Keck School Faculty

Clinical spectrum and genetic causes of mitochondrial hepatopathy phenotype in children Hepatol Commun. 2023 Jun 01; 7(6). . View in PubMed

Model for End-Stage Liver Disease/Pediatric End-Stage Liver Disease exception policy and outcomes in pediatric patients with hepatopulmonary syndrome requiring liver transplantation Liver Transpl. 2023 Feb 01; 29(2):134-144. . View in PubMed

Special Population: Pediatric Nonalcoholic Fatty Liver Disease Clin Liver Dis. 2023 05; 27(2):471-482. . View in PubMed

Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease Hepatology. 2023 02 01; 77(2):530-545. . View in PubMed

GI Multisociety Strategic Plan on Environmental SustainabilityGastroenterology. 2022 Dec; 163(6):1695-1701. e2. . View in PubMed

GI multisociety strategic plan on environmental sustainability Hepatology. 2022 Dec; 76(6):1836-1844. . View in PubMed

Liver Transpl 2022 Aug 21; 134-144. . View in PubMed

Pediatric NASH therapies: A speedbump on the road to success Hepatology. 2022 08; 76(2):292-294. . View in PubMed

Impact of long-term administration of maralixibat on children with cholestasis secondary to Alagille syndrome Hepatol Commun. 2022 08; 6(8):1922-1933. . View in PubMed

Changes in Resting Energy Expenditure After Sleeve Gastrectomy: a Review of the Literature Obes Surg. 2022 07; 32(7):2484-2487. . View in PubMed

Nature or Nurture in the Pathogenesis of Biliary Atresia? J Pediatr. 2022 07; 246:10-11.e1.. View in PubMed

Clinical Value of Surveillance Biopsies in Pediatric Liver Transplantation Liver Transpl. 2022 05; 28(5):843-854. . View in PubMed

Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis Environ Health Perspect. 2022 04; 130(4):46001. . View in PubMed

Stratification by obesity class, rather than age, can identify a higher percent of children at risk for non-alcoholic fatty liver disease and metabolic dysfunction Pediatr Obes. 2022 03; 17(3):e12862. . View in PubMed

Evaluation of Fontan-associated Liver Disease and Ethnic Disparities in Long-term Survivors of the Fontan Procedure: A Population-based Study Ann Surg. 2022 09 01; 276(3):482-490. . View in PubMed

Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial J Nutr. 2022 07 06; 152(7):1655-1665. . View in PubMed

Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection Front Immunol. 2022; 13:831103. . View in PubMed

Non-invasive biomarkers of Fontan-associated liver disease JHEP Rep. 2021 Dec; 3(6):100362. . View in PubMed

Living Donor Versus Deceased Donor Pediatric Liver Transplantation: A Systematic Review and Meta-analysis Transplant Direct. 2021 Oct; 7(10):e767. . View in PubMed

PNPLA3 Genotype, Arachidonic Acid Intake, and Unsaturated Fat Intake Influences Liver Fibrosis in Hispanic Youth with Obesity Nutrients. 2021 May 12; 13(5). . View in PubMed

Pediatric Nonalcoholic Fatty Liver Disease Pediatr Clin North Am. 2021 12; 68(6):1309-1320. . View in PubMed

The Role of FGF19 and MALRD1 in Enterohepatic Bile Acid Signaling Front Endocrinol (Lausanne). 2021; 12:799648. . View in PubMed

Hepatic Ago2 Regulates PPARa for Oxidative Metabolism Linked to Glycemic Control in Obesity and Post Bariatric Surgery Endocrinology. 2021 04 01; 162(4). . View in PubMed

A Diet High in Fat and Fructose Induces Early Hepatic Mitochondrial Aging J Pediatr Gastroenterol Nutr. 2021 07 01; 73(1):99-102. . View in PubMed

Assessment of the role of FGF15 in mediating the metabolic outcomes of murine Vertical Sleeve Gastrectomy (VSG) Am J Physiol Gastrointest Liver Physiol. 2020 Sep 23. . View in PubMed

