Steven Grossman

Professor of Medicine

The Ronald H. Bloom Family Chair in Cancer Research

Cancer Physician in Chief

Vice Chair for Cancer Programs in the Department for Medicine

Image of Steven Grossman
Is this your profile? Click to edit

Publications

  • Evidence for a causal link between intra-pancreatic fat deposition and pancreatic cancer: A prospective cohort and Mendelian randomization study Cell Rep Med. 2024 Dec 17; 5(12):101842. . View in PubMed
  • Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells Nat Biotechnol. 2024 Dec 09. . View in PubMed
  • The Causal Effect of Intrapancreatic Fat Deposition on Acute and Chronic Pancreatitis: A Mendelian Randomization Study Am J Gastroenterol. 2024 Dec 01; 119(12):2540-2544. . View in PubMed
  • Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis Cancer Lett. 2024 Nov 01; 604:217240. . View in PubMed
  • Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis Cancer Res Commun. 2024 10 01; 4(10):2685-2698. . View in PubMed
  • Genetic Evidence for a Causal Link between Intra-Pancreatic Fat Deposition and Pancreatitis: a Mendelian Randomization Study medRxiv. 2024 Jun 04. . View in PubMed
  • Evidence for a causal link between intra-pancreatic fat deposition and pancreatic cancer: A prospective cohort and Mendelian randomization study Cell Rep Med. 2024 Feb 20; 5(2):101391. . View in PubMed
  • Proteasome inhibition paradoxically degrades gain-of-function mutant p53 R273H in NSCLC and could have therapeutic implications Front Oncol. 2024; 14:1363543. . View in PubMed
  • Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma Oncogenesis. 2023 Nov 10; 12(1):53. . View in PubMed
  • Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer Cancer Res Commun. 2023 10 04; 3(10):2003-2013. . View in PubMed
  • Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis bioRxiv. 2023 Apr 28. . View in PubMed
  • Genetic Evidence Causally Linking Pancreas Fat to Pancreatic Cancer: A Mendelian Randomization Study medRxiv. 2023 Apr 26. . View in PubMed
  • Rising Incidence and Racial Disparities of Early-Onset Pancreatic Cancer in the United States, 1995-2018Gastroenterology. 2022 07; 163(1):310-312. e1. . View in PubMed
  • Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation Oncologist. 2021 07; 26(7):e1104-e1109. . View in PubMed
  • Cryo-EM structure of CtBP2 confirms tetrameric architectureStructure. 2021 04 01; 29(4):310-319. e5. . View in PubMed
  • The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3 Nat Commun. 2021 01 29; 12(1):704. . View in PubMed
  • CtBP determines ovarian cancer cell fate through repression of death receptors Cell Death Dis. 2020 04 24; 11(4):286. . View in PubMed
  • Harnessing the vulnerabilities of p53 mutants in lung cancer – Focusing on the proteasome: a new trick for an old foe? Cancer Biol Ther. 2020 04 02; 21(4):293-302.. View in PubMed
  • Extraction of high-quality RNA from mouse pancreatic tumors MethodsX. 2020; 7:101163. . View in PubMed
  • p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis Oncotarget. 2019 Dec 10; 10(65):6997-7009. . View in PubMed
  • CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma Oncogenesis. 2019 Oct 04; 8(10):55. . View in PubMed
  • Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities Mol Pharmacol. 2019 07; 96(1):99-108. . View in PubMed
  • DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 PolyubiquitinationCell Rep. 2019 03 19; 26(12):3323-3335. e4. . View in PubMed
  • An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition Oncotarget. 2018 Aug 21; 9(65):32408-32418. . View in PubMed
  • Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia Oncogene. 2017 08 17; 36(33):4810-4816. . View in PubMed
  • CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors Cancer Biol Ther. 2017 06 03; 18(6):379-391. . View in PubMed
  • Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells Mol Oncol. 2017 06; 11(6):696-711. . View in PubMed
  • Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication J Clin Invest. 2017 May 01; 127(5):1839-1855. . View in PubMed
  • Clinic Blood Pressure Underestimates Ambulatory Blood Pressure in an Untreated Employer-Based US Population: Results From the Masked Hypertension Study Circulation. 2016 Dec 06; 134(23):1794-1807. . View in PubMed
  • Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP) Bioorg Med Chem. 2016 06 15; 24(12):2707-15. . View in PubMed
  • Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination Mol Cancer Res. 2016 05; 14(5):423-36. . View in PubMed
  • Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter Oncotarget. 2016 Mar 15; 7(11):12426-46. . View in PubMed
  • Structure-guided design of a high affinity inhibitor to human CtBP ACS Chem Biol. 2015 Apr 17; 10(4):1118-27. . View in PubMed
  • The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing Nucleic Acids Res. 2014 Jan; 42(2):926-40. . View in PubMed
  • Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells Cell Cycle. 2014; 13(22):3506-18. . View in PubMed
  • Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl Genes Cancer. 2012 Jul; 3(7-8):491-502. . View in PubMed
  • Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer Clin Genitourin Cancer. 2012 Mar; 10(1):15-20. . View in PubMed
  • The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis Mol Cancer Res. 2011 Jul; 9(7):867-77. . View in PubMed
  • Therapeutic targeting of C-terminal binding protein in human cancer Cell Cycle. 2010 Sep 15; 9(18):3740-50. . View in PubMed
  • The accuracy of pain and fatigue items across different reporting periods Pain. 2008 Sep 30; 139(1):146-157. . View in PubMed
  • p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein Cancer Res. 2008 Jan 15; 68(2):476-82. . View in PubMed
  • The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor Cancer Res. 2007 Oct 01; 67(19):9322-9. . View in PubMed
  • Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis Mol Cell Biol. 2006 Mar; 26(6):2360-72. . View in PubMed
  • ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation Mol Cell Biol. 2005 Aug; 25(15):6639-48. . View in PubMed
  • Yin Yang 1 is a negative regulator of p53 Cell. 2004 Jun 25; 117(7):859-72. . View in PubMed
  • Physical and functional interactions between PML and MDM2 J Biol Chem. 2003 Aug 01; 278(31):29288-97. . View in PubMed