Keck School Faculty

Paul S. Gaynon

Paul S. Gaynon

Professor of Pediatrics
Pediatrics
CHL Mail Stop 54 Off Campus Los Angeles

Temsirolimus combined with cyclophosphamide and etoposide for pediatric patients with relapsed/refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium trial (TACL 2014-001) Haematologica. 2022 Feb 03. . View in PubMed

Survival of pediatric Hodgkin lymphoma patients treated with doxorubicin, bleomycin, vincristine, etoposide, prednisone, and cyclophosphamide (ABVE-PC) versus doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) at a single institution Pediatr Blood Cancer. 2022 05; 69(5):e29601. . View in PubMed

Acute myeloid leukemia with t(X;6)9p11;q23);MYB-GATA1 and female sex: GATA1 insufficiency may be insufficient for pathogenesis Cancer Genet. 2022 01; 260-261:37-40. . View in PubMed

A new standard of care for childhood T-cell acute lymphoblastic leukemia? Pediatr Blood Cancer. 2021 10; 68(10):e29238.. View in PubMed

A phase I study of panobinostat in children with relapsed and refractory hematologic malignancies Pediatr Hematol Oncol. 2020 Sep; 37(6):465-474. . View in PubMed

Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study Clin Cancer Res. 2020 05 15; 26(10):2297-2307. . View in PubMed

Preexisting or therapy-induced mutations in relapsed acute lymphoblastic leukemia? Blood. 2020 11 05; 136(19):2233-2235.. View in PubMed

Methotrexate and asparaginase: not so simple Leuk Lymphoma. 2019 12; 60(12):2849-2850. . View in PubMed

Treatment of higher risk acute lymphoblastic leukemia in young people (CCG-1961), long-term follow-up: a report from the Children's Oncology Group Leukemia. 2019 09; 33(9):2144-2154. . View in PubMed

Excellent long-term survival of children with Down syndrome and standard-risk ALL: a report from the Children's Oncology Group Blood Adv. 2019 06 11; 3(11):1647-1656. . View in PubMed

Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study Leukemia. 2018 11; 32(11):2316-2325. . View in PubMed

Myeloid lineage switch following chimeric antigen receptor T-cell therapy in a patient with TCF3-ZNF384 fusion-positive B-lymphoblastic leukemia Pediatr Blood Cancer. 2018 09; 65(9):e27265. . View in PubMed

Remission is good - relapse is bad Haematologica. 2018 01; 103(1):4-5. . View in PubMed

A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium Blood. 2018 03 08; 131(10):1145-1148. . View in PubMed

First pediatric experience of SL-401, a CD123-targeted therapy, in patients with blastic plasmacytoid dendritic cell neoplasm: report of three cases J Hematol Oncol. 2018 05 02; 11(1):61. . View in PubMed

Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomization J Clin Oncol. 2018 10 10; 36(29):2926-2934. . View in PubMed

A neoplasm with FIP1L1-PDGFRA fusion presenting as pediatric T-cell lymphoblastic leukemia/lymphoma without eosinophilia Cancer Genet. 2017 Oct; 216-217:91-99. . View in PubMed

Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL): Overview and introduction to the proceedings of the 2016 TACL investigator meeting Pediatr Hematol Oncol. 2017 Sep - Oct; 34(6-7):349-354. . View in PubMed

Redefining treatment failure for pediatric acute leukemia in the era of minimal residual disease testing Pediatr Hematol Oncol. 2017 Sep - Oct; 34(6-7):395-408. . View in PubMed

Mercaptopurine in childhood acute lymphoblastic leukaemia Lancet Oncol. 2017 04; 18(4):425-426. . View in PubMed

Historical Controls? Haematologica. 2017 03; 102(3):e117.. View in PubMed

"The Second Time is Sweeter After All" Br J Haematol. 2017 02; 176(4):511-512. . View in PubMed

A Phase I Study of Quizartinib Combined with Chemotherapy in Relapsed Childhood Leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study Clin Cancer Res. 2016 Aug 15; 22(16):4014-22. . View in PubMed

Oligoclonality and new agent evaluation in acute lymphoblastic leukaemia Br J Haematol. 2016 Jun; 173(6):950-7. . View in PubMed

Reply: T-Cell Acute Lymphoblastic Leukemia, Minimal Residual Disease, and Lymphocyte Recovery Pediatr Blood Cancer. 2016 May; 63(5):945. . View in PubMed

Outcome of Children with Standard-Risk T-Lineage Acute Lymphoblastic Leukemia--Comparison among Different Treatment Strategies Pediatr Blood Cancer. 2016 Feb; 63(2):255-61. . View in PubMed

