Keck School Faculty

EphrinB2: Expression of a novel potential target in renal cell carcinoma Indian J Urol. 2023 Jul-Sep; 39(3):223-227. . View in PubMed

EphrinB2 Inhibition and Pembrolizumab in Metastatic Urothelial Carcinoma J Clin Oncol. 2023 01 20; 41(3):640-650. . View in PubMed

The Impact of Facility Surgical Caseload Volumes on Survival Outcomes in Patients Undergoing Radical Cystectomy Cancers (Basel). 2022 Dec 03; 14(23). . View in PubMed

PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-a Production and Restricts Progression of Metastatic Melanoma Front Immunol. 2021; 12:733136. . View in PubMed

The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection J Biol Chem. 2021 Jan-Jun; 296:100759. . View in PubMed

Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways Biol Open. 2021 02 25; 10(2). . View in PubMed

EphrinB2 expression in prostate adenocarcinoma: Implications for targeted therapy Pathol Res Pract. 2020 Jun; 216(6):152967. . View in PubMed

Reply by Authors J Urol. 2020 10; 204(4):660. . View in PubMed

Programmed Death 1 and Programmed Death Ligand 1 Inhibitors in Advanced and Recurrent Urothelial Carcinoma: Meta-analysis of Single-Agent StudiesClin Genitourin Cancer. 2020 10; 18(5):351-360. e3. . View in PubMed

Association between Smoking Exposure, Neoadjuvant Chemotherapy Response and Survival Outcomes following Radical Cystectomy: Systematic Review and Meta-Analysis J Urol. 2020 10; 204(4):649-660. . View in PubMed

Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression Development. 2020 09 11; 147(17). . View in PubMed

GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer Life Sci Alliance. 2019 08; 2(4). . View in PubMed

Histological Validation of 11Carbon-Acetate Positron Emission Tomography/Computerized Tomography in Detecting Lymph Node Metastases in Prostate Cancer J Urol. 2019 02; 201(2):332-341. . View in PubMed

EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT Blood Adv. 2017 Sep 12; 1(20):1635-1644. . View in PubMed

Robotic salvage retroperitoneal and pelvic lymph node dissection for 'node-only' recurrent prostate cancer: technique and initial series BJU Int. 2017 09; 120(3):401-408. . View in PubMed

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4020-E4029. . View in PubMed

Identifying aggressive prostate cancer foci using a DNA methylation classifier Genome Biol. 2017 01 12; 18(1):3. . View in PubMed

Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis Oncogene. 2015 Oct; 34(43):5418-26. . View in PubMed

Axl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinoma Br J Cancer. 2015 Aug 11; 113(4):616-25. . View in PubMed

Design, synthesis, and validation of Axl-targeted monoclonal antibody probe for microPET imaging in human lung cancer xenograft Mol Pharm. 2014 Nov 03; 11(11):3974-9. . View in PubMed

Axl-targeted cancer imaging with humanized antibody h173 Mol Imaging Biol. 2014 Aug; 16(4):511-8. . View in PubMed

The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladder PLoS One. 2014; 9(8):e105326. . View in PubMed

Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis Clin Cancer Res. 2013 Dec 15; 19(24):6802-11. . View in PubMed

PET imaging of colorectal and breast cancer by targeting EphB4 receptor with 64Cu-labeled hAb47 and hAb131 antibodies J Nucl Med. 2013 Jul; 54(7):1094-100. . View in PubMed

EphB4 as a therapeutic target in mesothelioma BMC Cancer. 2013 May 30; 13:269. . View in PubMed

Targeting the EphB4 receptor for cancer diagnosis and therapy monitoring Mol Pharm. 2013 Jan 07; 10(1):329-36. . View in PubMed

Inhibition of Notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues Biochem Biophys Res Commun. 2012 Feb 03; 418(1):173-9. . View in PubMed

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis BMC Cancer. 2010 Nov 23; 10:641. . View in PubMed

