Keck School Faculty

Paul S. Gaynon, MD
Paul S. Gaynon, MD
Professor of Pediatrics
Pediatrics
CHL Mail Stop 54 Off Campus Los Angeles

Excellent long-term survival of children with Down syndrome and standard-risk ALL: a report from the Children's Oncology Group Blood Adv. 2019 Jun 11; 3(11):1647-1656. . View in PubMed

Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomization J Clin Oncol. 2018 10 10; 36(29):2926-2934. . View in PubMed

First pediatric experience of SL-401, a CD123-targeted therapy, in patients with blastic plasmacytoid dendritic cell neoplasm: report of three cases J Hematol Oncol. 2018 05 02; 11(1):61. . View in PubMed

A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium Blood. 2018 03 08; 131(10):1145-1148. . View in PubMed

A neoplasm with FIP1L1-PDGFRA fusion presenting as pediatric T-cell lymphoblastic leukemia/lymphoma without eosinophilia Cancer Genet. 2017 Oct; 216-217:91-99. . View in PubMed

Historical Controls? Haematologica. 2017 03; 102(3):e117.. View in PubMed

"The Second Time is Sweeter After All" Br J Haematol. 2017 02; 176(4):511-512. . View in PubMed

A Phase I Study of Quizartinib Combined with Chemotherapy in Relapsed Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study Clin Cancer Res. 2016 Aug 15; 22(16):4014-22. . View in PubMed

Bortezomib, Dexamethasone, Mitoxantrone, and Vinorelbine (BDMV): An Active Reinduction Regimen for Children With Relapsed Acute Lymphoblastic Leukemia and Asparaginase Intolerance J Pediatr Hematol Oncol. 2016 07; 38(5):345-9. . View in PubMed

Allergic reactions and antiasparaginase antibodies in children with high-risk acute lymphoblastic leukemia: A children's oncology group report Cancer. 2015 Dec 01; 121(23):4205-11. . View in PubMed

Comparative Toxicity by Sex Among Children Treated for Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Pediatr Blood Cancer. 2015 Dec; 62(12):2140-9. . View in PubMed

End of induction minimal residual disease alone is not a useful determinant for risk stratified therapy in pediatric T-cell acute lymphoblastic leukemia Pediatr Blood Cancer. 2015 Nov; 62(11):2040-3. . View in PubMed

ALL and osteonecrosis Blood. 2015 Oct 08; 126(15):1734-5. . View in PubMed

Feasibility Study of a Novel Experimental Induction Protocol Combining B43-PAP (Anti-CD19) Immunotoxin With Standard Induction Chemotherapy in Children and Adolescents With Relapsed B-Lineage ALL: A Report From the Children's Oncology Group J Immunother. 2015 Sep; 38(7):299-305. . View in PubMed

CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells Integr Biol (Camb). 2014 Aug; 6(8):766-80. . View in PubMed

A phase I study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium J Pediatr Hematol Oncol. 2014 Aug; 36(6):458-63. . View in PubMed

Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group J Clin Oncol. 2014 May 01; 32(13):1331-7. . View in PubMed

High-resolution melting curve analysis, a rapid and affordable method for mutation analysis in childhood acute myeloid leukemia Front Pediatr. 2014; 2:96. . View in PubMed

Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients PLoS One. 2013; 8(11):e80732. . View in PubMed

Anaphylactic reaction to etoposide phosphate Pediatr Blood Cancer. 2012 Oct; 59(4):765. . View in PubMed

ABT-751 in relapsed childhood acute lymphoblastic leukemia J Pediatr Hematol Oncol. 2012 Oct; 34(7):583-4. . View in PubMed

Effect of alternate-week versus continuous dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia: results from the CCG-1961 randomised cohort trial Lancet Oncol. 2012 Sep; 13(9):906-15. . View in PubMed

Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study Blood. 2012 Jul 12; 120(2):285-90. . View in PubMed

Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group J Clin Oncol. 2012 May 10; 30(14):1663-9. . View in PubMed

CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia Br J Haematol. 2012 Jan; 156(1):89-98. . View in PubMed

