Keck School Faculty

Steve Kay

Steve Kay

University and Provost Professor of Neurology, Biomedical Engineering and Biological Sciences, Director of Convergent Bioscience
Co-Director of the USC Norris Center for Cancer Drug Development
KAM 500 Health Sciences Campus Los Angeles

Watching the clock in glioblastoma Neuro Oncol. 2023 Nov 02; 25(11):1932-1946. . View in PubMed

Epidermal GIGANTEA adjusts the response to shade at dusk by directly impinging on PHYTOCHROME INTERACTING FACTOR 7 function bioRxiv. 2023 Mar 23. . View in PubMed

Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2214829120. . View in PubMed

E-box binding transcription factors in cancer Front Oncol. 2023; 13:1223208. . View in PubMed

Phosphorylation of RNA Polymerase II by CDKC;2 Maintains the Arabidopsis Circadian Clock Period Plant Cell Physiol. 2022 Apr 19; 63(4):450-462. . View in PubMed

CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy Proc Natl Acad Sci U S A. 2022 10 04; 119(40):e2203936119. . View in PubMed

The actin cytoskeleton-MRTF/SRF cascade transduces cellular physical niche cues to entrain the circadian clock J Cell Sci. 2022 10 01; 135(19). . View in PubMed

Clocking cancer: the circadian clock as a target in cancer therapy Oncogene. 2021 05; 40(18):3187-3200. . View in PubMed

A genome-wide microRNA screen identifies the microRNA-183/96/182 cluster as a modulator of circadian rhythms Proc Natl Acad Sci U S A. 2021 01 05; 118(1). . View in PubMed

Two bHLH transcription factors, bHLH48 and bHLH60, associate with phytochrome interacting factor 7 to regulate hypocotyl elongation in Arabidopsis Cell Rep. 2021 05 04; 35(5):109054. . View in PubMed

HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape Nat Commun. 2021 11 03; 12(1):6350. . View in PubMed

Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues Int J Mol Sci. 2020 Sep 03; 21(17). . View in PubMed

Changes in ambient temperature are the prevailing cue in determining Brachypodium distachyon diurnal gene regulation New Phytol. 2020 09; 227(6):1709-1724. . View in PubMed

Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis Osteoarthritis Cartilage. 2020 07; 28(7):966-976. . View in PubMed

Isoform-selective regulation of mammalian cryptochromes Nat Chem Biol. 2020 06; 16(6):676-685. . View in PubMed

A mobile ELF4 delivers circadian temperature information from shoots to roots Nat Plants. 2020 04; 6(4):416-426. . View in PubMed

An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in MammalsCell Chem Biol. 2020 09 17; 27(9):1192-1198. e5. . View in PubMed

Light Perception: A Matter of Time Mol Plant. 2020 03 02; 13(3):363-385. . View in PubMed

COP1 destabilizes DELLA proteins in Arabidopsis Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13792-13799. . View in PubMed

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock Cancer Discov. 2019 11; 9(11):1556-1573. . View in PubMed

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth Sci Adv. 2019 01; 5(1):eaau9060. . View in PubMed

GIGANTEA gates gibberellin signaling through stabilization of the DELLA proteins in Arabidopsis Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21893-21899. . View in PubMed

CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation Nat Commun. 2019 09 02; 10(1):3916. . View in PubMed

Multi-level Modulation of Light Signaling by GIGANTEA Regulates Both the Output and Pace of the Circadian ClockDev Cell. 2019 06 17; 49(6):840-851. e8. . View in PubMed

Functional dissection of the ARGONAUTE7 promoter Plant Direct. 2019 Jan; 3(1):e00102. . View in PubMed

Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11528-11536. . View in PubMed

Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Ia and d J Med Chem. 2019 02 28; 62(4):1989-1998. . View in PubMed

Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen Sci Rep. 2019 08 27; 9(1):12405. . View in PubMed

The 6xABRE Synthetic Promoter Enables the Spatiotemporal Analysis of ABA-Mediated Transcriptional Regulation Plant Physiol. 2018 08; 177(4):1650-1665. . View in PubMed

Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins Plant Physiol. 2018 07; 177(3):1170-1186. . View in PubMed

ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis Proc Natl Acad Sci U S A. 2018 05 08; 115(19):E4503-E4511. . View in PubMed

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12305-E12312. . View in PubMed

Guidelines for Genome-Scale Analysis of Biological Rhythms J Biol Rhythms. 2017 Oct; 32(5):380-393. . View in PubMed

Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis Nat Genet. 2017 Oct; 49(10):1546-1552. . View in PubMed

TCP4-dependent induction of CONSTANS transcription requires GIGANTEA in photoperiodic flowering in Arabidopsis PLoS Genet. 2017 Jun; 13(6):e1006856. . View in PubMed

Plant Stress Tolerance Requires Auxin-Sensitive Aux/IAA Transcriptional Repressors Curr Biol. 2017 Feb 06; 27(3):437-444. . View in PubMed

Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9655-E9664. . View in PubMed

Arabidopsis B-BOX32 interacts with CONSTANS-LIKE3 to regulate flowering Proc Natl Acad Sci U S A. 2017 01 03; 114(1):172-177. . View in PubMed

Comparative Analysis of Vertebrate Diurnal/Circadian Transcriptomes PLoS One. 2017; 12(1):e0169923. . View in PubMed

A Modified Yeast-one Hybrid System for Heteromeric Protein Complex-DNA Interaction Studies J Vis Exp. 2017 07 24; (125). . View in PubMed

The Plant Circadian Clock: From a Simple Timekeeper to a Complex Developmental Manager Cold Spring Harb Perspect Biol. 2016 Dec 01; 8(12). . View in PubMed

Molecular mechanisms at the core of the plant circadian oscillator Nat Struct Mol Biol. 2016 Dec; 23(12):1061-1069. . View in PubMed

Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBa Degradation Cell. 2016 Jun 16; 165(7):1644-1657. . View in PubMed

The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation Elife. 2016 Mar 04; 5:e11794. . View in PubMed

Cardiac Abnormalities in Adult Patients With Polymyositis or Dermatomyositis as Assessed by Noninvasive Modalities Arthritis Care Res (Hoboken). 2016 07; 68(7):1012-20. . View in PubMed

Identification of Evening Complex Associated Proteins in Arabidopsis by Affinity Purification and Mass Spectrometry Mol Cell Proteomics. 2016 Jan; 15(1):201-17. . View in PubMed

Identification of Arabidopsis Transcriptional Regulators by Yeast One-Hybrid Screens Using a Transcription Factor ORFeome Methods Mol Biol. 2016; 1398:107-18. . View in PubMed

Cultivated tomato clock runs slow Nat Genet. 2016 Jan; 48(1):8-9. . View in PubMed

Integration of Light and Photoperiodic Signaling in Transcriptional Nuclear Foci Dev Cell. 2015 Nov 09; 35(3):311-21. . View in PubMed

Identification of Open Stomata1-Interacting Proteins Reveals Interactions with Sucrose Non-fermenting1-Related Protein Kinases2 and with Type 2A Protein Phosphatases That Function in Abscisic Acid Responses Plant Physiol. 2015 Sep; 169(1):760-79. . View in PubMed

Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock ChemMedChem. 2015 Sep; 10(9):1489-97. . View in PubMed

Genome-wide identification of CCA1 targets uncovers an expanded clock network in Arabidopsis Proc Natl Acad Sci U S A. 2015 Aug 25; 112(34):E4802-10. . View in PubMed

Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9166-73. . View in PubMed

C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock Angew Chem Int Ed Engl. 2015 Jun 08; 54(24):7193-7. . View in PubMed

A parametric classification rule based on the exponentially embedded family IEEE Trans Neural Netw Learn Syst. 2015 Feb; 26(2):367-77. . View in PubMed

An Arabidopsis gene regulatory network for secondary cell wall synthesis Nature. 2015 Jan 29; 517(7536):571-5. . View in PubMed

Control of plant stem cell function by conserved interacting transcriptional regulators Nature. 2015 Jan 15; 517(7534):377-80. . View in PubMed

Identification of small-molecule modulators of the circadian clock Methods Enzymol. 2015; 551:267-82. . View in PubMed

