Parkash Singh Gill, MD

Dr. Gill’s primary research interest is in studying novel targets that are expressed both in tumor blood vessels as well as the tumor cell. He has demonstrated the ability to identify and validate novel targets, develop novel target therapeutics and collaborate with clinical investigators to conduct early stage clinical trials.

Dr. Gill has a strong history of clinical investigations and drug development. His clinical investigations led to the approval of three cancer drugs by the FDA. He also served on the advisory panel for the FDA advisory committee on biologics. Over the past several years his work has focused on the identification of novel cancer and cancer blood vessel targets, validation of the targets in various model systems including genetic mouse models.

• EphrinB2: Expression of a novel potential target in renal cell carcinoma Indian J Urol. 2023 Jul-Sep; 39(3):223-227. . View in PubMed
• EphrinB2 Inhibition and Pembrolizumab in Metastatic Urothelial Carcinoma J Clin Oncol. 2023 01 20; 41(3):640-650. . View in PubMed
• The Impact of Facility Surgical Caseload Volumes on Survival Outcomes in Patients Undergoing Radical Cystectomy Cancers (Basel). 2022 Dec 03; 14(23). . View in PubMed
• PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-a Production and Restricts Progression of Metastatic Melanoma Front Immunol. 2021; 12:733136. . View in PubMed
• The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection J Biol Chem. 2021 Jan-Jun; 296:100759. . View in PubMed
• Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways Biol Open. 2021 02 25; 10(2). . View in PubMed
• EphrinB2 expression in prostate adenocarcinoma: Implications for targeted therapy Pathol Res Pract. 2020 Jun; 216(6):152967. . View in PubMed
• Association between Smoking Exposure, Neoadjuvant Chemotherapy Response and Survival Outcomes following Radical Cystectomy: Systematic Review and Meta-Analysis J Urol. 2020 10; 204(4):649-660. . View in PubMed
• Reply by Authors J Urol. 2020 10; 204(4):660. . View in PubMed
• Programmed Death 1 and Programmed Death Ligand 1 Inhibitors in Advanced and Recurrent Urothelial Carcinoma: Meta-analysis of Single-Agent StudiesClin Genitourin Cancer. 2020 10; 18(5):351-360. e3. . View in PubMed
• Delta-like ligand 4-mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression Development. 2020 09 11; 147(17). . View in PubMed
• GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer Life Sci Alliance. 2019 08; 2(4). . View in PubMed
• Histological Validation of 11Carbon-Acetate Positron Emission Tomography/Computerized Tomography in Detecting Lymph Node Metastases in Prostate Cancer J Urol. 2019 02; 201(2):332-341. . View in PubMed
• EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT Blood Adv. 2017 Sep 12; 1(20):1635-1644. . View in PubMed
• Robotic salvage retroperitoneal and pelvic lymph node dissection for ‘node-only’ recurrent prostate cancer: technique and initial series BJU Int. 2017 09; 120(3):401-408. . View in PubMed
• Identifying aggressive prostate cancer foci using a DNA methylation classifier Genome Biol. 2017 01 12; 18(1):3. . View in PubMed
• GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4020-E4029. . View in PubMed
• Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis Oncogene. 2015 Oct; 34(43):5418-26. . View in PubMed
• Axl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinoma Br J Cancer. 2015 Aug 11; 113(4):616-25. . View in PubMed
• Design, synthesis, and validation of Axl-targeted monoclonal antibody probe for microPET imaging in human lung cancer xenograft Mol Pharm. 2014 Nov 03; 11(11):3974-9. . View in PubMed
• Axl-targeted cancer imaging with humanized antibody h173 Mol Imaging Biol. 2014 Aug; 16(4):511-8. . View in PubMed