Immune evasion by Kaposi's sarcoma-associated herpesvirus Future Microbiol. 2010 Sep; 5(9):1349-65. . View in PubMed

Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma Blood. 2010 Jul 15; 116(2):297-305. . View in PubMed

Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP J Biol Chem. 2010 May 14; 285(20):15065-15075. . View in PubMed

KSHV-induced notch components render endothelial and mural cell characteristics and cell survival Blood. 2010 Jan 28; 115(4):887-95. . View in PubMed

Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):543-52. . View in PubMed

Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression Cancer Res. 2009 May 01; 69(9):3736-45. . View in PubMed

The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade Blood. 2009 Jan 01; 113(1):254-63. . View in PubMed

The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma Arch Otolaryngol Head Neck Surg. 2008 Sep; 134(9):985-91. . View in PubMed

Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma Blood. 2008 Apr 01; 111(7):3377-82. . View in PubMed

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion Blood. 2007 Jun 01; 109(11):4753-60. . View in PubMed

The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome Br J Cancer. 2007 Apr 10; 96(7):1083-91. . View in PubMed

Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer Mol Cancer Res. 2007 Apr; 5(4):351-62. . View in PubMed

The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma Arch Otolaryngol Head Neck Surg. 2006 Oct; 132(10):1053-9. . View in PubMed

EphB4 provides survival advantage to squamous cell carcinoma of the head and neck Int J Cancer. 2006 Sep 15; 119(6):1236-48. . View in PubMed

Receptor tyrosine kinase EphB4 is a survival factor in breast cancer Am J Pathol. 2006 Jul; 169(1):279-93. . View in PubMed

Phase I study of antisense oligonucleotide against vascular endothelial growth factor: decrease in plasma vascular endothelial growth factor with potential clinical efficacy J Clin Oncol. 2006 Apr 10; 24(11):1712-9. . View in PubMed

Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancer J Urol. 2006 Apr; 175(4):1245-52. . View in PubMed

EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival Oncogene. 2006 Feb 02; 25(5):769-80. . View in PubMed

Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4772-9. . View in PubMed

Up-regulation of EphB4 in mesothelioma and its biological significance Clin Cancer Res. 2005 Jun 15; 11(12):4305-15. . View in PubMed

EphB4 expression and biological significance in prostate cancer Cancer Res. 2005 Jun 01; 65(11):4623-32. . View in PubMed

Molecular prognostic factors in bladder cancer BJU Int. 2005 Apr; 95(6):739-42. . View in PubMed

Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium Blood. 2005 Feb 01; 105(3):1310-8. . View in PubMed

Th1 and Th2 cytokines and IgE levels in identical twins with varying levels of cigarette consumption J Clin Immunol. 2004 Nov; 24(6):617-22. . View in PubMed

IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma Blood. 2004 Apr 15; 103(8):3216-21. . View in PubMed

Expression of EphB4 in head and neck squamous cell carcinoma Ear Nose Throat J. 2003 Nov; 82(11):866869-70887. . View in PubMed

Natural killer cell cytolytic activity is necessary for in vivo antitumor activity of the dipeptide L-glutamyl-L-tryptophan Int J Cancer. 2003 Sep 10; 106(4):528-533. . View in PubMed

Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops Int J Cancer. 2003 May 01; 104(5):603-10. . View in PubMed

Multicenter trial of low-dose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma Cancer. 2002 Jul 01; 95(1):147-54. . View in PubMed

Multidrug resistance (MDR-1) expression in AIDS-related lymphomas Leuk Res. 2002 Feb; 26(2):121-7. . View in PubMed

Human herpesvirus-8-transformed endothelial cells have functionally activated vascular endothelial growth factor/vascular endothelial growth factor receptor Am J Pathol. 2002 Jan; 160(1):23-9. . View in PubMed

Retroviral vectors bearing IgG-binding motifs for antibody-mediated targeting of vascular endothelial growth factor receptors Int J Mol Med. 2001 Oct; 8(4):335-43. . View in PubMed