A remembrance: James BNachman 1948-2011. Pediatr Blood Cancer. 2011 Oct; 57(4):533-4. . View in PubMed

Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group Blood. 2011 Jul 14; 118(2):243-51. . View in PubMed

A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia Leukemia. 2009 Dec; 23(12):2259-64. . View in PubMed

Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study J Clin Oncol. 2009 Nov 01; 27(31):5175-81. . View in PubMed

An adjustment for patient heterogeneity in the design of two-stage phase II trials Stat Med. 2009 Sep 10; 28(20):2566-79. . View in PubMed

Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study Leukemia. 2008 Dec; 22(12):2142-50. . View in PubMed

Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group Blood. 2008 Mar 01; 111(5):2548-55. . View in PubMed

Asparagine depletion after pegylated Ecoli asparaginase treatment and induction outcome in children with acute lymphoblastic leukemia in first bone marrow relapse: a Children's Oncology Group study (CCG-1941). Pediatr Blood Cancer. 2006 Aug; 47(2):141-6. . View in PubMed

Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG-1941 J Clin Oncol. 2006 Jul 01; 24(19):3150-6. . View in PubMed

Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: a Children's Cancer Group study Blood. 2005 Dec 15; 106(13):4043-9. . View in PubMed

Childhood acute lymphoblastic leukaemia and relapse Br J Haematol. 2005 Dec; 131(5):579-87. . View in PubMed

High concordance from independent studies by the Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10, and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic Leukemia: a Children's Oncology Group (COG) initiative Leukemia. 2005 May; 19(5):734-40. . View in PubMed

Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group Leukemia. 2004 May; 18(5):939-47. . View in PubMed

Asparaginase antibody and asparaginase activity in children with higher-risk acute lymphoblastic leukemia: Children's Cancer Group Study CCG-1961 J Pediatr Hematol Oncol. 2004 Apr; 26(4):217-26. . View in PubMed

Changes of amino acid serum levels in pediatric patients with higher-risk acute lymphoblastic leukemia (CCG-1961) In Vivo. 2004 Mar-Apr; 18(2):107-12. . View in PubMed

Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961) Anticancer Res. 2004 Mar-Apr; 24(2C):1121-5. . View in PubMed

Altered patterns of T cell cytokine production induced by relapsed pre-B ALL cells Leuk Res. 2003 Dec; 27(12):1135-42. . View in PubMed

Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group Blood. 2003 May 15; 101(10):3809-17. . View in PubMed

CNS-directed therapy for childhood acute lymphoblastic leukemia: Childhood ALL Collaborative Group overview of 43 randomized trials J Clin Oncol. 2003 May 01; 21(9):1798-809. . View in PubMed

Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements Leukemia. 2003 Apr; 17(4):700-6. . View in PubMed

Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia Blood. 2002 Jul 01; 100(1):67-71. . View in PubMed

A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study Blood. 2002 Mar 15; 99(6):1986-94. . View in PubMed

A pharmacoeconomic analysis of pegaspargase versus native Escherichia coli L-asparaginase for the treatment of children with standard-risk, acute lymphoblastic leukemia: the Children's Cancer Group study (CCG-1962) J Pediatr Hematol Oncol. 2002 Mar-Apr; 24(3):175-81. . View in PubMed

From where do clinical trials come? J Pediatr Hematol Oncol. 2002 Mar-Apr; 24(3):172-4.. View in PubMed

Abnormalities of chromosome bands 15q13-15 in childhood acute lymphoblastic leukemia Cancer. 2002 Feb 15; 94(4):1102-10. . View in PubMed

Expression of TEL-AML1 fusion transcripts and response to induction therapy in standard risk acute lymphoblastic leukemia Leuk Lymphoma. 2001 Jun; 42(1-2):41-56. . View in PubMed

Duration of hospitalization as a measure of cost on Children's Cancer Group acute lymphoblastic leukemia studies J Clin Oncol. 2001 Apr 01; 19(7):1916-25. . View in PubMed