Tissue-specific clocks in Arabidopsis show asymmetric coupling Nature. 2014 Nov 20; 515(7527):419-22. . View in PubMed

HsfB2b-mediated repression of PRR7 directs abiotic stress responses of the circadian clock Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16172-7. . View in PubMed

Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15267-72. . View in PubMed

FBH1 affects warm temperature responses in the Arabidopsis circadian clock Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14595-600. . View in PubMed

A genome-scale resource for the functional characterization of Arabidopsis transcription factors Cell Rep. 2014 Jul 24; 8(2):622-32. . View in PubMed

Transcriptional regulation of LUX by CBF1 mediates cold input to the circadian clock in Arabidopsis Curr Biol. 2014 Jul 07; 24(13):1518-24. . View in PubMed

CD84 is a survival receptor for CLL cells Oncogene. 2014 Feb 20; 33(8):1006-16. . View in PubMed

Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):2040-5. . View in PubMed

Daily changes in temperature, not the circadian clock, regulate growth rate in Brachypodium distachyon PLoS One. 2014; 9(6):e100072. . View in PubMed

Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock Dev Biol. 2013 Aug 15; 380(2):259-73. . View in PubMed

Global approaches for telling time: omics and the Arabidopsis circadian clock Semin Cell Dev Biol. 2013 May; 24(5):383-92. . View in PubMed

BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis Plant Cell. 2013 Apr; 25(4):1228-42. . View in PubMed

Circadian surprise--it's not all about transcription Science. 2012 Oct 19; 338(6105):338-40. . View in PubMed

CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):17129-34. . View in PubMed

Identification of small molecule activators of cryptochrome Science. 2012 Aug 31; 337(6098):1094-7. . View in PubMed

Complexity in the wiring and regulation of plant circadian networks Curr Biol. 2012 Aug 21; 22(16):R648-57. . View in PubMed

Linking photoreceptor excitation to changes in plant architecture Genes Dev. 2012 Apr 15; 26(8):785-90. . View in PubMed

Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3167-72. . View in PubMed

ELF3 recruitment to the PRR9 promoter requires other Evening Complex members in the Arabidopsis circadian clock Plant Signal Behav. 2012 Feb; 7(2):170-3. . View in PubMed

Cell-autonomous hepatic circadian clock regulates polyamine synthesis Cell Cycle. 2012 Feb 01; 11(3):422-3. . View in PubMed

[Circadian clocks and photoperiodism] Fukuoka Igaku Zasshi. 2012 Feb; 103(2):29-34. . View in PubMed

Gene transfer in Leptolyngbya spstrain BL0902, a cyanobacterium suitable for production of biomass and bioproducts. PLoS One. 2012; 7(1):e30901. . View in PubMed

Rapid in vivo testing of drug response in multiple myeloma made possible by xenograft to turkey embryos Br J Cancer. 2011 Nov 22; 105(11):1708-18. . View in PubMed

Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis Proc Natl Acad Sci U S A. 2011 Nov 08; 108(45):18560-5. . View in PubMed

A small molecule modulates circadian rhythms through phosphorylation of the period protein Angew Chem Int Ed Engl. 2011 Nov 04; 50(45):10608-11. . View in PubMed

Enhanced Y1H assays for Arabidopsis Nat Methods. 2011 Oct 30; 8(12):1053-5. . View in PubMed

The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth Nature. 2011 Jul 13; 475(7356):398-402. . View in PubMed

GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11698-703. . View in PubMed

Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis Plant J. 2011 Mar; 65(6):991-1000. . View in PubMed

LUX ARRHYTHMO encodes a nighttime repressor of circadian gene expression in the Arabidopsis core clock Curr Biol. 2011 Jan 25; 21(2):126-33. . View in PubMed

Global profiling of rice and poplar transcriptomes highlights key conserved circadian-controlled pathways and cis-regulatory modules PLoS One. 2011; 6(6):e16907. . View in PubMed

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIa as a clock regulatory kinase PLoS Biol. 2010 Dec 14; 8(12):e1000559. . View in PubMed

Clocks not winding down: unravelling circadian networks Nat Rev Mol Cell Biol. 2010 Nov; 11(11):764-76. . View in PubMed