Bortezomib, Dexamethasone, Mitoxantrone, and Vinorelbine (BDMV): An Active Reinduction Regimen for Children With Relapsed Acute Lymphoblastic Leukemia and Asparaginase Intolerance J Pediatr Hematol Oncol. 2016 07; 38(5):345-9. . View in PubMed

Comparative Toxicity by Sex Among Children Treated for Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Pediatr Blood Cancer. 2015 Dec; 62(12):2140-9. . View in PubMed

Allergic reactions and antiasparaginase antibodies in children with high-risk acute lymphoblastic leukemia: A children's oncology group report Cancer. 2015 Dec 01; 121(23):4205-11. . View in PubMed

End of induction minimal residual disease alone is not a useful determinant for risk stratified therapy in pediatric T-cell acute lymphoblastic leukemia Pediatr Blood Cancer. 2015 Nov; 62(11):2040-3. . View in PubMed

ALL and osteonecrosis Blood. 2015 Oct 08; 126(15):1734-5. . View in PubMed

Feasibility Study of a Novel Experimental Induction Protocol Combining B43-PAP (Anti-CD19) Immunotoxin With Standard Induction Chemotherapy in Children and Adolescents With Relapsed B-Lineage ALL: A Report From the Children's Oncology Group J Immunother. 2015 Sep; 38(7):299-305. . View in PubMed

Improving access to novel agents for childhood leukemia Cancer. 2015 Jun 15; 121(12):1927-36. . View in PubMed

Increased post-induction intensification improves outcome in children and adolescents with a markedly elevated white blood cell count (=200 × 10(9) /l) with T cell acute lymphoblastic leukaemia but not B cell disease: a report from the Children's Oncology Group Br J Haematol. 2015 Feb; 168(4):533-46. . View in PubMed

CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells Integr Biol (Camb). 2014 Aug; 6(8):766-80. . View in PubMed

A phase I study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium J Pediatr Hematol Oncol. 2014 Aug; 36(6):458-63. . View in PubMed

Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children's Oncology Group study AALL0031 Leukemia. 2014 Jul; 28(7):1467-71. . View in PubMed

Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group J Clin Oncol. 2014 May 01; 32(13):1331-7. . View in PubMed

Philadelphia chromosome-negative very high-risk acute lymphoblastic leukemia in children and adolescents: results from Children's Oncology Group Study AALL0031 Leukemia. 2014 Apr; 28(4):964-7. . View in PubMed

High-resolution melting curve analysis, a rapid and affordable method for mutation analysis in childhood acute myeloid leukemia Front Pediatr. 2014; 2:96. . View in PubMed

Recent advances in acute lymphoblastic leukemia in children and adolescents: an expert panel discussion Curr Opin Oncol. 2013 Dec; 25 Suppl 3:S1-13; quiz S14-6. . View in PubMed

Subcutaneous Panniculitis-like T-cell lymphoma in two pediatric patients: an HIV-positive adolescent and a 4-month-old infant Fetal Pediatr Pathol. 2013 Jun; 32(3):175-83. . View in PubMed

Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemia Blood. 2013 May 23; 121(21):4348-54. . View in PubMed

Once upon a time--a personal view on episodes in leukemia research in Germany, and beyond Klin Padiatr. 2013 May; 225 Suppl 1:S5. . View in PubMed

The principle and practice of reinduction therapy (in ALL): repetita iuvant! Klin Padiatr 2013 May; 225 Suppl 1:S57-61. . View in PubMed

Constitutive function of the Ikaros transcription factor in primary leukemia cells from pediatric newly diagnosed high-risk and relapsed B-precursor ALL patients PLoS One. 2013; 8(11):e80732. . View in PubMed

Anaphylactic reaction to etoposide phosphate Pediatr Blood Cancer. 2012 Oct; 59(4):765. . View in PubMed

ABT-751 in relapsed childhood acute lymphoblastic leukemia J Pediatr Hematol Oncol. 2012 Oct; 34(7):583-4. . View in PubMed

Effect of alternate-week versus continuous dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia: results from the CCG-1961 randomised cohort trial Lancet Oncol. 2012 Sep; 13(9):906-15. . View in PubMed

Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study Blood. 2012 Jul 12; 120(2):285-90. . View in PubMed

The role of cytotoxic therapy with hematopoietic stem cell transplantation in the treatment of pediatric acute lymphoblastic leukemia: update of the 2005 evidence-based reviewASBMT Position Statement. Biol Blood Marrow Transplant. 2012 Jul; 18(7):979-81. . View in PubMed

Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group J Clin Oncol. 2012 May 10; 30(14):1663-9. . View in PubMed

