Parkash Singh Gill, MD

Professor of Medicine, Pathology and Urology

Renette and Marshall Ezralow Family Chair in Cancer Therapeutics

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Overview

Dr. Gill’s primary research interest is in studying novel targets that are expressed both in tumor blood vessels as well as the tumor cell. He has demonstrated the ability to identify and validate novel targets, develop novel target therapeutics and collaborate with clinical investigators to conduct early stage clinical trials.

Dr. Gill has a strong history of clinical investigations and drug development. His clinical investigations led to the approval of three cancer drugs by the FDA. He also served on the advisory panel for the FDA advisory committee on biologics. Over the past several years his work has focused on the identification of novel cancer and cancer blood vessel targets, validation of the targets in various model systems including genetic mouse models.

Research Funding

  • VEGFs in Artery-Vein Imbalance in AIDS-Kaposi Sarcoma
    NIH · R01CA079218 · Jun 1, 1999 – Feb 28, 2011 · Role: Principal Investigator
  • ANGIOGENIC FACTORS AND THEIR EXPRESSION/REGULATION IN KS
    NIH · R01HL048499 · May 1, 1992 – Jan 31, 1996 · Role: Principal Investigator
  • PATHOGENISIS OF KAPOSI'S SARCOMA
    NIH · R01CA051621 · Sep 30, 1989 – Jul 31, 1995 · Role: Principal Investigator

Publications

  • Systemic Therapy for Muscle-Invasive Urothelial Carcinoma of the Bladder (Muscle-Invasive Bladder Cancer): Insights From Real-World Data. JCO Oncol Pract. 2026 Sep; 22(9):1672-1682.. View in PubMed
  • EphB4-ephrin-B2 are targets in castration resistant prostate cancer. Br J Cancer. 2025 May; 132(8):679-689.. View in PubMed
  • Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma. Oncotarget. 2024 07 10; 15:444-458.. View in PubMed
  • EphrinB2: Expression of a novel potential target in renal cell carcinoma. Indian J Urol. 2023 Jul-Sep; 39(3):223-227.. View in PubMed
  • The Impact of Facility Surgical Caseload Volumes on Survival Outcomes in Patients Undergoing Radical Cystectomy. Cancers (Basel). 2022 Dec 03; 14(23).. View in PubMed
  • EphrinB2 Inhibition and Pembrolizumab in Metastatic Urothelial Carcinoma. J Clin Oncol. 2023 01 20; 41(3):640-650.. View in PubMed
  • PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma. Front Immunol. 2021; 12:733136.. View in PubMed
  • The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection. J Biol Chem. 2021 Jan-Jun; 296:100759.. View in PubMed
  • Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biol Open. 2021 02 25; 10(2).. View in PubMed
  • Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression. Development. 2020 09 11; 147(17).. View in PubMed