Olivier Pernet

Assistant Professor of Research Pediatrics

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Overview

Dr. Olivier Pernet is a virologist with over 15 years of research experience in the field of emerging zoonotic viruses, with a special attention on bat related diseases (Nipah Virus, Ebola Virus, SARS-CoV-1, SARS-CoV-2,…). Dr. Pernet work focuses on host-virus interactions and how to use them for biomedical applications (outbreak preparedness, surveillance, high-throughput serology, drug discovery, gene therapy,…).
After a brief period at bioMérieux where he worked on SARS-CoV-1 detection assay, Dr. Pernet moved to Paris and completed a Master Degree in Medical Virology at the Paris Diderot University and the Institut Pasteur. He then joined the École Normale Supérieure de Lyon for his PhD under the mentorship of Dr. Robin Buckland. There he studied Henipaviruses cellular entry in the Bio-Safety Level 4 Jean Mérieux “P4” laboratory. During his time in Lyon, he unraveled a new entry model for Paramyxoviruses and identify drugs with the potential to treat the dreaded Nipah Virus. He also worked on antivirals targeting Ebola Virus and Crimean-Congo Hemorrhagic Fever Virus. Additionally, while in France Dr. Pernet worked on outbreak prevention and mitigation by studying viral shedding in bats from France and Mali.
Dr. Pernet then moved to the US on a joint position at UCLA and UTMB/Galveston National Laboratory. Under the supervision of Dr. Benhur Lee and Dr. Alexander Freiberg, he continued his work on viral entry, using the Henipavirus glycoproteins to design new vectors for gene therapy. While at UCLA, Dr. Pernet also documented the first human cases of Henipavirus on the African continent and identified risk factors for zoonotic transmission in Cameroon.
He has since moved on to become a faculty at Keck Medicine of USC, in the department of Pediatrics where he works on immune response toward viral (co)infections in LA’s highly diverse population. During the ongoing COVID-19 outbreak, Dr. Pernet has continued his work at Keck Medicine of USC, where he developed a highly sensitive saliva-based assays against SARS-CoV-2 in order to increase hospitals testing capacities in the early days of the pandemic, and then worked the immune system interaction with COVID-19, vaccine response, and mother to child transmission of SARS-CoV-2.

Awards

  • University, Rennes, France: Academic Excellence Award – Rennes, 2005
  • Paris VII University, Paris, France: Master Degree with honors, 2006
  • École Normale Supérieure de Lyon, Lyon, France: Doctorate Degree with highest distinction, 2009
  • Clinical and Translational Science Institute (CTSI): Core Voucher Award, 2017
  • The 2017 Palm Springs Symposium on HIV/AIDS: HIV Disease from Resistance to Cure” Award, The 2017 Palm Springs Symposium on HIV/AIDS 2017
  • Nature Microbiology: NSV-2018 Nature Microbiology Poster Award, 2018 NSV-2018 Nature Microbiology Poster Award

Publications

  • Cord blood IgA/M reveals in utero response to SARS-CoV-2 with fluctuations in relation to circulating variants. Nat Commun. 2025 Apr 14; 16(1):3551.. View in PubMed
  • A temperature-sensitive and less immunogenic Sendai virus for efficient gene editing. J Virol. 2024 12 17; 98(12):e0083224.. View in PubMed
  • A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells. bioRxiv. 2024 May 05.. View in PubMed
  • In vivo selection of anti-HIV-1 gene-modified human hematopoietic stem/progenitor cells to enhance engraftment and HIV-1 inhibition. Mol Ther. 2024 02 07; 32(2):384-394.. View in PubMed
  • Association between levels of receptor binding domain antibodies of SARS-CoV-2, receipt of booster and risk of breakthrough infections: LA pandemic surveillance cohort study. Sci Rep. 2023 11 25; 13(1):20761.. View in PubMed
  • SARS-CoV-2 viral variants can rapidly be identified for clinical decision making and population surveillance using a high-throughput digital droplet PCR assay. Sci Rep. 2023 05 10; 13(1):7612.. View in PubMed
  • Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 and Variants Using Digital Droplet Polymerase Chain Reaction at a Large University and Healthcare System in California. Open Forum Infect Dis. 2023 Apr; 10(4):ofad147.. View in PubMed
  • Quantification of Severe Acute Respiratory Syndrome Coronavirus 2 Binding Antibody Levels To Assess Infection and Vaccine-Induced Immunity Using WHO Standards. Microbiol Spectr. 2023 02 14; 11(1):e0370922.. View in PubMed
  • The Evolutionary Dance between Innate Host Antiviral Pathways and SARS-CoV-2. Pathogens. 2022 May 03; 11(5).. View in PubMed
  • Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2. Acta Pharm Sin B. 2022 Apr; 12(4):1624-1635.. View in PubMed