Outcomes after induction failure in childhood acute lymphoblastic leukemia N Engl J Med. 2012 Apr 12; 366(15):1371-81. . View in PubMed

Role of cytotoxic therapy with hematopoietic stem cell transplantation in the treatment of pediatric acute lymphoblastic leukemia: update of the 2005 evidence-based review Biol Blood Marrow Transplant. 2012 Apr; 18(4):505-22. . View in PubMed

CD22 Exon 12 deletion is a characteristic genetic defect of therapy-refractory clones in paediatric acute lymphoblastic leukaemia Br J Haematol. 2012 Jan; 156(1):89-98. . View in PubMed

Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia Blood. 2011 Dec 01; 118(23):6043-9. . View in PubMed

A remembrance: James BNachman 1948-2011. Pediatr Blood Cancer. 2011 Oct; 57(4):533-4. . View in PubMed

James BNachman, 1948 to 2011: a remembrance. J Pediatr Hematol Oncol. 2011 Aug; 33(6):403-5. . View in PubMed

Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group Blood. 2011 Jul 14; 118(2):243-51. . View in PubMed

Population pharmacokinetics of clofarabine and its metabolite 6-ketoclofarabine in adult and pediatric patients with cancer Cancer Chemother Pharmacol. 2011 Apr; 67(4):875-90. . View in PubMed

Postrelapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: a report from the Children's Oncology Group Blood. 2011 Mar 17; 117(11):3010-5. . View in PubMed

Outcome for children treated for relapsed or refractory acute myelogenous leukemia (rAML): a Therapeutic Advances in Childhood Leukemia (TACL) Consortium study Pediatr Blood Cancer. 2010 Sep; 55(3):421-9. . View in PubMed

Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childhood leukemia (TACL) consortium Pediatr Blood Cancer. 2010 Aug; 55(2):254-9. . View in PubMed

Toxicity assessment of molecularly targeted drugs incorporated into multiagent chemotherapy regimens for pediatric acute lymphocytic leukemia (ALL): review from an international consensus conference Pediatr Blood Cancer. 2010 Jul 01; 54(7):872-8. . View in PubMed

Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial Blood. 2010 Apr 08; 115(14):2740-8. . View in PubMed

Long-term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: a Children's Oncology Group Report Leukemia. 2010 Feb; 24(2):285-97. . View in PubMed

Outcome of patients treated for relapsed or refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium study J Clin Oncol. 2010 Feb 01; 28(4):648-54. . View in PubMed

A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia Leukemia. 2009 Dec; 23(12):2259-64. . View in PubMed

Prospective monitoring for invasive aspergillosis using galactomannan and polymerase chain reaction in high risk pediatric patients J Pediatr Hematol Oncol. 2009 Dec; 31(12):920-6. . View in PubMed

Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study J Clin Oncol. 2009 Nov 01; 27(31):5175-81. . View in PubMed

Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: a report from the children's oncology group J Clin Oncol. 2009 Nov 01; 27(31):5189-94. . View in PubMed

An adjustment for patient heterogeneity in the design of two-stage phase II trials Stat Med. 2009 Sep 10; 28(20):2566-79. . View in PubMed

Phase II study of clofarabine in pediatric patients with refractory or relapsed acute myeloid leukemia J Clin Oncol. 2009 Sep 10; 27(26):4392-7. . View in PubMed

Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study Leukemia. 2008 Dec; 22(12):2142-50. . View in PubMed

Relapsed acute lymphoblastic leukemia: current status and future opportunities Curr Oncol Rep. 2008 Nov; 10(6):453-8. . View in PubMed

Blood. 2008 Sep 01; 112(5):1646-54. . View in PubMed

Reinduction platform for children with first marrow relapse of acute lymphoblastic Leukemia: A Children's Oncology Group Study[corrected] J Clin Oncol. 2008 Aug 20; 26(24):3971-8. . View in PubMed

Ten-year survival of children with acute lymphoblastic leukemia: a report from the Children's Oncology Group Leuk Lymphoma. 2008 Jun; 49(6):1142-54. . View in PubMed

Treating refractory leukemias in childhood, role of clofarabine Ther Clin Risk Manag. 2008 Apr; 4(2):327-36. . View in PubMed

Early postinduction intensification therapy improves survival for children and adolescents with high-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group Blood. 2008 Mar 01; 111(5):2548-55. . View in PubMed

Outcome after relapse among children with standard-risk acute lymphoblastic leukemia: Children's Oncology Group study CCG-1952 J Clin Oncol. 2007 Dec 20; 25(36):5800-7. . View in PubMed

Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia Genes Chromosomes Cancer. 2007 Jul; 46(7):684-93. . View in PubMed

