Keck School Faculty

Parviz Minoo, PhD
Parviz Minoo, PhD
Professor of Pediatrics;Director of Research Program
Pediatrics
2020 Zonal Avenue , IRD 820 Off Campus Los Angeles

Alteration of secretory leukocyte protease inhibitor in human myometrium during laborAm J Obstet Gynecol. 2009 Mar; 200(3):311. e1-311. e10. . View in PubMed

Grp78 Loss in Epithelial Progenitors Reveals an Age-Linked Role for ER Stress in Pulmonary Fibrosis Am J Respir Crit Care Med. 2019 Nov 18. . View in PubMed

Secondary crest myofibroblast PDGFRa controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis Development. 2019 Aug 09; 146(15). . View in PubMed

A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis Front Genet. 2018; 9:746. . View in PubMed

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J Clin Invest. 2018 03 01; 128(3):970-984. . View in PubMed

Origin and characterization of alpha smooth muscle actin-positive cells during murine lung development Stem Cells. 2017 06; 35(6):1566-1578. . View in PubMed

Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation Sci Rep. 2017 06 14; 7(1):3473. . View in PubMed

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia J Pathol. 2017 Jan; 241(1):91-103. . View in PubMed

Region-specific role for Pten in maintenance of epithelial phenotype and integrity Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L131-L142. . View in PubMed

p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC) J Biol Chem. 2016 Mar 18; 291(12):6569-82. . View in PubMed

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate BMC Biol. 2016 Mar 16; 14:19. . View in PubMed

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15; 310(2):L114-20. . View in PubMed

Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance Am J Respir Cell Mol Biol. 2016 09; 55(3):395-406. . View in PubMed

Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development Development. 2015 Dec 01; 142(23):4139-50. . View in PubMed

PTEN regulates lung endodermal morphogenesis through MEK/ERK pathway Dev Biol. 2015 Dec 01; 408(1):56-65. . View in PubMed

Non-canonical WNT signalling in the lung J Biochem. 2015 Nov; 158(5):355-65. . View in PubMed

Prognostic factors and concomitant anomalies in neonatal gastric perforation J Pediatr Surg. 2015 Aug; 50(8):1278-82. . View in PubMed

Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm Stem Cells. 2015 Mar; 33(3):999-1012. . View in PubMed

Conditional overexpression of TGFß1 promotes pulmonary inflammation, apoptosis and mortality via TGFßR2 in the developing mouse lung Respir Res. 2015 Jan 16; 16:4. . View in PubMed

A breath of fresh air on the mesenchyme: impact of impaired mesenchymal development on the pathogenesis of bronchopulmonary dysplasia Front Med (Lausanne). 2015; 2:27. . View in PubMed

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. . View in PubMed

Dihydrotestosterone potentiates EGF-induced ERK activation by inducing SRC in fetal lung fibroblasts Am J Respir Cell Mol Biol. 2014 Jul; 51(1):114-24. . View in PubMed

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally Development. 2014 Jan; 141(2):296-306. . View in PubMed

Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors Development. 2013 Sep; 140(18):3731-42. . View in PubMed

Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx21 via triggering TGF-beta signaling. Dev Biol. 2013 Jun 01; 378(1):13-24. . View in PubMed

Molecular determinants of lung development Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. . View in PubMed

Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype J Clin Invest. 2012 Nov; 122(11):3862-72. . View in PubMed

NOTCH1 is required for regeneration of Clara cells during repair of airway injury Stem Cells. 2012 May; 30(5):946-55. . View in PubMed

Embryonic epithelial Pten deletion through Nkx21-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-122. . View in PubMed

Interactions between ß-catenin and transforming growth factor-ß signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP) J Biol Chem. 2012 Mar 02; 287(10):7026-38. . View in PubMed

Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition J Pathol. 2012 Mar; 226(4):633-44. . View in PubMed

Conditional deletion of epithelial IKKß impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis Respir Res. 2011 Oct 10; 12:134. . View in PubMed

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. . View in PubMed

A subset of epithelial cells with CCSP promoter activity participates in alveolar development Am J Respir Cell Mol Biol. 2011 Jun; 44(6):804-12. . View in PubMed

Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis J Clin Invest. 2011 Jan; 121(1):277-87. . View in PubMed

Effect of 17-alpha hydroxyprogesterone caproate on the production of tumor necrosis factor-alpha and the expression of cyclooxygenase-2 in lipopolysaccharide-treated gravid human myometrial explants J Perinatol. 2010 Sep; 30(9):584-9. . View in PubMed

Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair Dev Dyn. 2010 Aug; 239(8):2288-97. . View in PubMed

Directed expression of Cre in alveolar epithelial type 1 cells Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. . View in PubMed

Cross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease Int J Biochem Cell Biol. 2010 Jun; 42(6):809-12. . View in PubMed

Bcr and Abr cooperate in negatively regulating acute inflammatory responses Mol Cell Biol. 2009 Nov; 29(21):5742-50. . View in PubMed

Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury Am J Respir Crit Care Med. 2009 Oct 15; 180(8):701-12. . View in PubMed

Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome Pediatr Res. 2009 Oct; 66(4):386-90. . View in PubMed

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice Am J Respir Crit Care Med. 2009 Sep 01; 180(5):424-36. . View in PubMed

Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways J Biol Chem. 2008 Dec 26; 283(52):36257-64. . View in PubMed

Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages Stem Cells. 2008 Nov; 26(11):2902-11. . View in PubMed

GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1 Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. . View in PubMed

Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx21 and Pten. Dev Biol. 2008 Aug 15; 320(2):340-50. . View in PubMed

Rat aquaporin-5 43-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. . View in PubMed

Foxp2 inhibits Nkx21-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. . View in PubMed

Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor J Biol Chem. 2008 Feb 08; 283(6):3023-30. . View in PubMed

NF-kB induces lung maturation during mouse lung morphogenesis Dev Dyn. 2008 Feb; 237(2):328-38. . View in PubMed

Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling PLoS One. 2008 Jan 30; 3(1):e1516. . View in PubMed

Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2 BMC Mol Biol. 2008 Jan 23; 9:11. . View in PubMed

Lung inflammation and pulmonary function in infants with meconium aspiration syndrome Pediatr Pulmonol. 2007 Oct; 42(10):898-905. . View in PubMed

Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development Dev Biol. 2007 Jul 15; 307(2):237-47. . View in PubMed

Effect of mifepristone on endometrial matrix metalloproteinase expression and leukocyte abundance in new medroxyprogesterone acetate users Contraception. 2007 Jul; 76(1):57-65. . View in PubMed

Role of APAF-1, E-cadherin and peritumoral lymphocytic infiltration in tumour budding in colorectal cancer J Pathol. 2007 Jul; 212(3):260-8. . View in PubMed

Role of BRAF-V600E in the serrated pathway of colorectal tumourigenesis J Pathol. 2007 Jun; 212(2):124-33. . View in PubMed

Prognostic significance of mucins in colorectal cancer with different DNA mismatch-repair status J Clin Pathol. 2007 May; 60(5):534-9. . View in PubMed

Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. . View in PubMed

Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. . View in PubMed

Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: a tissue microarray-based analysis Histopathology. 2007 Mar; 50(4):453-64. . View in PubMed

Physical and functional interactions between homeodomain NKX21 and winged helix/forkhead FOXA1 in lung epithelial cells. Mol Cell Biol. 2007 Mar; 27(6):2155-65. . View in PubMed

Constitutive IL-10 expression by lung inflammatory cells and risk for bronchopulmonary dysplasia Pediatr Res. 2007 Feb; 61(2):197-202. . View in PubMed

Mifepristone alters expression of endometrial steroid receptors and their cofactors in new users of medroxyprogesterone acetate Fertil Steril. 2007 Jan; 87(1):8-23. . View in PubMed

Expression of transforming growth factor beta (TGF-b1) by human preterm lung inflammatory cells Life Sci. 2006 Nov 17; 79(25):2349-56. . View in PubMed

Senescence and serration: a new twist to an old tale J Pathol. 2006 Oct; 210(2):137-40. . View in PubMed

Developmental pathways and specification of intrapulmonary stem cells Pediatr Res. 2006 Apr; 59(4 Pt 2):84R-93R. . View in PubMed

Effects of mifepristone on proliferation and apoptosis of human endometrium in new users of medroxyprogesterone acetate Hum Reprod. 2006 Mar; 21(3):798-809. . View in PubMed

Nonoxynol-9 induces apoptosis of endometrial explants by both caspase-dependent and -independent apoptotic pathways Biol Reprod. 2005 Aug; 73(2):382-8. . View in PubMed

Effect of mifepristone on proliferation and apoptosis of Ishikawa endometrial adenocarcinoma cells Fertil Steril. 2005 Jul; 84(1):202-11. . View in PubMed

Menstrual-like breakdown and apoptosis in human endometrial explants Hum Reprod. 2005 Jun; 20(6):1709-19. . View in PubMed

