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Robert Alan Kloner, MD, PhD

Professor of Medicine (Clinical Scholar)

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Phone +1 626 397 5811
Email [email protected]
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Awards

  • Alpha Omega Alpha: Member, 1973
  • Merck: Award for Outstanding Achievement in the Study of Medicine, 1975
  • American Society of Clinical Pathologists: Sheard-Sanford Award for Meritorius Original Student Research in Pathology During Medical School, 1976
  • American Heart Association: Recipient of the Established Investigatorship Award, 1981
     – 1986
  • American College of Physicians: Research Prize, 1988
  • 82nd Annual Scientific Assembly of the Southern Medical Association: Scientific Exhibit Achievement Award, 1988
  • American Society for Clinical Investigation: Elected Member, 1990
  • American Heart Association: Continuing Service Award, 1991
  • NIH: Cardiovascular Study Section A, 1995
     – 1998
  • United States Israel Binational Science Foundation: The Henry N. Neufeld Memorial Award, 1996
  • American Heart Association: Inaugural Fellow of the Council on Basic Cardiovascular Sciences, 2001
  • Institute for Scientific Information: Identified as one of the world’s most highly cited authors, 2002
  • Good Samaritan Hospital: Physician Leadership Award, 2003
  • Consumer’s Research Council of America: Listed in Guide to America’s Top Cardiologists, 2007

Research Funding

  • Mesenchymal Stem Cells for Myocardial Infarction
    NIH · R01HL073709 · Jul 15, 2003 – Jun 30, 2008 · Role: Principal Investigator
  • Biologic Ventricular Assist Device
    NIH · R21HL071965 · Sep 30, 2002 – Jul 31, 2006 · Role: Principal Investigator
  • MODERATE ALCOHOL EFFECT ON CARDIAC ISCHEMIA
    NIH · R03AA012258 · Jul 1, 1999 – Jun 30, 2001 · Role: Principal Investigator
  • COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    NIH · R01HL061488 · Jan 11, 1999 – Dec 31, 2004 · Role: Principal Investigator

Publications

  • Longevity. Clin Med Res. 2026 Jun; 24(2):80-86.. View in PubMed
  • Organ-Specific Efficacy of Postischemic Empagliflozin in Acute Stroke and Myocardial Infarction Using Preclinical Models. J Am Heart Assoc. 2026 06 02; 15(11):e047087.. View in PubMed
  • Sex Differences in the Adverse Effects of Nicotine-Free E-Cigarettes on Myocardial Oxygen Supply and Demand Balance: A Preclinical Rat Study. J Am Heart Assoc. 2026 May 19; 15(10):e046489.. View in PubMed
  • Comparing incidence of heart failure in individuals with enlarged cardiac chambers versus diabetes. Am J Prev Cardiol. 2026 Oct; 29:101656.. View in PubMed
  • AI-Derived LA Volume Index, LA/RA and LA/LV Volume Ratios From Coronary Artery Calcium Scans Predict Long-Term Atrial Fibrillation and Stroke. Stroke. 2026 Jun; 57(6):1586-1601.. View in PubMed
  • AI-derived left-to-right cardiac chamber volume ratios in coronary artery calcium scans strongly predict heart failure. Eur Heart J Cardiovasc Imaging. 2026 Mar 27; 27(4):791-802.. View in PubMed
  • AI-CVD-HF: A heart failure risk prediction model based on coronary artery calcium scans compared with PREVENT-HF. Am J Prev Cardiol. 2026 Jun; 27:101464.. View in PubMed
  • Artificial Intelligence-derived Measurements of Myosteatosis from Coronary Artery Calcium CT Scans to Predict COPD: The Multi-Ethnic Study of Atherosclerosis. Radiol Cardiothorac Imaging. 2026 02; 8(1):e250205.. View in PubMed
  • Stress and Acute Coronary Syndrome. Cardiol Res. 2025 Dec; 16(6):467-474.. View in PubMed
  • Coronary Artery Calcium (CAC) Imaging as a Diagnostic Test: Insurance Coverage Implications. JACC Cardiovasc Imaging. 2026 Feb; 19(2):266-273.. View in PubMed