Treatment of pediatric acute lymphoblastic leukemia: progress achieved and challenges remaining Curr Hematol Malig Rep. 2007 Jul; 2(3):193-201. . View in PubMed

Obesity and outcome in pediatric acute lymphoblastic leukemia J Clin Oncol. 2007 May 20; 25(15):2063-9. . View in PubMed

Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG) Blood. 2007 Feb 01; 109(3):926-35. . View in PubMed

Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children's Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Children's Oncology Group Blood. 2006 Aug 15; 108(4):1165-73. . View in PubMed

Asparagine depletion after pegylated Ecoli asparaginase treatment and induction outcome in children with acute lymphoblastic leukemia in first bone marrow relapse: a Children's Oncology Group study (CCG-1941). Pediatr Blood Cancer. 2006 Aug; 47(2):141-6. . View in PubMed

Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG-1941 J Clin Oncol. 2006 Jul 01; 24(19):3150-6. . View in PubMed

Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia J Clin Oncol. 2006 Apr 20; 24(12):1917-23. . View in PubMed

Treatment adherence and 6-mercaptopurine metabolites Pediatr Blood Cancer. 2006 Feb; 46(2):120-1. . View in PubMed

The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute lymphoblastic leukemia in adults: an evidence-based review Biol Blood Marrow Transplant. 2006 Jan; 12(1):1-30. . View in PubMed

Clinical characteristics and outcome of children with Down syndrome and acute lymphoblastic leukemia: a Children's Cancer Group study Blood. 2005 Dec 15; 106(13):4043-9. . View in PubMed

Childhood acute lymphoblastic leukaemia and relapse Br J Haematol. 2005 Dec; 131(5):579-87. . View in PubMed

The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of acute lymphoblastic leukemia in children: an evidence-based review Biol Blood Marrow Transplant. 2005 Nov; 11(11):823-61. . View in PubMed

The seventh international childhood acute lymphoblastic leukemia workshop report: Palermo, Italy, January 29--30, 2005 Leukemia. 2005 Jul; 19(7):1145-52. . View in PubMed

Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: a report from the Children's Oncology Group J Clin Oncol. 2005 May 20; 23(15):3376-82. . View in PubMed

High concordance from independent studies by the Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10, and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic Leukemia: a Children's Oncology Group (COG) initiative Leukemia. 2005 May; 19(5):734-40. . View in PubMed

No prognostic effect of additional chromosomal abnormalities in children with acute lymphoblastic leukemia and 11q23 abnormalities Leukemia. 2005 Apr; 19(4):557-63. . View in PubMed

Statement by members of the Ponte di Legno group on the right of children with leukemia to have full access to essential treatment for acute lymphoblastic leukemia Ann Oncol. 2005 Jan; 16(1):169-70. . View in PubMed

Lymphoblast biology and outcome among children with Down syndrome and ALL treated on CCG-1952 Pediatr Blood Cancer. 2005 Jan; 44(1):21-8. . View in PubMed

Population pharmacokinetics of clofarabine, a second-generation nucleoside analog, in pediatric patients with acute leukemia J Clin Pharmacol. 2004 Nov; 44(11):1309-22. . View in PubMed

Statement by members of the Ponte di Legno Group on the right of children to have full access to essential treatment for acute lymphoblastic leukemia Pediatr Blood Cancer. 2004 Aug; 43(2):103-4. . View in PubMed

Ponte di Legno Working Group: statement on the right of children with leukemia to have full access to essential treatment and report on the Sixth International Childhood Acute Lymphoblastic Leukemia Workshop Leukemia. 2004 Jun; 18(6):1043-53. . View in PubMed

Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group Leukemia. 2004 May; 18(5):939-47. . View in PubMed

RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia Leukemia. 2004 Apr; 18(4):685-92. . View in PubMed

Asparaginase antibody and asparaginase activity in children with higher-risk acute lymphoblastic leukemia: Children's Cancer Group Study CCG-1961 J Pediatr Hematol Oncol. 2004 Apr; 26(4):217-26. . View in PubMed

Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome Leukemia. 2004 Apr; 18(4):693-702. . View in PubMed

Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961) Anticancer Res. 2004 Mar-Apr; 24(2C):1121-5. . View in PubMed

Changes of amino acid serum levels in pediatric patients with higher-risk acute lymphoblastic leukemia (CCG-1961) In Vivo. 2004 Mar-Apr; 18(2):107-12. . View in PubMed

Altered patterns of T cell cytokine production induced by relapsed pre-B ALL cells Leuk Res. 2003 Dec; 27(12):1135-42. . View in PubMed

Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study J Pediatr Hematol Oncol. 2003 Sep; 25(9):688-95. . View in PubMed