• The differential expression of EphB2 and EphB4 receptor kinases in normal bladder and in transitional cell carcinoma of the bladder PLoS One. 2014; 9(8):e105326. . View in PubMed
• Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis Clin Cancer Res. 2013 Dec 15; 19(24):6802-11. . View in PubMed
• PET imaging of colorectal and breast cancer by targeting EphB4 receptor with 64Cu-labeled hAb47 and hAb131 antibodies J Nucl Med. 2013 Jul; 54(7):1094-100. . View in PubMed
• EphB4 as a therapeutic target in mesothelioma BMC Cancer. 2013 May 30; 13:269. . View in PubMed
• Targeting the EphB4 receptor for cancer diagnosis and therapy monitoring Mol Pharm. 2013 Jan 07; 10(1):329-36. . View in PubMed
• Inhibition of Notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues Biochem Biophys Res Commun. 2012 Feb 03; 418(1):173-9. . View in PubMed
• Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis BMC Cancer. 2010 Nov 23; 10:641. . View in PubMed
• Immune evasion by Kaposi’s sarcoma-associated herpesvirus Future Microbiol. 2010 Sep; 5(9):1349-65. . View in PubMed
• Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma Blood. 2010 Jul 15; 116(2):297-305. . View in PubMed
• Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP J Biol Chem. 2010 May 14; 285(20):15065-15075. . View in PubMed
• KSHV-induced notch components render endothelial and mural cell characteristics and cell survival Blood. 2010 Jan 28; 115(4):887-95. . View in PubMed
• Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):543-52. . View in PubMed
• Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression Cancer Res. 2009 May 01; 69(9):3736-45. . View in PubMed
• The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade Blood. 2009 Jan 01; 113(1):254-63. . View in PubMed
• The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma Arch Otolaryngol Head Neck Surg. 2008 Sep; 134(9):985-91. . View in PubMed
• Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma Blood. 2008 Apr 01; 111(7):3377-82. . View in PubMed
• Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion Blood. 2007 Jun 01; 109(11):4753-60. . View in PubMed
• The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome Br J Cancer. 2007 Apr 10; 96(7):1083-91. . View in PubMed
• Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer Mol Cancer Res. 2007 Apr; 5(4):351-62. . View in PubMed
• The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma Arch Otolaryngol Head Neck Surg. 2006 Oct; 132(10):1053-9. . View in PubMed
• EphB4 provides survival advantage to squamous cell carcinoma of the head and neck Int J Cancer. 2006 Sep 15; 119(6):1236-48. . View in PubMed
• Receptor tyrosine kinase EphB4 is a survival factor in breast cancer Am J Pathol. 2006 Jul; 169(1):279-93. . View in PubMed
• Phase I study of antisense oligonucleotide against vascular endothelial growth factor: decrease in plasma vascular endothelial growth factor with potential clinical efficacy J Clin Oncol. 2006 Apr 10; 24(11):1712-9. . View in PubMed
• Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancer J Urol. 2006 Apr; 175(4):1245-52. . View in PubMed
• EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival Oncogene. 2006 Feb 02; 25(5):769-80. . View in PubMed
• Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4772-9. . View in PubMed
• Up-regulation of EphB4 in mesothelioma and its biological significance Clin Cancer Res. 2005 Jun 15; 11(12):4305-15. . View in PubMed
• EphB4 expression and biological significance in prostate cancer Cancer Res. 2005 Jun 01; 65(11):4623-32. . View in PubMed
• Molecular prognostic factors in bladder cancer BJU Int. 2005 Apr; 95(6):739-42. . View in PubMed
• Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium Blood. 2005 Feb 01; 105(3):1310-8. . View in PubMed
• Th1 and Th2 cytokines and IgE levels in identical twins with varying levels of cigarette consumption J Clin Immunol. 2004 Nov; 24(6):617-22. . View in PubMed
• IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma Blood. 2004 Apr 15; 103(8):3216-21. . View in PubMed
• Expression of EphB4 in head and neck squamous cell carcinoma Ear Nose Throat J. 2003 Nov; 82(11):866869-70887. . View in PubMed
• Natural killer cell cytolytic activity is necessary for in vivo antitumor activity of the dipeptide L-glutamyl-L-tryptophan Int J Cancer. 2003 Sep 10; 106(4):528-533. . View in PubMed
• Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops Int J Cancer. 2003 May 01; 104(5):603-10. . View in PubMed
• Multicenter trial of low-dose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma Cancer. 2002 Jul 01; 95(1):147-54. . View in PubMed
• Multidrug resistance (MDR-1) expression in AIDS-related lymphomas Leuk Res. 2002 Feb; 26(2):121-7. . View in PubMed
• Human herpesvirus-8-transformed endothelial cells have functionally activated vascular endothelial growth factor/vascular endothelial growth factor receptor Am J Pathol. 2002 Jan; 160(1):23-9. . View in PubMed
• Retroviral vectors bearing IgG-binding motifs for antibody-mediated targeting of vascular endothelial growth factor receptors Int J Mol Med. 2001 Oct; 8(4):335-43. . View in PubMed
• Interleukin 8 is an autocrine growth factor and a surrogate marker for Kaposi’s sarcoma Clin Cancer Res. 2001 Sep; 7(9):2693-702. . View in PubMed
• Results of a collaborative study of the EDNAP group regarding the reproducibility and robustness of the Y-chromosome STRs DYS19, DYS389 I and II, DYS390 and DYS393 in a PCR pentaplex format Forensic Sci Int. 2001 Jun 01; 119(1):28-41. . View in PubMed
• Evolving characteristics of AIDS-related lymphoma Blood. 2000 Dec 15; 96(13):4084-90. . View in PubMed
• Kaposi sarcoma is a therapeutic target for vitamin D(3) receptor agonist Blood. 2000 Nov 01; 96(9):3188-94. . View in PubMed
• Results of a randomized study of IM862 nasal solution in the treatment of AIDS-related Kaposi’s sarcoma J Clin Oncol. 2000 Feb; 18(4):716-23. . View in PubMed
• Paclitaxel Induces Apoptosis in AIDS-Related Kaposi’s Sarcoma Cells Sarcoma. 2000; 4(1-2):37-45. . View in PubMed
• Expression of the human immunodeficiency virus-Tat gene in lymphoid tissues of transgenic mice is associated with B-cell lymphoma Blood. 1999 Jul 01; 94(1):275-82. . View in PubMed
• Paclitaxel is safe and effective in the treatment of advanced AIDS-related Kaposi’s sarcoma J Clin Oncol. 1999 Jun; 17(6):1876-83. . View in PubMed
• Antineoplastic urinary protein inhibits Kaposi’s sarcoma and angiogenesis in vitro and in vivo Blood. 1999 Feb 01; 93(3):1038-44. . View in PubMed
• Phase II trial of liposomal daunorubicin in the treatment of AIDS-related pulmonary Kaposi’s sarcoma J Clin Oncol. 1998 Oct; 16(10):3369-74. . View in PubMed
• Emerging treatments for epidemic (AIDS-related) Kaposi’s sarcoma Curr Opin Oncol. 1998 Sep; 10(5):413-21. . View in PubMed
• Evidence for multiclonality in multicentric Kaposi’s sarcoma Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):8257-61. . View in PubMed
• Extravasation of liposomal daunorubicin in patients with AIDS-associated Kaposi’s sarcoma: a report of four cases Oncol Nurs Forum. 1998 Jan-Feb; 25(1):67-70. . View in PubMed
• Phase I study of human chorionic gonadotropin given subcutaneously to patients with acquired immunodeficiency syndrome-related mucocutaneous Kaposi’s sarcoma J Natl Cancer Inst. 1997 Dec 03; 89(23):1797-802. . View in PubMed
• Treatment of epidemic (AIDS-related) Kaposi’s sarcoma Curr Opin Oncol. 1997 Sep; 9(5):433-9. . View in PubMed
• AIDS Clinical Trials Group Study 094: a phase I/II trial of ABV chemotherapy with zidovudine and recombinant human GM-CSF in AIDS-related Kaposi’s sarcoma Cancer J Sci Am. 1997 Sep-Oct; 3(5):278-83. . View in PubMed
• Glucocorticoids induce Kaposi’s sarcoma cell proliferation through the regulation of transforming growth factor-beta Blood. 1997 Mar 01; 89(5):1491-500. . View in PubMed
• Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma Proc Natl Acad Sci U S A. 1997 Feb 04; 94(3):979-84. . View in PubMed
• IL-4R expression in AIDS-KS cells and response to rhIL-4 and IL-4 toxin (DAB389-IL-4) Invest New Drugs. 1997; 15(4):279-87. . View in PubMed
• Interleukin-4 in the treatment of AIDS-related Kaposi’s sarcoma Ann Oncol. 1997 Jan; 8(1):79-83. . View in PubMed
• The effects of preparations of human chorionic gonadotropin on AIDS-related Kaposi’s sarcoma N Engl J Med. 1996 Oct 24; 335(17):1261-9. . View in PubMed
• Low dose methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone with zalcitabine in patients with acquired immunodeficiency syndrome-related lymphomaEffect on human immunodeficiency virus and serum interleukin-6 levels over time. Cancer. 1996 Aug 01; 78(3):517-26. . View in PubMed
• Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi’s sarcoma J Clin Oncol. 1996 Aug; 14(8):2353-64. . View in PubMed
• Increased radiosensitivity of normal tissue fibroblasts in patients with acquired immunodeficiency syndrome (AIDS) and with Kaposi’s sarcoma Int J Radiat Biol. 1995 Oct; 68(4):411-2. . View in PubMed
• Treatment of adult T-cell leukemia-lymphoma with a combination of interferon alfa and zidovudine N Engl J Med. 1995 Jun 29; 332(26):1744-8. . View in PubMed
• Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi’s sarcoma J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15; 8(5):455-60. . View in PubMed
• Phase I/II clinical and pharmacokinetic evaluation of liposomal daunorubicin J Clin Oncol. 1995 Apr; 13(4):996-1003. . View in PubMed
• Phase I AIDS Clinical Trials Group (075) study of adriamycin, bleomycin and vincristine chemotherapy with zidovudine in the treatment of AIDS-related Kaposi’s sarcoma AIDS. 1994 Dec; 8(12):1695-9. . View in PubMed
• An unusual case of metastatic intracardiac plasmacytoma Can J Cardiol. 1994 Oct; 10(8):857-60. . View in PubMed
• Extramedullary plasmacytoma of the heart presenting as cardiac emergencyReview of literature. Am J Clin Oncol. 1994 Oct; 17(5):427-9. . View in PubMed
• Inhibition of AIDS-associated Kaposi’s sarcoma cell growth by DAB389-interleukin 6 AIDS Res Hum Retroviruses. 1994 Aug; 10(8):969-75. . View in PubMed
• IL-10 inhibits HIV-1 replication and is induced by tat Biochem Biophys Res Commun. 1994 Jul 15; 202(1):374-83. . View in PubMed
• Oncostatin-M is an autocrine growth factor in Kaposi’s sarcoma Am J Pathol. 1994 Jul; 145(1):74-9. . View in PubMed
• Human T-cell lymphotropic virus type I-associated retinal lymphomaA clinicopathologic report. Arch Ophthalmol. 1994 Jul; 112(7):954-9. . View in PubMed
• Solid tumor treatment workshop summary Leukemia. 1994; 8 Suppl 3:S83-4. . View in PubMed
• All-trans retinoic acid for the treatment of AIDS-related Kaposi’s sarcoma: results of a pilot phase II study Leukemia. 1994; 8 Suppl 3:S26-32. . View in PubMed
• Potentiation of cytotoxicity of Kaposi’s sarcoma related to immunodeficiency syndrome (AIDS) by liposome-encapsulated doxorubicin AIDS Res Hum Retroviruses. 1993 Aug; 9(8):741-6. . View in PubMed
• Adriamycin, bleomycin and vincristine chemotherapy with recombinant granulocyte-macrophage colony-stimulating factor in the treatment of AIDS-related Kaposi’s sarcoma AIDS. 1992 Dec; 6(12):1477-81. . View in PubMed
• Treatment of ocular adnexal Kaposi’s sarcoma in acquired immune deficiency syndrome Ophthalmology. 1992 Jul; 99(7):1127-32. . View in PubMed
• Treatment of acquired immunodeficiency syndrome-related Kaposi’s sarcoma using bleomycin-containing combination chemotherapy regimens Semin Oncol. 1992 Apr; 19(2 Suppl 5):32-6; discussion 36-7. . View in PubMed
• Intravenous immunoglobulin in the treatment of human immunodeficiency virus-related thrombocytopenia Am J Hematol. 1991 Dec; 38(4):261-6. . View in PubMed
