Keck School Faculty

Qifa Zhou, PhD
Qifa Zhou, PhD
Professor of Ophthalmology and Biomedical Engineering
Ophthalmology
MMR 312 1333 San Pablo Street University Park Campus Los Angeles
Dr. Zhou’s research focuses on the design and fabrication of high frequency ultrasonic transducers using new piezoelectric single crystal and thin film technologies for medical imaging applications. He has integrated ultrasonic technology with advanced optical technology for intravascular imaging application. His current work is to develop miniaturized photoacoustic imaging (PA) probes using high frequency ultrasound transducers for endoscopic application. The primary motivations are to overcome the depth limitation of existing endoscopic imaging technologies and to provide functional information for disease states via photoacoustic imaging.

Three-Dimensional Printed Piezoelectric Array for Improving Acoustic Field and Spatial Resolution in Medical Ultrasonic Imaging Micromachines (Basel). 2019 Feb 28; 10(3). . View in PubMed

Novel Configurations of Ultrahigh Frequency (=600 MHz) Analog Frontend for High Resolution Ultrasound Measurement Sensors (Basel). 2018 Aug 08; 18(8). . View in PubMed

Recent Progress in Biomimetic Additive Manufacturing Technology: From Materials to Functional Structures Adv Mater. 2018 Jun 19; e1706539. . View in PubMed

3D-Printed Biomimetic Super-Hydrophobic Structure for Microdroplet Manipulation and Oil/Water Separation Adv Mater. 2018 Mar; 30(9). . View in PubMed

High-Frequency Ultrasonic Imaging with Lead-free (Na,K)(Nb,Ta)O3 Single Crystal Ultrason Imaging. 2017 Nov; 39(6):348-356. . View in PubMed

Biomimetic Anisotropic Reinforcement Architectures by Electrically Assisted Nanocomposite 3D Printing Adv Mater. 2017 Mar; 29(11). . View in PubMed

High-Frequency Ultrasonic Imaging with Lead-free (Na,K)(Nb,Ta)O3 Single Crystal Ultrason Imaging. 2017 11; 39(6):348-356. . View in PubMed

Multi-functional Ultrasonic Micro-elastography Imaging System Sci Rep. 2017 04 27; 7(1):1230. . View in PubMed

Functional Assay of Cancer Cell Invasion Potential Based on Mechanotransduction of Focused Ultrasound Front Oncol. 2017; 7:161. . View in PubMed

High-resolution harmonic motion imaging (HR-HMI) for tissue biomechanical property characterization Quant Imaging Med Surg. 2015 Feb; 5(1):108-17. . View in PubMed

A feasibility study of in vivo applications of single beam acoustic tweezers Appl Phys Lett. 2014 Oct 27; 105(17):173701. . View in PubMed

Piezoelectric single crystals for ultrasonic transducers in biomedical applications Prog Mater Sci. 2014 Oct 01; 66:87-111. . View in PubMed

Integrated IVUS-OCT Imaging for Atherosclerotic Plaque Characterization IEEE J Sel Top Quantum Electron. 2014 Mar; 20(2):7100108. . View in PubMed

Systematic study of high-frequency ultrasonic transducer design for laser-scanning photoacoustic ophthalmoscopy J Biomed Opt. 2014 Jan; 19(1):16015. . View in PubMed

Investigating contactless high frequency ultrasound microbeam stimulation for determination of invasion potential of breast cancer cells Biotechnol Bioeng. 2013 Oct; 110(10):2697-705. . View in PubMed

Development of lead-free single-element ultrahigh frequency (170-320MHz) ultrasonic transducers Ultrasonics. 2013 Jul; 53(5):1033-8. . View in PubMed

High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart Opt Express. 2013 Jun 17; 21(12):14636-42. . View in PubMed

Elevated electrochemical impedance in the endoluminal regions with high shear stress: implication for assessing lipid-rich atherosclerotic lesions Biosens Bioelectron. 2013 May 15; 43:237-44. . View in PubMed

Silver Doped 09PMN-PT-0. 1PZT Composite Films for very High Frequency Ultrasonic Transducer Applications. Appl Phys A Mater Sci Process. 2013 May 01; 111(2):459-463. . View in PubMed

Ultrahigh frequency lensless ultrasonic transducers for acoustic tweezers application Biotechnol Bioeng. 2013 Mar; 110(3):881-6. . View in PubMed