Preponderant mitotic activity of nonleukemic cells plays an important role in failures to detect abnormal clone in childhood acute lymphoblastic leukemia J Pediatr Hematol Oncol. 2003 Jul; 25(7):520-5. . View in PubMed

Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group Blood. 2003 May 15; 101(10):3809-17. . View in PubMed

Intensification of therapy for children with lower-risk acute lymphoblastic leukemia: long-term follow-up of patients treated on Children's Cancer Group Trial 1881 J Clin Oncol. 2003 May 01; 21(9):1790-7. . View in PubMed

CNS-directed therapy for childhood acute lymphoblastic leukemia: Childhood ALL Collaborative Group overview of 43 randomized trials J Clin Oncol. 2003 May 01; 21(9):1798-809. . View in PubMed

Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements Leukemia. 2003 Apr; 17(4):700-6. . View in PubMed

Racial and ethnic differences in survival of children with acute lymphoblastic leukemia Blood. 2002 Sep 15; 100(6):1957-64. . View in PubMed

Response to Donadieu and Hill "Clinical trials in childhood acute lymphoblastic leukemia: a common prognostic classification and a common induction therapy are now warranted" J Pediatr Hematol Oncol. 2002 Aug-Sep; 24(6):426-8. . View in PubMed

Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia Blood. 2002 Jul 01; 100(1):67-71. . View in PubMed

Low incidence of second neoplasms among children diagnosed with acute lymphoblastic leukemia after 1983 Blood. 2002 Jun 15; 99(12):4257-64. . View in PubMed

Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region Lancet. 2002 Jun 01; 359(9321):1909-15. . View in PubMed

A randomized comparison of native Escherichia coli asparaginase and polyethylene glycol conjugated asparaginase for treatment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study Blood. 2002 Mar 15; 99(6):1986-94. . View in PubMed

A pharmacoeconomic analysis of pegaspargase versus native Escherichia coli L-asparaginase for the treatment of children with standard-risk, acute lymphoblastic leukemia: the Children's Cancer Group study (CCG-1962) J Pediatr Hematol Oncol. 2002 Mar-Apr; 24(3):175-81. . View in PubMed

From where do clinical trials come? J Pediatr Hematol Oncol. 2002 Mar-Apr; 24(3):172-4.. View in PubMed

Abnormalities of chromosome bands 15q13-15 in childhood acute lymphoblastic leukemia Cancer. 2002 Feb 15; 94(4):1102-10. . View in PubMed

Expression of TEL-AML1 fusion transcripts and response to induction therapy in standard risk acute lymphoblastic leukemia Leuk Lymphoma. 2001 Jun; 42(1-2):41-56. . View in PubMed

Duration of hospitalization as a measure of cost on Children's Cancer Group acute lymphoblastic leukemia studies J Clin Oncol. 2001 Apr 01; 19(7):1916-25. . View in PubMed

Bone marrow leukemic progenitor cell content in pediatric T-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse Leuk Lymphoma. 2001 Jan; 40(3-4):279-85. . View in PubMed

Long-term results of large prospective trials in childhood acute lymphoblastic leukemia Leukemia. 2000 Dec; 14(12):2193-4. . View in PubMed

Children's Cancer Group trials in childhood acute lymphoblastic leukemia: 1983-1995 Leukemia. 2000 Dec; 14(12):2223-33. . View in PubMed

Abnormalities of chromosome bands 13q12 to 13q14 in childhood acute lymphoblastic leukemia J Clin Oncol. 2000 Nov 15; 18(22):3837-44. . View in PubMed

Prognostic factors in acute lymphoblastic leukemia J Pediatr Hematol Oncol. 2000 Sep-Oct; 22(5):403-4. . View in PubMed

Residual bone marrow leukemic progenitor cell burden after induction chemotherapy in pediatric patients with acute lymphoblastic leukemia Clin Cancer Res. 2000 Aug; 6(8):3123-30. . View in PubMed

Prognostic impact of trisomies of chromosomes 10, 17, and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (> 50 chromosomes) J Clin Oncol. 2000 May; 18(9):1876-87. . View in PubMed

Prognostic significance of cytogenetic abnormalities of chromosome arm 12p in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group Cancer. 2000 Apr 15; 88(8):1945-54. . View in PubMed

Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia N Engl J Med. 2000 Apr 06; 342(14):998-1006. . View in PubMed

Clinical significance of deletions of chromosome arm 6q in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group Leuk Lymphoma. 2000 Feb; 36(5-6):467-78. . View in PubMed

Early testicular biopsy in males with acute lymphoblastic leukemia: lack of impact on subsequent event-free survival J Pediatr Hematol Oncol. 2000 Jan-Feb; 22(1):27-33. . View in PubMed

