Keck School Faculty

Parkash Singh Gill, MD
Parkash Singh Gill, MD
Professor of Medicine;Renette and Marshall Ezralow Family Chair in Cancer Therapeutics
Medicine
1441 Eastlake Ave. Health Sciences Campus Los Angeles
Dr. Gill's primary research interest is in studying novel targets that are expressed both in tumor blood vessels as well as the tumor cell. He has demonstrated the ability to identify and validate novel targets, develop novel target therapeutics and collaborate with clinical investigators to conduct early stage clinical trials.

Dr. Gill has a strong history of clinical investigations and drug development. His clinical investigations led to the approval of three cancer drugs by the FDA. He also served on the advisory panel for the FDA advisory committee on biologics. Over the past several years his work has focused on the identification of novel cancer and cancer blood vessel targets, validation of the targets in various model systems including genetic mouse models.

EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells Cell Death Dis. 2019 Oct 22; 10(11):801. . View in PubMed

GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer Life Sci Alliance. 2019 08; 2(4). . View in PubMed

Histological Validation of 11Carbon-Acetate Positron Emission Tomography/Computerized Tomography in Detecting Lymph Node Metastases in Prostate Cancer J Urol. 2019 02; 201(2):332-341. . View in PubMed

Correction: AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma Clin Cancer Res. 2018 Dec 01; 24(23):6099. . View in PubMed

EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT Blood Adv. 2017 Sep 12; 1(20):1635-1644. . View in PubMed

Identifying aggressive prostate cancer foci using a DNA methylation classifier Genome Biol. 2017 01 12; 18(1):3. . View in PubMed

EphB4/EphrinB2 therapeutics in Rhabdomyosarcoma PLoS One. 2017; 12(8):e0183161. . View in PubMed

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4020-E4029. . View in PubMed

Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas Sci Rep. 2016 12 12; 6:38792. . View in PubMed

Correction: Identification of Androgen Receptor Splice Variants in the Pten Deficient Murine Prostate Cancer Model PLoS One. 2016; 11(3):e0152243. . View in PubMed

Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways Oncotarget. 2015 Oct 06; 6(30):29143-60. . View in PubMed

Axl receptor tyrosine kinase is a potential therapeutic target in renal cell carcinoma Br J Cancer. 2015 Aug 11; 113(4):616-25. . View in PubMed

AXL Is a Logical Molecular Target in Head and Neck Squamous Cell Carcinoma Clin Cancer Res. 2015 Jun 01; 21(11):2601-12. . View in PubMed

Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy PLoS One. 2015; 10(8):e0134346. . View in PubMed

Identification of Androgen Receptor Splice Variants in the Pten Deficient Murine Prostate Cancer Model PLoS One. 2015; 10(7):e0131232. . View in PubMed

Expression of the EPHB4 receptor tyrosine kinase in head and neck and renal malignancies--implications for solid tumors and potential for therapeutic inhibition Growth Factors. 2014 Dec; 32(6):202-6. . View in PubMed

Design, synthesis, and validation of Axl-targeted monoclonal antibody probe for microPET imaging in human lung cancer xenograft Mol Pharm. 2014 Nov 03; 11(11):3974-9. . View in PubMed

AXL mediates resistance to cetuximab therapy Cancer Res. 2014 Sep 15; 74(18):5152-64. . View in PubMed

Axl-targeted cancer imaging with humanized antibody h173 Mol Imaging Biol. 2014 Aug; 16(4):511-8. . View in PubMed

EphB4-targeted imaging with antibody h131, h131-F(ab')2 and h131-Fab Mol Pharm. 2013 Dec 02; 10(12):4527-33. . View in PubMed

EphB4 as a therapeutic target in mesothelioma BMC Cancer. 2013 May 30; 13:269. . View in PubMed

Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers Cancer Res. 2013 Jan 01; 73(1):184-94. . View in PubMed

Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2 Cancer Res. 2012 Jul 15; 72(14):3582-92. . View in PubMed

Biophysical characterization and stabilization of the recombinant albumin fusion protein sEphB4-HSA J Pharm Sci. 2012 Jun; 101(6):1969-84. . View in PubMed