Combined chirp coded tissue harmonic and fundamental ultrasound imaging for intravascular ultrasound: 20-60 MHz phantom and ex vivo results Ultrasonics. 2013 Feb; 53(2):369-76. . View in PubMed

20 MHz forward-imaging single-element beam steering with an internal rotating variable-angle reflecting surface: Wire phantom and ex vivo pilot study Ultrasonics. 2013 Feb; 53(2):561-9. . View in PubMed

In vivo Sonothrombolysis of Ear Marginal Vein of Rabbits Monitored with High-frequency Ultrasound Needle Transducer J Med Biol Eng. 2013; 33(1):103-110. . View in PubMed

Pulse inversion chirp coded tissue harmonic imaging (PI-CTHI) of Zebrafish heart using high frame rate ultrasound biomicroscopy Ann Biomed Eng. 2013 Jan; 41(1):41-52. . View in PubMed

Thermal-independent properties of PIN-PMN-PT single-crystal linear-array ultrasonic transducers IEEE Trans Ultrason Ferroelectr Freq Control. 2012 Dec; 59(12):2777-84. . View in PubMed

Intravascular photoacoustic imaging at 35 and 80 MHz J Biomed Opt. 2012 Oct; 17(10):106005. . View in PubMed

PMN-PT-PZT composite films for high frequency ultrasonic transducer applications Sens Actuators A Phys. 2012 Jun; 179:121-124. . View in PubMed

Development of integrated preamplifier for high-frequency ultrasonic transducers and low-power handheld receiver IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Dec; 58(12):2646-58. . View in PubMed

80-MHz intravascular ultrasound transducer using PMN-PT free-standing film IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Nov; 58(11):2281-8. . View in PubMed

Structure and electrical properties of (111)-oriented Pb(Mg1/3Nb2/3)O3-PbZrO3-PbTiO3 thin film for ultra-high-frequency transducer applications IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Sep; 58(9):1962-7. . View in PubMed

Piezoelectric films for high frequency ultrasonic transducers in biomedical applications Prog Mater Sci. 2011 Feb; 56(2):139-174. . View in PubMed

Thickness Dependent Characteristics of High Permittivity PMN-032PT Single Crystal for High Frequency Medical Imaging Applications. Ferroelectrics. 2011; 422(1):70-76. . View in PubMed

Micro-machined high-frequency (80 MHz) PZT thick film linear arrays IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Oct; 57(10):2213-20. . View in PubMed

Photoacoustic ophthalmoscopy for in vivo retinal imaging Opt Express. 2010 Feb 15; 18(4):3967-72. . View in PubMed

Very high frequency (beyond 100 MHz) PZT kerfless linear arrays IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Oct; 56(10):2304-10. . View in PubMed

Dielectric and Piezoelectric Properties of PZT Composite Thick Films with Variable Solution to Powder Ratios J Am Ceram Soc. 2009 May 08; 92(6):1276-1279. . View in PubMed

Micro-electrocardiograms to study post-ventricular amputation of zebrafish heart Ann Biomed Eng. 2009 May; 37(5):890-901. . View in PubMed

Alumina/epoxy nanocomposite matching layers for high-frequency ultrasound transducer application IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Jan; 56(1):213-9. . View in PubMed

Determining the acoustic properties of the lens using a high-frequency ultrasonic needle transducer Ultrasound Med Biol. 2007 Dec; 33(12):1971-7. . View in PubMed

PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Mar; 54(3):668-75. . View in PubMed

Coded excitation using biphase-coded pulse with mismatched filters for high-frequency ultrasound imaging Ultrasonics. 2006 Jul; 44(3):330-6. . View in PubMed

Development of a 35-MHz piezo-composite ultrasound array for medical imaging IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Jan; 53(1):224-36. . View in PubMed

Design and fabrication of broadband graded ultrasonic transducers with rectangular kerfs IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Nov; 52(11):2096-102. . View in PubMed

Fabrication and characterization of micromachined high-frequency tonpilz transducers derived by PZT thick films IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):350-7. . View in PubMed

An analytical model of multilayer ultrasonic transducers with an inversion layer IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):469-79. . View in PubMed

Half-thickness inversion layer high-frequency ultrasonic transducers using LiNbO3 single crystal IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Jan; 52(1):127-33. . View in PubMed

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