):1488-99. . View in PubMed

Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress Gastroenterology. 2003 Mar; 124(3):708-24. . View in PubMed

2003 Jan 21; 138(2):159-60; author reply 159-60. . View in PubMed

Biochemical and cellular mechanisms of toxic liver injury Semin Liver Dis. 2002; 22(2):137-44. . View in PubMed

Drug-induced liver disorders: implications for drug development and regulation Drug Saf. 2001; 24(7):483-90. . View in PubMed

Causality assessment versus guilt-by-association in drug hepatotoxicity Hepatology. 2001 Jan; 33(1):308-10. . View in PubMed

Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody J Clin Invest. 2000 Feb; 105(3):329-39. . View in PubMed

Cell death at the millenniumImplications for liver diseases. Clin Liver Dis. 2000 Feb; 4(1):1-23, v. . View in PubMed

Avoiding hepatic injury from drugs Gastroenterology. 1999 Oct; 117(4):759. . View in PubMed

Changes in glutathione homeostasis during liver regeneration in the rat Hepatology. 1998 Jan; 27(1):147-53. . View in PubMed

Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats Hepatology. 1996 Jul; 24(1):253-8. . View in PubMed

Evidence that interference with binding to hepatic cytosol binders can inhibit bile acid excretion in rats Hepatology. 1996 Jun; 23(6):1642-9. . View in PubMed

Evidence for the existence of a sodium-dependent glutathione (GSH) transporterExpression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. . View in PubMed

Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathioneExpression studies in Xenopus laevis oocytes. J Biol Chem. 1995 Jul 07; 270(27):15946-9. . View in PubMed

Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye Exp Eye Res. 1994 Oct; 59(4):487-96. . View in PubMed

Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes J Clin Invest. 1994 Jul; 94(1):193-201. . View in PubMed

Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. . View in PubMed

Expression cloning of a rat hepatic reduced glutathione transporter with canalicular characteristics J Clin Invest. 1994 Apr; 93(4):1841-5. . View in PubMed

Distribution of 3 alpha-hydroxysteroid dehydrogenase (bile acid binder) in rat small intestine: comparison with glutathione S-transferase subunits J Gastroenterol. 1994 Apr; 29(2):115-9. . View in PubMed

Bidirectional membrane transport of intact glutathione in Hep G2 cells Am J Physiol. 1993 Dec; 265(6 Pt 1):G1128-34. . View in PubMed

Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles J Biol Chem. 1992 Nov 05; 267(31):22256-64. . View in PubMed

Contribution of no-reflow phenomenon to hepatic injury after ischemia-reperfusion: evidence for a role for superoxide anion Hepatology. 1992 Mar; 15(3):507-14. . View in PubMed

Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats J Biol Chem. 1992 Jan 25; 267(3):1667-73. . View in PubMed

Effect of phorone and allopurinol on ischemia-reperfusion injury in gastrointestinal mucosa of the rat Pharmacology. 1992; 44(6):334-43. . View in PubMed

Effect of indomethacin on the uptake, metabolism and excretion of 3-oxocholic acid: studies in isolated hepatocytes and perfused rat liver Biochim Biophys Acta. 1991 Jul 30; 1084(3):247-50. . View in PubMed

Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat J Clin Invest. 1990 Jun; 85(6):2009-13. . View in PubMed

Calcium compartmentation and exchange rates in primary hepatocyte culture Anal Biochem. 1990 May 15; 187(1):187-96. . View in PubMed

Effects of chronic ethanol feeding on rat hepatocytic glutathioneRelationship of cytosolic glutathione to efflux and mitochondrial sequestration. J Clin Invest. 1989 Apr; 83(4):1247-52. . View in PubMed

Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes Am J Physiol. 1988 Oct; 255(4 Pt 1):G403-8. . View in PubMed

Comparison of the effects of bile acids and GSH on the fluorescence of bound 1-anilino-8-naphthalene sulfonate and the enzymatic activity of cationic and neutral human hepatic GSH S-transferases Biochim Biophys Acta. 1988 Apr 28; 954(1):37-43. . View in PubMed

Comparison of the binding sites of GSH S-transferases of the Ya- and Yb-subunit classes: effect of glutathione on the binding of bile acids J Lipid Res. 1988 Mar; 29(3):279-86. . View in PubMed

Effect of age on the sinusoidal release of hepatic glutathione from the perfused rat liver Biochem Pharmacol. 1987 Nov 15; 36(22):4015-7. . View in PubMed

Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by rat hepatic 3 alpha-hydroxysteroid dehydrogenaseI. Studies with the purified enzyme, isolated rat hepatocytes, and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):852-60. . View in PubMed

Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by 3 alpha-hydroxysteroid dehydrogenaseII. Studies in the prograde and retrograde single-pass, perfused rat liver and inhibition by indomethacin. J Clin Invest. 1987 Sep; 80(3):861-6. . View in PubMed

Effect of chronic ethanol feeding on rat hepatocytic glutathioneCompartmentation, efflux, and response to incubation with ethanol. J Clin Invest. 1987 Jul; 80(1):57-62. . View in PubMed