Emergence of noise-induced oscillations in the central circadian pacemaker PLoS Biol. 2010 Oct 12; 8(10):e1000513. . View in PubMed

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis Nat Med. 2010 Oct; 16(10):1152-6. . View in PubMed

Climate change and the integrity of science Science. 2010 May 07; 328(5979):689-90. . View in PubMed

An expanding universe of circadian networks in higher plants Trends Plant Sci. 2010 May; 15(5):259-65. . View in PubMed

F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression Plant Cell. 2010 Mar; 22(3):606-22. . View in PubMed

Circadian control of global gene expression patterns Annu Rev Genet. 2010; 44:419-44. . View in PubMed

Suprachiasmatic nucleus: cell autonomy and network properties Annu Rev Physiol. 2010; 72:551-77. . View in PubMed

A genome-wide RNAi screen for modifiers of the circadian clock in human cells Cell. 2009 Oct 02; 139(1):199-210. . View in PubMed

High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms Chem Biol. 2009 Sep 25; 16(9):921-7. . View in PubMed

A model of the cell-autonomous mammalian circadian clock Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11107-12. . View in PubMed

HSP90, a capacitor of behavioral variation J Biol Rhythms. 2009 Jun; 24(3):183-92. . View in PubMed

Cytochrome P450 monooxygenases as reporters for circadian-regulated pathways Plant Physiol. 2009 Jun; 150(2):858-78. . View in PubMed

A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock Science. 2009 Mar 13; 323(5920):1481-5. . View in PubMed

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2097-103. . View in PubMed

Exploring the transcriptional landscape of plant circadian rhythms using genome tiling arrays Genome Biol. 2009 Feb 11; 10(2):R17. . View in PubMed

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20746-51. . View in PubMed

The CXCR4 antagonist AMD3100 impairs survival of human AML cells and induces their differentiation Leukemia. 2008 Dec; 22(12):2151-5158. . View in PubMed

SnapShot: circadian clock proteinsCell. 2008 Oct 17; 135(2):368-368. e1. . View in PubMed

A morning-specific phytohormone gene expression program underlying rhythmic plant growth PLoS Biol. 2008 Sep 16; 6(9):e225. . View in PubMed

[Molecular mechanism by which plant determines flowering timing with circadian clock] Tanpakushitsu Kakusan Koso. 2008 May; 53(6):739-46. . View in PubMed

Photoperiodic flowering occurs under internal and external coincidence Plant Signal Behav. 2008 Apr; 3(4):269-71. . View in PubMed

Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms PLoS Genet. 2008 Feb 29; 4(2):e1000023. . View in PubMed

Network discovery pipeline elucidates conserved time-of-day-specific cis-regulatory modules PLoS Genet. 2008 Feb; 4(2):e14. . View in PubMed

Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development Genome Biol. 2008; 9(8):R130. . View in PubMed

Circadian rhythmsDaily watch on metabolism. Science. 2007 Dec 14; 318(5857):1730-1. . View in PubMed

PRR7 protein levels are regulated by light and the circadian clock in Arabidopsis Plant J. 2007 Nov; 52(3):548-60. . View in PubMed

PRR3 Is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock Plant Cell. 2007 Nov; 19(11):3462-73. . View in PubMed

Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP J Biol Chem. 2007 Oct 26; 282(43):31349-57. . View in PubMed

FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis Science. 2007 Oct 12; 318(5848):261-5. . View in PubMed

Mammalian circadian signaling networks and therapeutic targets Nat Chem Biol. 2007 Oct; 3(10):630-9. . View in PubMed

Plant biology: time for growth Nature. 2007 Jul 19; 448(7151):265-6. . View in PubMed

Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12057-62. . View in PubMed

In SYNC: the ins and outs of circadian oscillations in calcium Sci STKE. 2007 Jun 12; 2007(390):pe32. . View in PubMed

Intercellular coupling confers robustness against mutations in the SCN circadian clock network Cell. 2007 May 04; 129(3):605-16. . View in PubMed

Impaired clock output by altered connectivity in the circadian network Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5650-5. . View in PubMed

