Noah Malmstadt, PhD

Noah Malmstadt received a BS in Chemical Engineering from Caltech and a PhD in Bioengineering from the University of Washington. Following postdoctoral work at UCLA, he joined the Mork Family Department of Chemical Engineering and Materials Science at USC in 2007. His research focuses on synthetic cell membrane systems and multiphase microfluidic strategies for nanofabrication. He is the recipient of an Office of Naval Research Young Investigator award. His work in engineering education focuses on integrating team-based design projects into the core chemical engineering curriculum.

• Solvent Dependence of Ionic Liquid-Based Pt Nanoparticle Synthesis: Machine Learning-Aided In-Line Monitoring in a Flow Reactor ACS Nano. 2024 Sep 17; 18(37):25542-25551. . View in PubMed
• Multivariate Bayesian Optimization of CoO Nanoparticles for CO2 Hydrogenation Catalysis J Am Chem Soc. 2024 May 22; 146(20):14246-14259. . View in PubMed
• 3D-printed microfluidic device for high-throughput production of lipid nanoparticles incorporating SARS-CoV-2 spike protein mRNA Lab Chip. 2024 01 17; 24(2):162-170. . View in PubMed
• A Multistep, Multicomponent Extraction and Separation Microfluidic Route to Recycle Water-Miscible Ionic Liquid Solvents Ind Eng Chem Res. 2024 Jan 10; 63(1):489-497. . View in PubMed
• Elucidating the Molecular Interactions between Lipids and Lysozyme: Evaporation Resistance and Bacterial Barriers for Dry Eye Disease Nano Lett. 2023 10 25; 23(20):9451-9460. . View in PubMed
• Curvature preference of cubic CsPbBr3 quantum dots embedded onto phospholipid bilayer membranes Soft Matter. 2023 May 31; 19(21):3966-3974. . View in PubMed
• Oxidation of Membrane Lipids Alters the Activity of the Human Serotonin 1A Receptor Langmuir. 2022 06 07; 38(22):6798-6807. . View in PubMed
• Compatibility of Popular Three-Dimensional Printed Microfluidics Materials with In Vitro Enzymatic Reactions ACS Appl Bio Mater. 2022 02 21; 5(2):818-824. . View in PubMed
• In-situ transfer vat photopolymerization for transparent microfluidic device fabrication Nat Commun. 2022 02 17; 13(1):918. . View in PubMed
• Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs) J Vis Exp. 2022 02 05; (180). . View in PubMed
• Light-Triggered Unique Shape Transformation of Giant Polymersomes with Tubular Protrusions Macromol Rapid Commun. 2021 Nov; 42(22):e2100474. . View in PubMed
• Characterization of binding kinetics of A2AR to Gas protein by surface plasmon resonance Biophys J. 2021 05 04; 120(9):1641-1649. . View in PubMed
• Carbon dioxide transport across membranes Interface Focus. 2021 Apr 06; 11(2):20200090. . View in PubMed
• An integrated microfluidic platform to fabricate single-micrometer asymmetric giant unilamellar vesicles (GUVs) using dielectrophoretic separation of microemulsions Biomicrofluidics. 2021 Mar; 15(2):024112. . View in PubMed
• Enabling Flow-Based Kinetic Off-Rate Selections Using a Microfluidic Enrichment Device Anal Chem. 2020 08 04; 92(15):10218-10222. . View in PubMed
• Self-optimizing parallel millifluidic reactor for scaling nanoparticle synthesis Chem Commun (Camb). 2020 Apr 04; 56(26):3745-3748. . View in PubMed
• An Exceptionally Mild and Scalable Solution-Phase Synthesis of Molybdenum Carbide Nanoparticles for Thermocatalytic CO2 Hydrogenation J Am Chem Soc. 2020 01 15; 142(2):1010-1019. . View in PubMed
• Spectrophotometry in modular microfluidic architectures Biomicrofluidics. 2019 Nov; 13(6):064121. . View in PubMed
• Liposome production and concurrent loading of drug simulants by microfluidic hydrodynamic focusing Eur Biophys J. 2019 Sep; 48(6):549-558. . View in PubMed
• Continuous Flow Methods of Fabricating Catalytically Active Metal Nanoparticles ACS Appl Mater Interfaces. 2019 Aug 07; 11(31):27479-27502. . View in PubMed
• The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state Chem Commun (Camb). 2019 May 14; 55(40):5724-5727. . View in PubMed
• Giant Lipid Vesicle Formation Using Vapor-Deposited Charged Porous Polymers Langmuir. 2018 07 31; 34(30):9025-9035. . View in PubMed
• Photolithographic patterned surface forms size-controlled lipid vesicles APL Bioeng. 2018 Mar; 2(1):016104. . View in PubMed
• Modular microfluidics for double emulsion formation Methods Cell Biol. 2018; 148:161-176. . View in PubMed
• Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes Soft Matter. 2017 Aug 23; 13(33):5580-5588. . View in PubMed
• Dynamics of Hydrogel-Assisted Giant Unilamellar Vesicle Formation from Unsaturated Lipid Systems Langmuir. 2016 12 06; 32(48):12702-12709. . View in PubMed
• G Protein-Coupled Receptors Incorporated into Rehydrated Diblock Copolymer Vesicles Retain Functionality Small. 2016 Oct; 12(38):5256-5260. . View in PubMed
• The Functional Activity of the Human Serotonin 5-HT1A Receptor Is Controlled by Lipid Bilayer Composition Biophys J. 2016 06 07; 110(11):2486-2495. . View in PubMed