  • Opportunistic AI-derived adiposity measures from coronary artery calcium scans predict new-onset type 2 diabetes in adults without obesity or hyperglycemia: insights from the AI-CVD study within MESA. Diabetol Metab Syndr. 2025 Nov 06; 17(1):419.. View in PubMed
  • A new hybrid echocardiography and arterial pressure waveform approach for non-invasive reconstruction of the entire left ventricular pressure waveform. Eur Heart J Imaging Methods Pract. 2025 Oct; 3(4):qyaf136.. View in PubMed
  • An overview of adjunctive therapies and alternatives to reperfusion management to reduce cerebral infarct size. Neuroscience. 2026 Jan 09; 592:255-279.. View in PubMed
  • Assessment of Myocardial Injury Size Metrics Using Carotid Pressure Waveform: Proof-of-Concept in Coronary Occlusion/Reperfusion Rat Model. FASEB J. 2025 Sep 15; 39(17):e71029.. View in PubMed
  • Low HDL-The Challenge. Clin Med Res. 2025 08; 23(2):60-66.. View in PubMed
  • Effects of Intracoronary SuperSaturated Oxygen Therapy on Myocardial Blood Flow, Microvascular Obstruction, and Myocardial Salvage in ST-Segment-Elevation Myocardial Infarction in Swine Ischemia/Reperfusion Model. J Am Heart Assoc. 2025 Aug 05; 14(15):e038891.. View in PubMed
  • Inflammatory response to chronic nicotine-containing electronic cigarette exposure in a rat model of myocardial infarction. Tob Induc Dis. 2025; 23.. View in PubMed
  • Coronary Artery Bypass Grafting Is Rarely Done in the Acute Care of ST-elevation Myocardial Infarction Patients Treated by Emergency Medical Services. West J Emerg Med. 2025 May 20; 26(3):729-736.. View in PubMed
  • Empagliflozin demonstrates neuroprotective and cardioprotective effects by reducing ischemia/reperfusion damage in rat models of ischemic stroke and myocardial infarction. Sci Rep. 2025 Mar 15; 15(1):8986.. View in PubMed
  • Reperfused Myocardial Infarction: The Road to CCS Classification of Acute MI and Beyond. JACC Adv. 2025 Feb; 4(2):101528.. View in PubMed
  • Coronary Artery Calcium Scoring Improves Allocation of the GLP-1 Receptor Agonist Semaglutide. JACC Cardiovasc Imaging. 2025 Apr; 18(4):462-464.. View in PubMed
  • A Review of Cardiovascular Effects of Marijuana Use. J Cardiopulm Rehabil Prev. 2025 01 01; 45(1):2-7.. View in PubMed
  • Impact of electronic cigarette vaping on the cardiovascular function in young and old rats. Sci Rep. 2024 12 06; 14(1):30420.. View in PubMed
  • Androgen Society Position Paper on Cardiovascular Risk With Testosterone Therapy. Mayo Clin Proc. 2024 Nov; 99(11):1785-1801.. View in PubMed
  • Proceedings of PRINCETON IV: PDE5 inhibitors and cardiac health symposium. Sex Med Rev. 2024 09 25; 12(4):681-709.. View in PubMed
  • Higher sodium in older individuals or after stroke/reperfusion, but not in migraine or Alzheimer’s disease – a study in different preclinical models. Sci Rep. 2024 09 16; 14(1):21636.. View in PubMed
  • Adverse Cardiovascular Effects of Nicotine Delivered by Chronic Electronic Cigarettes or Standard Cigarettes Captured by Cardiovascular Intrinsic Frequencies. J Am Heart Assoc. 2024 09 17; 13(18):e035462.. View in PubMed
  • Disrupted brain functional connectivity as early signature in cognitively healthy individuals with pathological CSF amyloid/tau. Commun Biol. 2024 08 23; 7(1):1037.. View in PubMed
  • The Princeton IV Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease. Mayo Clin Proc. 2024 Sep; 99(9):1500-1517.. View in PubMed
  • An Urgent Call for Studies That Address the Cardiovascular Consequences of Legalization of Marijuana. Cardiol Res. 2024 Apr; 15(2):86-89.. View in PubMed