Inhibition of Notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues Biochem Biophys Res Commun. 2012 Feb 03; 418(1):173-9. . View in PubMed

Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesis PLoS One. 2012; 7(1):e29863. . View in PubMed

Ethnic differences in common carotid intima-media thickness, and the relationship to cardiovascular risk factors and peripheral arterial disease: the Ethnic-Echocardiographic Heart of England Screening Study QJM. 2011 Mar; 104(3):245-54. . View in PubMed

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis BMC Cancer. 2010 Nov 23; 10:641. . View in PubMed

Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 cooperates with Myc to promote lymphoma in mice Cancer Biol Ther. 2010 Nov 15; 10(10):1033-40. . View in PubMed

Immune evasion by Kaposi's sarcoma-associated herpesvirus Future Microbiol. 2010 Sep; 5(9):1349-65. . View in PubMed

Converging evidence for efficacy from parallel EphB4-targeted approaches in ovarian carcinoma Mol Cancer Ther. 2010 Aug; 9(8):2377-88. . View in PubMed

Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma Blood. 2010 Jul 15; 116(2):297-305. . View in PubMed

Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP J Biol Chem. 2010 May 14; 285(20):15065-75. . View in PubMed

KSHV-induced notch components render endothelial and mural cell characteristics and cell survival Blood. 2010 Jan 28; 115(4):887-95. . View in PubMed

Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli BMC Dev Biol. 2008 Dec 16; 8:117. . View in PubMed

Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma Blood. 2008 Apr 01; 111(7):3377-82. . View in PubMed

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion Blood. 2007 Jun 01; 109(11):4753-60. . View in PubMed

Identification of Hendra virus G glycoprotein residues that are critical for receptor binding J Virol. 2007 Jun; 81(11):5893-901. . View in PubMed

Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties Mol Immunol. 2007 Apr; 44(11):3049-60. . View in PubMed

Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer Mol Cancer Res. 2007 Apr; 5(4):351-62. . View in PubMed

EphB4 provides survival advantage to squamous cell carcinoma of the head and neck Int J Cancer. 2006 Sep 15; 119(6):1236-48. . View in PubMed

Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancer J Urol. 2006 Apr; 175(4):1245-52. . View in PubMed

EphB4 receptor tyrosine kinase is expressed in bladder cancer and provides signals for cell survival Oncogene. 2006 Feb 02; 25(5):769-80. . View in PubMed

EphB4 expression and biological significance in prostate cancer Cancer Res. 2005 Jun 01; 65(11):4623-32. . View in PubMed

Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team J Clin Oncol. 2005 Feb 10; 23(5):990-8. . View in PubMed

Ephrin B2 expression in Kaposi sarcoma is induced by human herpesvirus type 8: phenotype switch from venous to arterial endothelium Blood. 2005 Feb 01; 105(3):1310-8. . View in PubMed

Alpha-chemokine-mediated signal transduction in human Kaposi's sarcoma spindle cells Biochim Biophys Acta. 2004 May 03; 1691(2-3):129-39. . View in PubMed

IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma Blood. 2004 Apr 15; 103(8):3216-21. . View in PubMed

Expression of EphB4 in head and neck squamous cell carcinoma Ear Nose Throat J. 2003 Nov; 82(11):866869-70887. . View in PubMed

A multicenter phase II study of the intravenous administration of liposomal tretinoin in patients with acquired immunodeficiency syndrome-associated Kaposi's sarcoma Cancer. 2002 Dec 15; 95(12):2555-61. . View in PubMed

Human herpesvirus-8-transformed endothelial cells have functionally activated vascular endothelial growth factor/vascular endothelial growth factor receptor Am J Pathol. 2002 Jan; 160(1):23-9. . View in PubMed

Interleukin 8 is an autocrine growth factor and a surrogate marker for Kaposi's sarcoma Clin Cancer Res. 2001 Sep; 7(9):2693-702. . View in PubMed

Evolving characteristics of AIDS-related lymphoma Blood. 2000 Dec 15; 96(13):4084-90. . View in PubMed

