Keck School Faculty

Pat R. Levitt, PhD
Pat R. Levitt, PhD
Professor of Pediatrics;W.M. Keck Chair in Neurogenetics;Chief Scientific Officer, Vice President, and Director of The Saban Research Institute;Director of the Program in Developmental Neurogenetics at The Saban Research Institute
4640 West Sunset Boulevard Off Campus Los Angeles
Dr. Levitt received his BA in Biological Sciences from the University of Chicago, PhD in Neuroscience at the University of California, San Diego. He completed a postdoctoral fellowship in Neuroscience at Yale University. Dr. Levitt has held leadership positions at University of Pittsburgh, Vanderbilt University and University of Southern California. Dr. Levitt was elected as a member into the prestigious Institute of Medicine (IOM), part of the National Academy of Sciences. Named a McKnight Foundation Scholar in 2002, Dr. Levitt also was a MERIT awardee from the National Institute of Mental Health and served as a member of the National Advisory Mental Health Council for the National Institute of Mental Health. He is an elected Fellow of the American Association for the Advancement of Science (AAAS), Chair-elect of the Neuroscience Division of the AAAS, and an elected member of the Dana Alliance for Brain Initiatives. He is a Senior Fellow at the Center for the Developing Child at Harvard University, and serves as Scientific Director of the National Scientific Council on the Developing Child, a policy council that brings the best research from child development and neuroscience to assist policy makers and business leaders in making wise program investment decisions. He is a member of a number of scientific advisory boards for foundations and university programs, served as Senior Editor for Journal of Neuroscience, and currently serves on the editorial boards of eLife, Neuron, Cerebral Cortex, Autism Research, Journal of Neurodevelopmental Disorders and Disease Models and Mechanisms. Dr. Levitt’s research focuses on the development of brain architecture that controls learning, emotional and social behavior. His research focuses on genetic and environment factors that increase risk for neurodevelopmental and neuropsychiatric disorders, such as autism and schizophrenia. His clinical research studies address autism heterogeneity by studying children with autism who also have co-occurring medical conditions, such as gastrointestinal disorders, with the goal of developing better diagnostic criteria and personalized treatments. He has published over 250 papers.

Precision in the Development of Neocortical Architecture: from Progenitors to Cortical Networks Prog Neurobiol. 2019 Jan 21. . View in PubMed

Developmental Connectivity and Molecular Phenotypes of Unique Cortical Projection Neurons that Express a Synapse-Associated Receptor Tyrosine Kinase Cereb Cortex. 2019 Jan 01; 29(1):189-201. . View in PubMed

Differential impact of Met receptor gene interaction with early-life stress on neuronal morphology and behavior in mice Neurobiol Stress. 2018 Feb; 8:10-20. . View in PubMed

Analysis of shared heritability in common disorders of the brain Science. 2018 06 22; 360(6395). . View in PubMed

Integrative functional genomic analysis of human brain development and neuropsychiatric risks Science. 2018 12 14; 362(6420). . View in PubMed

Distinct projection targets define subpopulations of mouse brainstem vagal neurons that express the autism-associated MET receptor tyrosine kinase J Comp Neurol. 2017 Dec 15; 525(18):3787-3808. . View in PubMed

Developmental Connectivity and Molecular Phenotypes of Unique Cortical Projection Neurons that Express a Synapse-Associated Receptor Tyrosine Kinase Cereb Cortex. 2017 Nov 28; 1-13. . View in PubMed

Beyond Hat in Hand: Science Advocacy Is Foundational for Policy Decisions Neuron. 2017 May 17; 94(4):708-712. . View in PubMed

MUPET-Mouse Ultrasonic Profile ExTraction: A Signal Processing Tool for Rapid and Unsupervised Analysis of Ultrasonic VocalizationsNeuron. 2017 May 03; 94(3):465-485. e5. . View in PubMed

Correction: Pleiotropic Mechanisms Indicated for Sex Differences in Autism PLoS Genet. 2017 06; 13(6):e1006831. . View in PubMed

Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder J Autism Dev Disord. 2017 06; 47(6):1673-1681. . View in PubMed

EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development J Comp Neurol. 2016 Jul 01; 524(10):2080-92. . View in PubMed

