Qifa Zhou, PhD

Professor of Biomedical Engineering and Ophthalmology

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Overview

Dr. Zhou’s research focuses on the design and fabrication of high frequency ultrasonic transducers using new piezoelectric single crystal and thin film technologies for medical imaging applications. He has integrated ultrasonic technology with advanced optical technology for intravascular imaging application. His current work is to develop miniaturized photoacoustic imaging (PA) probes using high frequency ultrasound transducers for endoscopic application. The primary motivations are to overcome the depth limitation of existing endoscopic imaging technologies and to provide functional information for disease states via photoacoustic imaging.

Publications

  • Wearable bioadhesive ultrasound shear wave elastography Sci Adv. 2024 Feb 09; 10(6):eadk8426. . View in PubMed
  • A comparison of five point-of-care ultrasound devices for use in ophthalmology and facial aesthetics Ultrasound. 2024 Feb; 32(1):28-35. . View in PubMed
  • Non-Invasive Hybrid Ultrasound Stimulation of Visual Cortex In Vivo Bioengineering (Basel). 2023 May 10; 10(5). . View in PubMed
  • A Mechanistic Model of Aqueous Humor Flow to Study Effects of Angle Closure on Intraocular Pressure Transl Vis Sci Technol. 2023 01 03; 12(1):16. . View in PubMed
  • Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation Micromachines (Basel). 2022 Sep 16; 13(9). . View in PubMed
  • Focused ultrasound stimulation on meibomian glands for the treatment of evaporative dry eye Exp Biol Med (Maywood). 2022 03; 247(6):519-526. . View in PubMed
  • Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses Nat Commun. 2022 07 04; 13(1):3853. . View in PubMed
  • Erratum to “Highly Integrated Multiplexing and Buffering Electronics for Large Aperture Ultrasonic Arrays” BME Front. 2022; 2022:9818934. . View in PubMed
  • Development of Moderate Intensity Focused Ultrasound (MIFU) for Ocular Drug Delivery BME Front. 2022; 2022:9840678. . View in PubMed
  • Noninvasive Ultrasound Retinal Stimulation for Vision Restoration at High Spatiotemporal Resolution BME Front. 2022; 2022:9829316. . View in PubMed
  • Highly Integrated Multiplexing and Buffering Electronics for Large Aperture Ultrasonic Arrays BME Front. 2022; 2022. . View in PubMed
  • High resolution optical coherence elastography of retina under prosthetic electrode Quant Imaging Med Surg. 2021 Mar; 11(3):918-927. . View in PubMed
  • Ultrasonic elastography to assess biomechanical properties of the optic nerve head and peripapillary sclera of the eye Ultrasonics. 2021 Feb; 110:106263. . View in PubMed
  • Layer-specific ultrasound elastography using a multi-layered shear wave dispersion model for assessing the viscoelastic properties Phys Med Biol. 2021 01 26; 66(3):035003. . View in PubMed
  • Ultrasound-Induced Wireless Energy Harvesting: From Materials Strategies to Functional Applications Nano Energy. 2020 Nov; 77. . View in PubMed
  • Ultrasonic Retinal Neuromodulation and Acoustic Retinal Prosthesis Micromachines (Basel). 2020 Oct 13; 11(10). . View in PubMed
  • 3D-Printing Piezoelectric Composite with Honeycomb Structure for Ultrasonic Devices Micromachines (Basel). 2020 Jul 23; 11(8). . View in PubMed
  • A combined ultrasonic B-mode and color Doppler system for the classification of breast masses using neural network Eur Radiol. 2020 May; 30(5):3023-3033. . View in PubMed
  • In vivo evaluation of posterior eye elasticity using shaker-based optical coherence elastography Exp Biol Med (Maywood). 2020 02; 245(4):282-288. . View in PubMed
  • Editorial for the Special Issue on MEMS Technology for Biomedical Imaging Applications Micromachines (Basel). 2019 Sep 16; 10(9). . View in PubMed
  • Electrically assisted 3D printing of nacre-inspired structures with self-sensing capability Sci Adv. 2019 Apr; 5(4):eaau9490. . View in PubMed
