Qilong Ying, PhD

Ying Lab Website

• International Society for Stem Cell Research: McEwen Award for Innovation, 2016
• University of Southern California: Phi Kappa Phi Faculty Award, 2011

• GSK3α negatively regulates GSK3β by decreasing its protein levels and enzymatic activity in mouse embryonic stem cells. Stem Cell Reports. 2025 Jul 08; 20(7):102512.. View in PubMed
• A Universal 6iL/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells Across Mammalian Species. bioRxiv. 2025 May 21.. View in PubMed
• Selective GSK3α Inhibition Promotes Self-Renewal Across Different Stem Cell States. bioRxiv. 2025 May 17.. View in PubMed
• Selective RNA sequestration in biomolecular condensates directs cell fate transitions. bioRxiv. 2025 May 10.. View in PubMed
• Relationship of PSC to embryos: Extending and refining capture of PSC lines from mammalian embryos. Bioessays. 2024 Dec; 46(12):e2400077.. View in PubMed
• Kcnh2 deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex. Int J Mol Med. 2024 02; 53(2).. View in PubMed
• A novel chemical genetic approach reveals paralog-specific role of ERK1/2 in mouse embryonic stem cell fate control. Front Cell Dev Biol. 2024; 12:1415621.. View in PubMed
• Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids. bioRxiv. 2023 May 25.. View in PubMed
• Extracting keyframes of breast ultrasound video using deep reinforcement learning. Med Image Anal. 2022 08; 80:102490.. View in PubMed
• Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge. Mol Cancer. 2022 06 24; 21(1):136.. View in PubMed
• An optimized proliferation system of embryonic stem cells for generating the rat model with large fragment modification. Biochem Biophys Res Commun. 2021 09 24; 571:8-13.. View in PubMed
• ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling. Stem Cells. 2021 04; 39(4):443-457.. View in PubMed
• Long-term self-renewal of naïve neural stem cells in a defined condition. Biochim Biophys Acta Mol Cell Res. 2019 06; 1866(6):971-977.. View in PubMed
• Laminin promotes differentiation of rat embryonic stem cells into cardiomyocytes by activating the integrin/FAK/PI3K p85 pathway. J Cell Mol Med. 2019 05; 23(5):3629-3640.. View in PubMed
• A Chemical-Genetic Approach Reveals the Distinct Roles of GSK3α and GSK3β in Regulating Embryonic Stem Cell Fate. Dev Cell. 2017 12 04; 43(5):563-576.e4.. View in PubMed
• Cytoplasmic and Nuclear TAZ Exert Distinct Functions in Regulating Primed Pluripotency. Stem Cell Reports. 2017 09 12; 9(3):732-741.. View in PubMed
• The Art of Capturing Pluripotency: Creating the Right Culture. Stem Cell Reports. 2017 06 06; 8(6):1457-1464.. View in PubMed
• Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal. Biol Open. 2017 Apr 15; 6(4):511-517.. View in PubMed
• Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment. Sci Rep. 2016 Feb 05; 6:20605.. View in PubMed
• Wnt/β-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal. J Cell Sci. 2016 Jan 15; 129(2):269-76.. View in PubMed
• Efficient Assessment of Developmental, Surgical and Pathological Lymphangiogenesis Using a Lymphatic Reporter Mouse and Its Embryonic Stem Cells. PLoS One. 2016; 11(6):e0157126.. View in PubMed
• Stem cell maintenance by manipulating signaling pathways: past, current and future. BMB Rep. 2015 Dec; 48(12):668-76.. View in PubMed
• New insights into the conserved mechanism of pluripotency maintenance. Curr Opin Genet Dev. 2015 Oct; 34:1-9.. View in PubMed
• Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency. Stem Cell Reports. 2015 Sep 08; 5(3):314-22.. View in PubMed
• The stromal genome heterogeneity between breast and prostate tumors revealed by a comparative transcriptomic analysis. Oncotarget. 2015 Apr 20; 6(11):8687-97.. View in PubMed
• Dual Function of Wnt Signaling during Neuronal Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int. 2015; 2015:459301.. View in PubMed