Hepatocyte Growth Factor Modulates MET Receptor Tyrosine Kinase and ß-Catenin Functional Interactions to Enhance Synapse Formation eNeuro. 2016 Jul-Aug; 3(4). . View in PubMed

Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder J Autism Dev Disord. 2016 Mar; 46(3):1124-30. . View in PubMed

Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine Neuropsychopharmacology. 2016 Mar; 41(4):949-59. . View in PubMed

Brief Report: Recruitment and Retention of Minority Children for Autism Research J Autism Dev Disord. 2016 Feb; 46(2):698-703. . View in PubMed

Pleiotropic Mechanisms Indicated for Sex Differences in Autism PLoS Genet. 2016 11; 12(11):e1006425. . View in PubMed

Distinct intracellular signaling mediates C-MET regulation of dendritic growth and synaptogenesis Dev Neurobiol. 2016 10; 76(10):1160-81. . View in PubMed

Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse Placenta. 2016 06; 42:74-83. . View in PubMed

EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development J Comp Neurol. 2016 07 01; 524(10):2080-92. . View in PubMed

Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing J Neurosci. 2016 08 03; 36(31):8200-9. . View in PubMed

Early-Life Stress Paradigm Transiently Alters Maternal Behavior, Dam-Pup Interactions, and Offspring Vocalizations in Mice Front Behav Neurosci. 2016; 10:142. . View in PubMed

Patterns of Risk for Multiple Co-Occurring Medical Conditions Replicate Across Distinct Cohorts of Children with Autism Spectrum Disorder Autism Res. 2015 Dec; 8(6):771-81. . View in PubMed

Complete or partial reduction of the Met receptor tyrosine kinase in distinct circuits differentially impacts mouse behavior J Neurodev Disord. 2015; 7:35. . View in PubMed

Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters Front Synaptic Neurosci. 2015; 7:20. . View in PubMed

Neurodevelopment and the origins of brain disorders Neuropsychopharmacology. 2015 Jan; 40(1):1-3. . View in PubMed

MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus J Neurosci. 2014 Dec 03; 34(49):16166-79. . View in PubMed

Comparative DNA methylation among females with neurodevelopmental disorders and seizures identifies TAC1 as a MeCP2 target gene J Neurodev Disord. 2013 Jun 11; 5(1):15. . View in PubMed

EphA signaling impacts development of topographic connectivity in auditory corticofugal systems Cereb Cortex. 2013 Apr; 23(4):775-85. . View in PubMed

Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse Front Behav Neurosci. 2013; 7:195. . View in PubMed

Enrichment of elevated plasma F2t-isoprostane levels in individuals with autism who are stratified by presence of gastrointestinal dysfunction PLoS One. 2013; 8(7):e68444. . View in PubMed

Autism-associated promoter variant in MET impacts functional and structural brain networks Neuron. 2012 Sep 06; 75(5):904-15. . View in PubMed

Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors Autism Res. 2012 Apr; 5(2):101-8. . View in PubMed

Placental source for 5-HT that tunes fetal brain development Neuropsychopharmacology. 2012 Jan; 37(1):299-300. . View in PubMed

Modeling of autism genetic variations in mice: focusing on synaptic and microcircuit dysfunctions Dev Neurosci. 2012; 34(2-3):88-100. . View in PubMed

One-month-old human infants learn about the social world while they sleep Dev Sci. 2011 Sep; 14(5):1134-41. . View in PubMed

A new synaptic player leading to autism risk: Met receptor tyrosine kinase J Neurodev Disord. 2011 Sep; 3(3):282-92. . View in PubMed

Conserved subcortical and divergent cortical expression of proteins encoded by orthologs of the autism risk gene MET Cereb Cortex. 2011 Jul; 21(7):1613-26. . View in PubMed

Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder J Neurodev Disord. 2011 Jun; 3(2):101-12. . View in PubMed

A transient placental source of serotonin for the fetal forebrain Nature. 2011 Apr 21; 472(7343):347-50. . View in PubMed

Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase J Neurosci. 2011 Apr 13; 31(15):5855-64. . View in PubMed

Developmental expression mapping of a gene implicated in multiple neurodevelopmental disorders, A2bp1 (Fox1) Dev Neurosci. 2011; 33(1):64-74. . View in PubMed

Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain Neural Dev. 2010 Dec 01; 5:32. . View in PubMed

Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain J Comp Neurol. 2010 Nov 01; 518(21):4463-78. . View in PubMed