• Oxidation of Membrane Curvature-Regulating Phosphatidylethanolamine Lipid Results in Formation of Bilayer and Cubic Structures Langmuir. 2016 Mar 15; 32(10):2450-7. . View in PubMed
• Flow invariant droplet formation for stable parallel microreactors Nat Commun. 2016 Feb 23; 7:10780. . View in PubMed
• Addition of Cleaved Tail Fragments during Lipid Oxidation Stabilizes Membrane Permeability Behavior Langmuir. 2016 Jan 26; 32(3):779-86. . View in PubMed
• Temperature Sensing in Modular Microfluidic Architectures Micromachines (Basel). 2016 Jan 18; 7(1). . View in PubMed
• Predicting the behavior of microfluidic circuits made from discrete elements Sci Rep. 2015 Oct 30; 5:15609. . View in PubMed
• Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption J Biol Chem. 2015 Oct 23; 290(43):25782-93. . View in PubMed
• Viscoelastic deformation of lipid bilayer vesicles Soft Matter. 2015 Oct 07; 11(37):7385-91. . View in PubMed
• Glucose transport machinery reconstituted in cell models Chem Commun (Camb). 2015 Feb 11; 51(12):2316-9. . View in PubMed
• Low levels of lipid oxidation radically increase the passive permeability of lipid bilayers Soft Matter. 2015 Jan 21; 11(3):499-505. . View in PubMed
• Asymmetric giant lipid vesicle fabrication Methods Mol Biol. 2015; 1232:79-90. . View in PubMed
• Discrete elements for 3D microfluidics Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15013-8. . View in PubMed
• The dynamics of giant unilamellar vesicle oxidation probed by morphological transitions Biochim Biophys Acta. 2014 Oct; 1838(10):2615-24. . View in PubMed
• Human serotonin receptor 5-HT(1A) preferentially segregates to the liquid disordered phase in synthetic lipid bilayers J Am Chem Soc. 2014 Oct 01; 136(39):13530-3. . View in PubMed
• Fluoropolymer surface coatings to control droplets in microfluidic devices Lab Chip. 2014 Jun 07; 14(11):1834-41. . View in PubMed
• Preparation of size tunable giant vesicles from cross-linked dextran(ethylene glycol) hydrogels Chem Commun (Camb). 2014 Feb 25; 50(16):1953-5. . View in PubMed
• Lipid directed intrinsic membrane protein segregation J Am Chem Soc. 2013 Nov 20; 135(46):17294-7. . View in PubMed
• Automated formation of multicomponent-encapuslating vesosomes using continuous flow microcentrifugation Biotechnol J. 2013 Nov; 8(11):1341-6. . View in PubMed
• Liposomes with double-stranded DNA anchoring the bilayer to a hydrogel core Biomacromolecules. 2013 Oct 14; 14(10):3380-5. . View in PubMed
• Optical stretching as a tool to investigate the mechanical properties of lipid bilayers RSC Adv. 2013 Oct 07; 3(37). . View in PubMed
• Cholesterol translocation in a phospholipid membrane Biophys J. 2013 Jun 04; 104(11):2429-36. . View in PubMed
• Effect of ionic liquid impurities on the synthesis of silver nanoparticles Langmuir. 2012 Nov 13; 28(45):15987-93. . View in PubMed
• Optical stretching of giant unilamellar vesicles with an integrated dual-beam optical trap Biomed Opt Express. 2012 Oct 01; 3(10):2419-27. . View in PubMed
• Two-phase microfluidic droplet flows of ionic liquids for the synthesis of gold and silver nanoparticles ACS Appl Mater Interfaces. 2012 Jun 27; 4(6):3077-83. . View in PubMed
• Lipid bilayers covalently anchored to carbon nanotubes Langmuir. 2012 May 29; 28(21):8174-82. . View in PubMed
• Vapor deposition of cross-linked fluoropolymer barrier coatings onto pre-assembled microfluidic devices Lab Chip. 2011 Sep 21; 11(18):3049-52. . View in PubMed
• Imaging molecular transport across lipid bilayers Biophys J. 2011 Aug 03; 101(3):700-8. . View in PubMed
• Microfluidic fabrication of asymmetric giant lipid vesicles ACS Appl Mater Interfaces. 2011 May; 3(5):1434-40. . View in PubMed
• Excitation of Cy5 in self-assembled lipid bilayers using optical microresonators Appl Phys Lett. 2011 Apr 04; 98(14):143703. . View in PubMed
• Flow-focused synthesis of monodisperse gold nanoparticles using ionic liquids on a microfluidic platform Lab Chip. 2010 Dec 21; 10(24):3377-9. . View in PubMed
• Confocal imaging to quantify passive transport across biomimetic lipid membranes Anal Chem. 2010 Sep 15; 82(18):7766-71. . View in PubMed
• Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. . View in PubMed
• Black lipid membranes stabilized through substrate conjugation to a hydrogel Biointerphases. 2008 Jun; 3(2):FA96. . View in PubMed
• Automated formation of lipid-bilayer membranes in a microfluidic device Nano Lett. 2006 Sep; 6(9):1961-5. . View in PubMed
• Hydrogel-encapsulated lipid membranes J Am Chem Soc. 2006 Jan 11; 128(1):42-3. . View in PubMed
• “Smart” mobile affinity matrix for microfluidic immunoassays Lab Chip. 2004 Aug; 4(4):412-5. . View in PubMed
• A smart microfluidic affinity chromatography matrix composed of poly(N-isopropylacrylamide)-coated beads Anal Chem. 2003 Jul 01; 75(13):2943-9. . View in PubMed
• Affinity thermoprecipitation and recovery of biotinylated biomolecules via a mutant streptavidin-smart polymer conjugate Bioconjug Chem. 2003 May-Jun; 14(3):575-80. . View in PubMed

• Langen, Ralf