Interleukin 8 is an autocrine growth factor and a surrogate marker for Kaposi's sarcoma Clin Cancer Res. 2001 Sep; 7(9):2693-702. . View in PubMed

Results of a collaborative study of the EDNAP group regarding the reproducibility and robustness of the Y-chromosome STRs DYS19, DYS389 I and II, DYS390 and DYS393 in a PCR pentaplex format Forensic Sci Int. 2001 Jun 01; 119(1):28-41. . View in PubMed

Evolving characteristics of AIDS-related lymphoma Blood. 2000 Dec 15; 96(13):4084-90. . View in PubMed

Kaposi sarcoma is a therapeutic target for vitamin D(3) receptor agonist Blood. 2000 Nov 01; 96(9):3188-94. . View in PubMed

Results of a randomized study of IM862 nasal solution in the treatment of AIDS-related Kaposi's sarcoma J Clin Oncol. 2000 Feb; 18(4):716-23. . View in PubMed

Paclitaxel Induces Apoptosis in AIDS-Related Kaposi's Sarcoma Cells Sarcoma. 2000; 4(1-2):37-45. . View in PubMed

Expression of the human immunodeficiency virus-Tat gene in lymphoid tissues of transgenic mice is associated with B-cell lymphoma Blood. 1999 Jul 01; 94(1):275-82. . View in PubMed

Paclitaxel is safe and effective in the treatment of advanced AIDS-related Kaposi's sarcoma J Clin Oncol. 1999 Jun; 17(6):1876-83. . View in PubMed

Antineoplastic urinary protein inhibits Kaposi's sarcoma and angiogenesis in vitro and in vivo Blood. 1999 Feb 01; 93(3):1038-44. . View in PubMed

Phase II trial of liposomal daunorubicin in the treatment of AIDS-related pulmonary Kaposi's sarcoma J Clin Oncol. 1998 Oct; 16(10):3369-74. . View in PubMed

Emerging treatments for epidemic (AIDS-related) Kaposi's sarcoma Curr Opin Oncol. 1998 Sep; 10(5):413-21. . View in PubMed

Evidence for multiclonality in multicentric Kaposi's sarcoma Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):8257-61. . View in PubMed

Extravasation of liposomal daunorubicin in patients with AIDS-associated Kaposi's sarcoma: a report of four cases Oncol Nurs Forum. 1998 Jan-Feb; 25(1):67-70. . View in PubMed

Phase I study of human chorionic gonadotropin given subcutaneously to patients with acquired immunodeficiency syndrome-related mucocutaneous Kaposi's sarcoma J Natl Cancer Inst. 1997 Dec 03; 89(23):1797-802. . View in PubMed

Treatment of epidemic (AIDS-related) Kaposi's sarcoma Curr Opin Oncol. 1997 Sep; 9(5):433-9. . View in PubMed

AIDS Clinical Trials Group Study 094: a phase I/II trial of ABV chemotherapy with zidovudine and recombinant human GM-CSF in AIDS-related Kaposi's sarcoma Cancer J Sci Am. 1997 Sep-Oct; 3(5):278-83. . View in PubMed

Glucocorticoids induce Kaposi's sarcoma cell proliferation through the regulation of transforming growth factor-beta Blood. 1997 Mar 01; 89(5):1491-500. . View in PubMed

Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma Proc Natl Acad Sci U S A. 1997 Feb 04; 94(3):979-84. . View in PubMed

IL-4R expression in AIDS-KS cells and response to rhIL-4 and IL-4 toxin (DAB389-IL-4) Invest New Drugs. 1997; 15(4):279-87. . View in PubMed

Interleukin-4 in the treatment of AIDS-related Kaposi's sarcoma Ann Oncol. 1997 Jan; 8(1):79-83. . View in PubMed

The effects of preparations of human chorionic gonadotropin on AIDS-related Kaposi's sarcoma N Engl J Med. 1996 Oct 24; 335(17):1261-9. . View in PubMed