• Fluoxetine regulates neurogenesis in vitro through modulation of GSK-3β/β-catenin signaling. Int J Neuropsychopharmacol. 2014 Dec 07; 18(5).. View in PubMed
• Signaling pathways in induced naïve pluripotency. Curr Opin Genet Dev. 2014 Oct; 28:10-5.. View in PubMed
• Stat3 signaling regulates embryonic stem cell fate in a dose-dependent manner. Biol Open. 2014 Sep 19; 3(10):958-65.. View in PubMed
• STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ESC fates. Stem Cells. 2014 May; 32(5):1149-60.. View in PubMed
• Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1. EMBO J. 2013 Oct 02; 32(19):2548-60.. View in PubMed
• Induced neural stem cells generated from rat fibroblasts. Genomics Proteomics Bioinformatics. 2013 Oct; 11(5):312-9.. View in PubMed
• p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release. J Hepatol. 2013 Oct; 59(4):762-8.. View in PubMed
• DNA damage-induced sustained p53 activation contributes to inflammation-associated hepatocarcinogenesis in rats. Oncogene. 2013 Sep 19; 32(38):4565-71.. View in PubMed
• Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. J Cell Sci. 2013 Mar 01; 126(Pt 5):1093-8.. View in PubMed
• Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun. 2013; 4:2403.. View in PubMed
• Rats deficient for p53 are susceptible to spontaneous and carcinogen-induced tumorigenesis. Carcinogenesis. 2012 Oct; 33(10):2001-5.. View in PubMed
• Rapid and cost-effective gene targeting in rat embryonic stem cells by TALENs. J Genet Genomics. 2012 Jun 20; 39(6):275-80.. View in PubMed
• Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012; 7(4):e35892.. View in PubMed
• Genetic manipulations in the rat: progress and prospects. Curr Opin Nephrol Hypertens. 2011 Jul; 20(4):391-9.. View in PubMed
• Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells. J Neural Transm (Vienna). 2011 Jul; 118(7):997-1001.. View in PubMed
• Generating gene knockout rats by homologous recombination in embryonic stem cells. Nat Protoc. 2011 Jun; 6(6):827-44.. View in PubMed
• Beyond knockout rats: new insights into finer genome manipulation in rats. Cell Cycle. 2011 Apr 01; 10(7):1059-66.. View in PubMed
• Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature. 2010 Sep 09; 467(7312):211-3.. View in PubMed
• Germline competent embryonic stem cells derived from rat blastocysts. Cell. 2008 Dec 26; 135(7):1299-310.. View in PubMed
• The ground state of embryonic stem cell self-renewal. Nature. 2008 May 22; 453(7194):519-23.. View in PubMed
• [Isolation and purification of human neutrophil elastase]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1986 Oct; 8(5):376-81.. View in PubMed
• Frequencies of ceruloplasmin alleles in a Chinese population. Hum Hered. 1985; 35(2):117-9.. View in PubMed
• Geographical variability of alpha-1-antitrypsin alleles in China: a study on six Chinese populations. Hum Genet. 1985; 69(2):184-7.. View in PubMed
• Alpha-1-antitrypsin types in five Chinese national minorities. Hum Genet. 1985; 71(3):225-6.. View in PubMed
• [Haptoglobinemia (HpO) in Chinese]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1984 Feb; 6(1):5-7.. View in PubMed
• [Staining method for oxidase activity of plasma ceruloplasmin and gene frequency of rare ceruloplasmin variants in a Chinese population]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1983 Jun; 5(3):146-50.. View in PubMed
• Types and subtypes of haptoglobin in the Chinese population. Hum Genet. 1983; 63(2):175-7.. View in PubMed
• The gene frequency of serum albumin variants in Chinese and the electrophoretic characterization of several serum albumin variants. Sci Sin. 1981 Nov; 24(11):1597-602.. View in PubMed
• [Studies on polymorphisms of blood proteins in Chinese populations. II. Study on polymorphism of serum transferrin in Chinese (author’s transl)]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1981 Mar; 3(1):1-5.. View in PubMed

• McMahon, Andrew
• Murry, Charles