  • Three-Dimensional Printed Piezoelectric Array for Improving Acoustic Field and Spatial Resolution in Medical Ultrasonic Imaging Micromachines (Basel). 2019 Feb 28; 10(3). . View in PubMed
  • Flexible piezoelectric ultrasonic energy harvester array for bio-implantable wireless generator Nano Energy. 2019 Feb; 56:216-224. . View in PubMed
  • High-Speed Integrated Endoscopic Photoacoustic and Ultrasound Imaging System IEEE J Sel Top Quantum Electron. 2019 Jan-Feb; 25(1). . View in PubMed
  • Novel Configurations of Ultrahigh Frequency (=600 MHz) Analog Frontend for High Resolution Ultrasound Measurement Sensors (Basel). 2018 Aug 08; 18(8). . View in PubMed
  • Recent Progress in Biomimetic Additive Manufacturing Technology: From Materials to Functional Structures Adv Mater. 2018 Jun 19; e1706539. . View in PubMed
  • 3D-Printed Biomimetic Super-Hydrophobic Structure for Microdroplet Manipulation and Oil/Water Separation Adv Mater. 2018 Mar; 30(9). . View in PubMed
  • Biomimetic Anisotropic Reinforcement Architectures by Electrically Assisted Nanocomposite 3D Printing Adv Mater. 2017 Mar; 29(11). . View in PubMed
  • High-Frequency Ultrasonic Imaging with Lead-free (Na,K)(Nb,Ta)O3 Single Crystal Ultrason Imaging. 2017 11; 39(6):348-356. . View in PubMed
  • Multi-functional Ultrasonic Micro-elastography Imaging System Sci Rep. 2017 04 27; 7(1):1230. . View in PubMed
  • Functional Assay of Cancer Cell Invasion Potential Based on Mechanotransduction of Focused Ultrasound Front Oncol. 2017; 7:161. . View in PubMed
  • High-resolution harmonic motion imaging (HR-HMI) for tissue biomechanical property characterization Quant Imaging Med Surg. 2015 Feb; 5(1):108-17. . View in PubMed
  • A feasibility study of in vivo applications of single beam acoustic tweezers Appl Phys Lett. 2014 Oct 27; 105(17):173701. . View in PubMed
  • Piezoelectric single crystals for ultrasonic transducers in biomedical applications Prog Mater Sci. 2014 Oct 01; 66:87-111. . View in PubMed
  • Integrated IVUS-OCT Imaging for Atherosclerotic Plaque Characterization IEEE J Sel Top Quantum Electron. 2014 Mar; 20(2):7100108. . View in PubMed
  • Systematic study of high-frequency ultrasonic transducer design for laser-scanning photoacoustic ophthalmoscopy J Biomed Opt. 2014 Jan; 19(1):16015. . View in PubMed
  • Investigating contactless high frequency ultrasound microbeam stimulation for determination of invasion potential of breast cancer cells Biotechnol Bioeng. 2013 Oct; 110(10):2697-705. . View in PubMed
  • Development of lead-free single-element ultrahigh frequency (170-320MHz) ultrasonic transducers Ultrasonics. 2013 Jul; 53(5):1033-8. . View in PubMed
  • High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart Opt Express. 2013 Jun 17; 21(12):14636-42. . View in PubMed
  • Elevated electrochemical impedance in the endoluminal regions with high shear stress: implication for assessing lipid-rich atherosclerotic lesions Biosens Bioelectron. 2013 May 15; 43:237-44. . View in PubMed
  • Silver Doped 09PMN-PT-0. 1PZT Composite Films for very High Frequency Ultrasonic Transducer Applications. Appl Phys A Mater Sci Process. 2013 May 01; 111(2):459-463. . View in PubMed
  • Ultrahigh frequency lensless ultrasonic transducers for acoustic tweezers application Biotechnol Bioeng. 2013 Mar; 110(3):881-6. . View in PubMed
  • 20 MHz forward-imaging single-element beam steering with an internal rotating variable-angle reflecting surface: Wire phantom and ex vivo pilot study Ultrasonics. 2013 Feb; 53(2):561-9. . View in PubMed
  • Combined chirp coded tissue harmonic and fundamental ultrasound imaging for intravascular ultrasound: 20-60 MHz phantom and ex vivo results Ultrasonics. 2013 Feb; 53(2):369-76. . View in PubMed
  • Pulse inversion chirp coded tissue harmonic imaging (PI-CTHI) of Zebrafish heart using high frame rate ultrasound biomicroscopy Ann Biomed Eng. 2013 Jan; 41(1):41-52. . View in PubMed