Neuroscience and the future of early childhood policy: moving from why to what and how Neuron. 2010 Sep 09; 67(5):689-91. . View in PubMed

Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity, and spatial memory deficit Biol Psychiatry. 2010 Jul 15; 68(2):197-204. . View in PubMed

Association of MET with social and communication phenotypes in individuals with autism spectrum disorder Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 05; 153B(2):438-446. . View in PubMed

Now you see it, now you don't--closing in on allostasis and developmental basis of psychiatric disorders Neuron. 2010 Feb 25; 65(4):437-9. . View in PubMed

Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report Pediatrics. 2010 Jan; 125 Suppl 1:S1-18. . View in PubMed

Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling Nature. 2009 Sep 24; 461(7263):524-8. . View in PubMed

Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain J Comp Neurol. 2009 Apr 10; 513(5):511-31. . View in PubMed

Prenatal exposure to drugs: effects on brain development and implications for policy and education Nat Rev Neurosci. 2009 Apr; 10(4):303-12. . View in PubMed

Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions Pediatrics. 2009 Mar; 123(3):1018-24. . View in PubMed

Adaptive changes in gene expression patterns in the somatosensory cortex after deletion of ephrinA5 Mol Cell Neurosci. 2008 Sep; 39(1):21-31. . View in PubMed

Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder Autism Res. 2008 Jun; 1(3):159-68. . View in PubMed

Future of individualized psychiatric treatment Pharmacogenomics. 2008 May; 9(5):493-5. . View in PubMed

It is time to take a stand for medical research and against terrorism targeting medical scientists Biol Psychiatry. 2008 Apr 15; 63(8):725-7. . View in PubMed

Genetic deletion of Lsamp causes exaggerated behavioral activation in novel environments Behav Brain Res. 2008 Apr 09; 188(2):380-90. . View in PubMed

Association of RGS2 and RGS5 variants with schizophrenia symptom severity Schizophr Res. 2008 Apr; 101(1-3):67-75. . View in PubMed

Fetal mechanisms in neurodevelopmental disorders Pediatr Neurol. 2008 Mar; 38(3):163-76. . View in PubMed

Gene x environment effects: stress and memory dysfunctions caused by stress and gonadal factor irregularities during puberty in control and TGF-alpha hypomorphic mice Neuropsychopharmacology. 2008 Feb; 33(3):557-65. . View in PubMed

Linkage disequilibrium patterns and functional analysis of RGS4 polymorphisms in relation to schizophrenia Schizophr Bull. 2008 Jan; 34(1):118-26. . View in PubMed

Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia Biol Psychiatry. 2008 Jan 01; 63(1):32-41. . View in PubMed

Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia Biol Psychiatry. 2007 Oct 01; 62(7):711-21. . View in PubMed

Bootstrap classification and point-based feature selection from age-staged mouse cerebellum tissues of matrix assisted laser desorption/ionization mass spectra using a fuzzy rule-building expert system Anal Chim Acta. 2007 Sep 19; 599(2):219-31. . View in PubMed

Disruption of cerebral cortex MET signaling in autism spectrum disorder Ann Neurol. 2007 Sep; 62(3):243-50. . View in PubMed

Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain Cereb Cortex. 2007 Sep; 17(9):2108-22. . View in PubMed

Pharmacokinetic profile of cocaine following intravenous administration in the female rabbit Eur J Pharmacol. 2007 Jun 01; 563(1-3):124-9. . View in PubMed

Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation J Neurosci. 2007 Mar 21; 27(12):3295-304. . View in PubMed

Autism spectrum disorders: developmental disconnection syndromes Curr Opin Neurobiol. 2007 Feb; 17(1):103-11. . View in PubMed

Prenatal exposure to cocaine produces unique developmental and long-term adaptive changes in dopamine D1 receptor activity and subcellular distribution J Neurosci. 2007 Jan 03; 27(1):152-7. . View in PubMed

A genetic variant that disrupts MET transcription is associated with autism Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16834-9. . View in PubMed

Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4) Biol Psychiatry. 2006 Sep 15; 60(6):534-7. . View in PubMed

Genetic or pharmacological inactivation of the dopamine D1 receptor differentially alters the expression of regulator of G-protein signalling (Rgs) transcripts Eur J Neurosci. 2006 Aug; 24(3):806-18. . View in PubMed

