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Steven Grossman

Professor of Medicine

The Ronald H. Bloom Family Chair in Cancer Research

Cancer Physician in Chief

Vice Chair for Cancer Programs in the Department for Medicine

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Email steveng5@usc.edu
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Publications

  • Evidence for a causal link between intra-pancreatic fat deposition and pancreatic cancer: A prospective cohort and Mendelian randomization study Cell Rep Med. 2024 Feb 20; 5(2):101391. . View in PubMed
  • Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma Oncogenesis. 2023 Nov 10; 12(1):53. . View in PubMed
  • Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis bioRxiv. 2023 Apr 28. . View in PubMed
  • Genetic Evidence Causally Linking Pancreas Fat to Pancreatic Cancer: A Mendelian Randomization Study medRxiv. 2023 Apr 26. . View in PubMed
  • Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer Cancer Res Commun. 2023 10 04; 3(10):2003-2013. . View in PubMed
  • Rising Incidence and Racial Disparities of Early-Onset Pancreatic Cancer in the United States, 1995-2018Gastroenterology. 2022 07; 163(1):310-312. e1. . View in PubMed
  • Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation Oncologist. 2021 07; 26(7):e1104-e1109. . View in PubMed
  • Cryo-EM structure of CtBP2 confirms tetrameric architectureStructure. 2021 04 01; 29(4):310-319. e5. . View in PubMed
  • Extraction of high-quality RNA from mouse pancreatic tumors MethodsX. 2020; 7:101163. . View in PubMed
  • CtBP determines ovarian cancer cell fate through repression of death receptors Cell Death Dis. 2020 04 24; 11(4):286. . View in PubMed
  • CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma Oncogenesis. 2019 Oct 04; 8(10):55. . View in PubMed
  • Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities Mol Pharmacol. 2019 07; 96(1):99-108. . View in PubMed
  • DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 PolyubiquitinationCell Rep. 2019 03 19; 26(12):3323-3335. e4. . View in PubMed
  • An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition Oncotarget. 2018 Aug 21; 9(65):32408-32418. . View in PubMed
  • Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia Oncogene. 2017 08 17; 36(33):4810-4816. . View in PubMed
  • CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors Cancer Biol Ther. 2017 06 03; 18(6):379-391. . View in PubMed
  • Clinic Blood Pressure Underestimates Ambulatory Blood Pressure in an Untreated Employer-Based US Population: Results From the Masked Hypertension Study Circulation. 2016 Dec 06; 134(23):1794-1807. . View in PubMed
  • Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination Mol Cancer Res. 2016 05; 14(5):423-36. . View in PubMed
  • Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP) Bioorg Med Chem. 2016 06 15; 24(12):2707-15. . View in PubMed
  • Structure-guided design of a high affinity inhibitor to human CtBP ACS Chem Biol. 2015 Apr 17; 10(4):1118-27. . View in PubMed
  • Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells Cell Cycle. 2014; 13(22):3506-18. . View in PubMed
  • Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer Clin Genitourin Cancer. 2012 Mar; 10(1):15-20. . View in PubMed
  • Therapeutic targeting of C-terminal binding protein in human cancer Cell Cycle. 2010 Sep 15; 9(18):3740-50. . View in PubMed
  • The accuracy of pain and fatigue items across different reporting periods Pain. 2008 Sep 30; 139(1):146-157. . View in PubMed
  • p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein Cancer Res. 2008 Jan 15; 68(2):476-82. . View in PubMed
  • The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor Cancer Res. 2007 Oct 01; 67(19):9322-9. . View in PubMed
  • Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis Mol Cell Biol. 2006 Mar; 26(6):2360-72. . View in PubMed

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