• Pathogenesis of HIV-related malignancies Curr Opin Oncol. 1991 Oct; 3(5):867-71. . View in PubMed
• Phase I/II trials of alpha-interferon alone or in combination with zidovudine as maintenance therapy following induction chemotherapy in the treatment of acquired immunodeficiency syndrome-related Kaposi’s sarcoma Semin Oncol. 1991 Oct; 18(5 Suppl 7):53-7. . View in PubMed
• Systemic treatment of AIDS-related Kaposi’s sarcoma: results of a randomized trial Am J Med. 1991 Apr; 90(4):427-33. . View in PubMed
• Recent advances in AIDS-related Kaposi’s sarcoma Curr Opin Oncol. 1990 Dec; 2(6):1161-6. . View in PubMed
• Interferon-alpha maintenance therapy after cytotoxic chemotherapy for treatment of acquired immunodeficiency syndrome-related Kaposi’s sarcoma J Biol Response Mod. 1990 Oct; 9(5):512-6. . View in PubMed
• The response of symptomatic gastrointestinal Kaposi’s sarcoma to chemotherapy: a prospective evaluation using an endoscopic method of disease quantification Am J Gastroenterol. 1990 Aug; 85(8):959-61. . View in PubMed
• Treatment of advanced Kaposi’s sarcoma using a combination of bleomycin and vincristine Am J Clin Oncol. 1990 Aug; 13(4):315-9. . View in PubMed
• Advanced acquired immune deficiency syndrome-related Kaposi’s sarcomaResults of pilot studies using combination chemotherapy. Cancer. 1990 Mar 01; 65(5):1074-8. . View in PubMed
• Treatment of epidemic Kaposi’s sarcoma with combination chemotherapy (vincristine and bleomycin) and zidovudine Ann Oncol. 1990; 1(2):147-9. . View in PubMed
• Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1) Ann Intern Med. 1989 Dec 01; 111(11):871-5. . View in PubMed
• Recent advances in AIDS-related Kaposi’s sarcoma Curr Opin Oncol. 1989 Oct; 1(1):57-61. . View in PubMed
• Pulmonary Kaposi’s sarcoma: clinical findings and results of therapy Am J Med. 1989 Jul; 87(1):57-61. . View in PubMed
• Clinical effect of glucocorticoids on Kaposi sarcoma related to the acquired immunodeficiency syndrome (AIDS) Ann Intern Med. 1989 Jun 01; 110(11):937-40. . View in PubMed
• Primary central nervous system lymphoma in AIDSResults of radiation therapy. Cancer. 1989 Mar 15; 63(6):1101-7. . View in PubMed
• Vitamin D metabolite-mediated hypercalcemia and hypercalciuria patients with AIDS- and non-AIDS-associated lymphoma Blood. 1989 Jan; 73(1):235-9. . View in PubMed
• Protein A immunoadsorption therapy in HIV-related immune thrombocytopenia: a preliminary report Artif Organs. 1988 Dec; 12(6):484-90. . View in PubMed
• Production of a positive direct antiglobulin test due to suramin Arch Pathol Lab Med. 1988 Sep; 112(9):898-900. . View in PubMed
• Autopsy findings in AIDS-related lymphoma Cancer. 1988 Aug 15; 62(4):735-9. . View in PubMed
• Third-World Hodgkin’s disease at Los Angeles County-University of Southern California Medical Center J Clin Oncol. 1988 Aug; 6(8):1285-92. . View in PubMed
• Radiation therapy for acquired immunodeficiency syndrome-related Kaposi’s sarcoma J Clin Oncol. 1988 May; 6(5):863-7. . View in PubMed
• Relationship of serum levels of oncostatin M to AIDS-related and classic Kaposi’s sarcoma J Acquir Immune Defic Syndr (1988). 1994 Apr; 7(4):410-4. . View in PubMed
• HIV-related malignant lymphoma: clinical aspects, treatment, and pathogenesis Cancer Invest. 1988; 6(4):413-6. . View in PubMed
• Serum erythropoietin titers in patients with human immunodeficiency virus (HIV) infection and anemia J Acquir Immune Defic Syndr (1988). 1991; 4(6):593-7. . View in PubMed
• A comparison of imaging, clinical, and pathologic aspects of space-occupying lesions within the brain in patients with acquired immune deficiency syndrome Am J Physiol Imaging. 1986; 1(3):134-41. . View in PubMed

• Daneshmand, Siamak
• Lenz, Heinz-Josef
• Lee, Amy
• Djaladat, Hooman
• Gill, Inderbir
• Matsuo, Koji
• Quinn, David