Critical appraisal of DNA microarrays in psychiatric genomics Biol Psychiatry. 2006 Jul 15; 60(2):163-76. . View in PubMed

Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples Biol Psychiatry. 2006 Jul 15; 60(2):152-62. . View in PubMed

Multiple receptors mediate the trophic effects of serotonin on ventroposterior thalamic neurons in vitro Brain Res. 2006 Jun 20; 1095(1):17-25. . View in PubMed

DNA self-polymers as microarray probes improve assay sensitivity J Neurosci Methods. 2006 Mar 15; 151(2):216-23. . View in PubMed

Dissociation of corticothalamic and thalamocortical axon targeting by an EphA7-mediated mechanism Neuron. 2005 Nov 23; 48(4):563-75. . View in PubMed

Prenatal cocaine exposure specifically alters spontaneous alternation behavior Behav Brain Res. 2005 Oct 14; 164(1):107-16. . View in PubMed

Early experience modifies the postnatal assembly of autonomic emotional motor circuits in rats J Neurosci. 2005 Oct 05; 25(40):9102-11. . View in PubMed

Direct profiling of the cerebellum by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: A methodological study in postnatal and adult mouse J Neurosci Res. 2005 Sep 01; 81(5):613-21. . View in PubMed

Anatomical abnormalities in dopaminoceptive regions of the cerebral cortex of dopamine D1 receptor mutant mice J Comp Neurol. 2005 Jul 04; 487(3):270-82. . View in PubMed

Developmental neurobiology and clinical disorders: lost in translation? Neuron. 2005 May 05; 46(3):407-12.. View in PubMed

Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia Neuropsychopharmacology. 2005 May; 30(5):974-83. . View in PubMed

Postpubertal sex differentiation of forebrain structures and functions depend on transforming growth factor-alpha J Neurosci. 2005 Apr 13; 25(15):3870-80. . View in PubMed

Disruption of interneuron development Epilepsia. 2005; 46 Suppl 7:22-8. . View in PubMed

Applications of gene targeting technology to mental retardation and developmental disability research Ment Retard Dev Disabil Res Rev. 2005; 11(4):295-302. . View in PubMed

Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia Biol Psychiatry. 2004 Dec 15; 56(12):943-50. . View in PubMed

Characterization of the genomic structure of the mouse limbic system-associated membrane protein (Lsamp) gene Genomics. 2004 May; 83(5):790-801. . View in PubMed

Multiple roles of ephrins during the formation of thalamocortical projections: maps and more J Neurobiol. 2004 Apr; 59(1):82-94. . View in PubMed

Drug exposure early in life: functional repercussions of changing neuropharmacology during sensitive periods of brain development Curr Opin Pharmacol. 2004 Feb; 4(1):65-71. . View in PubMed

NeuroscienceSealing cortical cell fate. Science. 2004 Jan 02; 303(5654):48-9. . View in PubMed

DNA microarray analysis of postmortem brain tissue Int Rev Neurobiol. 2004; 60:153-81. . View in PubMed

Autism and 15q11-q13 disorders: behavioral, genetic, and pathophysiological issues Ment Retard Dev Disabil Res Rev. 2004; 10(4):284-91. . View in PubMed

Distinct domains of the limbic system-associated membrane protein (LAMP) mediate discrete effects on neurite outgrowth Mol Cell Neurosci. 2003 Nov; 24(3):725-40. . View in PubMed

Differential regulation of thalamic and cortical axonal growth by hepatocyte growth factor/scatter factor Dev Neurosci. 2003 Mar-Aug; 25(2-4):197-206. . View in PubMed

Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction J Neurosci. 2003 Jan 15; 23(2):622-31. . View in PubMed

Miswiring of limbic thalamocortical projections in the absence of ephrin-A5 J Neurosci. 2002 Nov 01; 22(21):9352-7. . View in PubMed

Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders Neurochem Res. 2002 Oct; 27(10):1049-63. . View in PubMed

Association and linkage analyses of RGS4 polymorphisms in schizophrenia Hum Mol Genet. 2002 Jun 01; 11(12):1373-80. . View in PubMed

Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia J Neurosci. 2002 Apr 01; 22(7):2718-29. . View in PubMed

Powered by SC CTSI
Go to Top