Exploring spatiotemporal organization of SCN circuits Cold Spring Harb Symp Quant Biol. 2007; 72:527-41. . View in PubMed

The DIURNAL project: DIURNAL and circadian expression profiling, model-based pattern matching, and promoter analysis Cold Spring Harb Symp Quant Biol. 2007; 72:353-63. . View in PubMed

A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development Plant Cell. 2006 Nov; 18(11):2919-28. . View in PubMed

Photoperiodic control of flowering: not only by coincidence Trends Plant Sci. 2006 Nov; 11(11):550-8. . View in PubMed

Arabidopsis FHY3 specifically gates phytochrome signaling to the circadian clock Plant Cell. 2006 Oct; 18(10):2506-16. . View in PubMed

Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription J Neurochem. 2006 Jul; 98(1):248-57. . View in PubMed

Feedback repression is required for mammalian circadian clock function Nat Genet. 2006 Mar; 38(3):312-9. . View in PubMed

A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9 Mol Syst Biol. 2006; 2:58. . View in PubMed

Circadian rhythms lit up in Chlamydomonas Genome Biol. 2006; 7(4):215. . View in PubMed

LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10387-92. . View in PubMed

FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis Science. 2005 Jul 08; 309(5732):293-7. . View in PubMed

Positive and negative factors confer phase-specific circadian regulation of transcription in Arabidopsis Plant Cell. 2005 Jul; 17(7):1926-40. . View in PubMed

Rapid array mapping of circadian clock and developmental mutations in Arabidopsis Plant Physiol. 2005 Jun; 138(2):990-7. . View in PubMed

Bioluminescence imaging in living organisms Curr Opin Biotechnol. 2005 Feb; 16(1):73-8. . View in PubMed

Overlapping and distinct roles of PRR7 and PRR9 in the Arabidopsis circadian clock Curr Biol. 2005 Jan 11; 15(1):47-54. . View in PubMed

Real-time reporting of circadian-regulated gene expression by luciferase imaging in plants and mammalian cells Methods Enzymol. 2005; 393:269-88. . View in PubMed

Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression Curr Biol. 2004 Dec 29; 14(24):2289-95. . View in PubMed

Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes Am J Transplant. 2004 Sep; 4(9):1475-89. . View in PubMed

A functional genomics strategy reveals Rora as a component of the mammalian circadian clock Neuron. 2004 Aug 19; 43(4):527-37. . View in PubMed

Universality and flexibility in gene expression from bacteria to human Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3765-9. . View in PubMed

Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana Nature. 2003 Dec 04; 426(6966):567-70. . View in PubMed

A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription FEBS Lett. 2003 Dec 04; 555(2):341-5. . View in PubMed

The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling Curr Biol. 2003 Dec 02; 13(23):2091-6. . View in PubMed

HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression Plant Physiol. 2003 Dec; 133(4):1565-77. . View in PubMed

A genomic analysis of the shade avoidance response in Arabidopsis Plant Physiol. 2003 Dec; 133(4):1617-29. . View in PubMed

FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis Nature. 2003 Nov 20; 426(6964):302-6. . View in PubMed

Gene arrays are not just for measuring gene expression Trends Plant Sci. 2003 Sep; 8(9):413-6. . View in PubMed

Melanopsin is required for non-image-forming photic responses in blind mice Science. 2003 Jul 25; 301(5632):525-7. . View in PubMed

Circadian clocks in daily and seasonal control of development Science. 2003 Jul 18; 301(5631):326-8. . View in PubMed

Living by the calendar: how plants know when to flower Nat Rev Mol Cell Biol. 2003 Apr; 4(4):265-75. . View in PubMed

DNA arrays: applications and implications for circadian biology J Biol Rhythms. 2003 Apr; 18(2):96-105. . View in PubMed

Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3380-5. . View in PubMed

Dual role of TOC1 in the control of circadian and photomorphogenic responses in Arabidopsis Plant Cell. 2003 Jan; 15(1):223-36. . View in PubMed

Circadian light input in plants, flies and mammals Novartis Found Symp. 2003; 253:73-82; discussion 82-8102-9281-4. . View in PubMed

