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Seiji Shibata, MD, PhD

Assistant Professor of Clinical Otolaryngology Head & Neck Surgery

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Email seijishi@usc.edu
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Overview

Seiji B. Shibata, MD, PhD, specializes in chronic ear disease, otosclerosis, cochlear implantation, vestibular disorders, facial nerve disorders, and skull base tumors including acoustic neuromas, meningiomas, and glomus tumors.

Dr. Shibata graduated from Kansai Medical University in Osaka Japan, where he earned both his medical doctorate and PhD. He completed his residency in Otolaryngology – Head and Neck Surgery at Kansai Medical University Hospitals in Osaka Japan. Dr. Shibata then pursued further training in the United States and completed his residency in Otolaryngology – Head and Neck Surgery and his surgical fellowship in Neurotology at the world-renowned University of Iowa Hospitals and Clinics.

Dr. Shibata has conducted cutting-edge inner ear research at both the University of Michigan and the University of Iowa. He has authored numerous peer-reviewed publications and textbook chapters in his field. He is a board-certified member of both the American Academy of Otolaryngology – Head and Neck Surgery and the Oto-Rhino-Laryngological Society of Japan. Dr. Shibata is a physician-scientist who strives to offer high quality, compassionate care to patients in his clinic while pursuing scientific advancements in his laboratory.

Publications

  • Ergonomics of Various Modalities for Ear Surgery OTO Open. 2024 Jul-Sep; 8(3):e162. . View in PubMed
  • Neomycin-induced deafness in neonatal mice J Neurosci Methods. 2023 05 01; 391:109852. . View in PubMed
  • Reduction of sporadic and neurofibromatosis type 2-associated vestibular schwannoma growth in vitro and in vivo after treatment with the c-Jun N-terminal kinase inhibitor AS602801 J Neurosurg. 2023 04 01; 138(4):962-971. . View in PubMed
  • Incidence of Postoperative CSF Leaks in Class III Obese Patients Undergoing Middle Cranial Fossa Approach for Spontaneous CSF Leak Repair Otol Neurotol. 2023 04 01; 44(4):382-387. . View in PubMed
  • Mutation-agnostic RNA interference with engineered replacement rescues Tmc1-related hearing loss Life Sci Alliance. 2023 03; 6(3). . View in PubMed
  • Comparative Analysis of Robotics-Assisted and Manual Insertions of Cochlear Implant Electrode Arrays Otol Neurotol. 2022 12 01; 43(10):1155-1161. . View in PubMed
  • Neuralgia and Atypical Facial, Ear, and Head Pain Otolaryngol Clin North Am. 2022 Jun; 55(3):595-606. . View in PubMed
  • The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature Laryngoscope Investig Otolaryngol. 2021 Jun; 6(3):458-468. . View in PubMed
  • Transmastoid and Transtemporal Drainage of Petrous Apicitis with Otitis Media Ann Otol Rhinol Laryngol. 2021 Mar; 130(3):314-318. . View in PubMed
  • Effects of Neurod1 Expression on Mouse and Human Schwannoma Cells Laryngoscope. 2021 01; 131(1):E259-E270. . View in PubMed
  • Gene therapy for hair cell regeneration: Review and new data Hear Res. 2020 09 01; 394:107981. . View in PubMed
  • Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae Mol Ther Methods Clin Dev. 2020 Jun 12; 17:1167-1177. . View in PubMed
  • An Osseous Destructive Mass of the Infratemporal Fossa JAMA Otolaryngol Head Neck Surg. 2020 02 01; 146(2):194-195. . View in PubMed
  • Gene therapy for hearing loss Hum Mol Genet. 2019 10 01; 28(R1):R65-R79. . View in PubMed
  • Targeted Allele Suppression Prevents Progressive Hearing Loss in the Mature Murine Model of Human TMC1 Deafness Mol Ther. 2019 03 06; 27(3):681-690. . View in PubMed
  • Enhanced viral-mediated cochlear gene delivery in adult mice by combining canal fenestration with round window membrane inoculation Sci Rep. 2018 02 14; 8(1):2980. . View in PubMed
  • Intravenous rAAV2/9 injection for murine cochlear gene delivery Sci Rep. 2017 08 29; 7(1):9609. . View in PubMed
  • RNA Interference Prevents Autosomal-Dominant Hearing Loss Am J Hum Genet. 2016 06 02; 98(6):1101-1113. . View in PubMed
  • Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss Hum Genet. 2016 Apr; 135(4):441-450. . View in PubMed
  • Differential effects of AAVBDNF and AAV. Ntf3 in the deafened adult guinea pig ear. Sci Rep. 2015 Mar 02; 5:8619. . View in PubMed
  • HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice PLoS Genet. 2015 Mar; 11(3):e1005137. . View in PubMed
  • TBC1D24 mutation causes autosomal-dominant nonsyndromic hearing loss Hum Mutat. 2014 Jul; 35(7):819-23. . View in PubMed
  • Brain Res. 2012 May 15; 1454:23-32. . View in PubMed
  • Hyaluronic acid enhances gene delivery into the cochlea Hum Gene Ther. 2012 Mar; 23(3):302-10. . View in PubMed
  • Cochlear infrastructure for electrical hearing Hear Res. 2011 Nov; 281(1-2):65-73. . View in PubMed
  • Nerve maintenance and regeneration in the damaged cochlea Hear Res. 2011 Nov; 281(1-2):56-64. . View in PubMed
  • Future approaches for inner ear protection and repair J Commun Disord. 2010 Jul-Aug; 43(4):295-310. . View in PubMed
  • Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae Exp Neurol. 2010 Jun; 223(2):464-72. . View in PubMed
  • Gene transfer using bovine adeno-associated virus in the guinea pig cochlea Gene Ther. 2009 Aug; 16(8):990-7. . View in PubMed
  • Administration of amitriptyline attenuates noise-induced hearing loss via glial cell line-derived neurotrophic factor (GDNF) induction Brain Res. 2007 May 04; 1144:74-81. . View in PubMed

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