Emerging New Diagnostic Modalities and Therapies of Nonalcoholic Fatty Liver Disease Curr Gastroenterol Rep. 2020 Aug 19; 22(10):52. . View in PubMed

Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis Hepatology. 2020 11; 72(5):1586-1604. . View in PubMed

Initial assessment and ongoing monitoring of lysosomal acid lipase deficiency in children and adults: Consensus recommendations from an international collaborative working group Mol Genet Metab. 2020 02; 129(2):59-66. . View in PubMed

Rebaudioside affords hepatoprotection ameliorating sugar sweetened beverage- induced nonalcoholic steatohepatitis Sci Rep. 2020 04 21; 10(1):6689. . View in PubMed

Designing Clinical Trials in Pediatric Nonalcoholic Steatohepatitis: Tips for Patient Selection and Appropriate Endpoints Hepatol Commun. 2019 Dec; 3(12):1563-1570. . View in PubMed

When the beverage is sweet, how does the liver feel? Curr Treat Options Pediatr. 2019 Dec; 5(4):458-465.. View in PubMed

Severe Late-Onset Acute Cellular Rejection in a Pediatric Patient With Isolated Small Intestinal Transplant Rescued With Aggressive Immunosuppressive Approach: A Case Report Transplant Proc. 2019 Nov; 51(9):3181-3185. . View in PubMed

Immunologic benefit of maternal donors in pediatric living donor liver transplantation Pediatr Transplant. 2019 11; 23(7):e13560. . View in PubMed

Case series and systematic review of acquired diaphragmatic hernia after liver transplantation Pediatr Transplant. 2018 12; 22(8):e13296. . View in PubMed

Postprandial Uridine Physiology Is Altered by Obesity Gastroenterology. 2018 11; 155(5):1645-1646. . View in PubMed

Hepatology. 2018 10; 68(4):1644-1646. . View in PubMed

"Twin" Biliary Trees in a Patient With Heterotaxy Syndrome J Pediatr Gastroenterol Nutr. 2018 06; 66(6):e158. . View in PubMed

Liver transplantation in children: state of the art and future perspectives Arch Dis Child. 2018 02; 103(2):192-198. . View in PubMed

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids Hepatology. 2018 02; 67(2):534-548. . View in PubMed

Increased glycine-amidated hyocholic acid correlates to improved early weight loss after sleeve gastrectomy Surg Endosc. 2018 02; 32(2):805-812. . View in PubMed

Quantitative Liver MRI-Biopsy Correlation in Pediatric and Young Adult Patients With Nonalcoholic Fatty Liver Disease: Can One Be Used to Predict the Other? AJR Am J Roentgenol. 2018 Jan; 210(1):166-174.. View in PubMed

Bile acid metabolism and signaling: potential therapeutic target for nonalcoholic fatty liver disease Clin Transl Gastroenterol. 2018 06 29; 9(6):164. . View in PubMed

Response to Letters Regarding the NASPGHAN NAFLD Guidelines J Pediatr Gastroenterol Nutr. 2017 Sep 01. . View in PubMed

Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis JCI Insight. 2017 Aug 03; 2(15). . View in PubMed

Hepatic Natural Killer T-cell and CD8+ T-cell Signatures in Mice with Nonalcoholic Steatohepatitis Hepatol Commun. 2017 Jun; 1(4):299-310. . View in PubMed

Response to the Letters Regarding the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition NAFLD Guidelines J Pediatr Gastroenterol Nutr. 2017 11; 65(5):e115-e116. . View in PubMed

Hepatic Issues and Complications Associated With Inflammatory Bowel Disease: A Clinical Report From the NASPGHAN Inflammatory Bowel Disease and Hepatology Committees J Pediatr Gastroenterol Nutr. 2017 04; 64(4):639-652. . View in PubMed

NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) J Pediatr Gastroenterol Nutr. 2017 02; 64(2):319-334. . View in PubMed

