Patrick Hsieh, MD

Professor of Clinical Neurological Surgery

Todd- Wells Professorship in Neurosurgery

Quality Director, USC Spine Center

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Overview

“As a top spine surgeon and specialist at the USC Spine Center, Dr. Patrick Hsieh specializes in highly complex reconstructive spine surgery and procedures, treating primary spine tumors like chordoma, managing severe adult scoliosis, and correcting failed previous spine surgeries (complex revisions).”

Dr. Hsieh is a highly respected expert whose dedication to advancing spinal care is truly inspiring. His research and clinical journey began as a distinguished scholar at the Howard Hughes Medical Institute in 1998, where he immersed himself in groundbreaking neurogenetics research at the National Institutes of Health. After completing a surgical internship and neurosurgery residency at Northwestern University’s McGaw Medical Center, he honed his skills with specialized training in spinal deformity surgery and minimally invasive spine surgery. He further expanded his expertise through advanced post-graduate fellowship training in spinal oncology and complex reconstructive procedures at Johns Hopkins University.

Driven by a passion for innovation, Dr. Hsieh actively seeks out clinical trials for challenging conditions like chordomas and other primary spinal tumors. His research focus includes transformative studies on spinal oncology, deformity correction, and minimally invasive techniques, all aimed at improving patient outcomes. He also explores critically needed research areas such as spinal biomechanics, osteobiologics, and nanoparticle applications for spine reconstruction.

Patients benefit from his deep clinical expertise in treating chordomas, sacral tumors, adult spinal deformity, kyphosis, and scoliosis. Throughout his illustrious career, Dr. Hsieh has participated in several pivotal research studies and earned numerous awards from top spine societies, including AANS/CNS, SRS, and NASS. Over the past two decades, he has authored over 100 research articles and several highly influential studies that have shaped our understanding and treatment of complex spine conditions, including tumor resection and deformity correction. He has been widely recognized worldwide for his work in complex spine conditions, spine tumor resection, and complex deformity correction, and has been invited to give lectures in over 25 countries over the past two decades. His work continues to inspire hope and advance spinal care quality and access worldwide.

Awards

  • Pasadena Magazine: Top Doctor, 2011
  • Congress of Neurological Surgeons Depuy Spine Fellowship Award, 2007

Education and Training

  • Johns Hopkins Medical School, Baltimore — Spine Fellowship — 06/2008 — Spinal Oncology and Complex Spine
  • Northwestern McGaw Medical Center, Chicago, Illinois — Residency and Fellowship — 06/2007 — Neurosurgery
  • University of Southern California Marshall School of Business , Los Angeles — MBA — 05/2022 — Master of Business Administration
  • University of Southern California School of Medicine, Los Angeles — MD — 06/2001 — Doctor of Medicine
  • UC Los Angeles , Los Angeles — B.S. and M.Sc — 06/1995 — Chemistry and Biochemistry

Research Keywords

  • Chordoma
  • Adult Spinal Deformity
  • Scoliosis
  • Primary Spinal Tumor Surgery
  • Kyphosis
  • Sarcoma of the Spine
  • Flat Back deformity
  • Complex Spine Surgery
  • Revision Spine Surgery
  • Schwannoma
  • Meningioma
  • Intradural Tumors
  • Spinal Cord Tumor surgery
  • Eppendymoma
  • Minimally Invasive Spine Surgery
  • Minimally invasive spine tumor surgery
  • MIS
  • MISS
  • Robotic Spine Surgery
  • Emerging Techniques and Innovation in Spine Surgery

Publications

  • A Modified Delphi Consensus Study to Quantify Surgical Burden of Degenerative Lumbar Spinal Procedures: The Minimally Invasive Spine Surgery Invasiveness Classification “MISS-INC (L)”. Global Spine J. 2026 Aug 04; 21925682261474508.. View in PubMed
  • Complications With Navigation-Assistance in Thoraco-Lumbar Spine Surgery. Global Spine J. 2026 Feb 27; 21925682261431286.. View in PubMed
  • A Commentary on “Beyond the Microscope: Is Endoscopic Discectomy the Next Gold Standard for Lumbar Disc Herniation?” Neurospine. 2026 01; 23(1):80-81. Hsieh PC . . View in PubMed
  • International Practice Patterns in the Surgical Management of Primary Lumbar Disc Herniation: An AO Spine Cross-Sectional Study. Neurospine. 2026 Jan; 23(1):31-39.. View in PubMed
  • Radiographic Assessment of Successful Lumbar Spinal Fusion: A Systematic Review of Fusion Criteria in Randomized Trials. Global Spine J. 2026 Apr; 16(3):1608-1618.. View in PubMed
  • Activation of CISD2 as a protective strategy against doxorubicin-induced cardiotoxicity. Redox Biol. 2025 10; 86:103840.. View in PubMed
  • Proceedings of the 2025 NASSi Annual Meeting. N Am Spine Soc J. 2025 Jul; 22(Suppl):100754.. View in PubMed
  • Young microbiome transplantation enhances recovery after myocardial infarction. Aging (Albany NY). 2025 07 15; 17(7):1852-1867.. View in PubMed
  • Management of Dural Tears in Spine Surgery: A Worldwide Survey of Current Practices and Complications. Global Spine J. 2026 Jan; 16(1):679-689.. View in PubMed
  • Gut microbiota-derived formate exacerbates pulmonary metastasis in cancer. Theranostics. 2025; 15(15):7693-7708.. View in PubMed