Nkx21 transcription factor in lung cells and a transforming growth factor-beta1 heterozygous mouse model of lung carcinogenesis. Mol Carcinog. 2004 Aug; 40(4):212-31. . View in PubMed

Expression of transforming growth factor beta (TGF-beta1) in human epithelial alveolar cells: a pro-inflammatory mediator independent pathway Life Sci. 2004 Apr 30; 74(24):2941-57. . View in PubMed

In vivo characterization of the Nkx21 promoter/enhancer elements in transgenic mice. Gene. 2004 Apr 28; 331:73-82. . View in PubMed

NKX21 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells. Gene. 2004 Feb 18; 327(1):25-36. . View in PubMed

Interleukin-1beta in the bronchoalveolar lavage fluid of premature neonates: a marker for maternal chorioamnionitis and predictor of adverse neonatal outcome J Matern Fetal Neonatal Med. 2003 Sep; 14(3):205-11. . View in PubMed

Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process? Am J Physiol Lung Cell Mol Physiol. 2002 Sep; 283(3):L510-7.. View in PubMed

Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD) Life Sci. 2001 Dec 07; 70(3):253-67. . View in PubMed

Lipopolysaccharide-induced tumor necrosis factor-alpha and IL-10 production by lung macrophages from preterm and term neonates Pediatr Res. 2001 Dec; 50(6):726-31. . View in PubMed

claudin-18, a novel downstream target gene for the T/EBP/NKX21 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Mol Cell Biol. 2001 Nov; 21(21):7380-90. . View in PubMed

Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation Biol Neonate. 2000 May; 77(4):217-23. . View in PubMed

A novel DNA element mediates transcription of Nkx21 by Sp1 and Sp3 in pulmonary epithelial cells. Biochim Biophys Acta. 2000 Feb 29; 1490(3):213-24. . View in PubMed

Inhibition of distal lung morphogenesis in Nkx21(-/-) embryos. Dev Dyn. 2000 Feb; 217(2):180-90. . View in PubMed

Defects in tracheoesophageal and lung morphogenesis in Nkx21(-/-) mouse embryos. Dev Biol. 1999 May 01; 209(1):60-71. . View in PubMed

Inhibition of vascular and epithelial differentiation in murine nitrofen-induced diaphragmatic hernia Am J Physiol. 1998 04; 274(4):L636-46. . View in PubMed

Differential regulation of IL-8 by IL-1beta and TNFalpha in hyaline membrane disease J Clin Immunol. 1998 Jan; 18(1):71-80. . View in PubMed

Impaired lung branching morphogenesis in the absence of functional EGF receptor Dev Biol. 1997 Jun 15; 186(2):224-36. . View in PubMed

Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages J Histochem Cytochem. 1996 Feb; 44(2):113-23. . View in PubMed

Epithelial-mesenchymal interactions in lung development Annu Rev Physiol. 1994; 56:13-45. . View in PubMed

Alterations in surfactant protein gene expression associated with premature birth and exposure to hyperoxia Am J Physiol. 1991 Dec; 261(6 Pt 1):L386-92. . View in PubMed

Nucleic acid binding characteristics of group A/B hnRNP proteins Biochem Biophys Res Commun. 1991 Apr 30; 176(2):747-55. . View in PubMed

Loss of proliferative potential during terminal differentiation coincides with the decreased abundance of a subset of heterogeneous ribonuclear proteins J Cell Biol. 1989 Nov; 109(5):1937-46. . View in PubMed

Regulation of lung cell proliferation by polypeptide growth factors Am J Physiol. 1989 Aug; 257(2 Pt 1):L23-38. . View in PubMed

Nonterminal differentiation represses the neoplastic phenotype in spontaneously and simian virus 40-transformed cells Proc Natl Acad Sci U S A. 1989 Mar; 86(5):1652-6. . View in PubMed

Integrated control of proliferation and differentiation of mesenchymal stem cells Environ Health Perspect. 1989 Mar; 80:117-25. . View in PubMed

Differentiation, cancer, and anticancer activity Biochem Cell Biol. 1988 Jun; 66(6):478-89. . View in PubMed

Organization and expression of a second chromosome follicle cell gene cluster in Drosophila Dev Biol. 1988 Jun; 127(2):248-56. . View in PubMed

Characterization and sequence of follicle cell genes selectively expressed during vitelline membrane formation in Drosophila Dev Biol. 1987 Dec; 124(2):441-50. . View in PubMed

20-Hydroxyecdysone stimulates the accumulation of translatable yolk polypeptide gene transcript in adult male Drosophila melanogaster Proc Natl Acad Sci U S A. 1983 Jan; 80(1):186-90. . View in PubMed

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