Circadian transcriptional output in the SCN and liver of the mouse Novartis Found Symp. 2003; 253:171-80; discussion 52-5102-9180-3 passim. . View in PubMed

Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting Science. 2002 Dec 13; 298(5601):2213-6. . View in PubMed

Molecular basis of seasonal time measurement in Arabidopsis Nature. 2002 Sep 19; 419(6904):308-12. . View in PubMed

tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator Dev Cell. 2002 Jul; 3(1):51-61. . View in PubMed

Circadian rhythms from flies to human Nature. 2002 May 16; 417(6886):329-35. . View in PubMed

Coordinated transcription of key pathways in the mouse by the circadian clock Cell. 2002 May 03; 109(3):307-20. . View in PubMed

Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis Curr Biol. 2002 Apr 30; 12(9):757-61. . View in PubMed

A P element with a novel fusion of reporters identifies regular, a C2H2 zinc-finger gene downstream of the circadian clock Mol Cell Neurosci. 2002 Apr; 19(4):501-14. . View in PubMed

A role for LKP2 in the circadian clock of Arabidopsis Plant Cell. 2001 Dec; 13(12):2659-70. . View in PubMed

Regulation of the cycling of timeless (tim) RNA J Neurobiol. 2001 Jun 05; 47(3):161-75. . View in PubMed

The limits of GMO detection Nat Biotechnol. 2001 May; 19(5):405. . View in PubMed

Analysis of the function of two circadian-regulated CONSTANS-LIKE genes Plant J. 2001 Apr; 26(1):15-22. . View in PubMed

Sequence interpretationFunctional annotation of mouse genome sequences. Science. 2001 Feb 16; 291(5507):1251-5. . View in PubMed

Circadian photoperception Annu Rev Physiol. 2001; 63:677-94. . View in PubMed

Orchestrated transcription of key pathways in Arabidopsis by the circadian clock Science. 2000 Dec 15; 290(5499):2110-3. . View in PubMed

Specific sequences outside the E-box are required for proper per expression and behavioral rescue J Biol Rhythms. 2000 Dec; 15(6):472-82. . View in PubMed

The period E-box is sufficient to drive circadian oscillation of transcription in vivo J Biol Rhythms. 2000 Dec; 15(6):462-71. . View in PubMed

Cryptochromes are required for phytochrome signaling to the circadian clock but not for rhythmicity Plant Cell. 2000 Dec; 12(12):2499-2510. . View in PubMed

Functional interaction of phytochrome B and cryptochrome 2 Nature. 2000 Nov 09; 408(6809):207-11. . View in PubMed

Circadian rhythm genetics: from flies to mice to humans Nat Genet. 2000 Sep; 26(1):23-7. . View in PubMed

Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog Science. 2000 Aug 04; 289(5480):768-71. . View in PubMed

Flower arranging in Arabidopsis Science. 2000 Jun 02; 288(5471):1600-2. . View in PubMed

Fluorescent differential display identifies circadian clock-regulated genes in Arabidopsis thaliana J Biol Rhythms. 2000 Jun; 15(3):208-17. . View in PubMed

Microarrays: determining the balance of cellular transcription Plant Cell. 2000 May; 12(5):613-6. . View in PubMed

ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis Cell. 2000 Apr 28; 101(3):319-29. . View in PubMed

Time flies for Drosophila Cell. 2000 Feb 04; 100(3):297-300. . View in PubMed

Control of circadian rhythms and photoperiodic flowering by the Arabidopsis GIGANTEA gene Science. 1999 Sep 03; 285(5433):1579-82. . View in PubMed

A patient preference study comparing raltitrexed ('Tomudex') and bolus or infusional 5-fluorouracil regimens in advanced colorectal cancer: influence of side-effects and administration attributes Eur J Cancer Care (Engl). 1999 Sep; 8(3):154-61. . View in PubMed

Cryptochromes--bringing the blues to circadian rhythms Trends Cell Biol. 1999 Aug; 9(8):295-8. . View in PubMed

Light-dependent sequestration of TIMELESS by CRYPTOCHROME Science. 1999 Jul 23; 285(5427):553-6. . View in PubMed

Light-dependent translocation of a phytochrome B-GFP fusion protein to the nucleus in transgenic Arabidopsis J Cell Biol. 1999 May 03; 145(3):437-45. . View in PubMed