Kaposi sarcoma is a therapeutic target for vitamin D(3) receptor agonist Blood. 2000 Nov 01; 96(9):3188-94. . View in PubMed

Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma Cancer Res. 2000 Aug 01; 60(15):4066-9. . View in PubMed

c-Src mediates mitogenic signals and associates with cytoskeletal proteins upon vascular endothelial growth factor stimulation in Kaposi's sarcoma cells J Immunol. 2000 Feb 01; 164(3):1169-74. . View in PubMed

Azidothymidine and interferon-alpha induce apoptosis in herpesvirus-associated lymphomas Cancer Res. 1999 Nov 01; 59(21):5514-20. . View in PubMed

Expression of the human immunodeficiency virus-Tat gene in lymphoid tissues of transgenic mice is associated with B-cell lymphoma Blood. 1999 Jul 01; 94(1):275-82. . View in PubMed

Antineoplastic urinary protein inhibits Kaposi's sarcoma and angiogenesis in vitro and in vivo Blood. 1999 Feb 01; 93(3):1038-44. . View in PubMed

Emerging treatments for epidemic (AIDS-related) Kaposi's sarcoma Curr Opin Oncol. 1998 Sep; 10(5):413-21. . View in PubMed

Liposome-anchored vascular endothelial growth factor aptamers Bioconjug Chem. 1998 Sep-Oct; 9(5):573-82. . View in PubMed

Evidence for multiclonality in multicentric Kaposi's sarcoma Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):8257-61. . View in PubMed

Detection and titration of human herpesvirus-8-specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi's sarcoma patients using a whole virus enzyme-linked immunosorbent assay Blood. 1998 Jul 01; 92(1):53-8. . View in PubMed

Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group studyAIDS Clinical Trial Group No. 215 Team. J Clin Oncol. 1998 Apr; 16(4):1444-9. . View in PubMed

Extravasation of liposomal daunorubicin in patients with AIDS-associated Kaposi's sarcoma: a report of four cases Oncol Nurs Forum. 1998 Jan-Feb; 25(1):67-70. . View in PubMed

AIDS Clinical Trials Group Study 094: a phase I/II trial of ABV chemotherapy with zidovudine and recombinant human GM-CSF in AIDS-related Kaposi's sarcoma Cancer J Sci Am. 1997 Sep-Oct; 3(5):278-83. . View in PubMed

Glucocorticoids induce Kaposi's sarcoma cell proliferation through the regulation of transforming growth factor-beta Blood. 1997 Mar 01; 89(5):1491-500. . View in PubMed

IL-4R expression in AIDS-KS cells and response to rhIL-4 and IL-4 toxin (DAB389-IL-4) Invest New Drugs. 1997; 15(4):279-87. . View in PubMed

Interleukin-4 in the treatment of AIDS-related Kaposi's sarcoma Ann Oncol. 1997 Jan; 8(1):79-83. . View in PubMed

Low dose methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone with zalcitabine in patients with acquired immunodeficiency syndrome-related lymphomaEffect on human immunodeficiency virus and serum interleukin-6 levels over time. Cancer. 1996 Aug 01; 78(3):517-26. . View in PubMed

Interleukin-10 gene expression in adult T-cell leukemia Blood. 1996 Aug 01; 88(3):1035-45. . View in PubMed

Increased radiosensitivity of normal tissue fibroblasts in patients with acquired immunodeficiency syndrome (AIDS) and with Kaposi's sarcoma Int J Radiat Biol. 1995 Oct; 68(4):411-2. . View in PubMed

Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi's sarcoma J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15; 8(5):455-60. . View in PubMed

Inhibition of AIDS-Kaposi's sarcoma cell proliferation following retinoic acid receptor activation Cancer Res. 1995 Feb 15; 55(4):823-9. . View in PubMed

Extramedullary plasmacytoma of the heart presenting as cardiac emergencyReview of literature. Am J Clin Oncol. 1994 Oct; 17(5):427-9. . View in PubMed

An unusual case of metastatic intracardiac plasmacytoma Can J Cardiol. 1994 Oct; 10(8):857-60. . View in PubMed