Treatment of Inferior Vena Cava Obstruction Following Pediatric Liver Transplantation: Novel Use of a Customized Endovascular Stent J Pediatr. 2017 01; 180:256-260. . View in PubMed

Impact of Fibroblast Growth Factors 19 and 21 in Bariatric Metabolism Dig Dis. 2017; 35(3):191-196. . View in PubMed

Alpha 1-antitrypsin levels can differentiate allelic phenotypes Dig Liver Dis. 2016 Dec; 48(12):1510-1511. . View in PubMed

Prospective Assessment of Correlation between US Acoustic Radiation Force Impulse and MR Elastography in a Pediatric Population: Dispersion of US Shear-Wave Speed Measurement Matters Radiology. 2016 Nov; 281(2):544-552. . View in PubMed

In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity ScoresGastroenterology. 2016 12; 151(6):1141-1154. e9. . View in PubMed

Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents Obesity (Silver Spring). 2016 11; 24(11):2377-2383. . View in PubMed

Lysosomal Acid Lipase Deficiency Unmasked in Two Children With Nonalcoholic Fatty Liver Disease Pediatrics. 2016 10; 138(4). . View in PubMed

Bariatric Surgery: The Rise and Fall of Bile Acids Surg Obes Relat Dis. 2016 05; 12(4):770-771. . View in PubMed

Pediatric Nonalcoholic Fatty Liver Disease: A Report from the Expert Committee on Nonalcoholic Fatty Liver Disease (ECON) J Pediatr. 2016 05; 172:9-13. . View in PubMed

Let the bile flow! Hepatology 2015 Dec; 62(6):1870. . View in PubMed

Familial homozygous hypercholesterolemia: When to turn to transplant? Pediatr Transplant. 2015 Sep; 19(6):577-9.. View in PubMed

Neurologic outcome of urea cycle disorder liver transplant recipients may be predicted by pretransplant neurological imaging Pediatr Transplant. 2015 Aug; 19(5):527-30. . View in PubMed

The evaluation of hepatic fibrosis scores in children with nonalcoholic fatty liver disease Dig Dis Sci. 2015 May; 60(5):1440-7. . View in PubMed

Improvement in liver histology is associated with reduction in dyslipidemia in children with nonalcoholic fatty liver disease J Pediatr Gastroenterol Nutr. 2015 Mar; 60(3):360-7. . View in PubMed

Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH? Dig Dis. 2015; 33(3):440-6.. View in PubMed

The role of small heterodimer partner in nonalcoholic fatty liver disease improvement after sleeve gastrectomy in mice Obesity (Silver Spring). 2014 Nov; 22(11):2301-11. . View in PubMed

Effect of guanylate cyclase-C activity on energy and glucose homeostasis Diabetes. 2014 Nov; 63(11):3798-804. . View in PubMed

Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia Gut. 2014 Aug; 63(8):1238-46. . View in PubMed

High prevalence of hepatitis B non-immunity in paediatric non-alcoholic fatty liver disease patients Dig Liver Dis. 2014 Aug; 46(8):760-1. . View in PubMed

NHE1 deficiency in liver: implications for non-alcoholic fatty liver disease Biochem Biophys Res Commun. 2014 Jul 25; 450(2):1027-31. . View in PubMed

FXR is a molecular target for the effects of vertical sleeve gastrectomy Nature. 2014 May 08; 509(7499):183-8. . View in PubMed

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice Hepatology. 2014 May; 59(5):1830-9. . View in PubMed

There's more under the nonalcoholic fatty liver disease umbrella than an elevated alanine aminotransferase level J Pediatr. 2014 Apr; 164(4):684-6. . View in PubMed

Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis Liver Int. 2014 Mar; 34(3):427-37. . View in PubMed

Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner Obesity (Silver Spring). 2014 Feb; 22(2):390-400. . View in PubMed

Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease J Pediatr. 2014 Jan; 164(1):186-8. . View in PubMed