  • In vivo Sonothrombolysis of Ear Marginal Vein of Rabbits Monitored with High-frequency Ultrasound Needle Transducer J Med Biol Eng. 2013; 33(1):103-110. . View in PubMed
  • Thermal-independent properties of PIN-PMN-PT single-crystal linear-array ultrasonic transducers IEEE Trans Ultrason Ferroelectr Freq Control. 2012 Dec; 59(12):2777-84. . View in PubMed
  • Intravascular photoacoustic imaging at 35 and 80 MHz J Biomed Opt. 2012 Oct; 17(10):106005. . View in PubMed
  • PMN-PT-PZT composite films for high frequency ultrasonic transducer applications Sens Actuators A Phys. 2012 Jun; 179:121-124. . View in PubMed
  • Development of integrated preamplifier for high-frequency ultrasonic transducers and low-power handheld receiver IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Dec; 58(12):2646-58. . View in PubMed
  • 80-MHz intravascular ultrasound transducer using PMN-PT free-standing film IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Nov; 58(11):2281-8. . View in PubMed
  • Structure and electrical properties of (111)-oriented Pb(Mg1/3Nb2/3)O3-PbZrO3-PbTiO3 thin film for ultra-high-frequency transducer applications IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Sep; 58(9):1962-7. . View in PubMed
  • Piezoelectric films for high frequency ultrasonic transducers in biomedical applications Prog Mater Sci. 2011 Feb; 56(2):139-174. . View in PubMed
  • Thickness Dependent Characteristics of High Permittivity PMN-032PT Single Crystal for High Frequency Medical Imaging Applications. Ferroelectrics. 2011; 422(1):70-76. . View in PubMed
  • Micro-machined high-frequency (80 MHz) PZT thick film linear arrays IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Oct; 57(10):2213-20. . View in PubMed
  • Photoacoustic ophthalmoscopy for in vivo retinal imaging Opt Express. 2010 Feb 15; 18(4):3967-72. . View in PubMed
  • Very high frequency (beyond 100 MHz) PZT kerfless linear arrays IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Oct; 56(10):2304-10. . View in PubMed
  • Dielectric and Piezoelectric Properties of PZT Composite Thick Films with Variable Solution to Powder Ratios J Am Ceram Soc. 2009 May 08; 92(6):1276-1279. . View in PubMed
  • Micro-electrocardiograms to study post-ventricular amputation of zebrafish heart Ann Biomed Eng. 2009 May; 37(5):890-901. . View in PubMed
  • Alumina/epoxy nanocomposite matching layers for high-frequency ultrasound transducer application IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Jan; 56(1):213-9. . View in PubMed
  • Determining the acoustic properties of the lens using a high-frequency ultrasonic needle transducer Ultrasound Med Biol. 2007 Dec; 33(12):1971-7. . View in PubMed
  • PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Mar; 54(3):668-75. . View in PubMed
  • Coded excitation using biphase-coded pulse with mismatched filters for high-frequency ultrasound imaging Ultrasonics. 2006 Jul; 44(3):330-6. . View in PubMed
  • Development of a 35-MHz piezo-composite ultrasound array for medical imaging IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Jan; 53(1):224-36. . View in PubMed
  • Design and fabrication of broadband graded ultrasonic transducers with rectangular kerfs IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Nov; 52(11):2096-102. . View in PubMed
  • Fabrication and characterization of micromachined high-frequency tonpilz transducers derived by PZT thick films IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):350-7. . View in PubMed
  • An analytical model of multilayer ultrasonic transducers with an inversion layer IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):469-79. . View in PubMed
  • Half-thickness inversion layer high-frequency ultrasonic transducers using LiNbO3 single crystal IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Jan; 52(1):127-33. . View in PubMed