Low dose methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone with zalcitabine in patients with acquired immunodeficiency syndrome-related lymphomaEffect on human immunodeficiency virus and serum interleukin-6 levels over time. Cancer. 1996 Aug 01; 78(3):517-26. . View in PubMed

Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma J Clin Oncol. 1996 Aug; 14(8):2353-64. . View in PubMed

Increased radiosensitivity of normal tissue fibroblasts in patients with acquired immunodeficiency syndrome (AIDS) and with Kaposi's sarcoma Int J Radiat Biol. 1995 Oct; 68(4):411-2. . View in PubMed

Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine N Engl J Med. 1995 Jun 29; 332(26):1744-8. . View in PubMed

Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi's sarcoma J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15; 8(5):455-60. . View in PubMed

Phase I/II clinical and pharmacokinetic evaluation of liposomal daunorubicin J Clin Oncol. 1995 Apr; 13(4):996-1003. . View in PubMed

Phase I AIDS Clinical Trials Group (075) study of adriamycin, bleomycin and vincristine chemotherapy with zidovudine in the treatment of AIDS-related Kaposi's sarcoma AIDS. 1994 Dec; 8(12):1695-9. . View in PubMed

An unusual case of metastatic intracardiac plasmacytoma Can J Cardiol. 1994 Oct; 10(8):857-60. . View in PubMed

Extramedullary plasmacytoma of the heart presenting as cardiac emergencyReview of literature. Am J Clin Oncol. 1994 Oct; 17(5):427-9. . View in PubMed

Inhibition of AIDS-associated Kaposi's sarcoma cell growth by DAB389-interleukin 6 AIDS Res Hum Retroviruses. 1994 Aug; 10(8):969-75. . View in PubMed

IL-10 inhibits HIV-1 replication and is induced by tat Biochem Biophys Res Commun. 1994 Jul 15; 202(1):374-83. . View in PubMed

Oncostatin-M is an autocrine growth factor in Kaposi's sarcoma Am J Pathol. 1994 Jul; 145(1):74-9. . View in PubMed

Human T-cell lymphotropic virus type I-associated retinal lymphomaA clinicopathologic report. Arch Ophthalmol. 1994 Jul; 112(7):954-9. . View in PubMed

Solid tumor treatment workshop summary Leukemia. 1994; 8 Suppl 3:S83-4. . View in PubMed

All-trans retinoic acid for the treatment of AIDS-related Kaposi's sarcoma: results of a pilot phase II study Leukemia. 1994; 8 Suppl 3:S26-32. . View in PubMed

Potentiation of cytotoxicity of Kaposi's sarcoma related to immunodeficiency syndrome (AIDS) by liposome-encapsulated doxorubicin AIDS Res Hum Retroviruses. 1993 Aug; 9(8):741-6. . View in PubMed

Adriamycin, bleomycin and vincristine chemotherapy with recombinant granulocyte-macrophage colony-stimulating factor in the treatment of AIDS-related Kaposi's sarcoma AIDS. 1992 Dec; 6(12):1477-81. . View in PubMed

Treatment of ocular adnexal Kaposi's sarcoma in acquired immune deficiency syndrome Ophthalmology. 1992 Jul; 99(7):1127-32. . View in PubMed

Treatment of acquired immunodeficiency syndrome-related Kaposi's sarcoma using bleomycin-containing combination chemotherapy regimens Semin Oncol. 1992 Apr; 19(2 Suppl 5):32-6; discussion 36-7. . View in PubMed

Intravenous immunoglobulin in the treatment of human immunodeficiency virus-related thrombocytopenia Am J Hematol. 1991 Dec; 38(4):261-6. . View in PubMed

Phase I/II trials of alpha-interferon alone or in combination with zidovudine as maintenance therapy following induction chemotherapy in the treatment of acquired immunodeficiency syndrome-related Kaposi's sarcoma Semin Oncol. 1991 Oct; 18(5 Suppl 7):53-7. . View in PubMed