Bone marrow leukemic progenitor cell content in pediatric T-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse Leuk Lymphoma. 2001 Jan; 40(3-4):279-85. . View in PubMed

Children's Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1995 Leukemia. 2000 Dec; 14(12):2223-33. . View in PubMed

Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia J Clin Oncol. 2000 Nov 15; 18(22):3837-44. . View in PubMed

Clinical significance of deletions of chromosome arm 6q in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group Leuk Lymphoma. 2000 Feb; 36(5-6):467-78. . View in PubMed

Early testicular biopsy in males with acute lymphoblastic leukemia: lack of impact on subsequent event-free survival J Pediatr Hematol Oncol. 2000 Jan-Feb; 22(1):27-33. . View in PubMed

Hypodiploidy with less than 45 chromosomes confers adverse risk in childhood acute lymphoblastic leukemia: a report from the children's cancer group Blood. 1999 Dec 15; 94(12):4036-45. . View in PubMed

Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia J Clin Oncol. 1999 Dec; 17(12):3753-66. . View in PubMed

Association of chromosome arm 9p abnormalities with adverse risk in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group Blood. 1999 Sep 01; 94(5):1537-44. . View in PubMed

Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia Clin Cancer Res. 1999 Aug; 5(8):2112-20. . View in PubMed

Glucocorticosteroid therapy in childhood acute lymphoblastic leukemia Adv Exp Med Biol. 1999; 457:593-605. . View in PubMed

Distinct in vivo engraftment and growth patterns of t(1;19)+/E2A-PBX1+ and t(9;22)+/BCR-ABL+ human leukemia cells in SCID mice Leuk Lymphoma. 1998 Dec; 32(1-2):77-87. . View in PubMed

Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies: a report from the Children's Cancer Group Cancer. 1998 Nov 01; 83(9):2030-9. . View in PubMed

Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation Blood. 1998 Aug 01; 92(3):810-21. . View in PubMed

Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy N Engl J Med. 1998 Jun 04; 338(23):1663-71. . View in PubMed

Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group J Clin Oncol. 1998 Apr; 16(4):1270-8. . View in PubMed

Biology and treatment of childhood T-lineage acute lymphoblastic leukemia Blood. 1998 Feb 01; 91(3):735-46. . View in PubMed

Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group J Clin Oncol. 1998 Feb; 16(2):527-35. . View in PubMed

Early response to therapy and outcome in childhood acute lymphoblastic leukemia: a review Cancer. 1997 Nov 01; 80(9):1717-26. . View in PubMed

A phase II study of carboplatin as a treatment for children with acute leukemia recurring in bone marrow: a report of the Children's Cancer Group Cancer. 1997 Jul 15; 80(2):311-6. . View in PubMed

Importance of the day 7 bone marrow biopsy as a prognostic measure of the outcome in children with acute lymphoblastic leukemia Med Pediatr Oncol. 1997 Jul; 29(1):16-22. . View in PubMed

Clinical features and treatment outcome of children with myeloid antigen positive acute lymphoblastic leukemia: a report from the Children's Cancer Group Blood. 1997 Jul 01; 90(1):28-35. . View in PubMed

Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study J Clin Oncol. 1997 Jun; 15(6):2214-21. . View in PubMed

Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: a Children's Cancer Group initiative Leuk Lymphoma. 1997 Jun; 26(1-2):57-65. . View in PubMed

Augmented Berlin-Frankfurt-Munster therapy abrogates the adverse prognostic significance of slow early response to induction chemotherapy for children and adolescents with acute lymphoblastic leukemia and unfavorable presenting features: a report from the Children's Cancer Group J Clin Oncol. 1997 Jun; 15(6):2222-30. . View in PubMed

Cellular expression of antiapoptotic BCL-2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukemia: a Children's Cancer Group Study Blood. 1997 May 15; 89(10):3769-77. . View in PubMed

Clinical features and treatment outcome of children with biphenotypic CD2+ CD19+ acute lymphoblastic leukemia: a Children's Cancer Group study Blood. 1997 Apr 01; 89(7):2488-93. . View in PubMed