Hypodiploidy with less than 45 chromosomes confers adverse risk in childhood acute lymphoblastic leukemia: a report from the children's cancer group Blood. 1999 Dec 15; 94(12):4036-45. . View in PubMed

Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia J Clin Oncol. 1999 Dec; 17(12):3753-66. . View in PubMed

Association of chromosome arm 9p abnormalities with adverse risk in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group Blood. 1999 Sep 01; 94(5):1537-44. . View in PubMed

Paucity of leukemic progenitor cells in the bone marrow of pediatric B-lineage acute lymphoblastic leukemia patients with an isolated extramedullary first relapse Clin Cancer Res. 1999 Sep; 5(9):2415-20. . View in PubMed

Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia Clin Cancer Res. 1999 Aug; 5(8):2112-20. . View in PubMed

Poor treatment outcome of Philadelphia chromosome-positive pediatric acute lymphoblastic leukemia despite intensive chemotherapy Leuk Lymphoma. 1999 Mar; 33(1-2):101-6. . View in PubMed

Treatment outcome and prognostic factors for infants with acute lymphoblastic leukemia treated on two consecutive trials of the Children's Cancer Group J Clin Oncol. 1999 Feb; 17(2):445-55. . View in PubMed

Prognostic significance of T-lineage leukemic cell growth in SCID mice: a Children's Cancer Group study Leuk Lymphoma. 1999 Feb; 32(5-6):475-87. . View in PubMed

Glucocorticosteroid therapy in childhood acute lymphoblastic leukemia Adv Exp Med Biol. 1999; 457:593-605. . View in PubMed

Low-dose cyclosporin A therapy in children with refractory immune thrombocytopenic purpura J Pediatr Hematol Oncol. 1999 Jan-Feb; 21(1):77-9. . View in PubMed

Distinct in vivo engraftment and growth patterns of t(1;19)+/E2A-PBX1+ and t(9;22)+/BCR-ABL+ human leukemia cells in SCID mice Leuk Lymphoma. 1998 Dec; 32(1-2):77-87. . View in PubMed

Clinical significance of Philadelphia chromosome positive pediatric acute lymphoblastic leukemia in the context of contemporary intensive therapies: a report from the Children's Cancer Group Cancer. 1998 Nov 01; 83(9):2030-9. . View in PubMed

Treatment of human B-cell precursor leukemia in SCID mice by using a combination of the anti-CD19 immunotoxin B43-PAP with the standard chemotherapeutic drugs vincristine, methylprednisolone, and L-asparaginase Leuk Lymphoma. 1998 Sep; 31(1-2):143-9. . View in PubMed

Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation Blood. 1998 Aug 01; 92(3):810-21. . View in PubMed

Prognostic significance of B-lineage leukemic cell growth in SCID mice: a Children's Cancer Group Study Leuk Lymphoma. 1998 Aug; 30(5-6):503-14. . View in PubMed

Primary blasts from infants with acute lymphoblastic leukemia cause overt leukemia in SCID mice Leuk Lymphoma. 1998 Jul; 30(3-4):269-77. . View in PubMed

Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy N Engl J Med. 1998 Jun 04; 338(23):1663-71. . View in PubMed

Survival after relapse in childhood acute lymphoblastic leukemia: impact of site and time to first relapse--the Children's Cancer Group Experience Cancer. 1998 Apr 01; 82(7):1387-95. . View in PubMed

Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group J Clin Oncol. 1998 Apr; 16(4):1270-8. . View in PubMed

Response of children with high-risk acute lymphoblastic leukemia treated with and without cranial irradiation: a report from the Children's Cancer Group J Clin Oncol. 1998 Mar; 16(3):920-30. . View in PubMed

Biology and treatment of childhood T-lineage acute lymphoblastic leukemia Blood. 1998 Feb 01; 91(3):735-46. . View in PubMed

Treatment of patients with acute lymphoblastic leukemia with bulky extramedullary disease and T-cell phenotype or other poor prognostic features: randomized controlled trial from the Children's Cancer Group Cancer. 1998 Feb 01; 82(3):600-12. . View in PubMed

Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group J Clin Oncol. 1998 Feb; 16(2):527-35. . View in PubMed

Prognostic significance of the CD10+CD19+CD34+ B-progenitor immunophenotype in children with acute lymphoblastic leukemia: a report from the Children's Cancer Group Leuk Lymphoma. 1997 Nov; 27(5-6):445-57. . View in PubMed

Early response to therapy and outcome in childhood acute lymphoblastic leukemia: a review Cancer. 1997 Nov 01; 80(9):1717-26. . View in PubMed