Pathogenesis of HIV-related malignancies Curr Opin Oncol. 1991 Oct; 3(5):867-71. . View in PubMed

Systemic treatment of AIDS-related Kaposi's sarcoma: results of a randomized trial Am J Med. 1991 Apr; 90(4):427-33. . View in PubMed

Recent advances in AIDS-related Kaposi's sarcoma Curr Opin Oncol. 1990 Dec; 2(6):1161-6. . View in PubMed

Interferon-alpha maintenance therapy after cytotoxic chemotherapy for treatment of acquired immunodeficiency syndrome-related Kaposi's sarcoma J Biol Response Mod. 1990 Oct; 9(5):512-6. . View in PubMed

Treatment of advanced Kaposi's sarcoma using a combination of bleomycin and vincristine Am J Clin Oncol. 1990 Aug; 13(4):315-9. . View in PubMed

The response of symptomatic gastrointestinal Kaposi's sarcoma to chemotherapy: a prospective evaluation using an endoscopic method of disease quantification Am J Gastroenterol. 1990 Aug; 85(8):959-61. . View in PubMed

Advanced acquired immune deficiency syndrome-related Kaposi's sarcomaResults of pilot studies using combination chemotherapy. Cancer. 1990 Mar 01; 65(5):1074-8. . View in PubMed

Treatment of epidemic Kaposi's sarcoma with combination chemotherapy (vincristine and bleomycin) and zidovudine Ann Oncol. 1990; 1(2):147-9. . View in PubMed

Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1) Ann Intern Med. 1989 Dec 01; 111(11):871-5. . View in PubMed

Recent advances in AIDS-related Kaposi's sarcoma Curr Opin Oncol. 1989 Oct; 1(1):57-61. . View in PubMed

Pulmonary Kaposi's sarcoma: clinical findings and results of therapy Am J Med. 1989 Jul; 87(1):57-61. . View in PubMed

Clinical effect of glucocorticoids on Kaposi sarcoma related to the acquired immunodeficiency syndrome (AIDS) Ann Intern Med. 1989 Jun 01; 110(11):937-40. . View in PubMed

Primary central nervous system lymphoma in AIDSResults of radiation therapy. Cancer. 1989 Mar 15; 63(6):1101-7. . View in PubMed

Vitamin D metabolite-mediated hypercalcemia and hypercalciuria patients with AIDS- and non-AIDS-associated lymphoma Blood. 1989 Jan; 73(1):235-9. . View in PubMed

Protein A immunoadsorption therapy in HIV-related immune thrombocytopenia: a preliminary report Artif Organs. 1988 Dec; 12(6):484-90. . View in PubMed

Production of a positive direct antiglobulin test due to suramin Arch Pathol Lab Med. 1988 Sep; 112(9):898-900. . View in PubMed

Autopsy findings in AIDS-related lymphoma Cancer. 1988 Aug 15; 62(4):735-9. . View in PubMed

Third-World Hodgkin's disease at Los Angeles County-University of Southern California Medical Center J Clin Oncol. 1988 Aug; 6(8):1285-92. . View in PubMed

Radiation therapy for acquired immunodeficiency syndrome-related Kaposi's sarcoma J Clin Oncol. 1988 May; 6(5):863-7. . View in PubMed

Relationship of serum levels of oncostatin M to AIDS-related and classic Kaposi's sarcoma J Acquir Immune Defic Syndr (1988). 1994 Apr; 7(4):410-4. . View in PubMed

HIV-related malignant lymphoma: clinical aspects, treatment, and pathogenesis Cancer Invest. 1988; 6(4):413-6. . View in PubMed

Serum erythropoietin titers in patients with human immunodeficiency virus (HIV) infection and anemia J Acquir Immune Defic Syndr (1988). 1991; 4(6):593-7. . View in PubMed

A comparison of imaging, clinical, and pathologic aspects of space-occupying lesions within the brain in patients with acquired immune deficiency syndrome Am J Physiol Imaging. 1986; 1(3):134-41. . View in PubMed