Acute lymphoblastic leukaemia: a guide to asparaginase and pegaspargase therapy BioDrugs. 1997 Jan; 7(1):30-9. . View in PubMed

Improved clinical outcome for children with T-lineage acute lymphoblastic leukemia after contemporary chemotherapy: a Children's Cancer Group Study Leuk Lymphoma. 1996 Dec; 24(1-2):57-70. . View in PubMed

CD2 antigen expression on leukemic cells as a predictor of event-free survival after chemotherapy for T-lineage acute lymphoblastic leukemia: a Children's Cancer Group study Blood. 1996 Dec 01; 88(11):4288-95. . View in PubMed

Craniospinal irradiation for acute lymphoblastic leukemia with central nervous system disease at diagnosis: a report from the Children's Cancer Group Int J Radiat Oncol Biol Phys. 1996 Aug 01; 36(1):19-27. . View in PubMed

Cytoreduction and prognosis in acute lymphoblastic leukemia--the importance of early marrow response: report from the Childrens Cancer Group J Clin Oncol. 1996 Feb; 14(2):389-98. . View in PubMed

Acute leukemia in children Curr Opin Hematol. 1995 Jul; 2(4):240-6. . View in PubMed

Carboplatin in pediatric malignancies Semin Oncol. 1994 Oct; 21(5 Suppl 12):65-76. . View in PubMed

A phase II study of carboplatin in children with recurrent or progressive solid tumorsA report from the Childrens Cancer Group. Cancer. 1994 Feb 15; 73(4):1297-301. . View in PubMed

Improved therapy for children with acute lymphoblastic leukemia and unfavorable presenting features: a follow-up report of the Childrens Cancer Group Study CCG-106 J Clin Oncol. 1993 Nov; 11(11):2234-42. . View in PubMed

A phase I study of carboplatin in children with acute leukemia in bone marrow relapseA report from the Childrens Cancer Group. Cancer. 1993 Aug 01; 72(3):917-22. . View in PubMed

Association of delivered drug dose and outcome for children with acute lymphoblastic leukemia and unfavorable presenting features Med Pediatr Oncol. 1991; 19(4):221-7. . View in PubMed

Granulocytic sarcoma of the ileum treated by bone marrow transplantation Am J Pediatr Hematol Oncol. 1991; 13(1):34-8. . View in PubMed

Carboplatin in childhood brain tumorsA Children's Cancer Study Group Phase II trial. Cancer. 1990 Dec 15; 66(12):2465-9. . View in PubMed

Day 7 marrow response and outcome for children with acute lymphoblastic leukemia and unfavorable presenting features Med Pediatr Oncol. 1990; 18(4):273-9. . View in PubMed

Improved survival of infants less than 1 year of age with acute lymphoblastic leukemia treated with intensive multiagent chemotherapy Cancer Treat Rep. 1987 Nov; 71(11):1033-8. . View in PubMed

Improved disease-free survival of children with acute lymphoblastic leukemia at high risk for early relapse with the New York regimen--a new intensive therapy protocol: a report from the Childrens Cancer Study Group J Clin Oncol. 1986 May; 4(5):744-52. . View in PubMed

Cerebral gigantism associated with Wilms' tumor Am J Dis Child. 1984 May; 138(5):486-8. . View in PubMed

Exaggerated eosinophilia and acute lymphoid leukemia Am J Pediatr Hematol Oncol. 1984; 6(3):334-7. . View in PubMed

Continuous infusion of 5-azacytidine as induction for acute nonlymphocytic leukemia in patients with previous exposure to 5-azacytidine Oncology. 1983; 40(3):192-4. . View in PubMed

A computer-based system for management of clinical and laboratory data of a comprehensive sickle cell center Methods Inf Med. 1974 Oct; 13(4):216. . View in PubMed

A retrieval system for a library of pathology reports, slides and kodachromes Methods Inf Med. 1972 Jul; 11(3):152-62. . View in PubMed

An automated parsing routine for diagnostic statements of surgical pathology reports Methods Inf Med. 1971 Jul; 10(3):168-75. . View in PubMed

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