A phase II study of carboplatin as a treatment for children with acute leukemia recurring in bone marrow: a report of the Children's Cancer Group Cancer. 1997 Jul 15; 80(2):311-6. . View in PubMed

Importance of the day 7 bone marrow biopsy as a prognostic measure of the outcome in children with acute lymphoblastic leukemia Med Pediatr Oncol. 1997 Jul; 29(1):16-22. . View in PubMed

Clinical features and treatment outcome of children with myeloid antigen positive acute lymphoblastic leukemia: a report from the Children's Cancer Group Blood. 1997 Jul 01; 90(1):28-35. . View in PubMed

Augmented Berlin-Frankfurt-Munster therapy abrogates the adverse prognostic significance of slow early response to induction chemotherapy for children and adolescents with acute lymphoblastic leukemia and unfavorable presenting features: a report from the Children's Cancer Group J Clin Oncol. 1997 Jun; 15(6):2222-30. . View in PubMed

Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: a Children's Cancer Group initiative Leuk Lymphoma. 1997 Jun; 26(1-2):57-65. . View in PubMed

Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study J Clin Oncol. 1997 Jun; 15(6):2214-21. . View in PubMed

Cellular expression of antiapoptotic BCL-2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukemia: a Children's Cancer Group Study Blood. 1997 May 15; 89(10):3769-77. . View in PubMed

Clinical features and treatment outcome of children with biphenotypic CD2+ CD19+ acute lymphoblastic leukemia: a Children's Cancer Group study Blood. 1997 Apr 01; 89(7):2488-93. . View in PubMed

Acute lymphoblastic leukaemia: a guide to asparaginase and pegaspargase therapy BioDrugs. 1997 Jan; 7(1):30-9. . View in PubMed

Improved clinical outcome for children with T-lineage acute lymphoblastic leukemia after contemporary chemotherapy: a Children's Cancer Group Study Leuk Lymphoma. 1996 Dec; 24(1-2):57-70. . View in PubMed

CD2 antigen expression on leukemic cells as a predictor of event-free survival after chemotherapy for T-lineage acute lymphoblastic leukemia: a Children's Cancer Group study Blood. 1996 Dec 01; 88(11):4288-95. . View in PubMed

Craniospinal irradiation for acute lymphoblastic leukemia with central nervous system disease at diagnosis: a report from the Children's Cancer Group Int J Radiat Oncol Biol Phys. 1996 Aug 01; 36(1):19-27. . View in PubMed

Cytoreduction and prognosis in acute lymphoblastic leukemia--the importance of early marrow response: report from the Childrens Cancer Group J Clin Oncol. 1996 Feb; 14(2):389-98. . View in PubMed

Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia J Clin Oncol. 1996 Jan; 14(1):18-24. . View in PubMed

Acute leukemia in children Curr Opin Hematol. 1995 Jul; 2(4):240-6. . View in PubMed

Tibial stress fracture mimicking neuroblastoma metastasis in two young children Skeletal Radiol. 1995 May; 24(4):287-90. . View in PubMed

Leukemic cell growth in SCID mice as a predictor of relapse in high-risk B-lineage acute lymphoblastic leukemia Blood. 1995 Feb 15; 85(4):873-8. . View in PubMed

The use of glucocorticoids in acute lymphoblastic leukemia of childhoodMolecular, cellular, and clinical considerations. J Pediatr Hematol Oncol. 1995 Feb; 17(1):1-12. . View in PubMed

Carboplatin in pediatric malignancies Semin Oncol. 1994 Oct; 21(5 Suppl 12):65-76. . View in PubMed

A phase II study of carboplatin in children with recurrent or progressive solid tumorsA report from the Childrens Cancer Group. Cancer. 1994 Feb 15; 73(4):1297-301. . View in PubMed

The role of radiation therapy in the treatment of acute lymphoblastic leukemia with lymphomatous presentation: a report from the Childrens Cancer Group Int J Radiat Oncol Biol Phys. 1993 Dec 01; 27(5):1001-9. . View in PubMed

Improved therapy for children with acute lymphoblastic leukemia and unfavorable presenting features: a follow-up report of the Childrens Cancer Group Study CCG-106 J Clin Oncol. 1993 Nov; 11(11):2234-42. . View in PubMed

A phase I study of carboplatin in children with acute leukemia in bone marrow relapseA report from the Childrens Cancer Group. Cancer. 1993 Aug 01; 72(3):917-22. . View in PubMed

Young adults 16-21 years of age at diagnosis entered on Childrens Cancer Group acute lymphoblastic leukemia and acute myeloblastic leukemia protocolsResults of treatment. Cancer. 1993 May 15; 71(10 Suppl):3377-85. . View in PubMed

