Keck School Faculty

Ralf Langen, PhD
Ralf Langen, PhD
Professor of Physiology & Neuroscience;Director, Protein Structure Center, Zilkha Neurogenetic Institute;Director of the Ph.D. Program in Medical Physiology
Zilkha Neurogenetic Institute
ZNI 121, 1501 San Pablo Street Health Sciences Campus Los Angeles
Our main interests lie in the basic areas of protein folding and misfolding, and particular emphasis is placed on these processes when they occur on or around membranes. The interaction of proteins with membranes underlies many important biological processes. Proteins can regulate the structure and function of biological membranes by controlling the composition, fluidity, permeability and curvature of cellular membranes. Membranes, in turn, can have a pronounced effect on the structure and function of proteins and help to promote physiologically important structural reorganizations of proteins. In addition, membrane interaction can also result in protein misfolding which could ultimately cause disease.

Electron tunneling in proteins: role of the intervening medium Journal of Biological Inorganic Chemistry. 1996; 1(3):221. . View in PubMed

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