Diabetes: the search for mechanisms underlying bariatric surgery Nat Rev Endocrinol. 2013 Oct; 9(10):572-4. . View in PubMed

MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet Am J Physiol Endocrinol Metab. 2013 Aug 15; 305(4):E549-56. . View in PubMed

A multidisciplinary clinical program is effective in stabilizing BMI and reducing transaminase levels in pediatric patients with NAFLD J Pediatr Gastroenterol Nutr. 2013 Jul; 57(1):119-23. . View in PubMed

A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery Endocrinology. 2013 Jul; 154(7):2341-51. . View in PubMed

Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids J Clin Endocrinol Metab. 2013 Apr; 98(4):E708-12. . View in PubMed

Fatty liver disease in children--what should one do? Indian J Pediatr. 2013 Mar; 80 Suppl 1:S109-14.. View in PubMed

Advances in the surgical treatment of morbid obesity Mol Aspects Med. 2013 Feb; 34(1):84-94. . View in PubMed

Isolated unilateral cytomegalovirus retinitis: a rare long-term complication after pediatric liver transplantation Pediatr Transplant. 2013 Feb; 17(1):E16-9. . View in PubMed

Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats Endocrinology. 2013 Jan; 154(1):9-15. . View in PubMed

An adolescent girl with belly pain: one gallbladder too many? J Pediatr Gastroenterol Nutr. 2012 Dec; 55(6):e142.. View in PubMed

The role of the gut hormone GLP-1 in the metabolic improvements caused by ileal transposition J Surg Res. 2012 Nov; 178(1):33-9. . View in PubMed

Treating pediatric nonalcoholic fatty liver disease with cysteamine: is adiponectin the key? J Pediatr. 2012 Oct; 161(4):579-81.. View in PubMed

Pediatric nonalcoholic fatty liver disease: Prevalence, diagnosis, risk factors, and management Clin Liver Dis (Hoboken). 2012 Sep; 1(4):125-128. . View in PubMed

Retrospective review of the incidence of cytomegalovirus infection and disease after liver transplantation in pediatric patients: comparison of prophylactic oral ganciclovir and oral valganciclovir Liver Transpl. 2012 Mar; 18(3):347-54. . View in PubMed

Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins PLoS One. 2012; 7(6):e38952. . View in PubMed

NASH animal models: are we there yet? J Hepatol. 2011 Oct; 55(4):941-3.. View in PubMed

Molecular insights from bariatric surgery Rev Endocr Metab Disord. 2011 Sep; 12(3):211-7. . View in PubMed

Mechanisms of lipotoxicity in NAFLD and clinical implications J Pediatr Gastroenterol Nutr. 2011 Aug; 53(2):131-40. . View in PubMed

Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease J Pediatr Gastroenterol Nutr. 2011 Feb; 52(2):190-7. . View in PubMed

Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G652-60. . View in PubMed

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis Hepatology. 2010 Sep; 52(3):934-44. . View in PubMed

Rapid progression of NASH in childhood J Pediatr Gastroenterol Nutr. 2010 Apr; 50(4):453-6. . View in PubMed

Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study Hepatology. 2009 Oct; 50(4):1113-20. . View in PubMed

Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathway J Biol Chem. 2007 Jul 20; 282(29):21327-36. . View in PubMed

Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G55-62. . View in PubMed

Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats Stroke. 2006 Feb; 37(2):524-30. . View in PubMed

Mesalamine-induced pneumonitis during therapy for chronic inflammatory bowel disease: a pediatric case report J Pediatr Gastroenterol Nutr. 2005 Oct; 41(4):479-82. . View in PubMed

Relative elevations of serum alanine and aspartate aminotransferase in muscular dystrophy J Pediatr Gastroenterol Nutr. 2005 Jul; 41(1):121-4. . View in PubMed

Differential diagnosis of recurrent abdominal pain: new considerations Pediatr Ann. 2004 Feb; 33(2):113-22. . View in PubMed