The ins and outs of circadian regulated gene expression Curr Opin Plant Biol. 1999 Apr; 2(2):114-20. . View in PubMed

Synchronous real-time reporting of multiple cellular events Methods Cell Biol. 1999; 58:283-91. . View in PubMed

The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila Cell. 1998 Nov 25; 95(5):681-92. . View in PubMed

Phytochromes and cryptochromes in the entrainment of the Arabidopsis circadian clock Science. 1998 Nov 20; 282(5393):1488-90. . View in PubMed

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim Science. 1998 Jun 05; 280(5369):1599-603. . View in PubMed

An Arabidopsis mutant hypersensitive to red and far-red light signals Plant Cell. 1998 Jun; 10(6):889-904. . View in PubMed

Transcription of Arabidopsis and wheat Cab genes in single tobacco transgenic seedlings exhibits independent rhythms in a developmentally regulated fashion Plant J. 1998 Feb; 13(4):563-9. . View in PubMed

The short-period mutant, toc1-1, alters circadian clock regulation of multiple outputs throughout development in Arabidopsis thaliana Development. 1998 Feb; 125(3):485-94. . View in PubMed

Independent photoreceptive circadian clocks throughout Drosophila Science. 1997 Nov 28; 278(5343):1632-5. . View in PubMed

Reporter gene expression for monitoring gene transfer Curr Opin Biotechnol. 1997 Oct; 8(5):617-22. . View in PubMed

Long-term monitoring of circadian rhythms in c-fos gene expression from suprachiasmatic nucleus cultures Curr Biol. 1997 Oct 01; 7(10):758-66. . View in PubMed

Attenuation of phytochrome A and B signaling pathways by the Arabidopsis circadian clock Plant Cell. 1997 Oct; 9(10):1727-43. . View in PubMed

Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila EMBO J. 1997 Aug 15; 16(16):5006-18. . View in PubMed

Coordination of Plant Metabolism and Development by the Circadian Clock Plant Cell. 1997 Jul; 9(7):1235-1244. . View in PubMed

Quantitative analysis of Drosophila period gene transcription in living animals J Biol Rhythms. 1997 Jun; 12(3):204-17. . View in PubMed

As time PASses: the first mammalian clock gene Science. 1997 May 16; 276(5315):1093. . View in PubMed

PAS, present, and future: clues to the origins of circadian clocks Science. 1997 May 02; 276(5313):753-4. . View in PubMed

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Dr. Steve Kay currently serves as the Director of the MESH (Medicine, Engineering, Sciences, and Humanities) Academy, the Director of the USC Michelson Center for Convergent Bioscience, and is a Provost Professor of Neurology, Biomedical Engineering and Biological Sciences at the Keck School of Medicine of USC. He held the position as the 21st dean of the USC Dornsife College of Letters, Arts and Sciences from 2012 to 2015.

Dr. Kay is one of the world’s top experts on the genetics and genomics of circadian rhythms. Having published more than 200 papers, he was named by Thomson Reuters as one of “The World’s Most Influential Scientific Minds” from 2014 to 2017 and has been cited in Science magazine’s “Breakthroughs of the Year” three times since 1997. In 2008, Dr. Kay was elected as a member of the National Academy of Sciences. In 2009 he was elected as a fellow of the American Association for the Advancement of Science, and in 2011 he was awarded the American Society of Plant Biologists’ 2011 Martin Gibbs Medal for his pioneering work in plant sciences. To learn more about the Kay Laboratory and current research visit

Dr. Kay received his PhD and DSc from the University of Bristol, United Kingdom. Prior to joining USC in 2012, Dr. Kay served as dean of biological sciences at the University of California, San Diego. He also has held faculty positions at The Rockefeller University, University of Virginia and The Scripps Research Institute, as well as served as the VP of discovery research at the Genomics Institute of the Novartis Research Foundation, where he focused on using high throughput technologies to push novel development candidates into the Novartis clinical pipeline. Dr. Kay served as president of The Scripps Research Institute from 2015 to 2016. In addition, he has founded several biotechnology companies.
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