  • Impact of symptom-to-reperfusion-time on transmural infarct extent and left ventricular strain in patients with ST-segment elevation myocardial infarction: a 3D view on the wavefront phenomenon. Eur Heart J Cardiovasc Imaging. 2024 Feb 22; 25(3):347-355.. View in PubMed
  • Effects of Electronic Cigarette Vaping on Cardiac and Vascular Function, and Post-myocardial Infarction Remodeling in Rats. Cardiovasc Toxicol. 2024 02; 24(2):199-208.. View in PubMed
  • The association of tadalafil exposure with lower rates of major adverse cardiovascular events and mortality in a general population of men with erectile dysfunction. Clin Cardiol. 2024 Feb; 47(2):e24234.. View in PubMed
  • Princeton IV consensus guidelines: PDE5 inhibitors and cardiac health. J Sex Med. 2024 01 30; 21(2):90-116.. View in PubMed
  • Choriocapillaris and Retinal Vascular Alterations in Presymptomatic Alzheimer’s Disease. Invest Ophthalmol Vis Sci. 2024 01 02; 65(1):47.. View in PubMed
  • Association of the COVID-19 Pandemic on Treatment Times for ST-Elevation Myocardial Infarction: Observations from the Los Angeles County Regional System. Am J Cardiol. 2024 02 15; 213:93-98.. View in PubMed
  • Flavoring Agents in E-cigarette Liquids: A Comprehensive Analysis of Multiple Health Risks. Cureus. 2023 Nov; 15(11):e48995.. View in PubMed
  • Instantaneous detection of acute myocardial infarction and ischaemia from a single carotid pressure waveform in rats. Eur Heart J Open. 2023 Sep; 3(5):oead099.. View in PubMed
  • Invasive versus Conservative Management in Coronary Artery Disease. Clin Med Res. 2023 06; 21(2):95-104.. View in PubMed
  • Resting heart rate (variability) and cognition relationships reveal cognitively healthy individuals with pathological amyloid/tau ratio. Front Epidemiol. 2023; 3.. View in PubMed
  • The connection between heart rate variability (HRV), neurological health, and cognition: A literature review. Front Neurosci. 2023; 17:1055445.. View in PubMed
  • Effect of phosphodiesterase type 5 inhibitors on major adverse cardiovascular events and overall mortality in a large nationwide cohort of men with erectile dysfunction and cardiovascular risk factors: A retrospective, observational study based on healthcare claims and national death index data. J Sex Med. 2023 01 14; 20(1):38-48.. View in PubMed
  • Effects of Electronic Cigarette Exposure on Myocardial Infarction and No-Reflow, and Cardiac Function in a Rat Model. J Cardiovasc Pharmacol Ther. 2023 Jan-Dec; 28:10742484231155992.. View in PubMed
  • One Acute Exposure to E-Cigarette Smoke Using Various Heating Elements and Power Levels Induces Pulmonary Inflammation. Cardiol Res. 2022 Dec; 13(6):323-332.. View in PubMed
  • Marijuana and electronic cigarettes on cardiac arrhythmias. Heart Rhythm. 2023 01; 20(1):87-88.. View in PubMed
  • The Correlation between COVID-19 Hospitalizations and Emergency Medical Services Responses for Time-Sensitive Emergencies during the COVID-19 Pandemic. Prehosp Emerg Care. 2023; 27(3):321-327.. View in PubMed
  • Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction. Sci Rep. 2022 03 22; 12(1):4922.. View in PubMed
  • Analysis of integrated clinical safety data of tadalafil in patients receiving concomitant antihypertensive medications. J Clin Hypertens (Greenwich). 2022 02; 24(2):167-178.. View in PubMed
  • Update on Cardioprotective Strategies for STEMI: Focus on Supersaturated Oxygen Delivery. JACC Basic Transl Sci. 2021 Dec; 6(12):1021-1033.. View in PubMed
  • Task switching reveals abnormal brain-heart electrophysiological signatures in cognitively healthy individuals with abnormal CSF amyloid/tau, a pilot study. Int J Psychophysiol. 2021 12; 170:102-111.. View in PubMed
  • Cardiac Effects of Phosphodiesterase-5 Inhibitors: Efficacy and Safety. Cardiovasc Drugs Ther. 2023 08; 37(4):793-806.. View in PubMed
