Keck School Faculty

Shannon M Mumenthaler, PhD
Shannon M Mumenthaler, PhD
Assistant Professor of Medicine
Provost - Ellison Institute
CSC 2250 Alcazar St. Ste. 240 Off Campus Los Angeles
Dr. Mumenthaler is an Assistant Professor of Research Medicine at the CAMM. She received a B.S. in Genetics from UC Davis and a Ph.D. in Cellular and Molecular Pathology from UCLA. Although her primary scientific training is in cell biology, Dr. Mumenthaler applies a unique multidisciplinary approach toward her research program, partnering with mathematicians, clinicians, and engineers to explore critical areas in cancer. Her current research interests focus on the development of tools to better understand the evolutionary dynamics of tumor progression and drug resistance with specific investigations into the influence of microenvironmental selective pressures on tumor cell behavior. Toward this goal, Dr. Mumenthaler is closely collaborating with mathematical modelers to combine novel computational platforms with diverse experimental measurements to test and refine biological hypotheses and make clinically relevant predictions.

USC: Medical Faculty Women's Association Award, 2013

National Cancer Institute: Junior Investigator Award, 2013

Third Annual National Cancer Institute Physical Sciences in Oncology Center: Best Poster Award, 2012

University of California, Los Angeles: Hortenese Fishbaugh Memorial Scholarship, 2006-2007

University of California, Los Angeles: Life Sciences Core Curriculum Teaching Assistant Honorarium Award, 2005-2006

University of California, Davis: Graduated with Honors, 2003

University of California, Davis: Undergraduate Student of the Year Award, Division of Biological Sciences, 2003

University of California, Davis: Howard Hughes Medical Institute Summer Honors Advanced Research Program (SHARP) Fellowship, 2002

University of California, Davis: Alumni Scholarship, 2000

Webber Foundation: Academic Scholarship, 1999-2003

AMPK variant, a candidate of novel predictor for chemotherapy in metastatic colorectal cancer: a meta-analysis using TRIBE, MAVERICC, and FIRE3 Int J Cancer. 2019 Mar 11. . View in PubMed

Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3 Eur J Cancer. 2019 Mar 07; 111:138-147. . View in PubMed

MALDI-MSI of Immunotherapy: Mapping the EGFR-Targeting Antibody Cetuximab in 3D Colon-Cancer Cell Cultures Anal Chem. 2018 Dec 18; 90(24):14156-14164. . View in PubMed

MALDI-MSI of Immunotherapy: Mapping the EGFR-Targeting Antibody Cetuximab in 3D Colon Cancer Cell Cultures Anal Chem. 2018 Nov 27. . View in PubMed

mTORC2 contributes to the metabolic reprogramming in EGFR tyrosine-kinase inhibitor resistant cells in non-small cell lung cancer Cancer Lett. 2018 Oct 10; 434:152-159. . View in PubMed

mTORC2 contributes to the metabolic reprogramming in EGFR tyrosine-kinase inhibitor resistant cells in non-small cell lung cancer Cancer Lett. 2018 Jul 20. . View in PubMed

MALDI Mass Spectrometry Imaging for Evaluation of Therapeutics in Colorectal Tumor Organoids J Am Soc Mass Spectrom. 2018 Mar; 29(3):516-526. . View in PubMed

PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems PLoS Comput Biol. 2018 Feb; 14(2):e1005991. . View in PubMed

PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems PLoS Comput Biol. 2018 02; 14(2):e1005991. . View in PubMed

Image-Based Tracking of Heterogeneous Single-Cell Phenotypes Methods Mol Biol. 2018; 1745:47-63. . View in PubMed

Characterization of the mechanical properties of resected porcine organ tissue using optical fiber photoelastic polarimetry Biomed Opt Express. 2017 Oct 01; 8(10):4663-4670. . View in PubMed

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques J Vis Exp. 2017 06 30; (124). . View in PubMed

Single cell dynamic phenotyping Sci Rep. 2016 Oct 06; 6:34785. . View in PubMed

Quantifying differences in cell line population dynamics using CellPD BMC Syst Biol. 2016 Sep 21; 10(1):92. . View in PubMed

Leveraging Hypoxia-Activated Prodrugs to Prevent Drug Resistance in Solid Tumors PLoS Comput Biol. 2016 Aug; 12(8):e1005077. . View in PubMed

A high-content image-based method for quantitatively studying context-dependent cell population dynamics Sci Rep. 2016 Jul 25; 6:29752. . View in PubMed

Leveraging Hypoxia-Activated Prodrugs to Prevent Drug Resistance in Solid Tumors PLoS Comput Biol. 2016 08; 12(8):e1005077. . View in PubMed

Single cell dynamic phenotyping Sci Rep. 2016 10 06; 6:34785. . View in PubMed

Progress Towards Computational 3-D Multicellular Systems Biology Adv Exp Med Biol. 2016; 936:225-246. . View in PubMed

A high-content image-based method for quantitatively studying context-dependent cell population dynamics Sci Rep. 2016 07 25; 6:29752. . View in PubMed

Significance of duon mutations in cancer genomes Sci Rep. 2016 06 08; 6:27437. . View in PubMed

Dual transcript and protein quantification in a massive single cell array Lab Chip. 2016 10 07; 16(19):3682-8. . View in PubMed

Predictive Modeling of Drug Response in Non-Hodgkin's Lymphoma PLoS One. 2015; 10(6):e0129433. . View in PubMed

The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells Cancer Inform. 2015; 14(Suppl 4):19-31. . View in PubMed

Phosphorylated ribosomal S6 (p-rpS6) as a post-treatment indicator of HER2 signalling targeted drug resistance Biomarkers. 2015; 20(5):313-22. . View in PubMed

Anti-MET immunoPET for non-small cell lung cancer using novel fully human antibody fragments Mol Cancer Ther. 2014 Nov; 13(11):2607-17. . View in PubMed

A physical sciences network characterization of non-tumorigenic and metastatic cells Sci Rep. 2013; 3:1449. . View in PubMed

The Need for Integrative Computational Oncology: An Illustrated Example through MMP-Mediated Tissue Degradation Front Oncol. 2013; 3:194. . View in PubMed

Cancer as a moving target: understanding the composition and rebound growth kinetics of recurrent tumors Evol Appl. 2013 Jan; 6(1):54-69. . View in PubMed

Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer Mol Pharm. 2011 Dec 05; 8(6):2069-79. . View in PubMed

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes Mol Cancer Ther. 2009 Oct; 8(10):2882-93. . View in PubMed

17beta-estradiol prevents early-stage atherosclerosis in estrogen receptor-alpha deficient female mice J Cardiovasc Transl Res. 2009 Sep; 2(3):289-99. . View in PubMed

CD4+ NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function Virology. 2009 Apr 25; 387(1):59-66. . View in PubMed

Disruption of arginase II alters prostate tumor formation in TRAMP mice Prostate. 2008 Oct 01; 68(14):1561-9. . View in PubMed

Expression of arginase II in prostate cancer Int J Oncol. 2008 Feb; 32(2):357-65. . View in PubMed

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