Keck School Faculty

Peter J Mullen

Peter J Mullen

Assistant Professor of Molecular Microbiology and Immunology
Molecular Microbiology and Immunology
1501 San Pablo St. Health Sciences Campus Los Angeles

The Metabolic Relationship Between Viral Infection and Cancer Annual Review of Cancer Biology. 2022; 6:1-15. . View in PubMed

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition Nat Commun. 2021 03 25; 12(1):1876. . View in PubMed

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growthCell Metab. 2021 05 04; 33(5):1013-1026. e6. . View in PubMed

A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer Prostate Cancer Prostatic Dis. 2020 12; 23(4):630-637. . View in PubMed

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer Mol Metab. 2019 07; 25:119-130. . View in PubMed

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP DestabilizationCell. 2018 09 20; 175(1):117-132. e21. . View in PubMed

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and TumorigenesisCancer Cell. 2018 10 08; 34(4):579-595. e8. . View in PubMed

Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins Cancer Res. 2018 03 01; 78(5):1347-1357. . View in PubMed

The interplay between cell signalling and the mevalonate pathway in cancer Nat Rev Cancer. 2016 11; 16(11):718-731. . View in PubMed

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo Arch Toxicol. 2016 Jan; 90(1):203-15. . View in PubMed

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death Oncotarget. 2015 Sep 29; 6(29):26909-21. . View in PubMed

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress Blood. 2015 Mar 26; 125(13):2120-30. . View in PubMed

Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop Cancer Res. 2014 Sep 01; 74(17):4772-82. . View in PubMed

Largen: a molecular regulator of mammalian cell size control Mol Cell. 2014 Mar 20; 53(6):904-15. . View in PubMed

Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells Breast Cancer Res Treat. 2014 Jan; 143(2):301-12. . View in PubMed

MYC phosphorylation at novel regulatory regions suppresses transforming activity Cancer Res. 2013 Nov 01; 73(21):6504-15. . View in PubMed

Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans Ther Drug Monit. 2012 Aug; 34(4):406-14. . View in PubMed

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt Biochim Biophys Acta. 2011 Dec; 1813(12):2079-87. . View in PubMed

Matrix metalloproteinases 2 and 9 in the cochlea: expression and activity after aminoglycoside exposition Neuroscience. 2011 May 05; 181:28-39. . View in PubMed

Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy Biochem Pharmacol. 2010 Apr 15; 79(8):1200-9. . View in PubMed

Peter J. Mullen, Ph.D., is an Assistant Professor of Microbiology and Immunology in the Keck School of Medicine at the University of Southern California (USC). He has a secondary appointment in the Leonard Davis School of Gerontology at USC.
He has spent over 10 years studying the regulation and role of metabolism in tumor growth and viral infections. The overall goal of his recently established lab is to understand how whole-body metabolism alters respiratory virus replication, cancer progression and aging. By elucidating specific requirements for different nutrients, he aims to identify and develop novel strategies that reduce disease and increase lifespan.
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