  • Post-Acute Sequelae of SARS-COVID-2 Syndrome: Just the Beginning. Cardiol Res. 2021 Oct; 12(5):279-285.. View in PubMed
  • Cardiac MRI to Visualize Myocardial Damage after ST-Segment Elevation Myocardial Infarction: A Review of Its Histologic Validation. Radiology. 2021 10; 301(1):4-18.. View in PubMed
  • Scalability of cardiovascular intrinsic frequencies: Validations in preclinical models and non-invasive clinical studies. Life Sci. 2021 Nov 01; 284:119880.. View in PubMed
  • Treating Acute Myocardial Infarctions With Anti-Inflammatory Agents. J Cardiovasc Pharmacol Ther. 2021 11; 26(6):736-738.. View in PubMed
  • Emergency Medical Services Responses to Out-of-Hospital Cardiac Arrest and Suspected ST-Segment-Elevation Myocardial Infarction During the COVID-19 Pandemic in Los Angeles County. J Am Heart Assoc. 2021 06 15; 10(12):e019635.. View in PubMed
  • Cardiovascular Health and Disease in the Context of COVID-19. Cardiol Res. 2021 Apr; 12(2):67-79.. View in PubMed
  • E-Cigarettes and Cardiopulmonary Health. Function (Oxf). 2021; 2(2):zqab004.. View in PubMed
  • Effects of OP2113 on Myocardial Infarct Size and No Reflow in a Rat Myocardial Ischemia/Reperfusion Model. Cardiovasc Drugs Ther. 2022 04; 36(2):217-227.. View in PubMed
  • Viral myocarditis: 1917-2020: From the Influenza A to the COVID-19 pandemics. Trends Cardiovasc Med. 2021 04; 31(3):163-169.. View in PubMed
  • Acute administration of nicotine induces transient elevation of blood pressure and increases myocardial infarct size in rats. Heliyon. 2020 Nov; 6(11):e05450.. View in PubMed
  • E-cigarette or Vaping Product Use-Associated Lung Injury Produced in an Animal Model From Electronic Cigarette Vapor Exposure Without Tetrahydrocannabinol or Vitamin E Oil. J Am Heart Assoc. 2020 09 15; 9(18):e017368.. View in PubMed
  • Therapeutic Hypothermia Improves Long-Term Survival and Blunts Inflammation in Rats During Resuscitation of Hemorrhagic Shock. Ther Hypothermia Temp Manag. 2020 Dec; 10(4):237-243.. View in PubMed
  • Medical Marijuana, Recreational Cannabis, and Cardiovascular Health: A Scientific Statement From the American Heart Association. Circulation. 2020 09 08; 142(10):e131-e152.. View in PubMed
  • The association of nadir CD4-T cell count and endothelial dysfunction in a healthy HIV cohort without major cardiovascular risk factors. SAGE Open Med. 2020; 8:2050312120924892.. View in PubMed
  • Different Effects of Volatile and Nonvolatile Anesthetic Agents on Long-Term Survival in an Experimental Model of Hemorrhagic Shock. J Cardiovasc Pharmacol Ther. 2020 07; 25(4):346-353.. View in PubMed
  • Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction. Cardiovasc Res. 2020 03 01; 116(4):787-805.. View in PubMed
  • Stunned and Hibernating Myocardium: Where Are We Nearly 4 Decades Later? J Am Heart Assoc. 2020 02 04; 9(3):e015502. Kloner RA . . View in PubMed
  • Remote Ischemic Conditioning in Acute Myocardial Infarction and Shock States. J Cardiovasc Pharmacol Ther. 2020 03; 25(2):103-109.. View in PubMed
  • Pathophysiology, Diagnosis, and Management of the No-Reflow Phenomenon. Cardiovasc Drugs Ther. 2019 10; 33(5):589-597.. View in PubMed
  • Editorial commentary: Continuing concerns about the cardiovascular safety of marijuana. Trends Cardiovasc Med. 2020 07; 30(5):308-309.. View in PubMed
  • Potential for stem cell-derived biologic pumps for cardiovascular and other medical therapies. Regen Med. 2019 07; 14(7):617-619.. View in PubMed
  • The Brain-Heart Connection and the Northridge Earthquake. Cardiol Rev. 2019 Jul.. View in PubMed
  • Lessons learned about stress and the heart after major earthquakes. Am Heart J. 2019 09; 215:20-26.. View in PubMed
