Keck School Faculty

Parviz Minoo, PhD
Parviz Minoo, PhD
Professor of Pediatrics;Director of Research Program
Pediatrics
2020 Zonal Avenue , IRD 820 Off Campus Los Angeles

Alteration of secretory leukocyte protease inhibitor in human myometrium during laborAm J Obstet Gynecol. 2009 Mar; 200(3):311. e1-311. e10. . View in PubMed

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J Clin Invest. 2018 Mar 01; 128(3):970-984. . View in PubMed

Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation Sci Rep. 2017 Jun 14; 7(1):3473. . View in PubMed

Origin and characterization of alpha smooth muscle actin-positive cells during murine lung development Stem Cells. 2017 06; 35(6):1566-1578. . View in PubMed

Region-specific role for Pten in maintenance of epithelial phenotype and integrity Am J Physiol Lung Cell Mol Physiol. 2017 Jan 01; 312(1):L131-L142. . View in PubMed

Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation Sci Rep. 2017 06 14; 7(1):3473. . View in PubMed

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia J Pathol. 2017 Jan; 241(1):91-103. . View in PubMed

Region-specific role for Pten in maintenance of epithelial phenotype and integrity Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L131-L142. . View in PubMed

p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC) J Biol Chem. 2016 Mar 18; 291(12):6569-82. . View in PubMed

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate BMC Biol. 2016 Mar 16; 14:19. . View in PubMed

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15; 310(2):L114-20. . View in PubMed

Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance Am J Respir Cell Mol Biol. 2016 09; 55(3):395-406. . View in PubMed

The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development Am J Respir Cell Mol Biol. 2016 07; 55(1):135-49. . View in PubMed

Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development Development. 2015 Dec 01; 142(23):4139-50. . View in PubMed

PTEN regulates lung endodermal morphogenesis through MEK/ERK pathway Dev Biol. 2015 Dec 01; 408(1):56-65. . View in PubMed

Non-canonical WNT signalling in the lung J Biochem. 2015 Nov; 158(5):355-65. . View in PubMed

Prognostic factors and concomitant anomalies in neonatal gastric perforation J Pediatr Surg. 2015 Aug; 50(8):1278-82. . View in PubMed

Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm Stem Cells. 2015 Mar; 33(3):999-1012. . View in PubMed

Conditional overexpression of TGFß1 promotes pulmonary inflammation, apoptosis and mortality via TGFßR2 in the developing mouse lung Respir Res. 2015 Jan 16; 16:4. . View in PubMed

A breath of fresh air on the mesenchyme: impact of impaired mesenchymal development on the pathogenesis of bronchopulmonary dysplasia Front Med (Lausanne). 2015; 2:27. . View in PubMed

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. . View in PubMed

Dihydrotestosterone potentiates EGF-induced ERK activation by inducing SRC in fetal lung fibroblasts Am J Respir Cell Mol Biol. 2014 Jul; 51(1):114-24. . View in PubMed

The p66Shc adapter protein regulates the morphogenesis and epithelial maturation of fetal mouse lungs Am J Physiol Lung Cell Mol Physiol. 2014 Feb 15; 306(4):L316-25. . View in PubMed

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally Development. 2014 Jan; 141(2):296-306. . View in PubMed

Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors Development. 2013 Sep; 140(18):3731-42. . View in PubMed

Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx21 via triggering TGF-beta signaling. Dev Biol. 2013 Jun 01; 378(1):13-24. . View in PubMed

Molecular determinants of lung development Ann Am Thorac Soc. 2013 Apr; 10(2):S12-6. . View in PubMed

Systems biology and pediatric research Pediatr Res. 2013 Apr; 73(4 Pt 2):499-501. . View in PubMed

Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling PLoS One. 2013; 8(4):e62215. . View in PubMed

Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype J Clin Invest. 2012 Nov; 122(11):3862-72. . View in PubMed

NOTCH1 is required for regeneration of Clara cells during repair of airway injury Stem Cells. 2012 May; 30(5):946-55. . View in PubMed

Embryonic epithelial Pten deletion through Nkx21-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-122. . View in PubMed

Interactions between ß-catenin and transforming growth factor-ß signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP) J Biol Chem. 2012 Mar 02; 287(10):7026-38. . View in PubMed

Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition J Pathol. 2012 Mar; 226(4):633-44. . View in PubMed

Conditional deletion of epithelial IKKß impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis Respir Res. 2011 Oct 10; 12:134. . View in PubMed

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. . View in PubMed

A subset of epithelial cells with CCSP promoter activity participates in alveolar development Am J Respir Cell Mol Biol. 2011 Jun; 44(6):804-12. . View in PubMed

Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis J Clin Invest. 2011 Jan; 121(1):277-87. . View in PubMed

Directed expression of Cre in alveolar epithelial type 1 cells Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. . View in PubMed

Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair Dev Dyn. 2010 Aug; 239(8):2288-97. . View in PubMed

Cross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease Int J Biochem Cell Biol. 2010 Jun; 42(6):809-12. . View in PubMed