Inhibition of AIDS-associated Kaposi's sarcoma cell growth by DAB389-interleukin 6 AIDS Res Hum Retroviruses. 1994 Aug; 10(8):969-75. . View in PubMed

IL-10 inhibits HIV-1 replication and is induced by tat Biochem Biophys Res Commun. 1994 Jul 15; 202(1):374-83. . View in PubMed

Human T-cell lymphotropic virus type I-associated retinal lymphomaA clinicopathologic report. Arch Ophthalmol. 1994 Jul; 112(7):954-9. . View in PubMed

All-trans retinoic acid for the treatment of AIDS-related Kaposi's sarcoma: results of a pilot phase II study Leukemia. 1994; 8 Suppl 3:S26-32. . View in PubMed

Adriamycin, bleomycin and vincristine chemotherapy with recombinant granulocyte-macrophage colony-stimulating factor in the treatment of AIDS-related Kaposi's sarcoma AIDS. 1992 Dec; 6(12):1477-81. . View in PubMed

Intravenous immunoglobulin in the treatment of human immunodeficiency virus-related thrombocytopenia Am J Hematol. 1991 Dec; 38(4):261-6. . View in PubMed

Interferon-alpha maintenance therapy after cytotoxic chemotherapy for treatment of acquired immunodeficiency syndrome-related Kaposi's sarcoma J Biol Response Mod. 1990 Oct; 9(5):512-6. . View in PubMed

Advanced acquired immune deficiency syndrome-related Kaposi's sarcomaResults of pilot studies using combination chemotherapy. Cancer. 1990 Mar 01; 65(5):1074-8. . View in PubMed

Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1) Ann Intern Med. 1989 Dec 01; 111(11):871-5. . View in PubMed

Clinical effect of glucocorticoids on Kaposi sarcoma related to the acquired immunodeficiency syndrome (AIDS) Ann Intern Med. 1989 Jun 01; 110(11):937-40. . View in PubMed

Autopsy findings in AIDS-related lymphoma Cancer. 1988 Aug 15; 62(4):735-9. . View in PubMed

HIV-related malignant lymphoma: clinical aspects, treatment, and pathogenesis Cancer Invest. 1988; 6(4):413-6. . View in PubMed

Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS) Ann Intern Med. 1987 Oct; 107(4):502-5. . View in PubMed

AIDS-related malignant lymphoma: results of prospective treatment trials J Clin Oncol. 1987 Sep; 5(9):1322-8. . View in PubMed

Immunohistology of persistent generalized lymphadenopathyEvidence for progressive lymph node abnormalities in some patients. Am J Clin Pathol. 1987 Jul; 88(1):10-9. . View in PubMed

Malignancies in the acquired immunodeficiency syndrome Curr Probl Cancer. 1987 Jul-Aug; 11(4):209-55. . View in PubMed

AIDS-related malignant lymphoma: clinical presentation and treatment approaches Oncology (Williston Park). 1987 Jun; 1(4):41-6. . View in PubMed

Characterization of immunologic function in homosexual men with persistent, generalized lymphadenopathy and acquired immune deficiency syndrome Cancer. 1987 Feb 15; 59(4):731-8. . View in PubMed

Malignant lymphoma: cardiac involvement at initial presentation J Clin Oncol. 1987 Feb; 5(2):216-24. . View in PubMed

Human T-cell lymphotropic virus type III associated disordersThe spectrum in the heterosexual population. Arch Intern Med. 1986 Aug; 146(8):1501-4. . View in PubMed

B cell acute lymphocytic leukemia in adultsClinical, morphologic, and immunologic findings. J Clin Oncol. 1986 May; 4(5):737-43. . View in PubMed

A comparison of imaging, clinical, and pathologic aspects of space-occupying lesions within the brain in patients with acquired immune deficiency syndrome Am J Physiol Imaging. 1986; 1(3):134-41. . View in PubMed

Human retrovirus-associated lymphoproliferative disorders in homosexual men Prog Allergy. 1986; 37:244-58. . View in PubMed

B-cell lymphoma in two monogamous homosexual men Arch Intern Med. 1985 Mar; 145(3):479-81. . View in PubMed

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