  • Coronary artery calcium testing: A call for universal coverage. Prev Med Rep. 2019 Sep; 15:100879.. View in PubMed
  • Myocardial hypothermia induced after reperfusion does not prevent adverse left ventricular remodeling nor improve cardiac function. Life Sci. 2019 Jul 15; 229:98-103.. View in PubMed
  • Improved Long-term Survival with Remote Limb Ischemic Preconditioning in a Rat Fixed-Pressure Hemorrhagic Shock Model. Cardiovasc Drugs Ther. 2019 04; 33(2):139-147.. View in PubMed
  • Proceedings of the 3rd annual Acute Cardiac Unloading and REcovery (A-CURE) symposium. BMC Cardiovasc Disord. 2019 02 07; 19(Suppl 2):27.. View in PubMed
  • Beyond Reperfusion: Acute Ventricular Unloading and Cardioprotection During Myocardial Infarction. J Cardiovasc Transl Res. 2019 04; 12(2):95-106.. View in PubMed
  • Do We Need Potent Intravenous Antiplatelet Inhibition at the Time of Reperfusion During ST-Segment Elevation Myocardial Infarction? J Cardiovasc Pharmacol Ther. 2019 05; 24(3):215-224. Allencherril J, . View in PubMed
  • A Thank You From the Editor-in-Chief. J Cardiovasc Pharmacol Ther. 2019 01; 24(1):90-91.. View in PubMed
  • Cardiovascular effects of marijuana. Trends Cardiovasc Med. 2019 10; 29(7):403-407.. View in PubMed
  • Acute and Subacute Triggers of Cardiovascular Events. Am J Cardiol. 2018 12 15; 122(12):2157-2165.. View in PubMed
  • The Case for Takotsubo Cardiomyopathy (Syndrome) as a Variant of Acute Myocardial Infarction. Circulation. 2018 08 28; 138(9):855-857.. View in PubMed
  • Effect of Patiromer in Hyperkalemic Patients Taking and Not Taking RAAS Inhibitors. J Cardiovasc Pharmacol Ther. 2018 11; 23(6):524-531.. View in PubMed
  • The pharmacist’s role in improving the treatment of erectile dysfunction and its underlying causes. Res Social Adm Pharm. 2019 05; 15(5):591-599.. View in PubMed
  • Cardiovascular Safety of Phosphodiesterase Type 5 Inhibitors After Nearly 2 Decades on the Market. Sex Med Rev. 2018 10; 6(4):583-594.. View in PubMed
  • No-reflow phenomenon in the heart and brain. Am J Physiol Heart Circ Physiol. 2018 09 01; 315(3):H550-H562.. View in PubMed
  • A New Perspective on the Nitrate-Phosphodiesterase Type 5 Inhibitor Interaction. J Cardiovasc Pharmacol Ther. 2018 09; 23(5):375-386.. View in PubMed
  • No-Reflow Phenomenon. A New Target for Therapy of Acute Myocardial Infarction Independent of Myocardial Infarct Size. J Cardiovasc Pharmacol Ther. 2018 05; 23(3):273-276.. View in PubMed
  • Cardiorenal Safety of OTC Analgesics. J Cardiovasc Pharmacol Ther. 2018 03; 23(2):103-118.. View in PubMed
  • Guidelines for experimental models of myocardial ischemia and infarction. Am J Physiol Heart Circ Physiol. 2018 04 01; 314(4):H812-H838.. View in PubMed
  • The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550.. View in PubMed
  • The importance of no-reflow/microvascular obstruction in the STEMI patient. Eur Heart J. 2017 12 14; 38(47):3511-3513.. View in PubMed
  • The authors reply. Crit Care Med. 2017 11; 45(11):e1201-e1202.. View in PubMed
  • Mitochondrial Protective Agents for Ischemia/Reperfusion Injury. Circ Cardiovasc Interv. 2017 09; 10(9).. View in PubMed
  • New and revisited approaches to preserving the reperfused myocardium. Nat Rev Cardiol. 2017 Nov; 14(11):679-693.. View in PubMed
  • The Cardiovascular Effects of Cocaine. J Am Coll Cardiol. 2017 Jul 04; 70(1):101-113.. View in PubMed
  • Noninvasive iPhone Measurement of Left Ventricular Ejection Fraction Using Intrinsic Frequency Methodology. Crit Care Med. 2017 Jul; 45(7):1115-1120.. View in PubMed
  • Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations. Eur Heart J. 2017 04 01; 38(13):935-941.. View in PubMed

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