Association of delivered drug dose and outcome for children with acute lymphoblastic leukemia and unfavorable presenting features Med Pediatr Oncol. 1991; 19(4):221-7. . View in PubMed

Granulocytic sarcoma of the ileum treated by bone marrow transplantation Am J Pediatr Hematol Oncol. 1991; 13(1):34-8. . View in PubMed

Prolonged response to carboplatin in an infant with brain stem glioma Cancer. 1991 Jan 01; 67(1):43-7. . View in PubMed

Carboplatin in childhood brain tumorsA Children's Cancer Study Group Phase II trial. Cancer. 1990 Dec 15; 66(12):2465-9. . View in PubMed

Primary treatment of childhood acute lymphoblastic leukemia of non-T cell lineage (including infants) Hematol Oncol Clin North Am. 1990 Oct; 4(5):915-36. . View in PubMed

Day 7 marrow response and outcome for children with acute lymphoblastic leukemia and unfavorable presenting features Med Pediatr Oncol. 1990; 18(4):273-9. . View in PubMed

Intensive therapy for children with acute lymphoblastic leukaemia and unfavourable presenting featuresEarly conclusions of study CCG-106 by the Childrens Cancer Study Group. Lancet. 1988 Oct 22; 2(8617):921-4. . View in PubMed

The effect of initial management of hyperleukocytosis on early complications and outcome of children with acute lymphoblastic leukemia J Clin Oncol. 1988 Sep; 6(9):1425-32. . View in PubMed

Modified BFM therapy for children with previously untreated acute lymphoblastic leukemia and unfavorable prognostic featuresReport of Children's Cancer Study Group Study CCG-193P. Am J Pediatr Hematol Oncol. 1988; 10(1):42-50. . View in PubMed

Pediatric phase I trial of carboplatin: a Childrens Cancer Study Group report Cancer Treat Rep. 1987 Nov; 71(11):1039-42. . View in PubMed

Improved survival of infants less than 1 year of age with acute lymphoblastic leukemia treated with intensive multiagent chemotherapy Cancer Treat Rep. 1987 Nov; 71(11):1033-8. . View in PubMed

Strategies for the treatment of children with acute lymphoblastic leukemia and unfavorable presenting features Haematol Blood Transfus. 1987; 30:167-72. . View in PubMed

Microcomputer-assisted data management for multiinstitutional pediatric clinical cancer trials Am J Pediatr Hematol Oncol. 1987; 9(1):33-41. . View in PubMed

Improved disease-free survival of children with acute lymphoblastic leukemia at high risk for early relapse with the New York regimen--a new intensive therapy protocol: a report from the Childrens Cancer Study Group J Clin Oncol. 1986 May; 4(5):744-52. . View in PubMed

Cerebral gigantism associated with Wilms' tumor Am J Dis Child. 1984 May; 138(5):486-8. . View in PubMed

Exaggerated eosinophilia and acute lymphoid leukemia Am J Pediatr Hematol Oncol. 1984; 6(3):334-7. . View in PubMed

Continuous infusion of 5-azacytidine as induction for acute nonlymphocytic leukemia in patients with previous exposure to 5-azacytidine Oncology. 1983; 40(3):192-4. . View in PubMed

Phase II trial of prednimustine in children with recurrent cancer: a Children's Cancer Study Group report Cancer Treat Rep. 1982 Jul; 66(7):1583-4. . View in PubMed

Phase II trail cisplatin in refractory childhood cancer: Children's Cancer Study Group Report Cancer Treat Rep. 1981 Sep-Oct; 65(9-10):815-22. . View in PubMed

Profile of a dictionary compiled from scanning over one million words of surgical pathology narrative text Comput Biomed Res. 1980 Aug; 13(4):382-98. . View in PubMed

Phase II study of cis-dichlorodiammineplatinum(II) in childhood osteosarcoma: Children's Cancer Study Group Report Cancer Treat Rep. 1979 Sep-Oct; 63(9-10):1621-7. . View in PubMed

A computer-based system for management of clinical and laboratory data of a comprehensive sickle cell center Methods Inf Med. 1974 Oct; 13(4):216. . View in PubMed

POLARS: a Pathology On-line Logging And Reporting System Comput Biomed Res. 1974 Feb; 7(1):83-99. . View in PubMed

A retrieval system for a library of pathology reports, slides and kodachromes Methods Inf Med. 1972 Jul; 11(3):152-62. . View in PubMed

An automated parsing routine for diagnostic statements of surgical pathology reports Methods Inf Med. 1971 Jul; 10(3):168-75. . View in PubMed

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