A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army N Engl J Med. 1987 Apr 16; 316(16):965-70. . View in PubMed

3 alpha-hydroxysteroid dehydrogenase activity of the Y' bile acid binders in rat liver cytosolIdentification, kinetics, and physiologic significance. J Clin Invest. 1987 Feb; 79(2):427-34. . View in PubMed

Binding of bile acids, oleic acid, and organic anions by rat and human hepatic Z protein Arch Biochem Biophys. 1986 Nov 15; 251(1):385-92. . View in PubMed

Binding of bile acids by glutathione S-transferases from rat liver J Lipid Res. 1986 Sep; 27(9):955-66. . View in PubMed

Drug-induced hepatotoxicity Ann Intern Med. 1986 Jun; 104(6):826-39. . View in PubMed

Comparison of the affinities of newly identified human bile acid binder and cationic glutathione S-transferase for bile acids J Lipid Res. 1986 Jun; 27(6):652-7. . View in PubMed

Cytosolic bile acid binding protein in rat liver: radioimmunoassay, molecular forms, developmental characteristics and organ distribution Hepatology. 1986 May-Jun; 6(3):433-9. . View in PubMed

Acetaldehyde-dependent oxidation of glutathione catalyzed by rat liver cytosol Biochem Biophys Res Commun. 1985 Jun 28; 129(3):949-57. . View in PubMed

Disease-specific amino acid infusion (F080) in hepatic encephalopathy: a prospective, randomized, double-blind, controlled trial JPEN J Parenter Enteral Nutr. 1985 May-Jun; 9(3):288-95. . View in PubMed

Evidence for a common high affinity binding site on glutathione S-transferase B for lithocholic acid and bilirubin J Lipid Res. 1984 Nov; 25(11):1177-83. . View in PubMed

Comparison of the binding affinities of five forms of rat glutathione S-transferases for bilirubin, sulfobromophthalein and hematin Biochem Pharmacol. 1984 Nov 01; 33(21):3511-3. . View in PubMed

Comparison of binding of thyroid hormone analogues to hepatic organic anion binding proteins Biochim Biophys Acta. 1984 Sep 28; 801(2):184-8. . View in PubMed

Binding of glutathione by rat liver cytosol Pharmacology. 1984; 28(2):61-6. . View in PubMed

Direct protection against acetaminophen hepatotoxicity by propylthiouracilIn vivo and in vitro studies in rats and mice. J Clin Invest. 1981 Mar; 67(3):688-95. . View in PubMed

Effect of pyridoxine deficiency on serum and liver transaminases in experimental liver injury in the rat Gastroenterology. 1980 Sep; 79(3):545-9. . View in PubMed

Estimation of glutathione in rat liver by reversed-phase high-performance liquid chromatography: separation from cysteine and gamma-glutamylcysteine J Chromatogr. 1980 Jun 27; 194(3):424-8. . View in PubMed

Bile acid tolerance tests: rationale Gastroenterology. 1980 Jun; 78(6):1654-5. . View in PubMed

Binding of ethacrynic acid to hepatic glutathione S-transferases in vivo in the rat Biochem Pharmacol. 1980 Apr 15; 29(8):1205-8. . View in PubMed

Effect of salicylates and phenobarbital on hepatic glutathione in the rat J Pharmacol Exp Ther. 1980 Feb; 212(2):240-5. . View in PubMed

Common bile duct stenosis from chronic pancreatitis: a clinical and pathologic spectrum Medicine (Baltimore). 1979 Nov; 58(6):385-412. . View in PubMed

Aplastic anemia associated with type B viral hepatitis Arch Intern Med. 1978 Oct; 138(10):1557-8. . View in PubMed

Cholestatic liver disease Hosp Pract. 1978 Aug; 13(8):83-92. . View in PubMed

Effect of dietary phenobarbital, 3,4-benzo(alpha)pyrene and 3-methylcholanthrene on hepatic, intestinal and renal glutathione s-transferase activities in the rat Biochem Pharmacol. 1978; 27(8):1284-7. . View in PubMed

Endocrine and metabolic alterations with food and water deprivation Am J Clin Nutr. 1977 Dec; 30(12):1953-62. . View in PubMed

Enzymatic thiolysis of azathioprine in vitro Biochem Pharmacol. 1976 Nov 01; 25(21):2421-6. . View in PubMed

Comparison of renal and hepatic glutathione S-transferases in the rat Biochem J. 1976 Aug 15; 158(2):243-8. . View in PubMed

Drug induction and sex differences of renal glutathione S-transferases in the rat Biochem J. 1975 Aug; 150(2):259-62. . View in PubMed

Drug induction of hepatic glutathione S-transferases in male and female rats* Biochem J. 1975 Feb; 146(2):351-6. . View in PubMed

Coproporphyrin I and 3 excretion in bile and urine J Clin Invest. 1972 Nov; 51(11):2895-9. . View in PubMed

Powered by SC CTSI
Go to Top