Paul Seidler

Assistant Professor of Pharmacology and Pharmaceutical Sciences

Is this your profile? Click to edit

Publications

Evidence for cPLA2 activation in Alzheimer’s disease synaptic pathology. Acta Neuropathol Commun. 2026 Feb 12; 14(1).. View in PubMed
Polyphyletic screen defines distinct classes of plant-derived natural products that oppose tauopathy. Life Sci Alliance. 2026 Feb; 9(2).. View in PubMed
Evidence for cPLA2 activation in Alzheimer’s Disease Synaptic Pathology. bioRxiv. 2025 Apr 01.. View in PubMed
Selective Inhibition of hsp90 Paralogs: Uncovering the Role of Helix 1 in Grp94-Selective Ligand Binding. Proteins. 2025 Mar; 93(3):654-672.. View in PubMed
An ultra-broadband photonic-chip-based parametric amplifier. Nature. 2025 Mar; 639(8056):928-934.. View in PubMed
Monoaminergic neurotransmitters are bimodal effectors of tau aggregation. Sci Adv. 2025 Jan 31; 11(5):eadr8055.. View in PubMed
Improving the solubility of pseudo-hydrophobic chemicals through co-crystal formulation. PNAS Nexus. 2025 Jan; 4(1):pgaf007.. View in PubMed
Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer’s disease. Chem Sci. 2024 Dec 11; 15(48):20467-20477.. View in PubMed
Tau seeds catalyze fibril-type structures from GFP tau biosensor cells. Structure. 2024 12 05; 32(12):2251-2258.e3.. View in PubMed
Selective inhibition of hsp90 paralogs: Uncovering the role of helix 1 in Grp94-selective ligand binding. bioRxiv. 2024 Aug 19.. View in PubMed
D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer’s disease. Sci Adv. 2024 05 03; 10(18):eadl2991.. View in PubMed
Oolonghomobisflavans from Camellia sinensis disaggregate tau fibrils across Alzheimer’s disease models. bioRxiv. 2024 Mar 01.. View in PubMed
A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathway. Chem Sci. 2023 Oct 18; 14(40):11022-11032.. View in PubMed
Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient-extracted tau fibrils. Proc Natl Acad Sci U S A. 2023 10 10; 120(41):e2300258120.. View in PubMed
A heterogeneously integrated lithium niobate-on-silicon nitride photonic platform. Nat Commun. 2023 Jun 13; 14(1):3499.. View in PubMed
Improving the solubility of pseudo-hydrophobic Alzheimer’s Disease medicinal chemicals through co-crystal formulation. bioRxiv. 2023 Apr 28.. View in PubMed
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nat Commun. 2023 04 25; 14(1):2379.. View in PubMed
Ultrafast tunable lasers using lithium niobate integrated photonics. Nature. 2023 03; 615(7952):411-417.. View in PubMed
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proc Natl Acad Sci U S A. 2023 02 14; 120(7):e2217835120.. View in PubMed
Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro. Nat Commun. 2022 09 16; 13(1):5451.. View in PubMed
De novo designed protein inhibitors of amyloid aggregation and seeding. Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2206240119.. View in PubMed
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies. Nat Struct Mol Biol. 2022 06; 29(6):529-536.. View in PubMed
Microwave-to-optical conversion with a gallium phosphide photonic crystal cavity. Nat Commun. 2022 Apr 19; 13(1):2065.. View in PubMed
Three-repeat and four-repeat tau isoforms form different oligomers. Protein Sci. 2022 03; 31(3):613-627.. View in PubMed
Maximizing Completion of the Two-Dose COVID-19 Vaccine Series with Aid from Infographics. Vaccines (Basel). 2021 Oct 22; 9(11).. View in PubMed
Correction to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimers Res Ther. 2021 Apr 19; 13(1):83.. View in PubMed
Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. bioRxiv. 2021 Mar 18.. View in PubMed
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer’s disease. J Biol Chem. 2020 07 31; 295(31):10662-10676.. View in PubMed
Structure-based inhibitors halt prion-like seeding by Alzheimer’s disease-and tauopathy-derived brain tissue samples. J Biol Chem. 2019 11 01; 294(44):16451-16464.. View in PubMed
Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimers Res Ther. 2019 10 18; 11(1):86.. View in PubMed
Structure-based inhibitors of amyloid beta core suggest a common interface with tau. Elife. 2019 10 15; 8.. View in PubMed
Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. J Biol Chem. 2018 02 23; 293(8):2888-2902.. View in PubMed
Structure-based inhibitors of tau aggregation. Nat Chem. 2018 02; 10(2):170-176.. View in PubMed
Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat Methods. 2017 Feb 13; 14(4):399-402.. View in PubMed
Characterization of the Grp94/OS-9 chaperone-lectin complex. J Mol Biol. 2014 Oct 23; 426(21):3590-605.. View in PubMed
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Nov; 9(11):677-84.. View in PubMed
Investigations of chemical modifications of amino-terminated organic films on silicon substrates and controlled protein immobilization. Langmuir. 2010 Feb 16; 26(4):2599-608.. View in PubMed
Formation, structure, and reactivity of amino-terminated organic films on silicon substrates. J Colloid Interface Sci. 2009 Jan 01; 329(1):114-9.. View in PubMed

Paul Seidler

Publications

Similar People