Signaling via Alk5 controls the ontogeny of lung Clara cells Development. 2010 Mar; 137(5):825-33. . View in PubMed

Bcr and Abr cooperate in negatively regulating acute inflammatory responses Mol Cell Biol. 2009 Nov; 29(21):5742-50. . View in PubMed

Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury Am J Respir Crit Care Med. 2009 Oct 15; 180(8):701-12. . View in PubMed

Wnt5a knock-out mouse as a new model of anorectal malformation J Surg Res. 2009 Oct; 156(2):278-82. . View in PubMed

Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis Dev Biol. 2009 Oct 01; 334(1):97-108. . View in PubMed

Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome Pediatr Res. 2009 Oct; 66(4):386-90. . View in PubMed

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice Am J Respir Crit Care Med. 2009 Sep 01; 180(5):424-36. . View in PubMed

Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways J Biol Chem. 2008 Dec 26; 283(52):36257-64. . View in PubMed

Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages Stem Cells. 2008 Nov; 26(11):2902-11. . View in PubMed

GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1 Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. . View in PubMed

Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx21 and Pten. Dev Biol. 2008 Aug 15; 320(2):340-50. . View in PubMed

Rat aquaporin-5 43-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. . View in PubMed

Foxp2 inhibits Nkx21-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. . View in PubMed

Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor J Biol Chem. 2008 Feb 08; 283(6):3023-30. . View in PubMed

NF-kB induces lung maturation during mouse lung morphogenesis Dev Dyn. 2008 Feb; 237(2):328-38. . View in PubMed

Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling PLoS One. 2008 Jan 30; 3(1):e1516. . View in PubMed

Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2 BMC Mol Biol. 2008 Jan 23; 9:11. . View in PubMed

SMAD3 prevents binding of NKX21 and FOXA1 to the SpB promoter through its MH1 and MH2 domains. Nucleic Acids Res. 2008 Jan; 36(1):179-88. . View in PubMed

Lung inflammation and pulmonary function in infants with meconium aspiration syndrome Pediatr Pulmonol. 2007 Oct; 42(10):898-905. . View in PubMed

Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells J Cell Physiol. 2007 Sep; 212(3):796-806. . View in PubMed

Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development Dev Biol. 2007 Jul 15; 307(2):237-47. . View in PubMed

Effect of mifepristone on endometrial matrix metalloproteinase expression and leukocyte abundance in new medroxyprogesterone acetate users Contraception. 2007 Jul; 76(1):57-65. . View in PubMed

TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells Gene. 2007 May 15; 393(1-2):70-80. . View in PubMed

Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. . View in PubMed

The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement Mol Cell Biol. 2007 Apr; 27(8):3131-42. . View in PubMed

Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. . View in PubMed

Physical and functional interactions between homeodomain NKX21 and winged helix/forkhead FOXA1 in lung epithelial cells. Mol Cell Biol. 2007 Mar; 27(6):2155-65. . View in PubMed

Constitutive IL-10 expression by lung inflammatory cells and risk for bronchopulmonary dysplasia Pediatr Res. 2007 Feb; 61(2):197-202. . View in PubMed

Mifepristone alters expression of endometrial steroid receptors and their cofactors in new users of medroxyprogesterone acetate Fertil Steril. 2007 Jan; 87(1):8-23. . View in PubMed

Developmental pathways and specification of intrapulmonary stem cells Pediatr Res. 2006 Apr; 59(4 Pt 2):84R-93R. . View in PubMed

Effects of mifepristone on proliferation and apoptosis of human endometrium in new users of medroxyprogesterone acetate Hum Reprod. 2006 Mar; 21(3):798-809. . View in PubMed

Wnt5a regulates Shh and Fgf10 signaling during lung development Dev Biol. 2005 Nov 01; 287(1):86-97. . View in PubMed

Nonoxynol-9 induces apoptosis of endometrial explants by both caspase-dependent and -independent apoptotic pathways Biol Reprod. 2005 Aug; 73(2):382-8. . View in PubMed

Effect of mifepristone on proliferation and apoptosis of Ishikawa endometrial adenocarcinoma cells Fertil Steril. 2005 Jul; 84(1):202-11. . View in PubMed

The effect of nonoxynol-9 on human endometrium Contraception. 2005 Feb; 71(2):137-42. . View in PubMed

Nkx21 transcription factor in lung cells and a transforming growth factor-beta1 heterozygous mouse model of lung carcinogenesis. Mol Carcinog. 2004 Aug; 40(4):212-31. . View in PubMed

In vivo characterization of the Nkx21 promoter/enhancer elements in transgenic mice. Gene. 2004 Apr 28; 331:73-82. . View in PubMed

NKX21 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells. Gene. 2004 Feb 18; 327(1):25-36. . View in PubMed

Timeless in lung morphogenesis Dev Dyn. 2003 Sep; 228(1):82-94. . View in PubMed

Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX21 and HNF-3 transcription factors. J Biol Chem. 2002 Oct 11; 277(41):38399-408. . View in PubMed

Wnt5a participates in distal lung morphogenesis Dev Biol. 2002 Aug 01; 248(1):68-81. . View in PubMed

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